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Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae Ryu Da-Woon Lee je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

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Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin je Kang-Won LEE Sang-Cheon PARK Jae-Gu KIM Doo-Sun choi Kyoung-Taik PARK Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

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Machining characteristics of complex prism pattern on electroplated roll by copper

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中国有色金属学会会刊：英文版 2009年第B9期19卷 288-294页

作者： Tae-Jin je Sang-Cheon PARK Kang-Won LEE Yeong-Eun YOO Doo-Sun choi Kyung-Hyun WHANG Myung-Chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

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Tm^(3+)-Doped Oxyfluoride Silicate Glasses for TDFA

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光学学报 2003年第S1期23卷 84-85页

作者： Doo-Hee Cho Hong-Seok Seo Bong-je Park Yong-Gyu choi Optical Communication Device Dept. Electronic and Telecommunication Research Institute 161 Kajong-dong Yusong-gu Daejon 305-350 Korea

The fluorine doping along with heavy metal oxides was remarkably raised the lifetime and the quantum efficiency of 3H4 in silicate glasses. The fluorine doping changed the local structure around Tm3+ ions, then low energy vibrations related to fluorine are considered to largely reduce the multi-phonon relaxation rates in the oxyfluoride silicate glasses.

关键词： quantum efficiency heavy metal

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Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee jeong-Tae Koh Hong-In Shin je-Yong choi Yun Hyun Huh je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

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Does the advantage of transcutaneous oximetry measurements in diabetic foot ulcer apply equally to free flap reconstruction?

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World Journal of Clinical Cases 2023年第31期11卷 7570-7582页

作者： Da Woon Lee Yong Seon Hwang je Yeon Byeon Jun Hyuk Kim Hwan Jun choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND Transcutaneous oxygen pressure(TcpO2)is a precise method for determining oxygen perfusion in wounded *** device uses either electrochemical or optical *** To evaluate the usefulness of TcpO2 measurements on free flaps(FFs)in diabetic foot ulcers(DFUs).METHODS TcpO2 was measured in 17 patients with DFUs who underwent anterolateral thigh(ALT)-FF surgery and compared with 30 patients with DFU without FF *** Significant differences were observed in the ankle-brachial index;duration of diabetes;and haemoglobin,creatinine,and C-reactive protein levels between the two ***2 values were similar between two groups except on postoperative days 30 and 60 when the values in the ALT-FF group remained50 *** Even if the flap is clinically stable,sympathectomy due to adventitia stripping during anastomosis and arteriovenous shunt progression due to diabetic polyneuropathy could lead to low TcpO2 values in the ALT-FF owing to its thick fat tissues,which is supported by the slow recovery of the sympathetic tone following ***,TcpO2 measurements in patients with DFU who underwent FF reconstruction may be less accurate than in those who did not.

关键词： Arteriovenous shunt Surgical Diabetic neuropathies Free tissue flaps Sympathectomy Blood gas monitoring Transcutaneous Diabetic angiopathies

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Ternary layered double hydroxide oxygen evolution reaction electrocatalyst for anion exchange membrane alkaline seawater electrolysis

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Journal of Energy Chemistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei Park Jae-Yeop jeong Myeong je Jang Chae-Yeon Kwon Geul Han Kim Jaehoon jeong Ji-hoon Lee Jooyoung Lee Sung Mook choi Department of Hydrogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from ***,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this *** this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)*** NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high *** on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.

关键词： Anion exchange membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis Hydrogen production

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Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation

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World Journal of Gastroenterology 2013年第29期19卷 4689-4701页

作者： Young-je Kim Myung-Sook choi Yong Bok Park Sang Ryong Kim Mi-Kyung Lee Un Ju Jung Department of Food Science and Nutrition Kyungpook National University Daegu 702-701 South Korea Center for Food and Nutritional Genomics Research Kyungpook National University Daegu 702-701 South Korea School of Life Sciences and Biotechnology Kyungpook National University Daegu 702-701 South Korea Brain Science and Engineering Institute Kyungpook National University Daegu 702-701 South Korea Department of Food and Nutrition Sunchon National University Jeonnam 540-742 South Korea

AIM: To investigate long-term effects of Garcinia Cambogia (GC), weight-loss supplement, on adiposity and non-alcoholic fatty liver disease in obese mice. METHODS: Obesity-prone C57BL/6J mice were fed a high-fat diet (HFD, 45 kcal% fat) with or without GC (1%, w/w) for 16 wk. The HFD contained 45 kcal% fat, 20 kcal% protein and 35 kcal% carbohydrate. They were given free access to food and distilled water, and food consumption and body weight were measured daily and weekly, respectively. Data were expressed as the mean ± SE. Statistical analyses were performed using the statistical package for the social science software program. Student's t test was used to assess the differences between the groups. Statistical significance was considered at P < 0.05. RESULTS: There were no significant changes in body weight and food intake between the groups. However, the supplementation of GC significantly lowered visceral fat accumulation and adipocyte size via inhibition of fatty acid synthase activity and its mRNA expression in visceral adipose tissue, along with enhanced enzymatic activity and gene expression involved in adipose fatty acid β-oxidation. Moreover, GC supplementation resulted in significant reductions in glucose intolerance and the plasma resistin level in the HFD-fed mice. However, we first demonstrated that it increased hepatic collagen accumulation, lipid peroxidation and mRNA levels of genes related to oxidative stress (superoxide dismutase and glutathione peroxidase) and inflammatory responses (tumor necrosis factor-α and monocyte chemoattractant protein-1) as well as plasma alanine transaminase and aspartate transaminase levels, although HFD-induced hepatic steatosis was not altered. CONCLUSION: GC protects against HFD-induced obesity by modulating adipose fatty acid synthesis and β-oxidation but induces hepatic fibrosis, inflammation and oxidative stress.

关键词： Garcinia Cambogia Anti-adiposity Metabolic changes Hepatic collagen accumulation Hepatic inflammation Hepatic oxidative stress

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Targeted knockout of duox causes defects in zebrafish growth, thyroid development, and social interaction

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Journal of Genetics and Genomics 2019年第2期46卷 101-104页

作者： Jong-Su Park Tae-ik choi Oc-Hee Kim Ted Inpyo Hong Woo-Keun Kim Won-Jae Lee Cheol-Hee Kim Department of Biology Chungnam National University Biosystem Research Group Korea Institute of Toxicology School of Biological Sciences Seoul National University

Reactive oxygen species(ROS) are believed to be inevitable and toxic by-products produced during cellular respiration. However,several lines of evidence show that diverse extracellular signals can activate ROS product... 详细信息

关键词： KO In Targeted knockout of duox causes defects in zebrafish growth thyroid development and social interaction

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Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain

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Neural Regeneration Research 2013年第10期8卷 922-929页

作者： Sung Jin Kwon jeongsook Park So Yun Park Kwang Seop Song Sun Tae Jung So Bong Jung ik Ryeul Park Wan Sung choi Sun Ok Kwon Department of Physical Education Gyeongsang National University Department of Anatomy and Neurobiology Medical Research Center for Neural DysfunctionInstitute of Health ScienceSchool of MedicineGyeongsang National University Department of Liberal Arts Gyeongnam National University of Science and Technology

The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. Male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise ＋ light groups （n = 9 per group）. The rats in the exercise group were subjected to treadmill exercise （5 days per week, 30 minutes per day, over a 4-week period）, the light group rats were irradiated （5 days per week, 30 minutes per day, 10 000 Ix, over a 4-week period）, the exercise ＋ light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise ＋ light groups. Moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise ＋ light group. These results indicate that low-intensity treadmill exercise （first 5 minutes at a speed of 2 m/min, second 5 minutes at a speed of 5 m/min, and the last 20 minutes at a speed of 8 m/min） or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural development.

关键词： neural regeneration neurogenesis neurorehabilitation exercise bright light brain-derivedneurotrophic factor hippocampus childhood grants-supported paper neuroregeneration

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