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Atypical Manifestations of Systemic Lupus Erythematosus (SLE) in Elderly Men

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Journal of Biosciences and Medicines 2023年第6期11卷 135-139页

作者： Naveen Vithanage ihsan Ul Haq Nirojan Karunanathan Colm Quigley Aidan Buckley Jabran Hasan Khan Internal Medicine Department Wexford General Hospital Wexford Ireland

This case report highlights the rare occurrence of SLE in an elderly male patient. Despite the unusual presentation, the team was able to make a diagnosis of SLE using a combination of an atypical clinical picture, with initial signs and symptoms of weight loss, anemia, leucopenia and arthlagia, in combination with investigation results, including a positive test for anti-dsDNA antibodies. A more indolent disease course, combined with non-specific initial manifestations and low prevalence within the elderly population, often leads to delayed diagnosis. This case underscores the importance of considering SLE in the differential diagnosis of elderly patients, even in those who do not fit the typical epidemiological profile.

关键词： SLE ANA Anti-dsDNA Antibodies C3

A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms

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Asian Journal of Andrology 2022年第3期24卷 255-259页

作者： Muhammad Zubair Ranjha Khan Ao Ma Uzma Hameed Mazhar Khan Tanveer Abbas Riaz Ahmad Jian-Teng Zhou Wasim Shah Ansar Hussain Nisar Ahmed ihsan Khan Khalid Khan Yuan-Wei Zhang Huan Zhang Li-Min Wu Qing-Hua Shi The First Affiliated Hospital of USTC The CAS Key Laboratory of Innate Immunity and Chronic DiseasesSchool of Life SciencesCAS Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center of Genetics and DevelopmentUniversity of Science and Technology of ChinaHefei 230027China Institute of Industrial Biotechnology Government College UniversityLahore 54000Pakistan Medical Genetics Research Laboratory Department of BiotechnologyQuaid-i-Azam UniversityIslamabad 45320Pakistan

Asthenoteratozoospermia is one of the most severe types of qualitative sperm *** cases are due to mutations in genes encoding the components of sperm flagella,which have an ultrastructure similar to that of motile ***-coil domain containing 103(CCDC103)is an outer dynein arm assembly factor,and pathogenic variants of CCDC103 cause primary ciliary dyskinesia(PCD).However,whether CCDC103 pathogenic variants cause severe asthenoteratozoospermia has yet to be ***-exome sequencing(WES)was performed for two individuals with nonsyndromic asthenoteratozoospermia in a consanguineous family.A homozygous CCDC103 variant segregating recessively with an infertility phenotype was identified(ENST00000035776.2,c.461A>C,***154Pro).CCDC103 ***154Pro was previously reported as a high prevalence mutation causing PCD,though the reproductive phenotype of these PCD individuals is *** electron microscopy(TEM)of affected individuals’spermatozoa showed that the mid-piece was severely damaged with disorganized dynein arms,similar to the abnormal ultrastructure of respiratory ciliary of PCD individuals with the same ***,our findings expand the phenotype spectrum of CCDC103 ***154Pro as a novel pathogenic gene for nonsyndromic asthenospermia.

关键词： asthenoteratozoospermia CCDC103 dynein arms male infertility

Thiol/disulphide homeostasis in celiac disease

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 120-126页

作者： Mustafa Kaplan ihsan Ates Mahmut Yuksel Yasemin Ozderin Ozin Murat Alisik Ozcan Erel Ertugrul Kayacetin Department of Gastroenterology Turkey Yuksek Ihtisas Training and Research Hospital Department of Internal Medicine Ankara Numune Training and Research Hospital Department of Biochemistry Yildirim Beyazit University Medical Faculty

AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free *** Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis was examined with a new colorimetric method recently developed by Erel and Neselioglu. RESULTS In patients with celiac disease, native thiol(P = 0.027) and total thiol(P = 0.031) levels were lower, while disulphide(P < 0.001) level, disulphide/native thiol(P < 0.001) and disulphide/total thiol(P < 0.001) ratios were higher compared to the control group. In patients who do not comply with a gluten-free diet, disulphide/native thiol ratio was found higher compared to the patients who comply with the diet(P < 0.001). In patients withany autoantibody-positive, disulphide/native thiol ratio was observed higher compared to the patients with autoantibody-negative(P < 0.05). It is found that there is a negative correlation between celiac autoantibodies, and native thiol, total thiol levels and native thiol/total thiol ratio, while a positive correlation is observed between disulphide, disulphide/native thiol and disulphide/total thiol *** This study is first in the literature which found that the patients with celiac disease the dynamic thiol/disulphide balance shifts through disulphide form compared to the control group.

关键词： Anti-gliadin antibodies Anti-tissue transglutaminase antibody Gluten-free diet Oxidative stress Thiol oxidation

超越文明的冲突:土耳其伊斯兰教对西方的亲善(英文)

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超越文明的冲突:土耳其伊斯兰教对西方的亲善(英文)

北京论坛（2007）文明的和谐与共同繁荣——人类文明的多元发展模式

作者： ihsan Dagi Department of international relations Middle East Technical University Ankara 06531 Turkey

Modern Islamic political identity has historically positioned itself in opposition to the West. Given the form of relationship between Islam and the West especially in the last two centuries the rejection of the West,which was an act of identity construction from an Islamic point of view, has its historical and political *** latest wave of the clash of civilizations perspective seems vindicated by the 9/11 has further reinforced the image that Islam is inherently and inevitably in conflict with the West.

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心脏康复中药处方的特色分析

中医临床研究 2021年第5期13卷 46-47页

作者： ihsan ULLAH KHAN 杜廷海张露苗河南中医药大学河南郑州450000 河南中医药大学第一附属医院河南郑州450000

经筋与骨骼相连,主司四肢等关节的运动,经筋损伤与心脏康复达标与否关系密切。强筋骨、舒经络、补肝肾是心脏康复治疗和运动性疲劳防护的重要治则。破双心疾病之恶性循环,疏肝解郁为不可缺少的治法,也是运动性疲劳重要治则。心脏康复宜... 详细信息

经筋与骨骼相连,主司四肢等关节的运动,经筋损伤与心脏康复达标与否关系密切。强筋骨、舒经络、补肝肾是心脏康复治疗和运动性疲劳防护的重要治则。破双心疾病之恶性循环,疏肝解郁为不可缺少的治法,也是运动性疲劳重要治则。心脏康复宜善选剂型,兼顾色味;遣药平和,久服无弊,以适应长期化、个体化、家庭化的需要。心脏康复冲剂以强筋舒络、补益心肾、解郁安神为治法,以期达到心脏康复治疗和防护康复运动性疲劳的目的。

关键词：心脏康复运动性疲劳强筋舒络疏肝解郁剂型

Heterosis and Inbreeding Depression in F2Populations of Upland Cotton (Gossypium hirsutumL.)

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Agricultural Sciences 2017年第11期8卷 1283-1295页

作者： Bilal Ahmed Khan Naqib Ullah Khan Mehboob Ahmed Mazhar Iqbal ihsan Ullah Maria Saleem Isma Khurshid Aneela Kanwal Hazara Agriculture Research Station Abbottabad Pakistan University of Agriculture Peshawar Peshawar Pakistan

Hybrid cotton production through exploitation of heterosis is the only way for having vertical improvement and betterment in seed cotton yield which has been stagnated in the recent years. The current study was conducted to evaluate the performance of F2 population for studying mean performance, heterotic effects and inbreeding depression in upland cotton for polygenic traits. Parental genotypes and their F2s were sown at Khyber Pakhtunkhwa Agricultural University, Peshawar during 2010, manually. All the traits revealed highly significant (p ≤ 0.01) variations for both parents and their F2 hybrids. Mean performance for parents and their F2 hybrids is: (5.26 to 7.12 & 4.43 to 6.60) seeds locule-1, (21.10 to 28.03 & 20.40 to 28.50) seed boll-1, (32.20 to 34.80 & 32.22 to 35.05) lint% and (62.87 to 85.47 & 45.94 to 92.04) seed cotton yield plant-1, respectively. Heterotic effects found over mid parent and better parent were: 66.66% & 46.66% (seeds locule-1), 60% & 30% (seed boll-1), 43.33% & 30% (lint %) and 36.66% & 16.66% (seed cotton yield plant-1), respectively. For the parameters: seeds locule-1 (11 & 10), seeds boll-1 (2 & 1) and seed cotton yield plant-1 (3 & 1) showed positive highly significant heterosis for both mid and better parent, respectively while lint% did not reveal any positive significant heterosis. F2 populations i.e. CIM-499 × CIM-554 and CIM-554 × CIM-499 revealed highly significant heterotic effects over mid and better parent for all the traits except lint % while CIM-554 × CIM-707 showed highly significant heterotic effects for seeds locule-1 and seed cotton yield palnt-1. Positive economic heterotic effects were also exhibited by more than 50% of the F2 population i.e., 76.66% for seed locule-1, 50% for seeds boll-1, 3.33% for lint% and 20% for seed cotton yield plant-1, respectively. By comparing F2 mean values with F1s, only lint % showed (0.00% to 15.55%) maximum inbreeding depression while negligible amount of inbreeding depression was obs

关键词： Heterosis Inbreeding Depression Lint F2

Bio-catalyzed plastic degradation:a review

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Circular Agricultural Systems 2022年第1期2卷 23-29页

作者： Sehroon Khan Sadia Nadir shahid Iqbal Jianchu Xu Heng Gui Afsar Khan Masroor Hussain ihsan Ullah Department of Biotechnology Faculty of Natural SciencesUniversity of Science and TechnologyBannu 28100Khyber PakhtunkhwaPakistan Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Honghe Centre for Mountain Futures Kunming Institute of BotanyChinese Academy of ScienceHonghe 654400YunnanChina East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Department of Chemistry COMSATS University IslamabadAbbottabad CampusAbbottabad 22060Pakistan Department of Botany Faculty of Natural SciencesUniversity of Science and TechnologyBannu 28100Khyber PakhtunkhwaPakistan

The widespread use and production of plastic have led to increased accumulation of plastic waste in the environment which threatens terrestrial and marine *** methods for management of plastic waste remain a key *** of plastics is considered an environmentally safe method,but is still limited to laboratory *** previous studies have reported microbial enzymes capable of degrading *** discoveries offer a promising starting point for the development of biocatalyzed plastic degradation *** this review,we discuss recent advancements and applications of biocatalyst *** also describe the different steps for development of biocatalyzed plastic degradation technology and the major issues related to each *** in research into biocatalyzed plastic degradation would lead to new opportunities for sustainable alleviation of the worldwide problem of plastic waste accumulation.

关键词： starting steps plastics

Catalyzed Trisodium Citrate as a Medium for Heavy Metals Treatment in Green-Lipped Mussels (Perna viridis)

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Modern Research in Catalysis 2013年第2期2卷 50-56页

作者： ihsan Wan Azelee Razali Ismail Wan Azelee Wan Abu Bakar Rusmidah Ali Rugayah Mohamed Nurul Asma Samsudin Hashim Baharin Department of Chemistry Faculty of Science Universiti Teknologi Malaysia Johor Malaysia

This research was carried out to study the heavy metals removal like arsenic (As), lead (Pb), cadmium (Cd), nickel (Ni) and mercury (Hg) from Perna viridis. The trisodium citrate with Ru/Mn (25:75)-Al2O3 catalyst were used for the treatment medium with optimum treatment conditions at 500 μg/g of dosage, at temperature of 35°C ± 1°C, at pH 7, for 5 hours of duration and in the presence of compressed air (flow rate 895.50 mL/min). The introduction of Ru/Mn (25:75)-Al2O3 catalyst at 100°C calcination temperature on the trisodium citrate medium indicates the reduction of heavy metals which achieved the permissible limit by Malaysian Food Regulations (1985) and Commission Regulation of EU (2006). The original concentrations of As: 1.65 ± 0.89 μg/g, Hg: 12.42 ± 0.53 μg/g, Pb: 6.25 ± 0.69 μg/g, Cd: 1.27 ± 0.25 μg/g and Ni: 2.00 ± 1.05 μg/g were reduced to As: 0.75 ± 0.04 μg/g (54.34%), Hg: 0.4 ± 0.02 μg/g (96.79%), Pb: 1.07 ± 0.02 μg/g (82.89%), Cd: 0.32 ± 0.10 μg/g (75.02%) and Ni: 0.76 ± 0.01 μg/g (61.83%). ICP-MS and MHS-AAS techniques were used for the metals analysis and the catalyst was characterized through X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-Ray (EDX) and Nitrogen Absorption (NA).

关键词： Perna viridis Heavy Metal Trisodium Citrate Catalyst

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中巴传统药物研究比较

亚太传统医药 2017年第13期13卷 1-2页

作者：黄先菊陈慧 Awais ihsan 中南民族大学药学院湖北武汉430074 COMSATS科技大学生物科技学院

目的:探讨中巴两国传统药物资源的异同点,寻找潜在的合作点。方法:对巴基斯坦与中国传统药物的发展现状、药用资源、存在问题等进行了文献与实地调研研究。结果:巴基斯坦在医药保健品消费方面是最具潜力的市场之一。巴基斯坦的传统医药... 详细信息

目的:探讨中巴两国传统药物资源的异同点,寻找潜在的合作点。方法:对巴基斯坦与中国传统药物的发展现状、药用资源、存在问题等进行了文献与实地调研研究。结果:巴基斯坦在医药保健品消费方面是最具潜力的市场之一。巴基斯坦的传统医药体系是基于希波克拉底理论框架的希腊阿拉伯体系,农村医疗及农业经济发展与传统药物息息相关。过度开采、大量放牧、乱砍乱伐、土地退化等造成大量野生药用植物资源灭绝或濒临灭绝。巴基斯坦许多植物资源与我国共有,有些药用植物的临床功效与中国一致,还有一些药用植物在中巴两国的临床应用各有不同偏向。结论:巴基斯坦与中国生物技术和民族医药的合作可为两国带来互惠互利。通过人工种植或寻找替代品不仅可以缓解巴基斯坦药物资源耗竭问题,而且能够促进中国的贸易出口和科技输出,提升我国的国际竞争力与影响力。

关键词：巴基斯坦传统医药植物资源