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Molecular Detection of Pathogens Involved in Sexually Transmitted Infections in Brazzaville, Congo

Open Journal of Medical Microbiology 2024年第3期14卷 190-205页

作者： Jeanine Mireille Sita Maboundou Bitsi nina Esther Ngoyi Ontsira Edith Sophie Kombo Bayonne Tanguy Mieret Geril Sekangue Obili Herlen Tsoumou Lina Foungou Kessengue Samantha Potokoue Mpia Chloé Dupont Guilhem Conquet Gickel Mpika Bitsene Bienvenu Roland Ibara Ossibi Axel Aloumba Etienne Nguimbi Sylvain Godreuil Faculty of Sciences and Technology Marien NGOUABI University Brazzaville Republic of the Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of the Congo Bacteriology-Virology Laboratory University Hospital Center Brazzaville Republic of the Congo Department of Infectious Diseases Referral Hospital Center of Talanga Brazzaville Republic of the Congo Parasitology-Mycology Laboratory University Hospital Center Brazzaville Republic of the Congo Department of Gynecology-Obstetrics University Hospital Center Brazzaville Republic of the Congo UMR IRD224-CNRS5290-UM MIVEGEC Infectious Diseases and Vectors: Ecology Genetics Evolution and Control CREES (Reshearch Center in Ecology and Evolution Health) Montpellier France Bacteriology Laboratory Arnaud de Villeneuve University Hospital CHU of Montpellier Montpellier France Department of Infectious Diseases University Hospital Center Brazzaville Republic of the Congo

The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.

关键词： Prevalence Chlamydia trachomatis Neisseria gonorrhoeae Mycoplasma génitalium Trichomonas vaginalis

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Thyrotoxicity of the Chlorides of Cadmium and Mercury in Rabbit

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Biomedical and Environmental Sciences 1992年第3期5卷 236-240页

作者： nina GHOSH SHELLEY BHATTACARYA Environmental Toxicology Laboratory Department of Zoology Visva-Bharati UniversityEnvironmental Toxicology Laboratory Department of Zoology Visva-Bharati University Santiniketan-731235 IndiaSantiniketan-731235 India

Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg-kg-1 body weight (bw) and mercury chloride 20 ***-1 bw, thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronine (T3) titre. On the other hand, there was a remarkable fall in the thyroxine (T4) level, and the T3/T4 ratio was high as compared with the control. Evidence indicates that acute heavy metal lethality will induce unmediate hyperthyroidism. It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodination of T4 to T3. Measurement of T3 and T4 levels may thus be utilized as a reliable indicator of heavy metal lethality.

关键词： Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg·kg-1 body weight (bw) and mercury chloride 20 mg·kg-1 bw, thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronine (T3) titre. On the other hand, there was a remarkable fall in the thyroxine (T4) level, and the T3/T4 ratio was high as compared with the control. Evidence indicates that acute heavy metal lethality will induce immediate hyperthyroidism. It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodinafion of T4 to T3. Measurement of T3 and T4 levels may thus be utilized as a reliable indicator of heavy metal lethality.

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Ependymal cells and multiple sclerosis: proposing a relationship

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Neural Regeneration Research 2020年第2期15卷 263-264页

作者： Dale Hatrock nina Caporicci-nucci Jo Anne Stratton The Montreal Neurological Institute McGill UniversityMontrealCanada Integrated Program in Neuroscience McGill UniversityMontrealCanada

Multiple sclerosis (MS) currently affects ~2.5 million people worldwide. MS is typically diagnosed in young adults and is usually not fatal, meaning people live long lives with MS. Affected individuals usually suffer from progressive physical and/or cognitive disability, often including fatigue (89.6%), depression (53.9%), memory loss (49.0%), motor or sensory dysfunction (76.4%, 70.4%) and urinary incontinence (50.8%).

关键词： multiple sclerosis relationship dysfunction

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Liver metastases “siphon” off immunotherapy response

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 526-529页

作者： nina Cortese Federica Marchesi Department of Immunology and Inflammation IRCCS Humanitas Research HospitalMilanItaly Department of Medical Biotechnology and Translational Medicine University of MilanMilanItaly

For many different cancers,the advent of immunotherapy(IT)treatments,in particular immune checkpoint inhibitors,aimed at reviving the immune response against cancer cells,has led to a great improvement in terms of clinical *** the success of IT,even in advanced metastatic cancers,some patients still fail to respond for reasons yet unclear(1,2).Yu et *** an issue of Nature Medicine.

关键词： immunotherapy clinical

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660MW高水分褐煤锅炉超低负荷运行特性研究

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热力发电 2024年第5期53卷 82-92页

作者：李子祥张启超乌晓江叶妮娜许芸张忠孝上海交通大学机械与动力工程学院上海200240 上海能源建设工程设计研究有限公司上海200135 国家能源集团科学技术研究院有限公司南京210046

为揭示大容量高水分褐煤机组的超低负荷运行特性及性能优化方式,基于建立并验证的燃煤锅炉燃烧模型,研究了33%最大连续额定负荷下燃烧器运行方式对660 MW高水分褐煤锅炉炉内燃烧、传热及NO_(x)转化特性的影响。结果表明:超低负荷下炉内... 详细信息

为揭示大容量高水分褐煤机组的超低负荷运行特性及性能优化方式,基于建立并验证的燃煤锅炉燃烧模型,研究了33%最大连续额定负荷下燃烧器运行方式对660 MW高水分褐煤锅炉炉内燃烧、传热及NO_(x)转化特性的影响。结果表明:超低负荷下炉内仍可形成良好组织的流动及燃烧场,但锅炉综合性能显著下降,如燃烧温度及受热面吸热量显著降低、炉膛出口NO_(x)排放增加等;运行4层燃烧器时投运连续的下、中间组或中间、上组燃烧器,可有效防止燃烧、传热过程的显著恶化及NO_(x)排放的明显增加;燃烧器投运层数影响锅炉综合性能,运行2层燃烧器时炉内剧烈燃烧区域过于集中,不利于维持较高的燃烧温度及传热强度,炉膛出口NO_(x)排放升高。研究结果揭示了超低负荷下燃烧器投运位置及层数对660 MW高水分褐煤锅炉综合性能的影响,可为大规模可再生能源电力并网背景下高水分褐煤机组参与深度调峰的运行调整及优化提供指导。

关键词：褐煤超低负荷燃烧器位置燃烧器层数锅炉性能

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Application of an Optical Biosensor to Study the Interaction between Porphyrins and Wheat Germ Agglutinin

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Wuhan University Journal of Natural Sciences 2006年第2期11卷 432-436页

作者： QIN Yimin PAN nina ZOU Guolin College of life Sciences Wuhan University Wuhan 430072 Hubei China

An optical biosensor with a stirred cuvette has been used to monitor the interaction of immobilized wheat germ agglutinin （WGA） with two water-soluble cationic porphyrins, The association constants （Ka） of the free base porphyrin and its Zn（Ⅱ） complex form were 2. 66 and 27.31 × 10^5 l,/mol at 20 ℃ respectively. The interactions of the free base porphyrin were further investigated at temperatures between 15 ℃ and 37 ℃, The thermodynamics parameters, changes in free energy, enthalpy and entropy, were -31.23, 22.92, 54.15 ld/mol respectively. The heat capacity change was -355.53 J · mol^-1·K^-1 The binding was driven by entropic contribution, and showed strong enthalpy-entropy compensation. It was governed primarily by hydrophobic forces.

关键词： porphyrins wheat germ agglutinin interaction optical biosensor

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TAM-TOE整合视角下建设行业人工智能技术采纳行为研究

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工程研究（跨学科视野中的工程） 2024年第2期16卷 137-146页

作者：赵娜李怀琳杨妮娜长沙理工大学交通运输工程学院长沙410114 长沙理工大学公路工程教育部重点实验室长沙410114

随着建设行业的数字化转型,融合传统工程建设与人工智能技术已成为迫切需求。本研究以技术接受模型和技术-组织-环境框架为理论基础,运用结构方程模型分析了建设行业中人工智能技术采纳行为的影响因素。结果表明,在技术层面,人工智能技... 详细信息

随着建设行业的数字化转型,融合传统工程建设与人工智能技术已成为迫切需求。本研究以技术接受模型和技术-组织-环境框架为理论基础,运用结构方程模型分析了建设行业中人工智能技术采纳行为的影响因素。结果表明,在技术层面,人工智能技术的特性显著影响用户的感知易用性和有用性,进而直接影响采纳行为;而技术复杂性虽对感知有用性影响不显著,但明显增加了感知易用性的难度。在环境方面,外部环境对感知有用性有显著正向影响,但对感知易用性影响较弱,同时也直接影响采纳行为。组织层面上,针对人工智能技术的充分准备能显著提升员工的感知易用性、感知有用性并促进采纳行为,而领导层的支持则主要增强员工的感知易用性,进而推动其采纳行为。这表明,工程建设企业在推动人工智能技术应用时,应综合考虑技术、组织和环境三方面的关键因素,以制定更有效的战略。

关键词：人工智能技术接受(TAM)模型技术-组织-环境(TOE)模型建设行业技术采纳

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基于表面肌电信号的单轨吊驾驶员肌肉疲劳分析

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矿业研究与开发 2024年第7期44卷 221-229页

作者：辛运胜金泓懿宁振兵白伟董青苏妮娜太原科技大学机械工程学院山西太原030024 太原矿机电气股份有限公司山西太原030024 太原科技大学经济管理学院山西太原030024

单轨吊车作为一种煤矿井下运输机车,其工作环境会引发井下操作人员工作的舒适性等问题。为分析单轨吊驾驶员主要肌肉的疲劳状况,对易疲劳的16块肌肉进行肌电测试研究,并提取信号的积分肌电值(iEMG)和均方根值(RMS),结合时域分析和多元... 详细信息

单轨吊车作为一种煤矿井下运输机车,其工作环境会引发井下操作人员工作的舒适性等问题。为分析单轨吊驾驶员主要肌肉的疲劳状况,对易疲劳的16块肌肉进行肌电测试研究,并提取信号的积分肌电值(iEMG)和均方根值(RMS),结合时域分析和多元非线性回归分析方法,以iEMG和RMS为自变量,疲劳度为因变量分析肌肉疲劳特性。结果表明:驾驶员在上车和下车过程中的肌肉疲劳度远大于机车行走时的肌肉疲劳度;在机车操作过程中,由于驾驶员需要一直用右脚踩踏加速踏板来控制机车行走,使驾驶员右侧下肢肌肉中的股直肌、股二头肌、腓肠肌和比目鱼肌产生疲劳,且腓肠肌的疲劳度最大;为避免驾驶员出现一侧肌肉过度疲劳的情况,应该将驾驶室操作元件布置在两侧,减少一侧肌肉的使用率,降低驾驶员操作疲劳度,提高驾驶舒适度。

关键词：单轨吊车表面肌电信号积分肌电值均方根值肌肉疲劳

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Data-driven approaches for cyber defense of battery energy storage systems

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能源与人工智能(英文) 2021年第3期5卷 379-387页

作者： nina Kharlamova Seyedmostafa Hashemi Chresten Træholt Technical University of Denmark CopenhagenDenmark

Battery energy storage system(BESS)is an important component of a modern power system since it allows seamless integration of renewable energy sources(RES)into the grid.A BESS is vulnerable to various cyber threats that may influence its proper operation,which in turn impacts negatively the BESS and the electric *** potential failure of a BESS can cause economic issues and physical damage to its *** ensure cyber-secure and reliable BESS operation in grid-connected or islanded modes of the BESS operation,a cyber-defense strategy is ***,a comprehensive review on the requirements for the BESS design as well as the attack detection and mitigation methods is *** this paper,we review state-of-the-art attack detection and mitigation methods for various BESS applications focusing on machine learning(ML)and artificial intelligence(AI)-based *** addition,the state-of-the-art methods for designing and operating a cyber-secure BESS are *** on the literature review,we identified gaps in the current research,defined the possible cyberattacks against the BESS that have not been considered before,and suggested the potential approaches to detect them.

关键词： Cyber security Artificial intelligence Battery energy storage system False data injection attack Cyberattack Machine learning

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ABC-X模型护理干预联合奥马珠单抗治疗中重度过敏性哮喘患儿疗效及对家属负面情绪的影响

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医学新知 2024年第6期34卷 647-655页

作者：赵妮娜岳雪艳茹凉新疆医科大学第一附属医院儿内二科乌鲁木齐830054

目的探讨ABC-X模型护理干预联合奥马珠单抗对儿童中重度过敏性哮喘(allergic asthma,AA)的临床疗效及对家属负面情绪的影响。方法前瞻性招募2022年1月至2023年1月在新疆医科大学第一附属医院就诊的AA患儿及家属,根据随机数字表法,将AA... 详细信息

目的探讨ABC-X模型护理干预联合奥马珠单抗对儿童中重度过敏性哮喘(allergic asthma,AA)的临床疗效及对家属负面情绪的影响。方法前瞻性招募2022年1月至2023年1月在新疆医科大学第一附属医院就诊的AA患儿及家属,根据随机数字表法,将AA患儿及家属分为ABC-X组(ABC-X模型护理干预联合奥马珠单抗)和常规组(常规护理联合奥马珠单抗)。观察并比较两组干预前后患儿临床疗效、奥马珠单抗不良反应发生率、肺功能指标、免疫功能指标、炎性指标及家属负面情绪评分。结果本研究共招募120对哮喘患儿及家属,每组各60对。干预前,两组在C-ACT评分、肺功能指标、免疫功能指标、炎性指标、SAS评分、SDS评分方面差异无统计学意义(P>0.05)。干预16周后,在AA患儿临床疗效和安全性方面,ABC-X组治疗总有效率和C-ACT评分均显著高于常规组(P0.05);在家属负面情绪方面,两组SAS和SDS评分均较干预前显著下降(P<0.05),且干预后ABC-X组SAS和SDS评分显著低于常规组(P<0.05);在肺功能和免疫功能方面,两组FEV_(1)、FEV_(1)/FVC、PEF、CD3、CD4和CD4/CD8均较干预前显著上升(P<0.05),且干预后ABC-X组显著高于常规组(P<0.05);在炎性指标方面,两组MIP-1α、MCP-1、IL-1β和IL-8均较干预前显著下降(P<0.05),且干预后ABC-X组显著低于常规组(P<0.05)。结论ABC-X模型护理干预可促进奥马珠单抗治疗AA患儿的临床效果,改善肺功能和免疫功能,增强抗炎效应,缓解患儿家属负面情绪。

关键词： ABC-X模型护理干预奥马珠单抗中重度过敏性哮喘家属负面情绪

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