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Aluminum-Magnesium Silicate enhances release of virions of cultured Fowl Pox Virusand inhibits the virus

Health 2013年第9期5卷 1394-1396页

作者： Maduike C. O. Ezeibe Emmanuel Ekeanyanwu Augustine A. Ngene ijeo.a j. mbuko Department of Veterinary Medicine University of Nigeria Nsukka Nigeria

Antiviral effects of a synthetic Aluminum-Magnesium Silicate (AMS) were tested on Fowl Pox Virus (FPV). Five batches of the Nigerian brand of FPV vaccine were used as sources of the virus. The reconstituted vaccines were mixed with The Synthetic AMS on equal volume to weight basis and incubated at room temperature for one hour. They were centrifuged for 10 minutes at 2000 revolutions per minute. The incubation and centrifugation were repeated on a portion of each vaccine supernatant. The two sets of supernatants were tested by the Modified Passive Haemagglutination test, for FPV titres. Portions of the vaccines, not incubated with the AMS, were served as controls. Fowl Pox Virus titres of the vaccines increased from a mean of 2.8 ± 1.10 to 11.2 ± 4.38 when incubated with the AMS once. When incubation with the AMS was repeated, the titres reduced (P< 0.05) to zero in each sample.

关键词： Aluminum-Magnesium Silicate–Nanoparticles Antiviral Effects Anticancer Potentials Fowl Pox Virus

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Mortality rates from a Nigerian isolate of the Infectious Bursa Disease Virusand passive haemagglutination antibody titer that protects chicks against challenge with the virus isolate

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Health 2013年第9期5卷 1355-1359页

作者： Maduike C. O. Ezeibe j.hn O. A. Okoye Temitope M. Ogunniran Paul C. Animoke ijeo.a j. mbuko ijeo.a A. Nwankwo Augustine A. Ngene Department of Veterinary Medicine University of Nigeria Nsukka Nigeria Department of Veterinary Medicine University of Nigeria Nsukka Nigeria Department of Veterinary Microbiology and Pathology University of Nigeria Nsukka Nigeria

To determine passive haemagglutination (PHA) antibody titer that would protect chicks against Nigerian isolates of the Infectious Bursa Disease Virus (IBDV), five groups of chicks aged 30 days which had different antibody titers were challenged with a Nigerian isolate of virulent IBDV. Mortality rates of the different groups were plotted against their respective mean PHA antibody titers. A group with zero antibody titer had a mortality rate of 75% while those with PHA antibody titers of 185.6, 243.2, 256 and 307.2 had mortality rates of 40%, zero, zero and zero respectively. Linear equation generated for a line of best fit of the graph of mortality rates of the chicks on their IBD antibody titers gave antibody titer (X) at which mortality (Y) would be zero as 300. A mortality of 75% and the high antibody level needed to protect chicks suggest that the isolate may be a hypervirulent strain.

关键词： Protective Antibody Titer Hypervirulent Infectious Bursa Disease Virus Strain Nigerian Isolate

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Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant Escherichia coliinfection

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Health 2013年第10期5卷 1548-1552页

作者： Maduike C. O. Ezeibe Okechukwu K. Ezeobele Mfon E. Esen Augustine A. Ngene ijeo.a j. mbuko ijeo.a C. Chukwudi Valentine U. Omoj. Ikenna O. Ezeh Department of Veterinary Medicine University of Nigeria Nsukka Nigeria Department of Veterinary Parasitology and Entomology University of Nigeria Nsukka Nigeria Department of Veterinary Physiology and Pharmacology University of Nigeria Nsukka Nigeria

To treat resistant Escherichia coli infection in chicks, Ampicillin was stabilized with a synthetic aluminum-magnesium silicate (AMS) to prolong its bioavailability. Its dose was also reduced to minimize adverse side effects. Vitamins A, C, E and Selenium levels in the chicks’ feeds were increased to enhance immune response of the chicks. E. coli coloning forming units, per ml of bile of the chicks, treated with Ampicillin and with Ampicillin in AMS, were: 228800.00 ± 90103.50 and 134500.00 ± 44937.97 at 10 mg/kg, 104400.00 ± 36024.44 and 34800.00 ± 8014.97 at 7.5 mg/kg, 198400.00 ± 129301.80 and 156800.00 ± 109392.70 at 5 mg/kg. Mean bacterial loads of the untreated groups, fed normal feed and those fed the fortified feed were 824400.00 ± 322424.80 and 534800.00 ± 277832.80. At 7.5 mg/kg. Ampicillin in the AMS, effectively (P E. coli infection in chicks, fed immune-stimulants, with the infection rate reduced by 95.8%.

关键词： Prolonging Bioavailability of Drugs Minimizing Side Effects of Drugs Enhancing Immune Responses of Patients

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Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus

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Health 2012年第7期4卷 429-432页

作者： Maduike C. O. Ezeibe Antony N. Egbuj. Obianuj. N. Okoroafor j.mes I. Eze Omadi Ij.bo Augustine A. Ngene Ikechukwu C. Eze j.seph A. C. Ugonabo Mary E. Sanda ijeo.a j. mbuko Department of Microbiology University of Nigeria Nsukka Nigeria Department of Veterinary Medicine University of Nigeria Nsukka Nigeria Viral Research Laboratory National Veterinary Research Institute Vom Nigeria

Effects a synthetic Aluminium-Magnesium Silicate [AMS] has on Avian Influenza Virus (AIV) were tested. Equal amounts of AIV samples and of the AMS were mixed, kept one hour at room temperature before centrifuging. The supernatants were remeasured and tested for, viral titre, Mean Death Time (MDT) and Mortality Rate of chicken Embryos (EMR). Volumes of the viral samples reduced at rate of 23.4% ± 5.48%. Viral titres reduced significantly (P < 0.01) from HA, 73 ± 32.72 to 1.4 ± 0.43. Also, EMR of infected chicken embryos reduced from 100% to 65%, while MDT of those that died,increased significantly (P < 0.01) from 76 ± 4.38 to 136 ±18.93 hours. When incubation with AMS was repeated on portions of an AIV sample, MDT increased from 64 to 104 hours with the portion incubated once. AIV portions on which incubation with AMS was repeated could not kill chicken embryos.

关键词： Antiviral Synthetic Aluminium-Magnesium Silicate Avian Influenza Virus

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