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Molecular Weight and Aggregation of Erwinia Gum in Aqueous Solutions

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Chemical Research in Chinese Universities 2000年第2期16卷 156-162页

作者： ZHANG Lina XU Xiaojuan ZHU RongPing iijima hideki Wuhan Univ Dept Chem Wuhan 430072 Peoples R China Natl Res Ctr Certified Reference Mat Beijing 100013 Peoples R China Asahi Chem Ind Co Ltd Chem Technol Dept 4 Miyazaki 8828847 Japan

Erwinia(E) gum is composed of glucose, fucose, galactose and glucuronic acid. The weightaverage molecular weights M w, numberaverage molecular weights M n and intrinsic viscosities[η] of the four fractions and the unfractionated E gum in aqueous solutions at desired temperatures were studied by light scattering, membrane osmometry, size exclusion chromatography(SEC) and viscometry. The experimental results prove that E gum formed aggregates in the aqueous solution at 25 ℃ and the aggregates were broken gradually with increasing temperature. The dissociation of the aggregates of E gum in the aqueous solution started at 36 ℃, and was completed at around 90 ℃. The [η] values of E gum and its fractions are much higher than those of the conventional polymers with the similar molecular weights, and decrease with increasing NaCl concentration.

关键词： Erwinia gum Light scattering SEC Membrane osmometry Viscometry Molecular weight Aggregation

Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings

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World Journal of Gastrointestinal Pathophysiology 2019年第2期10卷 17-28页

作者： Tsutomu Nishida hideki iijima Shiro Adachi Department of Gastroenterology Toyonaka Municipal HospitalOsaka 560-8565Japan Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineOsaka 565-0871Japan Department of Pathology Toyonaka Municipal HospitalOsaka 560-8565Japan

The indications of immune checkpoint inhibitors(ICPIs)for cancer treatment have rapidly expanded,and their use is increasing in clinical settings *** the considerable clinical benefits of ICPIs,frequent immune-related adverse events(ir AEs)have become nonnegligible *** ir AEs,ICPIinduced colitis/diarrhea is frequent and recognized not only by oncologists but also by gastroenterologists or *** endoscopic findings show similarity to those of inflammatory bowel disease to a certain extent,particularly ulcerative colitis,but do not seem to be *** pathological findings of ICPI-induced colitis may vary among drug *** show acute or chronic inflammation,but it may depend on the time of colitis suggested by colonoscopy,including biopsy or treatment *** the case of chronic inflammation determined by biopsy,the endoscopy findings may overlap with those of inflammatory bowel ***,we provide a comprehensive review of ICPIinduced colitis based on clinical,endoscopic and pathologic findings.

关键词： Immune checkpoint inhibitor Colitis Diarrhea Endoscopic Pathologic

Choroidal and cutaneous metastasis from gastric adenocarcinoma

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World Journal of Gastroenterology 2013年第9期19卷 1485-1488页

作者： Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe hideki iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Osaka 565-0871 Japan Department of Ophthalmology Osaka University Graduate School of Medicine Osaka 565-0871 Japan

Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions.

关键词： Stomach neoplasms Neoplasm metastasis Choroid neoplasms Skin neoplasms

Endoscopic surveillance strategy after endoscopic resection for early gastric cancer

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World Journal of Gastrointestinal Pathophysiology 2014年第2期5卷 100-106页

作者： Tsutomu Nishida Masahiko Tsujii Motohiko Kato Yoshito Hayashi Tomofumi Akasaka hideki iijima Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine

Early detection of early gastric cancer(EGC)is important to improve the prognosis of patients with gastric *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and high-frequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection,a therapeutic option for gastric intraepithelial ***,short-term outcomes of endoscopic resection(ER)for EGC have ***,surveillance with endoscopy after ER for EGC is becoming more important,but how to perform endoscopic surveillance after ER has not been established,even though the follow-up strategy for more advanced gastric cancer has been ***,a surveillance strategy for patients with EGC after ER is needed.

关键词： Early gastric cancer Endoscopic resection Synchronous gastric cancer Metachronous gastric cancer Surveillance

Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

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World Journal of Gastroenterology 2021年第2期27卷 162-175页

作者： Kei Motooka Koichi Morishita Nami Ito Shinichiro Shinzaki Taku Tashiro Satoshi Nojima Kayoko Shimizu Mutsuhiro Date Natsumi Sakata Momoko Yamada Shinji Takamatsu Yoshihiro Kamada hideki iijima Tsunekazu Mizushima Eiichi Morii Tetsuo Takehara Eiji Miyoshi Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Pathology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan FUJIFILM Wako Pure Chemical Corporation Amagasaki 661-0963HyogoJapan Department of Gastroenterological Surgery Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan

BACKGROUND Inflammatory bowel disease(IBD)is a chronic,relapsing inflammation of the digestive *** fecal and serum biomarkers have been extremely important and supportive for monitoring of IBD,their low sensitivity and high variability characteristics limit clinical ***,the establishment of better biomarkers is *** is one of the most important glycosylation modifications of *** haptoglobin(Fuc-Hpt)is used as a biomarker for several cancers and inflammation-related *** recently established a novel glycan monoclonal antibody(mAb),designated 10-7G,which recognizes *** developed an enzyme-linked immunosorbent assay(ELISA)to measure serum levels of Fuc-Hpt(10-7G values).AIM To investigate the usefulness of the serum 10-7G values as a potential biomarker for monitoring disease activity in *** This was a case control *** tissues of IBD patients(n=10)were examined immunohistochemically using the 10-7G *** determined 10-7G values using serum from patients with ulcerative colitis(UC,n=110),Crohn’s disease(n=45),acute enteritis(AE,n=11),and healthy volunteers(HVs)who exhibited normal(n=20)or high(n=79)C-reactive protein(CRP)levels at medical *** investigated the correlation between the 10-7G value and various clinical parameters of IBD patients by correlation *** operating characteristic(ROC)curve analysis was performed to evaluate the usefulness of the 10-7G values as a biomarker for clinical and endoscopic remission of UC compared to conventional serum *** In the immunohistochemical analysis,positive 10-7G mAb staining was observed in lymphocytes infiltrating into inflammatory sites of the mucosal layer and lymphoid *** 10-7G values were significantly higher in patients with IBD(P<0.001)and AE(P<0.05)compared with *** addition,10-7G values were correlated with clinical examination parameters related to inflammation in patients with

关键词： Inflammatory bowel disease Biomarkers Glycosylation Fucosylated haptoglobin Prohaptoglobin Endoscopic remission

Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 756-762页

作者： Toshiyuki Yoshio Tsutomu Nishida Yoshito Hayashi hideki iijima Masahiko Tsujii Junko Fujisaki Tetsuo Takehara Department of Gastroenterology Cancer Institute Hospital Department of Gastroenterology Osaka National HospitalNational Hospital Organization Department of Gastroenterology Toyonaka Municipal Hospital Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Department of Gastroenterology Higashiosaka City General Hospital

Endoscopic submucosal dissection(ESD) is minimally invasive and thus has become a widely accepted treatment for gastric neoplasms,particularly for patients with *** agents are used to prevent thrombotic events in patients with comorbidities such as cardio-cerebrovascular diseases and atrial *** appropriate cessation,antithrombotic therapy does not increase delayed bleeding in low thrombosis-risk ***,high thrombosisrisk patients are often treated with combination therapy with antithrombotic agents and occasionally require the continuation of antithrombotic agents or heparin bridge therapy(HBT) in the perioperative *** antiplatelet therapy(DAPT),a representative combination therapy,is frequently used after placement of drug-eluting stents and has a high risk of delayed *** patients receiving DAPT,gastric ESD may be postponed until DAPT is no longer *** is often required for patients treated with anticoagulants and has an extremely high bleeding *** continuous use of warfarin or direct oral anticoagulants may be possible ***,we show that some antithrombotic therapies in high thrombosis-risk patients increase delayed bleeding after gastric ESD,whereas most antithrombotic therapies do *** management of high thrombosis-risk patients is crucial for improved outcomes.

关键词： Antithrombotic therapy Endoscopic submucosal dissection Heparin bridge therapy Dual antiplatelet therapy Delayed bleeding

Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan

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World Journal of Gastroenterology 2014年第15期20卷 4362-4369页

作者： Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa hideki iijima Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Department of Gastroenterology Osaka Kaisei HospitalOsaka 532-0003Japan Department of Gastroenterology Itami City HospitalItami 664-8540Japan Department of Gastroenterology Osaka Seamen’s Insurance HospitalOsaka 552-0021Japan Department of Gastroenterology Ashiya Municipal HospitalAshiya 659-8502Japan Department of Gastroenterology Osaka General Medical CenterOsaka 558-8558Japan Department of Gastroenterology Yao Municipal HospitalYao 581-0069Japan Department of Gastroenterology Osaka National HospitalOsaka 540-0006Japan Department of Gastroenterology Sumitomo HospitalOsaka 565-0871Japan Department of Gastroenterology Nishinomiya Municipal Central HospitalNishinomiya 663-8014Japan Department of Internal Medicine Osaka Police HospitalOsaka 543-0035Japan Department of Gastroenterology Higashiosaka City General HospitalHigashiosaka 578- 8588Japan Department of Gastroenterology Ikeda Municipal HospitalIkeda 563-0025Japan Department of Gastroenterology Toyonaka Municipal HospitalToyonaka 560-0055Japan Department of Gastroenterology Otemae HospitalOsaka 540-0008Japan Department of Gastroenterology Hyogo Prefectural Nishinomiya HospitalNishinomiya 662-0918Japan Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular DiseaseOsaka 537-0025Japan Department of Gastroenterology Minoh City HospitalMinoh 562-0014Japan Department of Gastroenterology Osaka Rosai HospitalSakai 591-8025Japan Department of Gastroenterology Kansai Rosai HospitalAmagasaki 660-8511Japan

AIM: To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori (H. pylori) in usual post-market... 详细信息

关键词： Helicobacter pylori Eradication Esomeprazole Lansoprazole Proton pomp inhibitor

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki hideki iijima Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility

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Asian Journal of Andrology 2020年第4期22卷 368-371页

作者： Masashi iijima Kazuyoshi Shigehara hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical ScienceKanazawa 920-8641Japan Kyono ART Clinic Sendai 980-0014Japan Kyono ART Clinic TakanawaTokyo 108-0074Japan Suzuki Lady's Hospital Kanazawa 921-8033Japan Ebisu Tsuji Clinic Tokyo 150-0021Japan Tenjin Tsuji Clinic Fukuoka 810-0001Japan Dokkyo Medical University Koshigaya Hospital Saitama 343-8555Japan Department of Urology Faculty of MedicineToho UniversityTokyo 143-8541Japan

The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and *** several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in *** this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were *** study enrolled 250 patients with severe oligospermia and 717 patients with *** the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,*** sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically *** conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion.

关键词： azoospermia factor Japanese infertile men sperm recovery rate Y chromosome microdeletion