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Journal of Environmental Sciences 2010年第6期22卷 878-884页

作者： Eisaku Shiratani Yoshiyuki Munakata ikuo Yoshinaga Tomijiro Kubota Koji Hamada Tadayoshi Hitomi National Institute for Rural Engineering Kokusai Kogyo Co.Ltd. National Agricultural Research Centre for Kyushu Okinawa Region

A model in which a river model was layered on a distributed model （double-layered model） was developed to analyse the transport of water and pollutants （nitrogen, phosphorus, and BOD as organic matter） in watersheds and rivers. The model was applied to the watershed of Abragafuchi Lake, Japan, where serious water pollution has occurred over three decades, and the applicability of the model was demonstrated. Scenarios of recycling of sewage treated-water into agriculture to reduce pollutant load discharged into the lake were analysed. The results showed that irrigating paddy fields with the sewage-treated water could contribute to conserving water and reducing pollutant load, with reduction rate in BOD, nitrogen, and phosphorus ranging from 6%-36%, 16%-46%, and 18%-51%, respectively. Particularly, the results indicated that, irrigating paddy fields with the treated water during non-cropping periods and the accompanying reduction in withdrawn water from the river were more effective in reducing pollutant loads discharged into the lake. Further study is required on the effect of recycled water on crop cultivation and soil conditions for safe implementation.

关键词： watershed management paddy field sewage treatment water reuse

Temporal trends in the relative prevalence of dysphagia etiologies from 1999-2009

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World Journal of Gastroenterology 2012年第32期18卷 4335-4341页

作者： Trilokesh Kidambi Erin Toto Nancy Ho Tiffany Taft ikuo Hirano Division of Gastroenterology Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Medicine University of California at San FranciscoSan FranciscoCA 94143United States Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

AIM:To examine the relative prevalence and temporal variation of dysphagia etiologies in patients undergoing upper endoscopy(EGD) over the past ***:EGDs with the indication of dysphagia at an urban,university medical center in 1999,2004 and 2009 were retrospectively identified from the electronic medical *** entire patient chart,including EGD,pathology,manometry,radiographic and clinician reports,was reviewed for demographic and clinical data and to determine the etiology of *** number of EGDs in which an esophageal biopsy was performed was also *** reflux disease(GERD) as a cause of dysphagia independent of peptic stricture was defined by symptoms with erosive esophagitis or symptom response to proton pump inhibition(PPI).Cases of eosinophilic esophagitis(EoE) were defined by an appropriate clinical history and histological criteria of ≥ 15 eosinophils per high powered ***-responsive esophageal eosinophilia was not routinely reported prior to *** analysis was performed using one-way analysis of variance to analyze for trends between 1999,2004 and 2009 and a post-hoc Tukey analysis was performed following a significant main ***:A total of 1371 cases(mean age 54 years,43% male) met pre-specified inclusion criteria with 191,504 and 675 cases in 1999,2004 and 2009,*** were older in 2004 compared to 2009(mean ± SD,54.0 ± 15.7 years vs 52.3 ± 16.8 years,P = 0.02) and there were more males in 1999 compared to 2004(57.5% vs 40.8%,P = 0.005).Overall,GERD(27.6%) and EoE(7.7%) were the most common identifiable causes of *** unspecified diagnosis accounted for 21% of overall *** were no significant differences in the relative prevalence of achalasia or other motility disorders,peptic stricture,Schatzki's ring,esophageal cancer or unspecified diagnoses over the 10-year time *** was,however,a decrease in the relative prevalence of GERD(39.3% vs 24.1%,P < 0.001

关键词： Eosinophilic esophagitis Gastroesophageal reflux disease Dysphagia Endoscopy Esophagitis Esophageal diseases

Thermodynamic assessment of the Ni-Sb binary system

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Rare Metals 2008年第4期27卷 384-392页

作者： CAO Zhanmin TAKAKU Yoshikazu OHNUMA ikuo KAINUMA Ryosuke ZHU Hongmin ISHIDA Kiyohito School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Department of Materials Science Graduate School of Engineering Tohoku University Sendal 980-8578 Japan

The Ni-Sb binary alloy system was thermodynamically assessed using CALPHAD approach in this article. Excess Gibbs energies of solution phases, liquid and fcc phases, were formulated using the Redlich-Kister expression. The intermediate phases were modeled by the sublattice model with （Ni,Va）0.5（Ni,Sb）0.25（Ni）0.25 for Ni3Sb_HT phase and （Ni,Va）0.3333（Sb）0.3333（Ni,Va）0.3333 for NiSb phase. The other phases including Ni3Sb, Ni7Sb3, and NiSb2 were treated as stoichiometric compound owing to their narrow composition ranges. Based on the reported thermodynamic properties and phase diagram data, the thermodynamic parameters of these phases were optimized, and the obtained values can reproduce the available experimental data well.

关键词： Ni-Sb binary system thermodynamic assessment CALPHAD phase diagram

Proposal of a new and simple staging system of colorectal liver metastasis

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World Journal of Gastroenterology 2006年第43期12卷 6961-6965页

作者： ikuo Nagashima Tadahiro Takada Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga Department of Surgery Teikyo University School of Medicine Tokyo Japan Department of Surgical Oncology Graduate School of Medicine University of Tokyo Tokyo Japan

AIM： To create a new, simple and useful staging system for colorectal liver metastasis analogous to the Tumor Node Metastasis classification system of International Union Against Cancer. METHODS： A retrospective review was undertaken of 81 consecutive patients who underwent partial hepatectomy for colorectal liver metastases （group 1）. Clinical and pathological features of both primary and metastatic liver cancers were entered into a multivariate analysis to determine independent variables helpful in accurately predicting long-term prognosis after hepatectomy. Using selected variables, we created a new staging system like TNM classification. The usefulness of the new staging system was examined in a series of 92 patients from another hospital （group 2）. RESULTS： Multivariate analysis showed that 81 patients in group 1 had significant multiple hepatic tumors with the largest tumor being more than 5 cm in diameter, resectable extrahepatic distant metastases, and independent prognostic factors for poor survival after hepatectomy. Using these three variables, we created a new staging system to classify patients with colorectal liver metastases. Finally, our new staging system classified the patients both in group 1 and in group 2. CONCLUSION： Our new staging system of colorecta liver metastasis is simple and useful for staging patients.

关键词： Colorectal liver metastasis Staging system Prognostic factor

Thermodynamic reassessment of Ni–Ga binary system

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Rare Metals 2015年第12期34卷 864-872页

作者： Zhan-Min Cao Xian Shi Wei Xie ikuo Ohnuma Kiyohito Ishida Zhi-Yu Qiao State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Department of Materials Science Graduate School of Engineering Tohoku University

New experimental measurements of the phase diagram and the mixing enthalpy of liquid phase along with the previous experimental data were used in a reassessment of the Ni–Ga system. A set of self-consistent thermodynamic parameters of the Ni–Ga system is obtained using the calculation of phase diagram (CALPHAD) technique, and the available phase diagram and thermodynamic data are reproduced well within experimental error limits. Some noticeable improvements are obtained in the present work compared with the previous assessment: (1) the calculated Ga-rich liquidus is more reasonable; (2) Ni3Ga7 is adopted as the most Ga-rich compound rather than NiGa4; (3) the Ni5Ga3 phase is treated as the nonstoichiometric compound with consideration of its narrow homogeneity range; (4) the phase transformation between B81.5_Ni3Ga2 and Ni13Ga9 is considered instead of treating them as Ni3Ga2 phase simply; (5) the latest experimental data of mixing enthalpy for the liquid phase are adopted. The present study can be used as a basis for the development of a thermodynamic database of the Ni-based semiconductor alloy systems.

关键词： Ni–Ga system CALPHAD technique Thermodynamic reassessment Phase diagram

Importance of considering nutrient loadings from small watersheds to a lake-A case study of the Lake Shinji watershed,Shimane Prefecture,Japan

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 124-130页

作者： Hiroaki Somura Hidenobu Kunii Yasumichi Yone ikuo Takeda Hirokazu Sato Graduate School of Environmental and Life Science Okayama UniversityOkayama 7008530Japan Estuary Research Center Shimane UniversityMatsue 6908504Japan Faculty of Life and Environmental Science Shimane UniversityMatsue 6908504Japan

Nutrient loadings from upstream watersheds can have significant impacts on the water quality of receiving water ***,a major river is selected as the target for water quality studies,and the impact of minor rivers tends to be *** is very important to evaluate whether the impact of small rivers on the downstream water quality is *** water sampling and discharge modeling using SWAT were used to analyze the contribution of small rivers to water quality in a receiving *** this analysis,it was determined that the inflowing total nitrogen(TN)and total phosphorus(TP)concentrations from all target rivers exceeded the lake water environmental standards set by the Ministry of the *** contribution of suspended sediment(SS)and TN loads from small rivers did not vary markedly compared with their relative discharge contributions to the lake,at approximately 20%.However,the impact on TP loads to the lake from small rivers was 9.1%higher than their relative flow contributions,accounting for 28.2% of the TP ***,there is a potential to underestimate the impact of ungauged small rivers if only the major river is selected to evaluate the downstream lake water quality.

关键词： suspended sediment(SS) total nitrogen(TN) total phosphorus(TP) watershed management SWAT model

Multi-modal Gesture Recognition using Integrated Model of Motion, Audio and Video

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 657-665页

作者： GOUTSU Yusuke KOBAYASHI Takaki OBARA Junya KUSAJIMA ikuo TAKEICHI Kazunari TAKANO Wataru NAKAMURA Yoshihiko Department of Mechano-Informatics School of Information Science and TechnologyUniversity of Tokyo7-3-1 HongoBunkyo-kuTokyoJapan

Gesture recognition is used in many practical applications such as human-robot interaction, medical rehabilitation and sign language. With increasing motion sensor development, multiple data sources have become available, which leads to the rise of multi-modal gesture recognition. Since our previous approach to gesture recognition depends on a unimodal system, it is difficult to classify similar motion patterns. In order to solve this problem, a novel approach which integrates motion, audio and video models is proposed by using dataset captured by Kinect. The proposed system can recognize observed gestures by using three models. Recognition results of three models are integrated by using the proposed framework and the output becomes the final result. The motion and audio models are learned by using Hidden Markov Model. Random Forest which is the video classifier is used to learn the video model. In the experiments to test the performances of the proposed system, the motion and audio models most suitable for gesture recognition are chosen by varying feature vectors and learning methods. Additionally, the unimodal and multi-modal models are compared with respect to recognition accuracy. All the experiments are conducted on dataset provided by the competition organizer of MMGRC, which is a workshop for Multi-Modal Gesture Recognition Challenge. The comparison results show that the multi-modal model composed of three models scores the highest recognition rate. This improvement of recognition accuracy means that the complementary relationship among three models improves the accuracy of gesture recognition. The proposed system provides the application technology to understand human actions of daily life more precisely.

关键词： gesture recognition multi-modal integration hidden Markov model random forests

Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors

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World Journal of Gastroenterology 2006年第39期12卷 6305-6309页

作者： ikuo Nagashima Tadahiro Takada Miki Adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga Department of Surgery Teikyo University School of Medicine Tokyo Japan Department of Surgical Oncology University of Tokyo Graduate School of Medicine Tokyo Japan

AIM： To select accurately good candidates of hepatic resection for colorectal liver metastasis.METHODS： Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital （Group Ⅰ ）. These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital （Group Ⅱ ）, comparing the number of selected variables.RESULTS： Among 81 patients of Group Ⅰ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy （P 〈 0.05）. In addition, these three factors： serosa invasion, local lymph node metastases of primary cancers, and postoperative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis （0.05 〈 P 〈 0.20）. Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in Group I very well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them well.CONCLUSION： Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection.

关键词： Colorectal cancer Liver metastasis Hepatic resection Prognostic factor

Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C

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World Journal of Gastroenterology 2007年第39期13卷 5180-5187页

作者： Atsushi Tanaka Satoko Uegaki Hiroko Kurihara Kiyoshi Aida Masaki Mikami ikuo Nagashima Junji Shiga Hajime Takikawa Department of Medicine Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605Japan Department of Pathology Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605 Japan Department of Surgery Teikyo University School of Medicine Kaga Itabashi-ku Tokyo 173-8605 Japan

AIM: To elucidate risk factors contributing to the development of hepatocellular carcinoma (HCC) among patients with sustained viral response (SVR) after interferon (IFN) treatment and to examine whether HCV-RNA still remained in the liver of SVR patients who developed HCC. METHODS: Two-hundred and sixty-six patients, who achieved SVR, were enrolled in this study. We retrospectively reviewed clinical, viral and histological features of the patients, and examined whether the development of HCC depends on several clinical variables using Kaplan-Meier Method. RT-PCR was used to seek HCV-RNA in 3 out of 7 patients in whom liver tissue was available for molecular analysis. RESULTS: Among the enrolled 266 patients with SVR, HCC developed in 7 patients (7/266; 2.6%). We failed to detect HCV-RNA both in cancer and non-cancerous liver tissue in all three patients. The cumulative incidence for HCC was significantly different depending on hepatic fibrosis (F3-4) (P = 0.0028), hepatic steatosis (Grade 2-3) (P = 0.0002) and age (≥ 55) (P = 0.021) at the pre-interferon treatment. CONCLUSION: The current study demonstrated that age, hepatic fibrosis, and hepatic steatosis at pre- interferon treatment might be risk factors for developing HCC after SVR.

关键词： Hepatitis C virus Chronic hepatitis C Hepatocellular carcinoma Hepatic steatosis Hepaticfibrosis Interferon therapy Sustained viral response

Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

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Protein & Cell 2010年第8期1卷 711-717页

作者： Takuma Hayashi Akiko Horiuchi Kenji Sano Nobuyoshi Hiraoka Yae Kanai Tanri Shiozawa Susumu Tonegawa ikuo Konishi Department of Immunology and Infectious Disease Shinshu University Graduate School of MedicineMatsumotoNagano 390-8621Japan Department of Obstetrics and Gynecology Shinshu University School of MedicineMatsumotoNagano 390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumotoNagano 390-8621Japan Pathology Division National Cancer Center Research InstituteTokyo 104-0045Japan Picower Institution and Department of Biology Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Obstetrics and Gynecology Kyoto University Graduate School of MedicineSakyo-kuKyoto 606-8501Japan Promoting Business using Advanced Technology Japan Science and Technology Agency(JST)Kawaguchi-shiSaitama 332-0012Japan

Uterine tumors are the most common type of gynecologic *** leiomyosarcoma(LMS)is rare,accounting for 2%to 5%of tumors of the uterine *** LMS develops more often in the muscle tissue layer of the uterine body than in the uterine *** development of gynecologic tumors is often correlated with female hormone secretion;however,the development of uterine LMS is not substantially correlated with hormonal conditions,and the risk factors are not yet *** evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine ***,a diagnostic biomarker,which distinguishes malignant LMS and benign tumor leiomyoma(LMA)is yet to be ***,it is necessary to analyze risk factors associated with uterine LMS in order to establish a method of ***2-deficient mice spontaneously develop uterine LMS,with a disease prevalence of~40%by 14 months of *** is therefore of interest whether human uterine LMS shows a loss of LMP2 *** found LMP2 expression is absent in human LMS,but present in human ***,defective LMP2 expression may be one of the risk factors for ***2 is potentially a diagnostic biomarker for uterine LMS,and gene therapy with LMP2-encording DNA may be a new therapeutic approach.

关键词： LMP2 uterine leiomyosarcoma uterine leiomyoma diagnostic biomarker