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A Scale of Parental Anxiety about Pediatric Emergency Medical Care Services of Japan: Development, Reliability, Validity, Generalizability and Usefulness

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Health 2017年第10期9卷 1427-1458页

作者： ikuko sobue Kimie Tanimoto Susumu Itoh Division of Nursing Science Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Division of Nursing Science Faculty of Medicine Kagawa University Kagawa Japan Division of Medical Science Faculty of Medicine Kagawa University Kagawa Japan

Aim: The purpose of this study was to develop a scale, “parental anxiety about pediatric emergency medical care services” (PAPEMCS), and to evaluate its psychometric properties. Methods: Participants were 14,510 parents with children 6 years old or younger in Kagawa Prefecture. Using each half of the participants, exploratory factor analysis was performed to generate items and factors for the PAPEMCS, and confirmatory factor analysis (CFA) was used to establish the construct validity. The generalizability of the PAPEMCS was evaluated by congruence tests and multigroup CFA. The usefulness of the PAPEMCS was established by the relationship between the PAPEMCS and non-urgent usage of pediatric emergency medical care services (PEMCS). Results: The PAPEMCS compromised 4 factors: “anxiety about quality of PEMCS”, “anxiety about PEMCS system”, “anxiety about public support”, and “anxiety about private support”. All reliability estimates (polychoric ordinal alpha coefficients, item-rest correlations), the item discrimination, 5 fit indices for CFA, the convergent validity (indicator reliabilities, composite reliabilities, average variance extracteds), and the discriminant validity fulfilled the acceptability thresholds. All generalizability estimates fulfilled the predetermined levels of acceptability (Tucker’s congruence coefficients, congruence tests, strict factorial invariance). The usefulness of the PAPEMCS was established by the higher scores of the PAPEMCS being related to non-urgent usage of PEMCS. Conclusions: The PAPEMCS demonstrated satisfactory reliability, validity, generalizability and usefulness. The PAPEMCS is useful to quantify the contents and extent of parental anxiety about PEMCS, and to clarify the mechanisms of non-urgent PEMCS usage.

关键词： Parental Anxiety Pediatric Emergency Medical Care Services Reliability Validity Generalizability and Usefulness Scale Development

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Benefit of Using Sick Child Care Facilities to the Children and Their Parents

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Health 2016年第11期8卷 1128-1141页

作者： Kyoko Fukumoto Mao Kawamura Mayu Yoshitsugu ikuko sobue Mazda Hospital Hiroshima Japan Hiroshima University Hospital Hiroshima Japan Division of Nursing Science Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan

Introduction: Sick child care is a form of nursing care provided temporarily for sick children when they cannot be cared for by their parents at home. To clarify the benefits of using sick child care facilities for children and their parents, we surveyed these parents about the benefits of such care and their needs. Method: Study design: Descriptive research. We studied parents whose children had used one of the 11 sick child care facilities for sick children in Hiroshima City in 2014. A total of 156 parents consented to participate in the study. We investigated their usage situation of sick child care, perceived benefits of such care, and care-related requests in a quantitative and qualitative manner. Results: Both nuclear families consisting of the dual income parents and their children and single-mother households reported that their children (mean age: 2.46 years [SD: 1.77 years]) had used sick child care because of infectious diseases. Approximately 10% of the parents were using the fee reduction systems of sick child care intended for people with a low income. Parents viewed sick child care as beneficial both in early the health recovery of children, and as support for child raising and working. On the other hand, some parents left their children at home alone when sick child care was not available due to the limited number of sick child care facilities and an insufficient capacity to accept children. Some parents desired an increased number of care facilities, as well as a reduction in or subsidies for care fees. Conclusion: The results of this study suggest that, to ensure children’s health and safety, and support their parents for working and child raising, there is a need to increase the number of sick child care facilities along with expanding care services.

关键词： Benefits Child Raising Support Sick Child Care

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Pain-Relieving Effect of Music on Preschoolers during Immunization: A Randomized Controlled Trial

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Health 2018年第1期10卷 145-158页

作者： Yui Shiroshita Kotaro Muraki Tatsuya Kamei ikuko sobue Division of Nursing Science Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Muraki Pediatric Clinic Hiroshima Japan

Background: Immunization is a medical procedure many children frequently undergo. As it involves pain, it is important to develop effective pain relief methods that are applicable from infancy. Objective: To clarify the pain-relieving effect of music from speakers on preschoolers during immunization. Methods: A randomized controlled trial using sex-based stratified randomization was conducted at a Japanese pediatric clinic between October and December 2016, involving 48 preschoolers aged 5 - 6. Among these, 25 listened to music (“Twinkle Twinkle Little Star” played by a music box) from speakers before, during, and after influenza immunization (Music group), while the other 23 were not treated with musical intervention (Control group), with the following outcomes: primary: the Face Scale score;and secondary: the heart rate (HR) and oxygen saturation (SpO2) and salivary alpha amylase (sAA) levels. Results: The Face Scale score and HR of the Control group immediately after influenza immunization were significantly higher than their baseline values (P < 0.0001, P < 0.05). There were no significant differences between the Music and Control groups in the Face Scale score, HR, or SpO2 level immediately after influenza immunization or in the sAA level 10 minutes after it. Conclusion: Influenza immunization was painful for preschoolers. When based on the Face Scale score, HR, SpO2 and sAA levels as indices to measure immunization-related pain, music did not show pain-relieving effects.

关键词： Pain Immunization Music Preschoolers

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New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： ikuko Maejima Ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

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Gut microbiota,inflammation and colorectal cancer

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Genes & Diseases 2016年第2期3卷 130-143页

作者： Jun Sun ikuko Kato Division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois at ChicagoChicagoILUSA Department of Oncology Wayne State University School of MedicineDetroitMI 48201USA Department of Pathology Wayne State University School of MedicineDetroitMI 48201USA

Although genes contribute to colorectal cancer,the gut microbiota are an important *** evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression.A variety of bacterial species and tumor-promoting virulence mechanisms have been *** advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in *** the current review,we discuss the novel roles of microbiota in the progression of colon *** microbiota technically include organisms other than bacteria e.g.,viruses and fungi,this review will primarily focus on *** summarize epidemiological studies of human microbiome and colon *** discuss the progress in the scientific understanding of the interplay between the gut microbiota,barrier function,and host responses in experimental ***,we discuss the potential application in prevention,diagnosis,and therapy of colon cancer by targeting *** discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.

关键词： Beta-catenin Colon cancer Cytokines Dysbiosis Epidemiologic Gut barrier Human microbiome Inflammation

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Discrete Plane Segmentation and Estimation from a Point Cloud Using Local Geometric Patterns

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International Journal of Automation and computing 2008年第3期5卷 246-256页

作者： Yukiko Kenmochi Lilian Buzer Akihiro Sugimoto ikuko Shimizu Université Paris-Est Laboratoire d'Informatique de l'Institut Gaspard-MongeUMR CNRS 8049 A2SI-ESIEECité DescartesBP 9993162 Noisy-le-Grand CedexFrance Department of Computer Information and Communication SciencesTokyo University of Agriculture and Technology

This paper presents a method for segmenting a 3D point cloud into planar surfaces using recently obtained discretegeometry results. In discrete geometry, a discrete plane is defined as a set of grid points lying between two parallel planes with a small distance, called thickness. In contrast to the continuous case, there exist a finite number of local geometric patterns （LGPs） appearing on discrete planes. Moreover, such an LGP does not possess the unique normal vector but a set of normal vectors. By using those LGP properties, we first reject non-linear points from a point cloud, and then classify non-rejected points whose LGPs have common normal vectors into a planar-surface-point set. From each segmented point set, we also estimate the values of parameters of a discrete plane by minimizing its thickness.

关键词： Discrete plane image segmentation parameter estimation discrete geometry local geometric pattern (LGP)

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Comparing Lifestyle Convenience of Multiple Daily Injection and Continuous Subcutaneous Insulin Infusion

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Open Journal of Nursing 2017年第12期7卷 1365-1374页

作者： ikuko Nishio Department of Adult Nursing Faculty of Nursing Soka University Hachioji City Japan

Aim: This study investigated the lifestyle convenience of Insulin therapy for adult women patients with type 1 diabetes. Methods: Participants were type 1 diabetes adult women patients who switched from multiple daily injection (MDI) therapy to Continuous Subcutaneous Insulin Infusion (CSII) therapy. We conducted semi-structured interviews with participants. To analyze, we referenced the classification table of Hamada’s study comparing the usefulness of both the NovoPen? and CSII. Semi-structured interviews were conducted with the research subjects. The questions focused mainly on diabetes management, instrument operation, everyday life, and social, psychological and lifestyle convenience aspects during MDI and CSII. Results: Research subjects were 4 women patients with type 1 diabetes. The average age was 35.3 ± 6.24 (SE) years old. Participants were undergoing MDI therapy;however, in the middle, they switched to CSII therapy. CSII therapy is convenient in terms of diabetes management, social and psychological. MDI therapy is convenient in terms of instrument operation and daily life. Compared to MDI therapy, CSII therapy is less convenient in terms of instrument operation and everyday life. However, since CSII therapy has more stable HbA1c and blood glucose levels compared to MDI therapy, it is more convenient in terms of social and psychological aspects and reduces those burdens. About economy CSII therapy, patients paid about 5000 yen more per month compared to MDI therapy. Conclusion: It is believed that patients prioritize therapeutic effects, and choose CSII, which is stable in psychological and social aspects, even though it is inconvenient with life.

关键词： Insulin Infusion Systems Lifestyle Disease Management Multiple Daily Injection Type 1 Diabetes Women’s Health

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The Study of Experiences during Pregnancy in a Woman with Type 1 Diabetes

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Open Journal of Nursing 2020年第11期10卷 1095-1108页

作者： ikuko Nishio Daisaku Nishimoto Masami Chujo School of Health Sciences Faculty of Medicine Kagoshima University Kagoshima City Japan School of Health Sciences Faculty of Medicine Tottori University Yonago City Japan

Background: This study aimed to elucidate the experiences of a woman with type 1 diabetes during the course of her pregnancy. Method: This case study involved 1 participant. Data were collected through a semi-structured interview. Results: The data of experiences during pregnancy of Mrs. A comprised 20 codes, 5 categories, and 11 subcategories. The 5 categories were [abnormalities in the delicate body], [difficulty in blood glucose control for safe childbirth], [the burden of visiting both obstetrics] and [internal medicine departments], and [hope for safe childbirth]. Conclusion: The categories extracted in this study included terms that suggested negative experiences, such as “abnormality”, “difficulty”, “inconvenience”, and “burden”. Mrs. A might have used these negative terms due to the difficulties in controlling her blood glucose levels.

关键词： Type 1 Diabetes Experiences Pregnancy Insulin

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Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 69-73页

作者： Masayuki Onodera Takashi Nishigami ikuko Torii Ayuko Sato Li-Hua Tao Tatsuki R Kataoka Reigetsu Yoshikawa Tohru Tsujimura Department of Pathology Hyogo College of Medicine Department of Surgery Hyogo College of Medicine

AIM:To explore useful prognostic factors for mucinous adenocarcinoma(MAC) in the colon and ***:MAC was divided into low-and high-grade types based on the degree of structural differentiation;low-grade MAC arisen from well to moderately differentiated adenocarcinoma and papillary carcinoma,and high-grade MAC from poorly differentiated adenocarcinoma and signet ring cell ***,the expression of 2 types of MUC1(MUC1/DF and MUC1/CORE),MUC2,2 types of MUC5AC(MUC5AC/CHL2 and HGM),MUC6,CDX2,and CD10 was examined in 16 cases of MAC consisting of 6 low-and 10 high-grade ***:MUC1/DF3 was expressed in 3 of 6 low-grade MAC(50) and 10 of 10 high-grade MAC(100).MUC1/CORE was expressed in 1 of 6 lowgrade MAC(16.7) and 7 of 10 high-grade MAC(70).MUC2 was expressed in all MAC regardless of the ***5AC was expressed in 6 of 6 low-grade MAC(100) and 4 of 10 high-grade MAC(40).HGM was expressed in 5 of 6 low-grade MAC(83.3) and 6 of 10 high-grade MAC(60).Expression of MUC6 and CD10 was undetected in all MAC regardless of the ***2 was expressed in 5 of 6 low-grade MAC(83.3) and 7 of 10 high-grade MAC(70).Taken together,MUC1/DF3 was expressed significantly more frequently in high-grade MAC than in low-grade,and MUC5AC/CHL2 was expressed significantly more frequently in low-grade MAC than in ***:It is proposed that MUC1/DF3 and MUC5AC/CHL2 immunostaining is useful to discriminate high-grade MAC from low-grade MAC.

关键词： Mucinous adenocarcinoma Colon Rectum MUC1 MUC5AC

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A predictive factor for the response to S-1 plus cisplatin in gastric cancer

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World Journal of Gastroenterology 2010年第36期16卷 4575-4582页

作者： ikuko Miyazaki Takashi Kawai Youji Harada Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Endoscope Center Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Department of Gastroenterology Toda Chuo General Hospital1-19-3 HonchoToda-shiSaitama 335-1132Japan

AIM:To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin(CDDP)chemotherapy in gastric ***:We measured the protein expression levels of thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-ferase(OPRT)in advanced gastric *** S-1/CDDP chemotherapy,tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent *** chemo-therapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP *** effects are a predictive factor for the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over ***:The protein expression level of TS was significantly higher(P40 ng/mg ***:We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer.

关键词： Gastric cancer Thymidylate synthase Dihy-dropyrimidine dehydrogenase Orotate phosphoribosyl-transferase Biopsy

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