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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis

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Cellular & Molecular Immunology 2023年第10期20卷 1140-1155页

作者： Abrar ul haq Khan Alaa Kassim Ali Bryan Marr Donghyeon Jo Simin Ahmadvand Claire Fong-McMaster Saeedah Musaed Almutairi Lisheng Wang Subash Sad Mary-Ellen Harper Seung-Hwan Lee Department of Biochemistry Microbiologyand ImmunologyFaculty of MedicineUniversity of OttawaOttawaONCanada The University of Ottawa Centre for Infection Immunityand InflammationOttawaONCanada Botany and Microbiology Department College of SciencesKing Saud UniversityRiyadhSaudi Arabia

Natural killer(NK)cells are predominant innate lymphocytes that initiate the early immune response during *** cells undergo a metabolic switch to fuel augmented proliferation and activation following *** necrosis factor-alpha(TNFα)is a well-known inflammatory cytokine that enhances NK cell function;however,the mechanism underlying NK cell proliferation in response to TNFαis not well ***,we demonstrated that upon infection/inflammation,NK cells upregulate the expression of TNF receptor 2(TNFR2),which is associated with increased proliferation,metabolic activity,and effector ***,IL-18 can induce TNFR2 expression in NK cells,augmenting their sensitivity toward TNFα.Mechanistically,TNFα-TNFR2 signaling upregulates the expression of CD25(IL-2Rα)and nutrient transporters in NK cells,leading to a metabolic switch toward aerobic *** analysis revealed significantly reduced expression levels of genes involved in cellular metabolism and proliferation in NK cells from TNFR2 KO ***,our data affirmed that genetic ablation of TNFR2 curtails CD25 upregulation and TNFα-induced glycolysis,leading to impaired NK cell proliferation and antiviral function during MCMV infection in ***,our results delineate the crucial role of the TNFα-TNFR2 axis in NK cell proliferation,glycolysis,and effector function.

关键词： Natural killer cells TNFa TNFR2 Glycolysis Proliferation Murine cytomegalovirus

Enhanced room temperature ferromagnetism in Cr-doped ZnO nanoparticles prepared by auto-combustion method

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Journal of Semiconductors 2018年第4期39卷 20-27页

作者： Khizar-ul haq M.Irfan Muhammad Masood Murtaza Saleem Tahir Iqbal Ishaq Ahmad M.A.Khan M.Zaffar Muhammad Irfan Department of Physics Mirpur University of Science and Technology (MUST) Department of Physics SBASST Lahore University of Management Sciences Experimental Physics Labs National Centre for Physics Quaid-e-Azam University Department of Physics University of Azad Jammu and Kashmir Muzaffarabad

Zn1-xCrxO （x = 0.00, 0.01, 0.03, 0.05, 0.07, and 0.09） nanoparticles were synthesized, by an auto-com- bustion method. Structural, optical, and magnetic characteristics of Cr-doped ZnO samples calcined at 600 ℃ have been analyzed by using X-ray diffraction （XRD）, field emission scanning electron microscope （FESEM）, UV-Vis spectroscopy and vibrating sample magnetometer （VSM）. The XRD data confirmed the hexagonal wurtzite structure of pure and Cr-doped ZnO nanoparticles. The calculated values of grain size using Scherrer＇s formula are in the range of 30.7-9.2 nm. The morphology of nanopowders has been observed by FESEM, and EDS results con- firmed a systematic increase of Cr content in the samples and clearly indicate with no impurity element. The band gaps, computed by UV-Vis spectroscopy, are in the range of 2.83-2.35 eV for different doping concentrations. By analyzing VSM data, significantly enhanced room temperature ferromagnetism is identified in Cr-doped ZnO samples. The value of magnetization is a 12 times increased of the value reported by Daun et al. （2010）. Room temperature ferromagnetism of the nanoparticles is of vital prominence for spintronics applications.

关键词： Cr-doped ZnO auto-combustion DMS ferromagnetism

Spatio-Temporal Analysis of Landuse/Landcover Change of District Pishin Using Satellite Imagery and GIS

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Journal of Geographic Information System 2016年第3期8卷 361-368页

作者： Sanaullah Khan Said Qasim Romana Ambreen Zia-ul-haq Syed Department of Geography University of Balochistan Quetta Pakistan

Detecting change on the face of the globe using GIS (Geographic Information System) aided by remotely sensed imagery is now becoming an indispensable tool in managing the resources of our planet. The present study with the help of GIS and remote sensing (RS) is also a similar attempt in recording and quantifying change in land use and land cover in district Pishin both in spatial and temporal extents. Satellite imagery was acquired from the USGS official website from three LANDSAT satellites. Theses satellites are LANDSAT 5, LANDSAT7 and LANDSAT 8. The data were acquired for the years 1992, 2003 and 2013. Satellite imagery was processed in ArcMap 10.1 and maximum likelihood supervised image classification was applied in reaching the goal of detecting change. The result of the analysis revealed that built-up area was increased by 5.84%;vegetation was increased by 3.89%;water bodies were increased by 0.05% and bare surfaces were decreased by 9.78%. The decrease in the barren surfaces was attributed to the increase in vegetation and built-up area which replaced the barren land in the study area. This paper also shows the significance and potential of digital change detection methods in managing the resources of our environment and keeping an eye on the land use and land cover of our Earth.

关键词： Spatial-Temporal Land-Cover Change District Pishin GIS Satellite Imagery

Plant genome editing:CRISPR,base editing,prime editing,and beyond

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Grassland Research 2022年第4期1卷 234-243页

作者： Yujie Xie Syed Inzimam ul haq Xingyu Jiang Dianfeng Zheng Naijie Feng Wenying Wang Jin-Sheng He Quan-Sheng Qiu MOE Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhouGansuChina College of Coastal Agricultural Sciences Guangdong Ocean UniversityZhanjiangGuangdongChina Academy of Plateau Science and Sustainability School of Life SciencesQinghai Normal UniversityXiningQinghaiChina Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization in Qinghai Tibet Plateau Qinghai Normal UniversityXiningQinghaiChina State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems Lanzhou UniversityLanzhouGansuChina

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system is a fast-growing,genome editing technology that has wide applications in identifying gene functions as well as improving agricultural production and crop ***,we summarized recent advances in the development and applications of genome editing technologies in *** briefly described CRISPR/Cas9 technology and examined the base and prime editing techniques that have been developed from CRISPR *** new prime editing-derived techniques were assessed.

关键词： base editing CRISPR/Cas9 plant genome editing prime editing prime editing-derived techniques

Machinability Investigation and Optimization of Process Parameters in Cryogenic Assisted Sustainable Turning of AISI‑L6 Tool Steel

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Transactions of Nanjing University of Aeronautics and Astronautics 2020年第3期37卷 403-415页

作者： JAMIL Muhammad haq Emran ul KHAN Aqib Mashood GUPTA Munish Kumar LI Liang SONG Qinghua College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061P.R.China National Demonstration Center for Experimental Mechanical Engineering Education School of Mechanical EngineeringShandong UniversityJinan 250061P.R.China

The application of cutting fluid is significantly increased in the machining sector to improve ***,the inherent characteristics of cutting fluids on ecology,environment,and society shift the interest of researchers to work on environmentally friendly cooling conditions such as cryogenic ***,the effect of cutting speed and feed rate on the machining performance of the AISI‑L6 tool steel is investigated under cryogenic cooling ***,the L9 Taguchi based grey relational analysis(GRA)is conducted to investigate the essential machining indices such as cutting energy,surface roughness,tool wear,and material removal rate(MRR).The results indicate that the cutting speed of 160 m/min and feed rate of 0.16 mm/r are the optimum parameters that significantly improves the machining performance of AISI‑L6 tool steel.

关键词： sustainable manufacturing cryogenic machining hardened steel energy consumption tool lif

Effects of homogeneous-heterogeneous reactions and thermal radiation on magneto-hydrodynamic Cu-water nanofluid flow over an expanding flat plate with non-uniform heat source

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Journal of Central South University 2019年第5期26卷 1161-1171页

作者： DOGONCHI A S CHAMKHA Ali J HASHEMI-TILEHNOEE M SEYYEDI S M RIZWAN-ul-haq GANJI D D Department of Mechanical Engineering Aliabad Katoul BranchIslamic Azad UniversityAliabad KatoulIran Mechanical Engineering Department Prince Sultan Endowment for Energy and EnvironmentPrince Mohammad Bin Fahd UniversityAl-Khobar 31952Saudi Arabia RAK Research and Innovation Center American University of Ras Al KhaimahP.O.Box 10021Ras Al KhaimahUnited Arab Emirates Department of Electrical Engineering Bahria UniversityIslamabadPakistan Mechanical Engineering Department Babol Noshirvani University of TechnologyBabolIran

This study presents the effect of non-uniform heat source on the magneto-hydrodynamic flow of nanofluid across an expanding plate with consideration of the homogeneous-heterogeneous reactions and thermal radiation effects.A nanofluid’s dynamic viscosity and effective thermal conductivity are specified with Corcione *** to this correlation,the thermal conductivity is carried out by the Brownian *** transformations reduce the governing equations concerned with energy,momentum,and concentration of nanofluid and then numerically *** influences of the effective parameters,e.g.,the internal heat source parameters,the volume fraction of nanofluid,the radiation parameter,the homogeneous reaction parameter,the magnetic parameter,the heterogeneous parameter and the Schmidt number are studied on the heat and flow transfer ***,regarding the effective parameters of the present work,the correlation for the Nusselt number has been *** outcomes illustrate that with the raising of the heterogeneous parameter and the homogeneous reaction parameter,the concentration profile *** addition,the outcomes point to a reverse relationship between the Nusselt number and the internal heat source parameters.

关键词： nanofluid non-uniform heat source homogeneous-heterogeneous reactions thermal radiation Brownian motion

Trajectory of cause of death among brought dead neonates in tertiary care public facilities of Pakistan: A multicenter study

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World Journal of Pediatrics 2017年第1期13卷 57-62页

作者： Muhammad Ayaz Mustufa Munir Ahmed Sheikh ijaz-ul-haque Taseer Syed Jamal Raza Muhammad Sohail Arshad Tasleem Akhter Ghazala Mohyuddin Arain Sultana Habibuilah Sohail Safdar Rukhsana Firdous Muhammad Adnan PMRC Specialized Research Center on Child Health National Institute of Child HealthKarachiPakistan PMRC Research Center Liaquat University of Health and Medical SciencesJamshoroHyderabadPakistan PMRC Research Center Nishtar MedicaI CollegeMultan.Pakistan PMRC Research Center Khyber Medical CollegePeshawarPakistan PMRC Research Center Punjab Medical CollegeFaisalabad.Pakistan PMRC Research Center Dow University of Health Sciences.Karachi.Pakistan PMRC Research Center Bolan Medical CollegeOuettaPakistan PMRc Research Center FJMCLahore.Pakistan.

Background:Considering the fact that Pakistan is amongst the countries with very high neonatal mortality rates,we conducted a research study to determine the possible causes and characteris廿cs of neonates presenting dead to the emergency department of tertiary public health care facilities of Pakistan using verbal ***:A descriptive case series study was conducted in emergency department/pediatrics ward/neonatal ward/nursery unit of ten tertiary care public health facilities,situated in seven malor cities of Pakistan from November,2011 to June。*** verbal autopsy proforma was used to collect information regarding cause of death,family narratives and other associated risks accountable for pathway to mortality.

关键词： autopsy child health services early childhood emergency department use neonatal mortality

Effect of Abscisic Acid on NaCI Stressed Callus Proliferation and Plant Regeneration in Rice

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Journal of Life Sciences 2012年第1期6卷 48-54页

作者： ikram-ul-haq Ghulam Yasin Mumtaz Hussain Ali Mohammad Dahri Institute of Biotechnology and Genetic Engineering （IBGE） University of Sindh Jamshoro 76080 Pakistan Institute of Pure and Applied Biology Bahauddin Zakariya University Multan Pakistan Department of Botany Universuity of Agriculture Faisalabad 38040 Pakistan

In rice, 2,4-Dichlorphenoxyacetic acid （MS2） has been considered best for callus induction and combination ofNAA, IAA, ABA （MS3） for somatic embryogenesis. Efficient plant regeneration was observed when MS basal salts supplied with 3% sorbitol and 3% maltose as carbon sources without hormones （MSac）. During this experiment, effect of sodium chloride （NaCl） and abscisic acid （ABA） was assessed on callus growth, plant regeneration and root induction efficiency of rice （Oryza sativa L.） varieties IR-6 and Basmati-370. Callus proliferation rate was highly decreased in both varieties on MS2b （100 mol.m3 NaCl ＋ 0.5 mg＇L1 ABA） than MS2a （100 mol＇m3 NaCl） cultures significantly. Proline, glycine-betaine and reducing sugars were increased significantly in MS2a and MS2b callusing cultures. However, total proteins were decreased in MS2a, while slightly increased in MS2b. Maximum plant regeneration （9.42 ±0.54 and 10.67 ±0.50 ***1） from somatic embryos was observed on MS4c in IR-6 and Basmati-370, while 1.56 ± 0.06 （IR-6） and 0.95 ±0.05 （Basmati-370） plantlets callus1 were observed on MSab （100 mol·m3 NaCl）. No plant regeneration was observed on MS4b （100 mol·m3 NaCl ＋ 0.5 mg·L-1 ABA） medium in both varieties. Inhibition of root induction efficiency was high in MSsb （100 mol·m3 NaCl ＋ 0.5 mg·L-1 ABA） than MS5a （100 mol·m3 NaCl） in the stressed cultures （P 〈 0.05）. In this experiment, it was concluded that ABA involved in somatic embryogenesis and elevation of NaCl stress, while it causes inhibition of cell＇s growth as well as its regeneration into plantlets from somatic embryos.

关键词： Oryza sativa L. NaCl ABA embryogenic callus somatic embryogenesis bio-contents.

Diabetic cardiomyopathy—What do we know about it?

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World Journal of Cardiovascular Diseases 2013年第5期3卷 26-32页

作者： Muhammad Asrar ul haq Vivek Mutha Nima Rudd Chiew Wong Department of Medicine University of Melbourne Melbourne Australia Department of Cardiology The Northern Hospital Melbourne Australia

Diabetic cardiomyopathy is defined as the presence of myocardial dysfunction in patients with diabetes in the absence of coronary artery disease, hypertension, or other known cardiac disease. Diabetes has been shown to affect the heart through various cellular mechanisms leading to enhanced myocardial fibrosis, left ventricular hypertrophy, systolic and diastolic dysfunction. With increasing incidence of type II diabetes mellitus, it has continuously rising health and financial implications in both developed and developing countries. Hyperglycaemia seems to be the main deriving force, and careful glycaemic control as well as early administration of neurohormonal antagonists currently remains the mainstay of therapy. Many newer treatment targets are currently being explored. Here we present a brief review of its pathophysiology, association with heart failure symptoms, and management strategies.

关键词： Cardiomyopathy Diabetes Heart Failure