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Searching for the emotional roots of breast cancer: A cross-disciplinary analysis integrating psychology, Chinese medicine, and oncology biomarkers

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Journal of Integrative Medicine 2022年第1期20卷 57-64页

作者： Ofer Baranovitch Meirav Wolff-Bar Meora Feinmesser Chen Sade-Zaltz ilan tsarfaty Victoria Neiman Integrative Unit Davidoff Cancer CenterRabin Medical CenterPetach Tikva 4941492Israel Maccabi Tivi(Maccabi Health Organization) Tel Aviv 6801294Israel Department of Pathology Rabin Medical CenterPetach Tikva 4941492Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel Department of Clinical Microbiology and Immunology Sackler School of MedicineTel Aviv UniversityTel Aviv 6997801Israel Institute of Oncology Davidoff Cancer CenterRabin Medical CenterPetach Tikva 4941492Israel

Objective: We employed a multidisciplinary approach incorporating theoretical ideas, clinical experience,psychology, physiology, traditional Chinese medicine(CM), modern practice of CM, and oncology to explore the effect of patients’ repression of negative emotions and traumatic events on breast cancer(BC) ***: BC female patients, older than 18 years of age, with available pathology reports who were treated at Rabin Medical Center were recruited. All participants completed questionnaires regarding medical history, behavioral tendencies, negative emotions, trauma, symptoms, and pathology(from a CM perspective). Data on tumor characteristics were collected from the pathology reports. The associations were examined using hierarchical binary logistic ***: A total of 155 BC patients were enrolled. The median age was 52 years, with a range of 26–79;95% were mothers;28% had estrogen receptor(ER)-negative BC, 52% had progesterone receptor(PR)-negative BC, 48% had human epidermal growth factor receptor 2-negative BC, and antigen Ki-67 ≥ 20%was reported for 52% of tumors. Statistically significant associations were found between the emotional markers(sense of motherhood failure, and lack of self-fulfillment), avoidance behavior, and physical symptoms that are related to emotional repression based on CM. Significant associations were also found between variables associated with physical symptoms of emotional repression, which involves the production and accumulation of non-substantial phlegm(i.e., ‘‘high-lipid Qi-like microscopic phlegm"),avoidance behavior which unconsciously uses ‘‘high-lipid Qi-like microscopic phlegm" in order to achieve emotional repression, and tumor parameters including tumor grade, PR status, and *** with higher levels of ‘‘high-lipid Qi-like microscopic phlegm" were more likely to have tumors with worse prognosis(PR-negative, higher grade, and higher Ki-67).Conclusion: We demonstrated a relationship between

关键词： Breast cancer Chinese medicine Negative emotions Repression Trauma Phlegm

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Serum AChE Activities Predict Exercise Heart Rate Parameters of Asymptomatic Individuals

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Neuroscience & Medicine 2010年第2期1卷 43-49页

作者： Canaani Jonathan Shenhar-tsarfaty Shani Weiskopf Nir Yakobi Reut Ben Assayag Einor Berliner Shlomo Soreq Hermona The Life Sciences Institute The Hebrew University Jerusalem Israel The Tel Aviv Sourasky Medical Center Israe The Tel Aviv Sourasky Medical Center Israel

Background specific heart rate parameters notably associate with variable risks of cardiovascular disease and mortal-ity, however, to date there are no readily available blood tests associated with these parameters. Because of the estab-lished parasympathetic contributions towards cardiac regulation, we challenged the working hypothesis that serum acetylcholinesterase (AChE) activity is involved. Methods A total of 403 Healthy men and women were included in the study and underwent treadmill exercise testing. Prior to exercise testing the subject’s serum AChE activity levels were assessed by measuring rates of acetylthiocholine hydrolysis. Results In male subjects AChE activity was positively cor-related to resting heart rate (r = 0.210, p = 0.001). Complementing this observation, AChE activity was negatively correlated to the exercise-induced heart rate increase (r = –0.181, p = 0.005) and to heart rate recovery at 1, 2 and 5 minutes following cessation of exercise (r = –0.150, p = 0.022;r = –0.157, p = 0.016;r = –0.176, p = 0.008 respec-tively). This indicated that lower than average AChE activities, which presumably reflect increased peripheral ACh levels, might be correlated to favorable heart rate parameters. Similar observations were made in female subjects, ex-cept for lack of correlation to their resting heart rate. Additionally, we observed that we were able to stratify subjects into two groups of significantly different AChE activity (p = 0.001) based on a cut point of heart rate recovery below 20 beats one minute after cessation of exercise. Conclusion In asymptomatic individuals lower than average AChE activity is associated with favorable indices of exercise-inducible heart rate increase as well as heart rate recovery. Future studies will be needed to evaluate the added prognostic significance gained by implementing this marker into routine practice.

关键词： Exercise Nervous System Autonomic Heart Rate

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Cell子刊:科学家发现关联焦虑和肥胖的新机制

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疾病监测 2016年第9期31卷 754-754,760页

作者： Meydan C Shenhar-tsarfaty S Soreq H

焦虑和代谢相关的疾病一直是科学家们研究的焦点,虽然很多研究都表明,这两者之间有很强的关联,但是一直缺乏有力的科学依据来证实。近日,来自耶路撒冷希伯来大学的研究人员在分子水平上揭示了焦虑和代谢的联系——一种类型的microRNA将... 详细信息

焦虑和代谢相关的疾病一直是科学家们研究的焦点,虽然很多研究都表明,这两者之间有很强的关联,但是一直缺乏有力的科学依据来证实。近日,来自耶路撒冷希伯来大学的研究人员在分子水平上揭示了焦虑和代谢的联系——一种类型的microRNA将这两者联系在一起,并影响着它们共同的生物学机制。这项研究发表在2016年9月的《Trends in Molecular Medicine》杂志上。

关键词：克罗恩氏病 microRNA 肠道炎症 Cell 应激状况生物学机制炎症反应心理创伤强迫症代谢综合征

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