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An update on the molecular biology of glioblastoma,with clinical implications and progress in its treatment

Cancer Communications 2022年第11期42卷 1083-1111页

作者： Elena Verdugo iker puerto MiguelÁngel Medina Department of Molecular Biology and Biochemistry University of MálagaMálagaMálaga E-29071Spain Biomedical Research Institute of Málaga(IBIMA-Plataforma Bionand) MálagaMálaga E-29071Spain Spanish Biomedical Research Network Center for Rare Diseases(CIBERER) Spanish Health Institute Carlos III(ISCIII)MálagaMálaga E-29071Spain

Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain *** with GBM often have poor prognoses,with a median survival of∼15 *** understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading *** review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its *** molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RNAs in glioblastoma ***-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBM of IDH-wildtype origin,but this remains *** metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other *** metabolism also contributes to glioblastoma’s resistance to conventional *** heterogeneity,a hallmark of GBM,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system ***’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as ANXA2,GBP2,FN1,PHIP,and ***,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this *** is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBM,and neoantigen and nuclei

关键词： cancer molecular biology diagnosis glioblastoma multiforme ongoing clinical trials targeted therapy tumor heterogeneity tumor metabolism

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Methodology for the assessment of the friction torque of ball slewing bearings considering preload scatter

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Friction 2024年第8期12卷 1838-1857页

作者： Iñigo ESCANCIANO iker HERAS Florian SCHLEICH Josu AGUIRREBEITIA Department of Mechanical Engineering University of the Basque CountryBilbao 48080Spain Fraunhofer-Institute for Wind Energy Systems IWES Hamburg 27572Germany

This manuscript presents an innovative methodology for the assessment of the friction torque of ball slewing *** methodology aims to overcome the limitations of state-of-the-art approaches,especially when the friction torque is conditioned by the preload of the *** this end,the authors propose to simulate the preload scatter when solving the load distribution problem,prior to the friction torque *** preload scatter allows to simulate a progressive transition of the balls from a four-point contact state to a two-point contact *** implementing this capability into an analytical model,the authors achieve a successful correlation with experimental ***,depending on the stiffness of the structures to which the bearing is assembled,it is demonstrated that the rigid ring assumption can lead to inaccurate friction torque results when a tilting moment is *** methodology described in this research work is meant to have a practical ***,the manuscript provides guidelines about how to use and tune the analytical model to get a reliable friction torque prediction tool.

关键词： slewing bearing ball bearing friction torque preload scatter

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Punctuated ancestral gene gains in streptophyte evolution

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Molecular Plant 2022年第5期15卷 799-801页

作者： iker Irisarri Jan de Vries University of Goettingen Institute for Microbiology and GeneticsDepartment of Applied BioinformaticsGoldschmidtstr.137077 GöttingenGermany Campus Institute Data Science(CIDAS) GöttingenGermany University of Goettingen Goettingen Center for Molecular Biosciences(GZMB)Department of Applied BioinformaticsGoldschmidtstr.137077

Understanding the genomic substrate behind evolutionary change is a major endeavor in biology,shedding light on impor-tant aspects of the evolutionary history as well as unraveling the mechanisms of genome *** of the ... 详细信息

关键词： evolution evolution evolutionary

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Heat dissipating upper body compression garment:Thermoregulatory,cardiovascular, and perceptual responses

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Journal of Sport and Health Science 2019年第5期8卷 450-456页

作者： iker Leoz-Abaurrea Nicholas Tam Roberto Aguado-Jiménez Department of Health Sciences Public University of NavarreNavarre 31500Spain UCT/MRC Research Unit for Exercise Science and Sports Medicine Department of Human BiologyUniversity of Cape TownCape Town 7725South Africa

Purpose:The aim of the present study was to determine the effects of an upper body compression garment(UBCG)on thermoregulatory responses during cycling in a controlled laboratory thermoneutral environment(~23℃).A secondary aim was to determine the cardiovascular and perceptual responses when wearing the ***:Sixteen untrained participants(age:21.3±5.7 years;peak oxygen consumption(V02 peak):50.88±8.00 mL/min/kg;mean±SD)performed 2 cycling trials in a thermoneutral environment(~23℃)wearing either UBCG or control(Con)*** consisted of a 5-min rest on a cycle ergometer,followed by 4 bouts of cycling for 14-min at ~50%VO2 peak,with 1-min rest between each *** the end of these bouts there was 10-min of passive *** the entire protocol rectal temperature(Trec),skin temperature(Tskin),mean body temperature(Tbody),and heat storage(HS)were *** rate(HR),VO2,pH,hematocrit(Hct),plasma electrolytes,weight loss(Wloss),and perceptual responses were also ***:There were no significant differences between garments for Tskin,HS,HR,VO2,pH,Hct,plasma electrolyte concentration,Wloss,and perceptual responses during the *** did not differ between garment conditions during rest,exercise,or recovery although a greater reduction in Trec wearing UBCG(p=0.01)was observed during *** Tbody during recovery was found when wearing UBCG(36.82℃±0.30℃ vs.36.99℃±0.24℃).Conclusion:Wearing a UBCG did not benefit thermoregulatory,cardiovascular,and perceptual responses during exercise although it was found to lower Tbody during recovery,which suggests that it could be used as a recovery tool after exercise.

关键词： Body temperature Compression garment Cycling Heat dissipation Thermoregulation

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Recurrent evolution of seaweed body plan complexity among photosynthetic eukaryotes

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Molecular Plant 2024年第7期17卷 999-1001页

作者： Elisa S.Goldbecker iker Irisarri Jan de Vries Department of Applied Bioinformatics Institute for Microbiology and GeneticsUniversity of GottingenGoldschmidtstr.137077 GottingenGermany Section Phylogenomics Center for Molecular Biodiversity ResearchLeibniz Institute for the Analysis of Biodiversity Change(LIB)Museum of Nature HamburgMartin-Luther-King-Platz 320146 HamburgGermany Department of Applied Bioinformatics Campus Institute Data Science(CIDAS)University of GottingenGoldschmidtstr.137077 GottingenGermany Department of Applied Bioinformatics Gottingen Center for Molecular Biosciences(GZMB)University of GottingenGoldschmidtstr.137077 GottingenGermany

The evolutionary origin of multicellularity is an age-old question in biological *** studies have delved into the evolutionary processes that led to the evolution of multicellular life forms from unicellular *** beauty and the challenge about this topic are that evolution has brought forth various forms of multicellular life,multiple times independently,scattered across the evolutionary tree of *** to the challenge,multicellular organisms exist in a diversity of forms and complexities,and the mechanisms by which multicellularity emerged are also likely different between animals,algae,or fungi(Niklas and Newman,2020).Recently,Nelson et al.(2024)presented a large-scale comparative genomics study focused on particularly intricate multicellular organisms:macroalgae(seaweeds),which emerged independently in three distinct eukaryotic lineages-green algae(Chlorophyta),red algae(Rhodophyta),and brown algae(Phaeophyceae).

关键词： algae seaweed evolution

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SIMULATION OF O_(2)-BLOWN CO-GASIFICATION OF WOOD CHIP AND POTATO PEEL FOR PRODUCING SYNGAS

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Frontiers of Agricultural Science and Engineering 2023年第3期10卷 448-457页

作者： Yulin HU Kang KANG iker Zulbaran ALVAREZ Nasim MIA Aadesh RAKHRA Faculty of Sustainable Design Engineering University of Prince Edward IslandCharlottetownPEC1A 4P3Canada Biorefining Research Institute Lakehead UniversityThunder BayONP7B 5E1Canada

Potato is the fifth largest agricultural crop in Canada and contributes to the generation of an abundant amount of potato ***,disposal/recycling this peel remains a challenge due to the stringent environmental ***,there is a lack of an appropriate recycling and valorization methods of potato *** is an effective technology for producing syngas and an ecofriendly waste disposal *** is an important industrial intermediate to produce synthetic fuels and *** develop an ecofriendly and cost-effective valorization approach for potato peel,this study used a mixture of woody biomass(i.e.,wood chips)and potato peel to produce syngas by co-gasification using O_(2) as the gasifying agent at a constant equivalence ratio of 0.3 using Aspen Plus simulation *** influences of gasification temperature and wood chip/potato peel weight ratio on the carbon conversion efficiency(CCE),and product gas composition(molar fraction)and lower heating value(LHV)of product gas were *** simulation indicated that a positive synergistic interaction occurs between wood chips and potato peel in co-gasification process in terms of an increase in CCE by comparing the arithmetic value and real value at all simulated wood chip to potato peel weight ratios(44.9%to 85.8%,46.5%to 76.2%,and 48.1%to 78.6%at ratios of 25:75,50:50,and 75:25,respectively,for wood chips to potato peel).While the molar fraction of H_(2) and CO decreased continuously with increase in the weight percentage of wood chips in the wood chip-potato peel mixture from 0 wt%to 100 wt%(H_(2),at 42.1 mol%to 41.4 mol%;and CO at 44.0 mol%to 40.4 mol%),accompanied by a decrease of the LHV of the product gas(10.3 to 9.78 MJ·Nm^(−3)).The study concluded that co-gasification for producing syngas is feasible and environmental-friendly option to recycle and valorize potato peel.

关键词： Aspen Plus co-gasification potato peel syngas simulation waste reduction wood chip

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Machine learning-based assessment of the impact of the manufacturing process on battery electrode heterogeneity

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Energy and AI 2021年第3期5卷 150-158页

作者： Marc Duquesnoy iker Boyano Larraitz Ganborena Pablo Cereijo Elixabete Ayerbe Alejandro A.Franco Laboratoire de Reactivite et Chimie des Solides(LRCS) UMR CNRS 7314Universite de Picardie Jules VerneHub de l’Energie15rue Baudelocque80039 Amiens CedexFrance Reseau sur le Stockage Electrochimique de l’Energie(RS2E) FR CNRS 3459Hub de l’Energie15rue Baudelocque80039 Amiens CedexFrance ALISTORE-European Research Institute FR CNRS 3104Hub de l’Energie15rue BaudelocqueAmiens Cedex80039France CIDETEC Basque Research and Technology Alliance(BRTA)P◦Miram´on 19620014 Donostia-San SebastianSpain Institut Universitaire de France 103 Boulevard Saint Michel75005 ParisFrance

Electrode manufacturing process strongly impacts lithium-ion battery *** electrode slurry properties and the coating parameters are among the main factors influencing the electrode heterogeneity which impacts the battery cell performance and ***,the analysis of the impact of electrode manufacturing parameters on the electrode heterogeneity is difficult to be quantified and automatized due to the large number of parameters that can be adjusted in the *** this work,a data-driven methodology was developed for automatic assessment of the impact of parameters such as the formulation and liquid-to-solid ratio in the slurry,and the gap used for its coating on the current collector,on the electrodes heterogeneity.A dataset generated by experimental measurements was used for training and testing a Machine Learning(ML)classifier namely Gaussian Naives Bayes algorithm,for predicting if an electrode is homogeneous or heterogeneous depending on the manufacturing ***,through a 2D representation,the impact of the manufacturing parameters on the electrode heterogeneity was assessed in detail,paving the way towards a powerful tool for the optimization of next generation of battery electrodes.

关键词： Machine learning Electrode manufacturing Battery Heterogeneity Data analysis

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Survival after pulmonary metastasectomy in colorectal cancer patients:does a history of resected liver metastases worsen the prognosis?A literature review

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Cancer Biology & Medicine 2017年第3期14卷 281-286页

作者： Jon Zabaleta Borja Aguinagalde iker Lopez Arantza Fernandez-Monge Jose M.Izquierdo Jose I.Emparanza Thoracic surgery service Hospital UniversitarioDonostiaGipuzkoa 20014Spain

Objective: To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung ***: We conducted a review of literature published from 2007 to 2014. The studies were identified by searching Pub Med,MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis. We selected retrospective and prospective studies published from 2007 to 2014 on patients with lung metastases from colorectal cancer and were undergoing surgery with curative intent. We excluded reviews, studies that focused on surgical techniques, patients who were treated non-surgically, analyses of specific subgroups of patients, and those that did not report follow-up of the patients undergoing ***: We identified 28 papers that assessed survival after lung metastases, 21 of which were mostly retrospective studies that identified previous liver metastases to explore their impact on patient survival. In more than half of the papers analyzed(63.2%),patients with a history of resected liver metastases had a lower survival rate than those who did not have such a history, and the difference was statistically significant in eight of these studies. However, data were presented differently, and authors reported mean survival time, survival rates, or hazard ***: A history of liver metastases seems to be a negative prognostic factor, but the individual data need to undergo a meta-analysis.

关键词： Lung metastasis liver colorectal cancer review

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Wheat ear carbon assimilation and nitrogen remobilization contribute significantly to grain yield

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Journal of Integrative Plant Biology 2016年第11期58卷 914-926页

作者： Bangwei Zhou Maria Dolores Serret Abdelhalim Elazab Jordi Bort Pie José Luis Araus iker Aranjuelo álvaro Sanz-Sáez Key Laboratory of Vegetation Ecology Ministry of EducationInstitute of Grassland ScienceNortheast Normal University Unit of Plant Physiology Faculty of BiologyUniversity of Barcelona Agrobiotechnology Institute Public University of Navarra-CSIC-Navarra GovernmentArrosadia Campus Department of Plant Biology University of the Basque Country Pharmacy Faculty

The role of wheat ears as a source of nitrogen （N） and carbon （C） in the grain filling process has barely been studied. To resolve this question, five wheat genotypes were labeled with 15N-enriched nutrient solution. N remobilization and absorption were estimated via the nitrogen isotope composition of total organic matter and Rubisco. Gas exchange analyses showed that ear photosynthesis contributed substantially to grain filling in spite of the great loss of C due to respiration. Of the total kernel N, 64.7% was derived from the N acquired between sowing and anthesis, while the remaining 35.3% was derived from the N acquired between anthesis and maturity. In addition, 1.87 times more N was remobilized to the developing kernel from the ear than from the flag leaf. The higher yielding genotypes showed an increased N remobflization to the kernel compared to the lower yielding genotypes. In addition, the higher yielding genotypes remobilized more N from the ears to the kernel than the lower yielding genotypes, while the lower yielding genotypes remobilized more N from the flag leaf to the kernel. Therefore, the ears contribute significantly toward fulfilling C and N demands during grain filling.

关键词： Carbon accumulation ear grain yield nitrogenaccumulation Rubisco

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Multiscale assessment of ground,aerial and satellite spectral data for monitoring wheat grain nitrogen content

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Information Processing in Agriculture 2023年第4期10卷 504-522页

作者： Joel Segarra Fatima Zahra Rezzouk Nieves Aparicio Jon González-Torralba iker Aranjuelo Adrian Gracia-Romero Jose Luis Araus Shawn C.Kefauver Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelona 08028Spain AGROTECNIO(Center for Research in Agrotechnology) Lleida 251981Spain Agro-technological Institute of Castilla y León(ITACyL) Valladolid 47071Spain Grupo AN Tajonar 31192NavarreSpain Instituto de Agrobiotecnología(IdAB) CSIC-Gobierno de NavarraMutilva Baja 31192PamplonaNavarreSpain

Wheat grain quality characteristics have experienced increasing attention as a central factor affecting wheat end-use products quality and human ***,in the last decades a reduction in grain quality has been ***,it is central to develop efficient quality-related phenotyping *** this sense,one of the most relevant wheat features related to grain quality traits is grain nitrogen content,which is directly linked to grain protein content and monitorable with remote sensing ***,the relation between nitrogen fertilization and grain nitrogen content(protein)plays a central role in the sustainability of *** aiming to develop efficient phenotyping tools using remote sensing instruments and to advance towards a field-level efficient and sustainable monitoring of grain nitrogen status,this paper studies the efficacy of various sensors,multispectral and visible red-greenblue(RGB),at different scales,ground and unmanned aerial vehicle(UAV),and phenological stages(anthesis and grain filling)to estimate grain nitrogen *** models were calculated using vegetation indices at each sensing level,sensor type and phenological ***,this study explores the up-scalability of the best performing model to satellite level Sentinel-2 equivalent *** found that models built at the phenological stage of anthesis with UAV-level multispectral cameras using red-edge bands outperformed grain nitrogen content estimation(R2=0.42,RMSE=0.18%)in comparison with those models built with RGB imagery at ground and aerial level,as well as with those built with widely used ground-level multispectral *** also demonstrated the possibility to use UAV-built multispectral linear models at the satellite scale to determine grain nitrogen content effectively(R2=0.40,RMSE=0.29%)at actual wheat fields.

关键词： Wheat Remote sensing Sentinel-2 Grain nitrogen content Phenotyping

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