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Zingiber officinale(Ginger)Methanol Extract Abates Kidney Dysfunction in Mice Co-exposed to Sub-chronic Alcohol Intoxication and Post-traumatic Stress Disorder

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 79-90页

作者： Olusegun G.Adebayo Benneth Ben-Azu Egwonor Akpofure Modo U.Emmanuel iheanyichukwu wopara Wadioni Aduema Lawrence Dayo Adedayo Jude Ijuo Abeje Neurosciences and Oral Physiology Unit Department of PhysiologyFaculty of Basic Medical SciencesCollege of MedicineUniversity of IbadanIbadan 200005Nigeria Department of Pharmacology Faculty of Basic Medical SciencesCollege of Health SciencesDelta State UniversityAbrakaDelta StateNigeria Department of Medicine Evercare HospitalLekkiLagos State 105102Nigeria Department of Biochemistry Faculty of Basic Medical SciencesPAMO University of Medical SciencesPort-HarcourtRiver State 500272Nigeria Department of Biochemistry Faculty of SciencesRiver State UniversityPort HarcourtRiver State 500004Nigeria Department of Physiology Faculty of Basic Medical SciencesBayelsa Medical UniversityYenagoaBayelsa State 178Nigeria Neurophysiology Division Physiology ProgrammeCollege of Health ScienceBowen UniversityIwo 232101Nigeria

Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological ***,ethnomedicinal use of Zingiber officinale Roscoe(Ginger)have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract(MEZO)on alcohol-use disorder(AUD)and post-traumatic stress disorder(PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal ***:To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in ***:Male Swiss mice were administered 30%ethanol for two weeks and thereafter introduced to single pro-longed stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin *** of oxidative stress,inflammatory cytokines,kidney functions,HPA-axis signaling molecules,vasodilator substance,and histopathology of the kidney were ***:Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress,altered the kidney function indices and HPA-axis,and reduced nitric oxide production,which were ameliorated by the phytother-apeutic treatment with ***,severe degeneration and atrophy of renal tubules were ***,MEZO interventions strongly abated all these ***:Herein,the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.

关键词： Zingiber officinale Kidney Alcohol Single prolonged stress Oxidative stress

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Up-regulation of oxidative stress and inflammation in the brain of albino wistar rats following sub-acute administration of Synclisia scabrida root extract

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TMR Integrative Medicine 2022年第30期6卷 1-7页

作者： Emmanuel Uchechukwu Modo Ijeoma Nina Eke Utibe Evans Bassey Anthony Chibuzor Nnamudi Ekam Ime Akpakpan Okon Effiom Etim iheanyichukwu wopara Prosper Great Legborsi Department of Biochemistry Faculty of Basic Medical SciencesPAMO University of Medical SciencesPort HarcourtRivers StateNigeria Department of Biochemistry Faculty of SciencesUniversity of Port HarcourtPort HarcourtRivers StateNigeria

Objective: Synclisia scabrida is a medicinal plant used over the years for the treatment ofseveral medical conditions yet there is paucity of information on its systemic and organspecific toxicity. Consequently, sub-acute neurotoxicity of root extract of Synclisia scabridawas evaluated in albino Wistar rats. Methods: Thirty male albino rats with average weightof 140g were randomized into 5 groups consisting of 6 rats in each group. Group 1 was thecontrol while 50 mg/kg, 100 mg/kg, 200 mg/kg and 400 mg/kg of the root extract wereadministered to Groups 2, 3, 4 and 5 respectively for 28 days. Malondialdehyde,glutathione, nitric oxide, protein, tumour necrosis factor-α, acetylcholine, catalase andacetylcholinesterase levels were measured in brain homogenates. Body weight of theanimals and histology of the hippocampus and cerebral cortex were evaluated. Results:Root extract of Synclisia scabrida was observed to increase malondialdehyde concentrationand decrease antioxidants biomarkers when compared with the control. Significantly(p<0.05) increased TNF-α concentration and acetylcholinesterase activity caused by theextract when compared with the control was observed. The concentration of acetylcholinesignificantly decreased in Synclisia scabrida treated groups in comparison with the *** histomorphology of the hippocampus and cerebral cortex revealed pyknotic pyramidalneurons in Synclisia scabrida treated rat relative to the control with normal pyramidalneurons. The body weight of the extract treated groups were significantly decreased whencompared to the control Group. Conclusion: The study has demonstrated that the rootextract of Synclisia scabrida induces and up-regulates oxidative stress and inflammation inthe brain of male albino Wistar rat coupled with reduced acetylcholine concentration hencethe extract possesses neurotoxic potentials.

关键词： Synclisia scabrida oxidative stress antioxidant inflammation neurotoxicity

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Anisotropy and Empirical Relations for the Estimation of Anisotropy Parameters in Niger Delta Depobelts

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International Journal of Geosciences 2016年第3期7卷 345-352页

作者： iheanyichukwu P. C. Okorie Joseph O. Ebeniro Chukwuemeka N. Ehirim Geophysics Research Group Physics Department University of Port Harcourt Port Harcourt Nigeria

The difficulty in achieving well-to-seismic ties due to errors arising from wrong time-to-depth conversions has been as a result of ignoring anisotropy in seismic processing. Anisotropy plays a vital role in the processing and interpretation of seismic data. In this work, an inversion method based on the elastic stiffness tensors was adopted to estimate and quantify anisotropy in two depobelts using petrophysical well logs in Niger delta (Central Swamp and Greater Ughelli). Results show that the estimated delta (δ), epsilon (ε), gamma (γ) and eta (η) exhibit a high degree of anisotropy in the shales than in the sands. The parameters were observed to be higher in the Central Swamp than the Greater Ughelli depobelt. This behavior could be associated with the alternating sequence of massive shale and sand beds geologically observed within this depobelt. This work was also able to derive empirical relations that could be used in estimating these parameters in the depobelts once appropriate information or data for any one parameter is available.

关键词： Anisotropy Velocity Depobelts Transverse Isotropy Seismic

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Biotechnology and Nanotechnology Drug Delivery: A Review

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Journal of Pharmacy and Pharmacology 2021年第4期9卷 127-132页

作者： Tenderwealth Clement Jackson Nkem Mercy Obiakor Irene Nkwachi iheanyichukwu Obo Okokon Ita Adaeze Salome Ucheokoro Department of Pharmaceutics and Pharmaceutical Technology University of UyoUyo 520003Nigeria Department of Biochemistry University of UyoUyo 520003Nigeria Department of Pharmaceutics and Pharmaceutical Technology University of CalabarCalabar 540271Nigeria Department of Pharmaceutics and Pharmaceutical Technology Gregory UniversityUturuAbia State 441107Nigeria

Nanobiotechnology is a blend of biotechnology and ***,as a field,has been tapped into in recent years,in search of alternatives to overcome challenges associated with drug *** techniques have been put together in order to fabricate nanoparticles with improved therapeutic efficacy enhanced drug stability,specific targeting of the cells and controlled release inside the *** review tends to look at the concepts involved in nanobiotechnology,the application of nanobiotechnology in nanomedicine,diagnosis,cancer treatment and drug delivery approaches.

关键词： Nanobiotechnolgy drug delivery targeting nanomedicine.

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