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Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 896-901页

作者： ik Soo Byon Dong Hyun Lee Eun Sook Jun min Kyu Shin Sung Who park Ji Eun Lee Department of Ophthalmology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 Korea College of Medicine Pusan National University Yangsan 50612 Korea Department of Ophthalmology Biomedical Research Institute Pusan National University Hospital Busan 49241 Korea Balgeunsesang Eye Clinic Busan 47286 Korea

AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS： Forty Sprague-Dawley rats were divided into 4 groups： control, diabetes mellitus （DM）, candesartan- treated DM, and enalapril-treated DM （each group, n---10）. After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/（kg · d）] and enalapril [ACEI, 10 mg/（kg · d）] were administered to rats orally for 4Wko Vascular endothelial growth factor （VEGF） and angiotensin II （Ang II） concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor （ATIR） levels were assessed at week 4 by Western blotting. RESULTS： Vitreous Ang II levels were significantly higher in the DM group and candesartan-treated DM group than in the control （P=0.04 and 0.005, respectively）. Vitreous ATIR increased significantly in DM compared to the other three groups （P〈0.007）. Candesartan-treated DM rats showed higher vitreal ATIR concentration than the enalapril-treated DM group and control （P〈0.001 and P=0.005, respectively）. No difference in vitreous Ang II and ATIR concentration was found between the enalapril- treated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups. CONCLUSION： Increased Ang II and ATIR in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB.

关键词： angiotensin converting enzyme inhibitor angiotensin II type 1 receptor blocker diabetic rat intraocularrenin-angiotensin system

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Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 1019-1020页

作者： Seung min Lee Jae Woo Jung Sung Who park Ji Eun Lee ik Soo Byon Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 Korea Department of Ophthalmology College of Medicine Pusan National University Yangsan 50612 Korea Biomedical Research Institute Pusan National University Hospital Busan 49241 Korea

Lee SM, Jung JW, park SW, Lee JE, Byon IS. Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye. Int J Ophthalmo12017; 10（6）： 1019-1020

关键词： ME Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye

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Manipulating the nonlinearity of transition-metal dichalcogenide polaritons

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Light(Science & Applications) 2023年第12期12卷 2540-2542页

作者： min-Soo Hwang Hong-Gyu park Department of Physics and Astronomy and Institute of Applied PhysicsSeoul National UniversitySeoul 08826Republic of Korea

The lithographically designed potential wells in monolayer WS2 microcavities are utilized to manipulate nonlinear transition-metal dichalcogenide polaritons and enhance the polariton-reservoir interaction strength.

关键词： strength. polar transition

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Macular hole closure induced by intravitreal injection in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1720-1722页

作者： Sang Yoon Kim Han Jo Kwon Sung Who park ik Soo Byon Seung min Lee Department of Ophthalmology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan 50612Republic of Korea Department of Ophthalmology Biomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Pusan National University School of Medicine Yangsan 50612Republic of Korea

Dear Editor,Macular hole(MH)formation is uncommon in patients with diabetic macular edema(DME).Few cases of MH associated with DME treatment have been described,including a report of four out of eight eyes with MH and diabetic retinopathy(DR)having DME[1].However,no case of resolution of MH after DME treatment has been *** report three consecutive cases of MH closure achieved by intravitreal injection for DME treatment.

关键词： injection diabetic edema

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Improved formaldehyde gas sensing properties of well-controlled Au nanoparticle-decorated In2O3 nanofibers integrated on low power MEMS platform

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Journal of Materials Science & Technology 2020年第3期38卷 56-63页

作者： Dongha Im Donghyun Kim Dasol Jeong Woon ik park Myoungpyo Chun Joon-Shik park Hyunjung Kim Hyunsung Jung Nano Materials&Nano Technology Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Department of mineral Resources and Energy Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Smart Sensor Research Center Korea Electronic Technology InstituteSeongnam 13509Republic of Korea

Approaches for the fabrication of a low power-operable formaldehyde(HCHO)gas sensor with high sensitivity and selectivity were performed by the utilization of an effective micro-structured platform with a micro-heater to reach high temperature with low heating power as well as by the integration of indium oxide(In2O3)nanofibers decorated with well-dispersed Au nanoparticles as a sensing *** In2O3 nanofibers with the large specific surface area were prepared by the electrospinning following by calcination *** nanoparticles with the well-controlled size as a catalyst were synthesized on the surface of In2O3 *** Au-decorated In2O3 nanofibers were reliably integrated as sensing materials on the bridge-type micro-platform including micro-heaters and *** micro-platform designed to maintain high temperature with low power consumption was fabricated by a microelectromechanical system(MEMS)*** micro-platform gas sensor consisting with Au-In2O3 nanofibers were fabricated effectively to detect HCHO gases with high sensitivity and *** HCHO gas sensing behaviors were schematically studied as a function of the gas concentration,the size of the adsorbed Au nanoparticles,the applied power to raise the temperature of a sensing part and the kind of target gases.

关键词： Gold nanoparticle In2O3 nanofiber Formaldehyde Gas sensor Low power Micro-platform

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Nanoscale visualization of hot carrier generation and transfer at non-noble metal and oxide interface

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Journal of Materials Science & Technology 2022年第3期98卷 151-159页

作者： Ranveer Singh Qadeer Akbar Sial Seung-ik Han Sanghee Nah Ji-Yong park Hyungtak Seo Department of Materials Science and Engineering Ajou UniversitySuwon16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon16499Republic of Korea Seoul Center Korea Basic Science InstituteSeoul02841Republic of Korea Department of Physics Ajou UniversitySuwon16499Republic of Korea

The conversion efficiency of energy-harvesting devices can be increased by utilizing hot-carriers(HCs).However,due to ultrafast carrier-carrier scattering and the lack of carrier injection dynamics,HC-based devices have low *** the present work,we report the effective utilization of HCs at the nanoscale and their transfer dynamics from a non-noble metal to a metal oxide interface by means of real-space photocurrent mapping by using local probe techniques and conducting femtosecond transient absorption(TA)*** photocurrent maps obtained under white light unambiguously show that the HCs are injected into the metal oxide layer from the TiN layer,as also confirmed by conductive atomic force *** addition,the increased photocurrent in the bilayer structure indicates the injection of HCs from both layers due to the broadband absorption efficiency of TiN layer,passivation of the surface states by the top TiN layer,and smaller barrier height of the ***,electrostatic force microscopy and Kelvin probe force microscopy provide direct evidence of charge injection from TiN to the MoO_(x)film at the *** TA absorption spectra show a strong photo-bleaching signal over wide spectral range and ultrafast decaying behavior at the picosecond time scale,which indicate efficient electron transfer from TiN to MoO_(x).Thus,our simple and effective approach can facilitate HC collection under white light,thereby achieving high conversion efficiency for optoelectronic devices.

关键词： Non-noble metal Hot carrier Real-space photocurrent mapping Local-probe force microscopy

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Guidance on the Choice of Threshold for Binary Forecast Modeling

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Advances in Atmospheric Sciences 2008年第1期25卷 83-88页

作者： Keon Tae SOHN Sun min park Department of Statistics Pusan National University

This paper proposes useful guidance on the choice of threshold for binary forecasts. In weather forecast systems, the probabilistic forecast cannot be used directly when estimated too smoothly. In this case, the binary forecast, whether a meteorological event will occur or not, is preferable to the probabilistic forecast. A threshold is needed to generate a binary forecast, and the guidance in this paper encompasses the use of skill scores for the choice of threshold according to the forecast pattern. The forecast pattern consists of distribution modes of estimated probabilities, occurrence rates of observations, and variation modes. This study is performed via Monte-Carlo simulation, with 48 forecast patterns considered. Estimated probabilities are generated by random variate sampling from five distributions separately. Varying the threshold from 0 to 1, binary forecasts are generated by threshold. For the assessment of binary forecast models, a 2×2 contingency table is used and four skill scores （Heidke skill score, hit rate, true skill statistic, and threat score） are compared for each forecast pattern. As a result, guidance on the choice of skill score to find the optimal threshold is proposed.

关键词： binary forecast Monte-Carlo simulation threshold skill score

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Al2O3-TiO2/ZrO2-SiO2 based porous ceramics from particle-stabilized wet foam

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Journal of Advanced Ceramics 2017年第2期6卷 129-138页

作者： Bijay BASNET Naboneeta SARKAR Jung Gyu park Sangram MAZUMDER ik Jin KIM Institute of Processing and Application of Inorganic Materials(PAIM) Hanseo University # 360 Seosan-siChungnam 356-706 Republic of Korea School of Mechanical and Materials Engineering Washington State University Pullman Washington United States

The porous ceramics based on Al2O3-TiO2/ZrO2-SiO2 from particle-stabilized wet foam by direct foaming were *** initial Al2O3-TiO2 suspension was prepared by adding TiO2 suspension to partially hydrophobized colloidal Al2O3 suspension with equimolar amount,to form Al2TiO5 on *** secondary ZrO2-SiO2 suspension was prepared using the equimolar composition,and to obtain ZrSiO4,ZrTiO4,and mullite phases in the sintered samples,the secondary suspension was blended into the initial suspension at 0,10,20,30,and 50 vol％.The wet foam exhibited an air content up to 87％,Laplace pressure from 1.38 to 2.23 mPa,and higher adsorption free energy at the interface of approximately 5.8×108 to 7.5×108J resulting an outstanding foam stability of 87％.The final suspension was foamed,and the wet foam was sintered from 1400 to 1600 ℃ for 1 *** porous ceramics with pore size from 150 to 400 μm on average were *** phase identification was accomplished using X-ray diffraction (XRD),differential thermal analysis (DTA),and thermogravimetric analysis (TGA),and microstructural analysis was performed using field emission scanning electron microscopy (FESEM).

关键词： Al2TiO5 direct foaming Laplace pressure adsorption free energy porous ceramics

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User Profile System Based on Sentiment Analysis for Mobile Edge Computing

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Computers, Materials & Continua 2020年第2期62卷 569-590页

作者： Sang-min park Young-Gab Kim Korea University 145 Anam-roSeongbuk-guSeoul02841Korea Sejong University 209Neungdong-roGwangjin-guSeoul05006Korea

Emotions of users do not converge in a single application but are scattered across diverse *** devices are the closest media for handling user data and these devices have the advantage of integrating private user information and emotions spread over different *** this paper,we first analyze user profile on a mobile device by describing the problem of the user sentiment profile system in terms of data granularity,media diversity,and server-side ***-grained data requires additional data and structural analysis in mobile *** diversity requires standard parameters to integrate user data from various applications.A server-side solution presents a potential risk when handling individual privacy ***,in order to overcome these problems,we propose a general-purposed user profile system based on sentiment analysis that extracts individual emotional preferences by comparing the difference between public and individual data based on particular *** proposed system is built based on a sentiment hierarchy,which is created by using unstructured data on mobile *** can compensate for the concentration of single media,and analyze individual private data without the invasion of privacy on mobile devices.

关键词： User profile sentiment analysis mobile edge computing social network

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Unexpected complication during extracorporeal membrane oxygenation support: Ventilator associated systemic air embolism

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World Journal of Clinical Cases 2018年第9期6卷 274-278页

作者： Se-min Ryu Sung-min park Department of Thoracic and Cardiovascular Surgery Kangwon National University Hospital School of Medicine Kangwon National Univerity

Systemic air embolism through a bronchovenous fistu-la(BVF) has been described in patients undergoing positive-pressure ventilation. However, no report has mentioned the potential risks of systemic air embolism through a BVF in patients undergoing extracorporeal membrane oxygenation(ECMO). Positive-pressure ventilation and ECMO support in patients with lung injury can increase the risk of systemic air embolism through a BVF. Increased alveolar pressure, decreased pulmonary venous pressure, and anticoagulation are thought to be the factors that contribute to this complication. Here, we present a case of systemic air embolism in a patient with ECMO and mechanical ventilator support.

关键词： Air embolism Extracorporeal membrane oxygenation Cerebral embolism Positive-pressure ventilation Cardio-pulmonary resuscitation

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