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Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali Khan Saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar Khawar Zhiguang Ren Xinying Ji Malik ihsan ullah Khan Institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, MYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful results.Still, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that facilitate its early identification.

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

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Structural and optoelectronic properties of CsLnZnTe_(3)(Ln=La,Pr,Nd and Sm)

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Journal of Rare Earths 2023年第3期41卷 388-396,I0003页

作者： Imad Khan ihsan ullah Izaz Ul Haq Akbar Ali A.Dahshan Zahid Ali Iftikhar Ahmad Center for Computational Materials Science Department of PhysicsUniversity of MalakandChakdaraPakistan Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics Faculty of SciencePort Said UniversityPort SaidEgypt Gomal University Dera Ismail KhanPakistan

Zinc telluride is a versatile wide band gap semiconductor used in many applications.But it has certain limitations like large dimensions and large band gaps.Introducing alkali metal to its bulk lattice(3D)can reduce its dimensions and lanthanide can produce a red shift in the energy gap by converting it into quaternary compounds.The alkali and lanthanide incorporated quaternary zinc tellurides CsLnZnTe_(3)(Ln=La,Pr,Nd and Sm)form layered crystal structure in which_(∞)^(2)[LnZnTe_(3)]-layers are separated by Cs+layer.The famous lanthanide contraction is experimental both from lattice constants and bond lengths.The calculated band gaps are 2.26,2.28,2.12,2.05 eV for CsLaZnTe_(3),CsPrZnTe_(3),CsNdZnTe_(3) and CsSmZnTe_(3),respectively.These compounds show direct band gap nature.The energy band gaps of these compounds have not been evaluated yet both experimentally and theoretically.Energy loss functions,refractive index and dielectric functions were also calculated to explore the potential applications of CsLnZnTe_(3) in optoelectronic devices.

关键词： Chalcogenides Optical materials Electronic structure Dimensions reduction Ab-initio calculations Rare earths

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Machine Learning-based Stable P2P IPTV Overlay

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Computers, Materials & Continua 2022年第6期71卷 5381-5397页

作者： Muhammad Javid Iqbal ihsan ullah Muhammad Ali Atiq Ahmed Waheed Noor Abdul Basit Directorate of Information Technology Sardar Bahadur Khan Women’s UniversityQuettaPakistan Department of Computer Science and Information Technology University of BalochistanQuettaPakistan

Live video streaming is one of the newly emerged services over the Internet that has attracted immense interest of the service providers.Since Internet was not designed for such services during its inception,such a service poses some serious challenges including cost and scalability.Peer-to-Peer(P2P)Internet Protocol Television(IPTV)is an application-level distributed paradigm to offer live video contents.In terms of ease of deployment,it has emerged as a serious alternative to client server,Content Delivery Network(CDN)and IP multicast solutions.Nevertheless,P2P approach has struggled to provide the desired streaming quality due to a number of issues.Stability of peers in a network is one of themajor issues among these.Most of the existing approaches address this issue through older-stable principle.This paper first extensively investigates the older-stable principle to observe its validity in different scenarios.It is observed that the older-stable principle does not hold in several of them.Then,it utilizes machine learning approach to predict the stability of peers.This work evaluates the accuracy of severalmachine learning algorithms over the prediction of stability,where the Gradient Boosting Regressor(GBR)out-performs other algorithms.Finally,this work presents a proof-of-concept simulation to compare the effectiveness of older-stable rule and machine learning-based predictions for the stabilization of the overlay.The results indicate that machine learning-based stability estimation significantly improves the system.

关键词： P2P IPTV live video streaming user behavior overlay networks stable peers machine learning

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Optimized Mechanical Properties,Corrosion Resistance and Bactericidal Ability of Ti-15Zr-xCu Biomedical Alloys During Aging Treatment

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Acta Metallurgica Sinica(English Letters) 2022年第2期35卷 304-316页

作者： Sharafadeen Kunle Kolawole Ling Ren Muhammad Ali Siddiqui ihsan ullah Hai Wang Shuyuan Zhang Ji Zhang Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Federal Polytechnic P.M.B.420OffaKwara StateNigeria

The effects of different aging conditions on the microstructure,strength,corrosion resistance,cytotoxicity and antibacterial ability of Ti-15Zr-xCu(3≤x≤7,wt%)(TZC)alloys were systematically investigated.Microstructural evolution and behavior were analyzed by X-ray diffraction(XRD)patterns and scanning electron microscopy with energy-dispersive spectroscopy(SEM-EDS),while potentiodynamic polarization technique was employed to characterize the corrosion response of the alloys after solution-treatment and aging(STA).High-temperature aging at 660℃ for 4 h(660-4)gave the best combination of properties by enabling significant precipitation of the Cu-rich Ti_(2)Cu and Zr_(2)Cu compounds,and mild formation of the Zr_(7)Cu_(10) secondary phase.The high kinetics at this condition was beneficial to the complete precipitation and more homogeneous distribution of the intermetallic particles.These led to the inhibition of dislocation movements and allowed for significantly improved mechanical strengths with added ductility,availability of more Cu ions for the desired oligodynamic activity without evoking cytotoxicity,better corrosion resistance and very high antibacterial ability(over 99.5%),thus improving the overall properties of the TZC alloys for biomedical applications.

关键词： Ti-15Zr-xCu alloys Solution treatment and aging Cu-rich precipitates Improved strength Corrosion resistance Antibacterial ability

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审计委员会、CEO双重性和所有权结构对公司财务业绩的影响—来自巴基斯坦的非金融公司的证据

审计委员会、CEO双重性和所有权结构对公司财务业绩的影响—来自...

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作者： ihsan ullah 中北大学

学位级别：硕士

本研究旨在研究审查小组、首席执行官二元性、公司管理部门对巴基斯坦陷入困境和非陷入困境的非金融公司财务执行的影响。本研究将行政所有权结构、机构所有权、独立审查委员会、CEO双重性、所有权焦点视为自由因素。董事会设计和杠杆... 详细信息

本研究旨在研究审查小组、首席执行官二元性、公司管理部门对巴基斯坦陷入困境和非陷入困境的非金融公司财务执行的影响。本研究将行政所有权结构、机构所有权、独立审查委员会、CEO双重性、所有权焦点视为自由因素。董事会设计和杠杆率已被视为控制变量。同时,财务执行被视为依赖变量。巴基斯坦的非财务困境和非困境公司已决定测试之前引用的本次审查因素之间的联系。从2019年到2022年,已利用可选的信息源（年度财务公告）对本次审查的因素进行信息分类。已得出1350个示例规模以解决全体民众。然后,通过利用Strata的关系和复发等事实工具对收集到的信息进行剖析。鉴于这些发现,有理由认为行政所有权结构完全影响财务执行资源回报率（ROA）,而对陷入困境的非金融巴基斯坦公司的（ROE）影响不大。一方面,行政独资结构从根本上影响财务执行资源回报率（ROA）,而对非陷入困境的非金融巴基斯坦公司的价值回报率（ROE）产生无关紧要的影响。尽管机构拥有本质上会影响财务执行资源回报率（ROA）,而对陷入困境的非金融巴基斯坦公司的（ROE）影响不大。另一方面,机构所有权完全影响非陷入困境的非金融巴基斯坦公司的资源利润和价值回报（ROA和ROE）财务执行。此外,自主审查委员会对非陷入困境的非金融巴基斯坦公司的股本回报率（ROA和ROE）财务执行的资源利润产生了不重要的影响。CEO双重性本质上会影响两者都从非陷入困境的非金融巴基斯坦公司的股本回报(ROA和ROE财务执行资源中获利。

关键词： CEO 二元性董事会结构杠杆作用财务业绩资产回报率股本回报率

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A Novel Approach to Energy Optimization:Efficient Path Selection in Wireless Sensor Networks with Hybrid ANN

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Computers, Materials & Continua 2024年第5期79卷 2945-2970页

作者： Muhammad Salman Qamar ihsan ulHaq Amil Daraz Atif MAlamri Salman A.AlQahtani Muhammad Fahad Munir Department of Electrical and Computer Engineering International Islamic UniversityIslamabad44000Pakistan School of Information Science and Engineering NingboTech UniversityNingbo315100China Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11495Saudi Arabia Computer Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11495Saudi Arabia

In pursuit of enhancing the Wireless Sensor Networks(WSNs)energy efficiency and operational lifespan,this paper delves into the domain of energy-efficient routing protocols.InWSNs,the limited energy resources of Sensor Nodes(SNs)are a big challenge for ensuring their efficient and reliable operation.WSN data gathering involves the utilization of a mobile sink(MS)to mitigate the energy consumption problem through periodic network traversal.The mobile sink(MS)strategy minimizes energy consumption and latency by visiting the fewest nodes or predetermined locations called rendezvous points(RPs)instead of all cluster heads(CHs).CHs subsequently transmit packets to neighboring RPs.The unique determination of this study is the shortest path to reach RPs.As the mobile sink(MS)concept has emerged as a promising solution to the energy consumption problem in WSNs,caused by multi-hop data collection with static sinks.In this study,we proposed two novel hybrid algorithms,namely“ Reduced k-means based on Artificial Neural Network”(RkM-ANN)and“Delay Bound Reduced kmeans with ANN”(DBRkM-ANN)for designing a fast,efficient,and most proficient MS path depending upon rendezvous points(RPs).The first algorithm optimizes the MS’s latency,while the second considers the designing of delay-bound paths,also defined as the number of paths with delay over bound for the MS.Both methods use a weight function and k-means clustering to choose RPs in a way that maximizes efficiency and guarantees network-wide coverage.In addition,a method of using MS scheduling for efficient data collection is provided.Extensive simulations and comparisons to several existing algorithms have shown the effectiveness of the suggested methodologies over a wide range of performance indicators.

关键词： Wireless Sensor Networks(WSNs) mobile sink(MS) rendezvous point(RP) machine learning Artificial Neural Networks(ANNs)

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Socio-Economic Drivers of Deforestation in Roghani Valley,Hindu-Raj Mountains,Northern Pakistan

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Journal of Mountain Science 2014年第1期11卷 167-179页

作者： Fazlur RAHMAN Fazlul HAQ Iffat TABASSUM ihsan ullah Institute of Geography Urban & Regional Planning University of Peshawar

Deforestation and associated ecological disturbances are the issues of global concern.Researchers have investigated a number of driving forces which accelerate the rate of deforestation at local and regional levels.These include poverty,population growth,market demand and prices,political instability,agricultural expansion and changes in property right and ownership regimes.This paper seeks to explore the impacts of population growth,changing tenure system and other socioeconomic factors on the forest cover of Roghani Valley,located in Hindu Raj Mountains,Northern Pakistan.The present study is mainly based on information collected through participatory observation,selfadministered interviews and questionnaire survey.Geographical Information System(GIS) database is also used for mapping and quantification.The results reveal that in the past three to four decades the study area has been subjected to severe deforestation and about half of the forest area has been converted into barren land.Thus,the area under natural forests decreased from 2099 to 1444 hectares in four decades.This large-scale deforestation is attributed to both proximate and under lying causes particularly traditional land tenure system and demographic development.Consequently,forest resources have been degraded and a number of plant species have disappeared from the forests of the study area while several others are in the process of disappearance.

关键词： Deforestation Natural Vegetation Cover Population Growth Traditional Tenure Systems Land Use and Land Cover Change Household Dynamics

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Understanding the catalysis of chromium trioxide added magnesium hydride for hydrogen storage and Li ion battery applications

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Journal of Magnesium and Alloys 2024年第3期12卷 1117-1130页

作者： D.Pukazhselvan ihsanÇaha Catarina de Lemos Sergey M.Mikhalev Francis Leonard Deepak Duncan Paul Fagg Department of Mechanical Engineering TEMA-Centre for Mechanical Technology and AutomationUniversity of AveiroAveiro 3810-193Portugal LASI-Intelligent Systems Associate Laboratory Guimarães 4800-058Portugal Nanostructured Materials Group International Iberian Nanotechnology Laboratory(INL)Avenida Mestre Jose VeigaBraga 4715-330Portugal

This study explores how the chemical interaction between magnesium hydride(MgH_(2))and the additive CrO_(3) influences the hydrogen/lithium storage characteristics of MgH_(2).We have observed that a 5 wt.%CrO_(3) additive reduces the dehydrogenation activation energy of MgH_(2) by 68 kJ/mol and lowers the required dehydrogenation temperature by 80℃.CrO_(3) added MgH_(2) was also tested as an anode in an Li ion battery,and it is possible to deliver over 90%of the total theoretical capacity(2038 mAh/g).Evidence for improved reversibility in the battery reaction is found only after the incorporation of additives with MgH_(2).In depth characterization study by X-ray diffraction(XRD)technique provides convincing evidence that the CrO_(3) additive interacts with MgH_(2) and produces Cr/MgO byproducts.Gibbs free energy analyses confirm the thermodynamic feasibility of conversion from MgH_(2)/CrO_(3) to MgO/Cr,which is well supported by the identification of Cr(0)in the powder by X ray photoelectron spectroscopy(XPS)technique.Through high resolution transmission electron microscopy(HRTEM)and energy dispersive spectroscopy(EDS)we found evidence for the presence of 5 nm size Cr nanocrystals on the surface of MgO rock salt nanoparticles.There is also convincing ground to consider that MgO rock salt accommodates Cr in the lattice.These observations support the argument that creation of active metal–metal dissolved rock salt oxide interface may be vital for improving the reactivity of MgH_(2),both for the improved storage of hydrogen and lithium.

关键词： Hydrogen storage Rechargeable batteries Binary hydrides Metal oxides Catalytic mechanism.

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Preliminary study of adsorption behavior of bovine serum albumin(BSA) protein and its effect on antibacterial and corrosion property of Ti-3Cu alloy

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Journal of Materials Science & Technology 2021年第21期80卷 117-127页

作者： Muhammad Ali Siddiqui ihsan ullah Hui Liu Shuyuan Zhang Ling Ren Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026China Department of Metallurgical Engineering NED University of Engineering and TechnologyUniversity RoadKarachi75270Pakistan

The adsorption behavior, antibacterial, and corrosion properties of a Ti-3 Cu alloy were studied in a phosphate-buffered saline solution containing 0, 1, 3, and 6 gL^(-1) bovine serum albumin protein at 37℃ and pH = 7.4(±0.2). The protein adsorption behavior was examined via cyclic voltammetry, secondary ions mass spectroscopy(SIMS), and angle-resolved X-ray photoelectron spectroscopy(ARXPS). The corrosion property was analyzed by the open circuit potential(OCP), potentiodynamic polarization(PD),and electrochemical impedance spectroscopy(EIS) examinations. The antibacterial test was conducted according to the GB/T 21510 China Standard. It was observed that the surface charge density(QA DS) was directly proportional to the amount of the adsorbed BSA protein, signifying that the protein adsorption was accompanied by the charge transfer, pointing to chemisorptions phenomena. BSA amino groups and other organic species were observed in the surface analysis examinations. It was shown that the formation of barrier complexes between the TiO_(2) oxide-layer and PBS solution resulted in decreasing the release of Cu-ions, which consequently reduced the antibacterial activity. On the other hand, these barrier complexes improved the corrosion resistance by increasing the charge transfer resistance and double-layer capacitance of the Ti-3 Cu alloy.

关键词： Bovine serum albumin protein Ti-3Cu alloy Antibacterial Corrosion Adsorption behavior

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Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity

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Journal of Materials Science & Technology 2020年第13期47卷 130-139页

作者： Hui Liu Rui Liu ihsan ullah Shuyuan Zhang Ziqing Sun Ling Ren Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026China Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related GenesRenji Hospital160 Pujian RoadShanghai220127China

Implant-related infection and early bone integration are the main risk factors of implants for long-term service,to overcome these difficulties,SLA-TiCu surface was prepared by sandblasting and large-grits etching(SLA)treatment on a novel antibacterial titanium-copper alloy(TiCu),which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants.Effects of SLA-TiCu surface on the adhesion,proliferation,apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen(Staphylococcus aureus)were studied.Compared to the following surfaces:sandblasting and large-grits etched pure titanium(SLATi),mechanically ground pure titanium and TiCu alloy(M-Ti and M-TiCu),these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions(alkaline phosphates(ALP),collagen typeⅠ(COLⅠ),Runt-related transcription factor 2(RUN x 2),and osteopontin(OPN)).Moreover,SLA-TiCu surface could maintain a sustainable release of Cu2+ions and effectively inhibited the viability of bacteria.This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity,making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants.

关键词： Titanium Copper Roughness surface Osteogenesis Antibacterial

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