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Influence of a-tocopherol on nickel induced alteration of serum lipid profile in male albino rats

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Asian Pacific Journal of Tropical Medicine 2008年第1期1卷 14-18页

作者： Gupta ad Dhundasi sa Dhara PC Das KK Department of Physiology Al-Ameen Medical CollegeBijapur 586108 KarnatakaIndia Department of Human Physiology & Community Health Vidyasagar UniversityMidnapur(West) 721102West BengalIndia

We studied the effect of the simultaneous treatment withα-tocopherol(100 mg / kg;im) and nickel sulfate (20 mg/kg,ip) on nickel-induced changes in serum lipid ***-treated rats showed a significant increase in serum LDL cholesterol,total cholesterol,triglycerides,and a significant decrease in serum HDL cholesterol. Simultaneous administration ofα-tocopherol with nickel sulfate improved LDL-cholesterol and HDLcholesterol level when compared with rats receiving nickel sulfate *** results indicate thatα-tocopherol is beneficial in preventing nickel-induced lipid profile alterations.

关键词： nickel sulfate α-tocopherol serum lipid profile

NIBU: a new approach to representing and analysing interior utility networks within 3D geo-information systems

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International Journal of Digital Earth 2012年第1期5卷 22-42页

作者： ihab Hamzi Hijazi Manfred Ehlers Sisi Zlatanova Institute for Geoinformatics and Remote SensingIGF University of OsnabrueckOsnabrueckGermany OTB Research Institute for HousingUrban and Mobility StudiesDelft University of TechnologyDelftThe Netherlands

Facility management departments’responsibilities include monitoring and maintenance of building infrastructure,such as water,gas or *** often these tasks are completed using paper maps,which make integrated analysis of networks *** to consider interior network structure and provide semantic and connectivity information supporting the required analysis operations are thus *** paper presents an approach relying on Building Information Model(BIM)as a data source for obtaining information about interior *** semantic and connectivity information of BIM is mapped onto a new model called Network for Interior Building Utilities(NIBU).NIBU is based on the semantic categorisation of utilities,and the spatial functions that have to be *** scenarios(‘maintenance operation’,‘emergency response’and‘inspection operation’)are developed to test the proposed *** model and its functions are implemented in spatial *** model is populated directly from a BIM server applying an Industrial Foundation Class(IFC)parser developed *** analysis functions are implemented to support spatial operations:trace upstream,trace downstream,find ancestors,find source and find *** investigation proves that BIM provides both the required semantics and attributes,and connectivity information that can facilitate analysis of interior utility *** provides a simple yet flexible way to manage interior network information,which can be integrated into Digital Earth.

关键词： building information model(BIM) building service system graph spatial DBMS utility network industrial foundation class(IFC)

NIBU:An Integrated Framework for Representing the Relation Among Building Structure and Interior Utilities in Micro-Scale Environment

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Geo-Spatial Information Science 2011年第2期14卷 98-108页

作者： ihab HIJAZI Sisi ZLATANOVA Manfred EHLERS Institute for Geoinformatics and Remote Sensing (IGF) University of Osnabrueck OTB Research Institute for HousingUrban and Mobility Studies Delft University of Technology

This paper describes a framework for modeling interdependencies between different network systems and building *** provides an approach for the integrated analysis of interior building utilities by describing a framework to model and simulate infrastructure interdependencies and their complex *** is a graph-based spatial model that can support use cases such as providing the location and specifications of interior utilities to a technician who wants to perform a maintenance *** location could be needed for maintenance or replacement,or to investigate the result of damage to the building structure on another utility network,or to estimate the effect of different maintenance operations in different locations along utilities service *** model accounts for two important aspects:first,the relationship between interior utilities and building elements or spaces and second,the building hierarchy structure to which the utilities network is related.A proper hierarchy of the building is developed which supports the generation of human-oriented descriptions of interior utilities,where a method for partitions of large building element and spaces as well as a method to reference a network element to another building are *** connection of the different utilities network systems and buildings are generated using joints,which are based on a containment *** example is presented which shows the effectiveness of this approach for supporting maintenance operations,as well as the independences between the maintenance operation location and the other network *** paper presents the data model and explains the links with current 3D building model standards.

关键词： Building Information Model (BIM) building service system utility network graph city models

Integrated Fault Diagnosis Model Using Tiny Residual Network

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Integrated Fault Diagnosis Model Using Tiny Residual Network

作者： sa’ad Abdo-Alkawi Ali Hassan Almageedy（青山）华南理工大学

学位级别：硕士

随着制造业的快速发展,使得相关企业对机械设备安全防护系统的需求在不断提高。同时,机械设备的智能故障诊断技术是迈向智能制造的关键过程,也是未来工业发展的趋势。然而,由于现有故障诊断技术的不足,导致需要耗费较大的人工成本来协... 详细信息

随着制造业的快速发展,使得相关企业对机械设备安全防护系统的需求在不断提高。同时,机械设备的智能故障诊断技术是迈向智能制造的关键过程,也是未来工业发展的趋势。然而,由于现有故障诊断技术的不足,导致需要耗费较大的人工成本来协助完成机械设备故障的监测和诊断。针对该问题,深度学习时代的来临让机械设备故障诊断领域步入了迅速发展的轨道,并且引起了学术界和工业界的广泛关注。传统的故障诊断方法需要经过特征提取、特征选择和特征分类的过程,处理过程繁杂并且实际的应用成本高。另外,传统故障诊断方法可能还需要依靠相关领域专业知识的协助和分析,否则将会导致最终诊断结果的不确定性较大。因此,本文基于深度学习技术的思想,结合微小残差网络、时频分析方法和特定的激活函数等技术,提出了一种新的机械故障诊断模型。本文的主要工作内容如下:1.针对传统方法故障诊断过程繁杂并且识别准确率不确定性较大等问题,本文提出了一种基于残差网络的深度卷积神经网络故障诊断模型,简称ITResNet。ITResNet模型采用基于残差网络的设计能够有效克服梯度消失的问题,并且能够直接采用原始故障数据对模型进行训练,从而达到自动识别机械设备故障的目的。2.针对ITResNet模型难以处理原始故障数据噪声污染严重的问题,本文提出采用三种不同的时频分析方法对原始故障进行预处理。时频分析方法能够将原始的一维故障数据通过时频转换,可以转变为二维故障数据。通过结合时频分析技术对ITResNet模型的训练过程进行改进,有效提高了模型对机械故障数据的学习和分类能力。通过实验表明,改进后的ITResNet模型对正常状态和故障状态的数据区分能力更强。3.针对ITResNet模型的分类拟合能力难以达到理想状态的问题,本文基于新的Mish激活函数、Nadam优化器技术和空间金字塔池以及压缩激励结构对ITResNet模型进行了进一步改进,简称ITResNet-SPP-SE。结合这些技术进行改进后,能够有效减少模型的参数数量。通过实验表明,ITResNet-SPP-SE模型的故障分类准确率和稳定性要优于ITResNet模型,并且运行耗时更低。采用轴承故障数据集对本文提出的模型进行了验证和分析。实验结果表明,本文提出的ITResNet模型、采用时频分析方法改进的ITResNet模型和ITRees Net-SPP-SE模型在故障分类准确率方面,分别达到了99.8%,99.99%和99.999%。并且ITRees Net-SPPSE模型的拟合能力比ITResNet模型和改进的ITResNet模型更强。另外,在采用其它方法模型的对比实验方面,传统方法例如SVM、KNN和MLP的预测准确率分别为71%,33%,87%;基于深度学习技术的方法,例如深度完全卷积神经网络（DFCNN）,堆叠降噪自动编码器（SDAE）和自适应卷积神经网络,它们对特定类型的信号进行操作,其准确度分别为99.22%,91.79%和97.90%。因此,可以看出我们提出的集成模型在机械故障分类预测方面表现的更好。

关键词：智能故障诊断卷积神经网络残差网络深度学习旋转机械

Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第9期22卷 2668-2677页

作者： Hend Mohamed El Tayebi Ahmed ihab Abdelaziz The Molecular Pathology Research Group Department of Pharmacology and Toxicology Faculty of Pharmacy and Biotechnology German University in Cairo

The insulin-like growth factor(IGF) signaling path-way is an important pathway in the process of hepa-tocarcinogenesis,and the IGF network is clearly dysregulated in many cancers and developmental *** hepatocellular carcinoma(HCC),only a minority of patients are eligible for curative treatments,such as tumor resection or liver ***,there is a high recurrence of HCC after surgical tumor *** research efforts have focused on targeting IGF axis members in an attempt to find therapeutic options for many health *** this review,we shed lights on the regulation of members of the IGF axis,mainly by micro RNAs in *** RNAs in HCC attempt to halt the aberrant expression of the IGF network,and a single micro RNA can have multiple downstream targets in one or more signaling *** micro RNAs is a relatively new approach for identifying an efficient radical cure for HCC.

关键词： Hepatocellular carcinoma Insulin-like growth factors Insulin-like growth factor receptors Epigenetics microRNAs

Positioning patients for spine surgery: Avoiding uncommon position-related complications

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World Journal of Orthopedics 2014年第4期5卷 425-443页

作者： ihab Kamel Rodger Barnette Temple University School of Medicine Philadelphia PA 19140 United States

Positioning patients for spine surgery is pivotal for optimal operating conditions and operative-site exposure. During spine surgery, patients are placed in positions that are not physiologic and may lead to complications. Perioperative peripheral nerve injury(PPNI) and postoperative visual loss(POVL) are rare complications related to patient positioning during spine surgery that result in significant patient disability and functional loss. PPNI is usually due to stretch or compression of the peripheral nerve. PPNI may present as a brachial plexus injury or as an isolated injury of single nerve, most commonly the ulnar nerve. Understanding the etiology, mechanism and pattern of injury with each type of nerve injury is important for the prevention of PPNI. Intraoperative neuromonitoring has been used to detect peripheral nerve conduction abnormalities indicating peripheral nerve stress under general anesthesia and to guide modification of the upper extremity position to prevent PPNI. POVL usually results in permanent visual loss. Most cases are associated with prolonged spine procedures in the prone position under general anesthesia. The most common causes of POVL after spine surgery are ischemic optic neuropathy and central retinal artery occlusion. Posterior ischemic opticneuropathy is the most common cause of POVL after spine surgery. It is important for spine surgeons to be aware of POVL and to participate in safe, collaborative perioperative care of spine patients. Proper education of perioperative staff, combined with clear communication and collaboration while positioning patients in the operating room is the best and safest approach. The prevention of uncommon complications of spine surgery depends primarily on identifying high-risk patients, proper positioning and optimal intraoperative management of physiological parameters. Modification of risk factors extrinsic to the patient may help reduce the incidence of PPNI and POVL.

关键词： Spine surgery Complication Position Nerve injury Visual loss

Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice

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World Journal of Gastroenterology 2003年第4期9卷 779-783页

作者： ad Suchitra sa Dkhar DG Shewade CH Shashindran Department of Pharmacology JIPMERPondicherry 605006INDIA

AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either *** groups included were control,morphine 1 mg/kg(s.c.15 rain before test meal)alone or with(45 rain before test meal p.o.)cisapride 10 mg/kg,metoclopramide 20 mg/kg, domperidone 20 mg/kg,erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS:Cisapride,metoclopramide and mosapride were effective in enhancing gastric emptying significantly(Psapride. Metoclopramide alone was effective when given to normal mice in increasing the ***,though it did not show any significant effect on SIT in normal mice,was able to reverse morphine induced delay in SIT significantly(Psapride. CONCLUSION:Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.

关键词： Animals Benzamides Cisapride Domperidone Drug Interactions Erythromycin Female Gastric Emptying Gastrointestinal Transit Male Metoclopramide Mice Morphine Morpholines

Methane Flux and Its Environmental Impact Factors in Dajiuhu Wetland of Shennongjia

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Wuhan University Journal of Natural Sciences 2019年第5期24卷 455-460页

作者： ihab ALFadHEL GE Jiwen SINAN Yongxi LIU Yaoyao School of Environmental Studies China University of Geosciences

Methane(CH4) flux was measured by using the Eddy covariance technique in the Dajiuhu Wetland of Shennongjia Forestry District, Hubei Province, China. The seasonal and daily variation of CH4 emissions was investigated, and the correlation of CH4 fluxes with the environmental impact factors were discussed to understand the activity of CH4 flux and the effects of environmental factors including air temperature, soil temperature, photosynthetic photon flux density(PPFD), and rainfall on a wetland ecosystem. The results indicated that CH4 flux was significantly correlated with air temperature and photosynthetic photon flux density(PPFD), which may be the primary driver of controlling peatland CH4 flux.

关键词： methane (CH4) flux Dajiuhu Wetlands eddy covariance growing season environmental factors

Regional anesthesia for orthopedic procedures:What orthopedic surgeons need to know

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World Journal of Orthopedics 2022年第1期13卷 11-35页

作者： ihab Kamel Muhammad F Ahmed Anish Sethi Department of Anesthesiology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140United States

Regional anesthesia is an integral component of successful orthopedic *** anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative *** evaluation for regional anesthesia should include neurological,pulmonary,cardiovascular,and hematological *** blocks include spinal,epidural,and combined spinal *** extremity peripheral nerve blocks include interscalene,supraclavicular,infraclavicular,and *** extremity peripheral nerve blocks include femoral nerve block,saphenous nerve block,sciatic nerve block,iPACK block,ankle block and lumbar plexus *** choice of regional anesthesia is a unanimous decision made by the surgeon,the anesthesiologist,and the patient based on a risk-benefit *** choice of the regional block depends on patient cooperation,patient positing,operative structures,operative manipulation,tourniquet use and the impact of postoperative motor blockade on initiation of physical *** anesthesia is safe but has an inherent risk of failure and a relatively low incidence of complications such as local anesthetic systemic toxicity(LAST),nerve injury,falls,hematoma,infection and allergic *** should be used for regional anesthesia procedures to improve the efficacy and minimize *** treatment guidelines and rescue medications(intralipid)should be readily available during the regional anesthesia administration.

关键词： Orthopedic surgery Regional anesthesia Spinal Epidural Combined spinal epidural Peripheral nerve blocks Neuraxial blocks Upper extremity Lower extremity Interscalene Supraclavicular Infraclavicular Axillary Femoral Fascia iliaca Popliteal Sciatic saphenous adductor canal Lumbar plexus Brachial plexus Ankle iPACK Complication Local anesthetic systemic toxicity Nerve injury Block failure Continuous nerve block catheters