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World Journal of Gastroenterology 2005年第45期11卷 7218-7221页

作者： Yukiko Ito Natsuyo Yamamoto Ryo Nakata Yoshihisa Kato Masashi Iori Keisuke Sakai Tamiko Takemura Ryosuke Tateishi Haruhiko Yoshida Takao Kawabe masao Omata Department of Gastroenterology

A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response.

关键词： Hepatocellular carcinoma Interferon HCV Eradication

Mast Cell Infiltration and Leukotriene Receptor Expression in Various Tumors: Possible Clinical Application of Common Pathological Findings Concerned with Tumor Development

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Journal of Cancer Therapy 2015年第7期6卷 606-612页

作者： masao Sugamata Tomomi Ihara Miho Sugamata Department of Pathology Tochigi Institute of Clinical Pathology Tochigi Japan

Since the mechanisms of the developmental processes of tumors remain unclear, early detection and early treatment of the tumors is necessary to save patients with malignant tumors. Therapies currently available to patients are surgery, chemotherapy, and radiotherapy. However, there are many patients who cannot be saved by such therapies. In this study, we found the common features of various tumor tissues, and we demonstrated the effect of therapeutics that target them by using experimental rats with spontaneous tumors. 26 kinds of human tumors (epithelial or mesenchymal origin, and malignant or benign) and Sprague-Dawley rats with spontaneous mammary gland tumors were examined by light and electron microscope. To detect of mast cells and leukotriene receptor, toluidine blue stain and immunohistochemical stain were performed. The rats were orally administered one of leukotriene receptor antagonists. We found that the presence of numerous mast cells and expression of leukotriene receptors in various tumor (human tumors and rat spontaneous tumors). And the therapeutic effects, which suppressed not only tumor progress but also angiogenesis and nerve formation, for rat tumors by administration of leukotriene receptor antagonist could obtain. Our data suggest the possibility that allergic reactions, in which leukotriene and leukotriene receptors in particular appear to play an important role, are involved in the development and progression of tumors and that it may be possible to control tumor progression by regulating such reactions. Our results might be useful for clinical applications of oncotherapy.

关键词： Mast Cell Leukotriene Receptor Anti-Leikotriene Therapy Apoptosis

Discrete Differential Evolution for Mixed Discrete Non-Linear Problems

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Journal of Civil Engineering and Architecture 2012年第5期6卷 594-605页

作者： Satoshi Kitayama masao Arakawa Koetsu Yamazaki College of Science and Engineering Kanazawa University Kanazawa 920-1192 Japan Kagawa University Hayashi-cho Takamatsu Kagawa 761-0396 Japan

Differential evolution （DE） is a global optimizer for continuous design variables. To enhance DE, it is necessary to handle discrete design variables. In this paper, a discrete differential evolution （DDE） algorithm is proposed to handle discrete design variables The proposed DDE is based on the DE/l/rand/bin method. In the proposed DDE, the mutation ratio is regarded as the exchange probability, and thus, no modifications of DE/l/rand/bin are required. In addition, in order to maintain diversity through the search process, we initialize all search points. By introducing the initialization of all search points, global or quasi-optimum solution can be found. We validate the proposed DDE by applying it to several benchmark problems.

关键词： Global optimization differential evolution mixed-discrete nonlinear problems.

Development of PC Worker’s Management System in PC Training Room and Office by Using IoT Technology

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Journal of Electrical Engineering 2018年第4期6卷 221-228页

作者： Keiichi Abe Yuki Takabayashi masao Isshiki Kanagawa Institute of Technology Atsugi City Kanagawa 243-0292 Japan

At present time, there has been a demand for management systems that can survey and monitor a PC （personal computer） practice room, movement of people in an office, situation of utilization of facilities and so on in real time without causing psychological stress. For example, PC administrators in Japanese national educational institutions must report operation status of PC practice rooms once a year. But, there is currently no system for automatically recording PC operating situations. Therefore, the burden on the PC administrators is big. In this study, we aimed at systems for accurately managing the sitting and work time without psychologically stressing PC users. This time, we propose uniform management systems of sitting and work time using smart tap node and mat sensor node by IoT （Internet of Things） technology. The smart tap was connected to PCs to acquire the operating status of the PCs. In parallel with this smart tap, the mat sensor was used to acquire human presence state. By calculating binary data representing the PC operating status and human presence state from the two sensing data （smart tap and mat sensor） by the proposed technique, we can exactly calculate wasteful power consumption etc. The use of IoT technology makes it unnecessary to use large installation services when introducing our system. Therefore, this our proposal system can be easily installed even by unskilled workers.

关键词： PC worker’s management system smart tap node mat sensor node IoT technology sensor network.

A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis

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Open Journal of Obstetrics and Gynecology 2015年第6期5卷 313-318页

作者： masao Sugamata Tomomi Ihara Ichiro Uchiide Department of Pathology Tochigi Institute of Clinical Pathology Tochigi Japan Department of Obstetrics and Gynecology Japan Red Cross Hospital Omori Tokyo Japan

Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases showed significantly decreased r-AFS score. Furthermore, a significant correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and some patients achieved pregnancy. Morphologically, lesions in LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen fibers. Our findings revealed that LTR-As had significant therapeutic value for the treatment of human endometriosis. Anti-LT therapy appears efficacious not only in the treatment of clinical symptoms and lesions, but also in improving fertility.

关键词： Endometriosis Leukotriene Receptor Apoptosis r-AFS Score Infertility

Evolution History of Gassan Volcano, Northeast Japan Arc

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Open Journal of Geology 2018年第7期8卷 647-661页

作者： Ryo Oizumi masao Ban Naoyoshi Iwata Graduate School of Science and Technology Yamagata University Yamagata Japan Faculty of Science Yamagata University Yamagata Japan

Evolution history of the volcano is essential not only to characterize the volcano, but also consider magma genesis beneath the volcano. Most of the stratovolcanoes in northeast Japan follow a general evolutional course: cone building, horse-shoe shaped caldera forming collapse, and post-caldera stages. However, the detailed history of each stage is not well investigated. We investigated evolution history of young edifice of Gassan volcano, representative stratovolcano in rear side of northeast Japan arc. Most of the products are lavas, which are divided into two groups by geomorphologic and geologic features. The former (Gassan lower lavas) is composed of relatively thin and fluidal lavas, whose original geomorphology remains a little, while the latter (Gassan upper lavas) is composed of relatively thick and viscous lavas, whose original geomorphology is moderately preserved. Based on geologic features, the upper lavas can be further divided into Gassan upper north lavas and upper summit lavas in ascending order. After the formation of the thick lavas, horse-shoe shaped caldera was formed by the instability of the edifice, probably triggered by fault activity. No evidence of post caldera activity inner part of it is observed. Based on K-Ar data, estimated age of Gassan lower lavas is ca. 0.75 to ca. 0.6 Ma, those of Gassan upper north and upper summit lavas are ca. 0.60 to ca. 0.55 Ma and ca. 0.55 to ca. 0.45 Ma. The eruption rate is estimated to be ca. 0.0004 km3/1000 years in Gassan lower lavas and ca. 0.02 km3/1000 years in Gassan upper summit lavas. These values are lower than the eruption rate of representative Japanese stratovolcanoes.

关键词： Stratovolcano Andesitic Lava Evolution History Gassan Volcano NE Japan K-Ar Age Dating

Elucidation of Latent Risk of Navigation Using an Actual Ship Behavior Analysis

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Journal of Traffic and Transportation Engineering 2016年第3期4卷 131-140页

作者： Xinjia Gao Hidenari Makino masao Furusho Graduate School of Maritime Sciences Kobe University Hyogo 658-0022 Japan Naval Architecture & Ocean Engineering Osaka University Osaka 565-0871 Japan

In recent years, maritime transportation has played an important role in global economy development. As a result, ship traffic has become more congested. Moreover, ship navigation is susceptible to weather and environmental conditions, and in some cases, it may become dangerous. Therefore, vessels are subjected to high-risk navigation conditions. To understand the latent risk of ship navigation, this study focused on the actual ship behavior. Thus, an analysis of ship behavior was carded out using historical ship navigation based on automatic identification system data. Consequently, a dynamic analysis of the speed and encounter situation was performed. One of the main results of this work was the understanding of the latent risk involved in ships navigating the Seto Inland Sea, which is one of the most congested routes in Japan. Moreover, the risk areas were obtained, and visualized using a geographical information system. The obtained results can be applied to ensure safe navigation and the development of a safe and efficient navigation model.

关键词： Maritime traffic latent risk ship behavior analysis AIS (automatic identification system) data navigation model

Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases

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Synthesis of dammarane-type triterpene derivatives and their...

Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis

作者：危英 masao Hattori Institute of Natural Medicine University of Toyama 2630 SugitaniToyama 930-0194Japan Department of Pharmacy Guiyang College of Traditional Chinese Medicine50 Shidong RoadGuiyangGuizhou 550002China

We synthesized dammarane-type triterpene derivatives and evaluated their ability to inhibit HIV-1 and HCV proteases to understand their structure-activity *** of the mono- and disuccinyl derivatives(5a-5f) were powerful inhibitors of HIV-1 protease(IC1000 lM).These findings indicated that the mono-succinyl dammarane type derivatives(5a- 5d) selectively inhibited HIV-1 protease and that the di-succinyl(5e,5f) as well as 2,3-seco-2,3-dioic acid(3b) derivatives preferably inhibited both viral proteases.

关键词： Dammarane Triterpene 2,3-seco-Derivative Succinyl derivative HIV-1 protease HCV protease

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World Journal of Gastroenterology 2012年第47期18卷 6974-6980页

作者： Yasushi Ihama Akira Hokama Kenji Hibiya Kazuto Kishimoto Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Haley L Cash Futoshi Higa masao Tateyama Fukunori Kinjo Jiro Fujita Department of Infectious Respiratoryand Digestive MedicineFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan

AIM:To investigate the utility of immunohistochemical(IHC) staining with an antibody to Mycobacterium tuberculosis(***) for the diagnosis of intestinal tuberculosis(TB).METHODS:We retrospectively identified 10 patients(4 males and 6 females;mean age = 65.1 ± 13.6 years) with intestinal *** characteristics,including age,gender,underlying disease,and symptoms were *** radiograph and laboratory tests,including sputum Ziehl-Neelsen(ZN) staining,*** culture,and sputum polymerase chain reaction(PCR) for tubercle bacilli DNA,as well as Tuberculin skin test(TST) and QuantiFERON-TB gold test(QFT),were *** records recorded on the basis of Sato's classification were also reviewed,in addition to data from intestinal biopsies examined for histopathological findings,including hematoxylin and eosin staining,and ZN staining,as well as *** culture,and PCR for tubercle bacilli *** the present study,archived formalin-fixed paraffin-embedded(FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the *** *** sections were also stained with the pan-macrophage marker CD68 ***:From the clinical data,we found that no patients were immunocompromised,and that the main symptoms were diarrhea and weight *** patients displayed active pulmonary TB,six patients(60%) had a positive TST,and 4 patients(40%) had a positive *** findings revealed that all patients had type 1 findings(linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules),all of which were located in the right hemicolon and/or terminal *** patients(70%) had concomitant healed lesions in the ileocecal *** acid-fast bacilli were detected with ZN staining of the intestinal tissue samples,and both *** culture and PCR

关键词： Colonoscopy Intestinal tuberculosis Immunohistochemistry Monoclonal antibody Mycobacterium tuberculosis

Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria

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Journal of Biomedical Science and Engineering 2012年第1期5卷 10-14页

作者： Tadashi Miura Koji Tanabe masao Yoshinari 不详

Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II) disodium salt (Ca (II)-EDTA) was investigated for its antibacterial activity against the periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. We determined the minimum inhibitory concentrations (MIC) of Ca (II)-EDTA and its bactericidal activity. Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II) disodium salt inhibited the growth of all the periodontopathic bacteria tested in broth. An MIC of 60 mM was the most effective against P. gingivalis. An adenosine triphosphate bioluminescence assay revealed that Ca (II)-EDTA showed bactericidal activity against the bacteria tested in a time-dependent manner. To determine its safety in mammalian cells, we investigated the viability of murine L929 cells subjected to Ca (II)-EDTA treatment. At 75 mM, 93% ± 0.13% of the cells survived. These results indicate that Ca (II)-EDTA is a candidate chelating agent for prevention of infection by periodontopathic bacteria.

关键词： Chelating Agent Periodontopathic Bacteria Peri-Implantitis Antimicrobial Activity