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Quantitative detection of citrate for early stage diagnosing of prostate cancer:Discriminating normal to cancer in prostate tissues

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Chinese Chemical Letters 2024年第2期35卷 501-506页

作者： Selvaraj Muthusamy Kanagaraj Rajalakshmi Palanisamy Kannan Yun-Sik Nam Dongwei Zhu Yeonggil Seo Jong-Won Song Dong Nyoung Heo il keun kwon Yuanguo Xu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Advanced Analysis Center Korea Institute of Science & TechnologySeongbuk-guSeoul02792Republic of Korea School of Medicine Jiangsu UniversityZhenjiang 212013China Department of Chemistry Education Daegu UniversityGyeongsan-siGyeongsangbuk-do 38453Republic of Korea Department of Dental Materials School of DentistryKyung Hee UniversitySeoulRepublic of Korea

Prostate cancer(PC)biomarker-citrate detection is clinically important to diagnose PC in early stages.Methylquinolinium iodide(Q)conjugated indole-phenylboronic acid(IB)was designed as a red-emissive QIB probe for the detection of citrate through Lewis acid-base reaction and intramolecular charge transfer(ICT)sensing mechanisms.Boronic acid acts as Lewis acid as well as citrate(Lewis base)recognition unit.The probe reacted with citrate,showing enhanced red emissions.Since the probe has excellent water solubility and great biocompatibility,practical application in biological systems is possible.Citrate was monitored precisely in the mitochondria organelle(in vitro)of living cells with a positive charge on QIB.Also,endogenous(in situ)citrate was detected quantitatively to discriminate non-cancerous and PC mice,observed strong and lower(negligible)emission intensity on non-cancerous and cancerous prostate tissues,respectively.Because,the concentration of citrate is higher in healthy prostate compared with PC prostate.Furthermore,the analysis of sliced prostate tissues can give PC-related information for clinical diagnosis to prevent and treat PC in the initial stages.Therefore,we believe that the present probe is a promising biochemical reagent in diagnosing PC.

关键词： Prostate cancer Biomarker-citrate Boronic acid Lewis acid/base-ICT Red-emissive Mitochondria targeting Prostate tissue

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Degradable and Tunable Keratin-fibrinogen Hydrogel as Controlled Release System for Skin Tissue Regeneration

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Journal of Bionic Engineering 2023年第3期20卷 1049-1059页

作者： Sung Jun Min Jae Seo Lee Haram Nah Ho-Jin Moon Sang Jin Lee Hyeon Jeong Kang Yu-Shik Hwang il keun kwon Dong Nyoung Heo Department of Dentistry Graduate SchoolKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Biofriends Inc 26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Dental Materials School of DentistryKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology School of DentistryKyung Hee UniversitySeoul02447Korea Kyung Hee University Medical Science Research Institute Kyung Hee University23 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea

Biodegradable hydrogels are promising biomaterials for use in controlled-release systems for skin tissue regeneration. Controlled delivery systems constitute an important aspect of tissue engineering because they can modulate various physiological responses, including early immune response, tissue remodeling, and cell proliferation and maturation in the wound-healing process. Hydrogels composed of various biomaterials have been developed to overcome the limitations of conventional drug- or protein-delivery systems, such as limited targeting ability, low stability, and the induction of drug resistance. Hydrogels based on keratin, a natural polymer extracted from human hair, can provide adequate cell support and control homeostasis. Consequently, they can be applied for skin tissue engineering. In this study, we prepared degradable, tunable, and biocompatible hydrogels for controllable protein delivery. We synthesized keratin-fibrinogen (KER-FBG) by the chemical coupling reaction and prepared hydrogels through polymerization with thrombin. The structures and morphologies of the KER-FBG hydrogels were confirmed. Furthermore, the mechanical properties, swelling ratio, degradation, release behavior, and biocompatibility were investigated. The KER-FBG hydrogels presented promising biological performance, indicating that the material is suitable as a controlled protein delivery carrier.

关键词： Keratin Fibrinogen Hydrogel Drug delivery Degradable

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Material and mechanical factors:new strategy in cellular neurogenesis

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Neural Regeneration Research 2014年第20期9卷 1810-1813页

作者： Hillary Stoll il keun kwon Jung Yul Lim Department of Biological Systems Engineering University of Nebraska-LincolnLincolnNEUSA The Graduate School of Dentistry Kyung Hee UniversitySeoulKorea Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNEUSA

Since damaged neural circuits are not generally self-recovered, developing methods to stimulate neurogenesis is critically required. Most studies have examined the effects of soluble pharma- cological factors on the cellular neurogenesis. On the other hand, it is now recognized that the other extracellular factors, including material and mechanical cues, also have a strong potential to induce cellular neurogenesis. This article will review recent data on the material （chemical patterning, micro/nano-topography, carbon nanotube, graphene） and mechanical （static cue from substrate stiffness, dynamic cue from stretch and flow shear） stimulations of cellular neuro- genesis. These approaches may provide new neural regenerative medicine protocols. Scaffolding material templates capable of triggering cellular neurogenesis can be explored in the presence of neurogenesis-stimulatory mechanical environments, and also with conventional soluble factors, to enhance axonal growth and neural network formation in neural tissue engineering.

关键词： neural regenerative medicine cellular neurogenesis material cue mechanical factor soluble signal

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Fabrication of 3D Printed PCL/PEG Polyblend Scaffold Using Rapid Prototyping System for Bone Tissue Engineering Application

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Journal of Bionic Engineering 2018年第3期15卷 435-442页

作者： Su A Park Sang Jin Lee Ji Min Seok Jun Hee Lee Wan Doo Kim il keun kwon Department of Nature-Inspired Nanoconvergence Systems Korea Institute of Machinery and Materials 156 Gajeongbuk-ro Yuseong-gu Daejeon 34103 Republic of Korea Department of Dental Materials School of Dentistry Kyung Hee University 26 Kyungheedae-ro Dongdaemun-gu Seou102447 Republic of Korea

Three-dimensional （3D） printing is a novel process used to manufacture bone tissue engineered scaffolds. This process allows for easy control of the architecture at the micro structure. However, the scaffold properties are typically limited in terms of cellular activity at the scaffold surface due to the printed materials properties. In this study, we developed a polycaprolactone （PCL） blended with polyethylene glycol （PEG） 3D printed scaffold using a rapid prototyping system. The manufactured scaffolds were then washed out to form small pores on the surface in order to improve the scaffolds hydrophilicity. We analyzed the resultant material by using Scanning Electron Microscopy （SEM）, water absorption, water contact angle, in vitro WST-1, and the Bradford assay. Additionally, cells incubated on the fabricated scaffolds were visualized by Confocal Laser Scanning Microscopy （CLSM）. The developed scaffolds exhibited small pores on the strand surface which served to increase hydrophilicity as well as improve cellular proliferation and increase total protein content. Our findings suggest that the presence of small pores on the scaffolds can be used as an effective tool for improving implant cellular interaction. This research indicates that these modified scaffolds can be considered useful for bone tissue engineering applications to improve human health.

关键词： polycaprolactone polyethylene glycol polyblend 3D printing porosity bone tissue engineering

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Systemic lupus erythematosus in a 15-year-old female with multiple splenic nodules:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2128-2133页

作者： Mi il Kang Hyeok Chan kwon Division of Rheumatology Department of Internal MedicineDankook University College of MedicineCheonan-si 31116South Korea Division of Rheumatology Department of Internal MedicineDankook University HospitalDankook University College of MedicineCheonan-si 31116South Korea

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic inflammatory disease primarily affecting young females.SLE can invade any organ,and various forms of splenic invasion have been reported.Manifestations include splenomegaly and splenic infarction,rupture,and calcification.The study encountered a rare case of splenic involvement,with nodules of various sizes without calcifications or ruptures.CASE SUMMARY A 15-year-old girl presented with arthralgia,weight loss,fever,increased levels of inflammatory markers,and positive antinuclear antibody test results.The patient was diagnosed with SLE.She was asymptomatic while taking steroids and hydroxychloroquine.Ten months after discharge,the patient developed a fever and abdominal pain.Lupus enteritis was suspected,and abdominopelvic computed tomography(AP-CT)was performed.There were no specific findings in the gastrointestinal tract,but multiple splenic nodules were observed.Infection or hemangioma was considered;however,no specific radiological findings were observed.A biopsy of the spleen was performed to determine the possibility of malignancy.The histological findings of the spleen included extensive periarteriolar necrosis with hematoxylin bodies and numerous karyorrhectic debris.Based on the biopsy results,the patient was diagnosed with an SLE flare-up and was maintained on high-dose steroids and immunosuppressants.CONCLUSION As disease activity increased,multiple nodules in the spleen that were previously unseen were observed using AP-CT and histologically confirmed.Spleen invasion by SLE can appear in multiple nodular forms and patterns.Therefore,physicians should consider these findings when differentiating these nodules from infections and malignancies.

关键词： Multiple nodules Spleen Splenectomy Systemic lupus erythematosus Differential diagnosis Case report

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Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children

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Food Science and Human Wellness 2024年第3期13卷 1494-1502页

作者： Manman Liu Shiwen Han Boya Li Cheng Chen Lu Yao Jung-il kwon Juan Jin Huilian Che Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Maeil Innovation Center Maeil Dairies Co.Ltd.Seoul 03142South Korea

Diarrhea has become the leading cause of illness and death among infants and young children in developing countries.Clinically,patients with diarrhea showed damaged intestinal epithelial villi,usually accompanied by lactase deficiency.In this study,we evaluated the therapeutic effects of lactose-free milk powder on rats and children with diarrhea.Antibiotic-associated diarrhea(AAD)model was established by gavage with antibiotic mixture in SD rats,followed by administration of milk powder containing lactose or not.The results showed that lactose-free milk powder ameliorated A AD-related diarrhea symptoms,and accelerated the recovery from diarrhea.And 16S sequencing results indicated lactose-free milk powder contributed to increase theα-andβ-diversity of intestinal flora,and restore the intestinal microbiota disorder.In conclusion,our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.

关键词： Diarrhea Lactose-free Milk powder Intestinal barrier Gut microbiota

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa kwon Hyung il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee Seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)cancer.AIM To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative resection.METHODS This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and 2018.The impact of CCRT on advanced AoV cancer was analyzed.RESULTS The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,respectively.Lymphovas-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate analysis.Compared to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte ratio.CONCLUSION Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV cancer.These findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in vivo.Methods:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Cell proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay kit.Western blot analysis was performed to determine the protein expressions of related factors.The effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength assay.Chemical composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling pathway.It also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein kinase.In an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip strength.Additionally,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle strength.Conclusions:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Minimum dose path planning for facility inspection based on the discrete Rao-combined ABC algorithm in radioactive environments with obstacles

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Nuclear Science and Techniques 2023年第4期34卷 26-40页

作者： kwon Ryong Hong Su il O Ryon Hui Kim Tae Song Kim Jang Su Kim Faculty of Energy Science Kim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea High-Tech Research&Development Centre Institute of Information TechnologyKim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea

Workers who conduct regular facility inspections in radioactive environments will inevitably be affected by radiation.Therefore,it is important to optimize the inspection path to ensure that workers are exposed to the least amount of radiation.This study proposes a discrete Rao-combined artificial bee colony(ABC)algorithm for planning inspection paths with minimum exposure doses in radioactive environments with obstacles.In this algorithm,retaining the framework of the traditional ABC algorithm,we applied the directional solution update rules of Rao algorithms at the employed bee stage and onlooker bee stage to increase the exploitation ability of the algorithm and implement discretion using the swap operator and swap sequence.To increase the randomness of solution generation,the chaos algorithm was used at the initialization stage.The K-opt operation technique was introduced at the scout bee stage to increase the exploration ability of the algorithm.For path planning in an environment with complex structural obstacles,an obstacle detour technique using a recursive algorithm was applied.To evaluate the performance of the proposed algorithm,we performed experimental simulations in three hypothetical environments and compared the results with those of improved particle swarm optimization,chaos particle swarm optimization,improved ant colony optimization,and discrete Rao’s algorithms.The experimental results show the high performance of the proposed discrete Rao-combined ABC algorithm and its obstacle detour capability.

关键词： Minimum dose Path planning Nuclear facility inspection ABC algorithm Rao algorithms Swap sequence K-opt operation

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Wearable EEG electronics for a Brain–AI Closed-Loop System to enhance autonomous machine decision-making

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npj Flexible Electronics 2022年第1期6卷 296-307页

作者： Joo Hwan Shin Junmo kwon Jong Uk Kim Hyewon Ryu Jehyung Ok SJoon kwon Hyunjin Park Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan University(SKKU)Suwon 16419Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University(SKKU)Suwon 16419Korea Center for Neuroscience Imaging Research Institute for Basic ScienceSuwon 16419Korea Biomedical Institue for Convergence(BICS)SKKU Suwon 16419Korea

Human nonverbal communication tools are very ambiguous and difficult to transfer to machines or artificial intelligence(AI).If the AI understands the mental state behind a user’s decision,it can learn more appropriate decisions even in unclear situations.We introduce the Brain-AI Closed-Loop System(BACLoS),a wireless interaction platform that enables human brain wave analysis and transfers results to AI to verify and enhance AI decision-making.We developed a wireless earbud-like electroencephalography(EEG)measurement device,combined with tattoo-like electrodes and connectors,which enables continuous recording of high-quality EEG signals,especially the error-related potential(ErrP).The sensor measures the ErrP signals,which reflects the human cognitive consequences of an unpredicted machine response.The AI corrects or reinforces decisions depending on the presence or absence of the ErrP signals,which is determined by deep learning classification of the received EEG data.We demonstrate the BACLoS for AIbased machines,including autonomous driving vehicles,maze solvers,and assistant interfaces.

关键词： autonomous EEG enable

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