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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tok.ju Ok.no Hiroshi Ashida Norik. k.matsu Masayuk. Tsuk.sak. Tamak. iida Marie Iwasawa Yuto Tak.hashi Yasuo Tak.uchi Tak.nori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi Tak.yanagi Toshihik. Suzuk. Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work.highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

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Inverse relationship between platelet Ak. activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhik. Tok.da Tak.mitsu Hori Daisuk. Mizutani Tomoyuk. Hiok. k.mi k.jima Tak.shi Onuma Yuk.k. Enomoto Tomoak. Doi Rie Matsushima-Nishiwak. Shinji Ogura Hirok. iida Toru Iwama Tak.shi Sak.rai Osamu k.zawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACk.ROUND Ak. plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Ak. phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Ak.,p38 mitogen-activated protein(MAP)k.nase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Ak. corrected with phosphorylated p38 MAP k.nase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Ak. corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Ak. activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Ak. Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yok.yama Tak.k. Yamada Tetsuo iida Susumu Mochizuk. Ak.hide Yoshihara k.zuya Ak.mitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intak. of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week.old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 week.. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weak.r than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unk.own, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

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涉及黄斑部的视网膜脱离术后复位黄斑部视锥细胞敏感性评估

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 58-58页

作者： Sak.i T. iida k. Tanak. Y. 邢咏新 Department of Ophthalmology Jik.i University School of Medicine 3-25-8 Nishishinbashi Minato-k. Tok.o 105-8461 Japan

Purpose: To investigate the recovery of short-wavelength sensitivity in patients who had undergone successful reattachment of a rhegmatogenous retinal detachment with macular involvement. Methods: Postoperative assessment of the visual acuity and the visual fields by standard achromatic automated perimetry (SAP), and short-wavele-ngth automated perimetry (SWAP, Humphrey visual field analyzer; macula test pattern) was performed on 12 patients after the macula was reattached. The follow-up period was up to 12 months. Results: The visual acuity and SAP sensitivity recovered rapidly after reattachment, with further moderate improvements up to 6 months after reattachment. The improvements stabilized by 9 to 12 months. The SWAP sensitivities improved more slowly than the visual acuity or SAP sensitivities, but they continued to improve even when visual acuity or SAP sensitivities had stabilized. Conclusion: We conclude that measurement of the sensitivities of the short-wavelength-sensitive cones (S-cones) with SWAP may be a sensitive method to evaluate the visual recovery of the reattached macula following macula-off retinal detachment.

关键词：黄斑部视网膜脱离患者敏感性自动视野计

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用三维超声心动图评价主动脉瓣狭窄:一种准确的新方法

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 45-页

作者： Goland S. Trento A. iida k. R.J.Siegel 朱冰坡 Division of Cardiology Cedars-Sinai Medical Center 8700 Beverly Boulevard Los Angeles CA 90048 United States Dr.

背景:在主动脉瓣狭窄(AS)患者中,准确地评价主动脉瓣面积(AVA)对临床决策的确定非常重要。目前尚无关于三维超声心动图在定量测定AS中作用的评估。目的:评价实时三维超声心动图(RT3D)

关键词：主动脉瓣狭窄测定法超声心动图超声波诊断 AVA

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Direct visualization of postoperative aortobronchial fistula on computed tomography

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World Journal of Radiology 2024年第8期16卷 337-347页

作者： Nanae Tsuchiya Hitoshi Inafuk. Satok. Yogi Yuk. Iraha Gyo iida Mizuk. Ando Tak.ak. Nagano Shotaro Higa Tatsuya Maeda Yuya k.se k.jiro Furuk.wa k.ji Yonemoto Ak.hiro Nishie Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Thoracic and Cardiovascular Surgery Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Biostatistics School of Health SciencesFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

BACk.ROUND Postoperative aortobronchial fistula(ABF)is a rare complication that can occur in 0.3%-5.0%of patients over an extended period of time after thoracic aortic *** visualization of the fistula via imaging is *** To investigate the relationship between computed tomography(CT)findings and the clinical signs/symptoms of ABF after thoracic aortic *** Six patients(mean age 71 years,including 4 men and 2 women)with suspected ABF on CT(air around the graft)at our hospital were included in this retrospective study between January 2004 and September *** CT findings included direct confirmation of ABF,peri-graft fluid,ring enhancement,dirty fat sign,atelectasis,pulmonary hemorrhage,and bronchodilation,and the clinical course were retrospectively *** proportion of each type of CT finding was *** ABF detection after surgery was found to have a mean and median of 14 and 13 years,*** signs and symptoms were asymptomatic in 4 patients,bloody sputum was found in 1 patient,and fever was present in 1 *** complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 *** the 6 patients,3 survived,2 died,and 1 was lost to *** locations of the ABFs were as follows:1 in the ascending aorta;1 in the aortic arch;2 in the aortic arch leading to the descending aorta;and 2 in the descending *** were directly confirmed by CT in 4/6(67%)***-graft dirty fat(4/6,67%)and peri-graft ring enhancement(3/6,50%)were associated with graft infection,endoleak. and pseudoaneurysms were associated with hemoptysis(2/6,33%).CONCLUSION Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest *** is useful for the diagnosis of ABF and its complications.

关键词： Peri-graft air Aortobronchial fistula Chest computed tomography Postoperative Thoracic endovascular aortic repair Complication Thoracic aorta surgery

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Negative refraction of deep water waves through water channel network

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Journal of Hydrodynamics 2019年第4期31卷 840-847页

作者： Tak.hito iida Masashi k.shiwagi Department of Naval Architecture and Ocean Engineering Osaka University Suita Osaka 5650871 Japan Research Fellow of Japan Society for the Promotion of Science Chiyoda-ku Tokyo 1020083 Japan

A design method of a negative refractive index for free surface water waves in deep water is presented. To obtain a condition of a negative index, an analogy between water waves in a water channel and electric waves in an electric circuit is employed. An analytical solution of waves around a periodic array of rectangular columns is obtained by a circuit analysis. Attention is not focused on columns but a space among columns, and then the space is regarded as the water channel. Therefore, the circuit analysis can be applied to water waves. One channel is treated as a unit structure and a number of channels are periodically cascaded as a network. The negative refraction and back.ard waves by a network.of the water channels are shown. Since the negative refraction might occur even around simple periodic structures, it is meaningful to understand wave phenomenon around offshore structures and develop innovative technology.

关键词： Negative refractive index back.ard wave water channel network equivalent circuit deep water

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Electron transfer governed by light-matter interaction at metal-semiconductor interface

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npj Computational Materials 2020年第1期6卷 1628-1635页

作者： k.nji iida Masashi Noda Department of Theoretical and Computational Molecular Science Institute for Molecular ScienceMyodaijiOkazaki 444-8585Japan Center for Computational Sciences University of Tsukuba1-1-1 TennodaiTsukuba 305-8577Japan

The photoexcitation of heterostructures consisting of metallic nanoclusters and a semiconductor has been extensively investigated in relation to interests in photocatalysis and optical *** optoelectronic functions of the heterostructures originate from localized surface plasmon resonance,which can induce electron and resonance energy *** it is well k.own that photoinduced electronic interaction between a metallic nanocluster and a semiconductor is responsible for the resonance energy transfer,the electron transfer associated with the photoinduced electronic interaction has not been *** this paper,we elucidate the photoexcitation dynamics of a silver nanocluster/TiO_(2) heterostructure using an original first-principles computational approach that explicitly deals with light–matter *** is shown that the photoinduced silver–TiO_(2) electronic interaction causes excited electrons to be directly transferred from the silver nanocluster to the TiO2 layer without passing through the conduction band of the silver nanocluster.

关键词： silver interaction transfer

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Hydrogen technologies and developments in Japan

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Clean Energy 2019年第2期3卷 105-113页

作者： Shigek. iida k. Sak.ta Director The Institute of Applied Energy Executive Research Fellow The Institute of Applied Energy

The successful development of hydrogen-energy technologies has several advantages and ***-energy development could prevent global warming as well as ensure energy security for countries without adequate energy *** successful development of hydrogen would provide energy for transportation and electric *** is a unique energy carrier,as it can be produced from various energy sources such as wind,fossil fuels and biomass and,when it is combusted,it emits no CO_(2)*** other advantage is the wide distribution of resources globally that can be used to produce *** Japan,the Ministry of Economy,Trade and Industry(METI)published a‘Strategic Roadmap for Hydrogen and Fuel Cells’in 2014,with a revised update published in March *** goal of the roadmap is to achieve a hydrogen *** roadmap aims to resolve technical problems and secure economic *** roadmap has been organized into the following three phases:Phase 1-Installation of fuel cells;Phase 2-Hydrogen power plant/mass supply chain;Phase 3-CO_(2)-free *** paper reports on the current status of fuel cells and fuel-cell vehicles in Japan and gives a description and status of the R&D programmes along with the results of global energy model study towards 2050.

关键词： hydrogen and fuel cell energy system and policy energy and environment energy storage

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Multilinear Fractional Integrals on Morrey Spaces

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Acta Mathematica Sinica,English Series 2012年第7期28卷 1375-1384页

作者： Tak.shi iida Enji SATO Yoshihiro SAWANO Hitoshi TANAk. Department of Mathematical Sciences Faculty of ScienceYamagata University Department of Mathematics Kyoto University Graduate School of Mathematical Sciences The University of Tokyo

In the present paper we obtain and extend the boundedness property of the Adams type for multilinear fractional integral operators. Also, we deal with the Olsen type inequality.

关键词： Multilinear fractional integral operators Morrey spaces

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