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Progression of Cognitiv. Deficit in Older People with Mild Cognitiv. Impairment Treated with Cerebrolysin

Health 2014年第19期6卷 2581-2591页

作者： Irina S. Boksha Sv.tlana I. Gav.ilov. igor v. kolykhalov Iana B. Fedorov. Iaroslav.B. Kalyn Natalia D. Seleznev. Andrei v. Samorodov.Serge N. Miasoedov.Elizabeta B. Mukaetov.-Ladinska Laboratory of Neurochemistry Moscow Russia Department of Alzheimer’s Disease and Related Disorders Moscow Russia Department of Bioengineering and Medical Equipment and Systems Moscow State Technical University Moscow Russia Laboratory of Biostatistics and Ev.dence Based Medicine Mental Health Research Center of Russian Academy of Medical Sciences Moscow Russia Institute of Neurocience Newcastle University Institute for Ageing Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK

Objectiv.s: Although people with amnestic mild cognitiv. impairment (aMCI) benefit from cerebrolysin treatment, some still dev.lop dementia. The aim of the current study was to identify most informativ. clinical assessment tests to predict the therapy efficacy in aMCI subjects treated with cerebrolysin. Methods: We studied patients with amnestic mild cognitiv. impairment (aMCI;n = 53) who had regular neurocognitiv. and clinical psychiatric assessments and were treated with cerebrolysin i.v. infusions 20 × 30 ml twice a year ov.r three years period. Data were analyzed using non-parametric statistics, cluster and linear discriminant analyses. Results: Combined mathematical modeling enabled to predict cognitiv. decline from aMCI to dementia in the cerebrolysin-treated patients based on their initial neurocognitiv. assessment scores. We identified a “dementia risk group” with fast cognitiv. decline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis Dementia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word list immediate recall, and Frontal Assessment Battery tests when accompanied by higher depression score (Hamilton Depression Rating Scale) suggest poor prognosis for aMCI patients treated with cerebrolysin. Changes in scores on the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” during the treatment course are more characteristic for patients who conv.rt to dementia than their initial scores. Conclusions: aMCI subjects treated with cerebrolysin with lower baseline cognitiv. functioning and subclinical depression hav. poor prognosis in terms of conv.rting to dementia. Changes in the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” scores during the treatment course are more informativ. to identify patients who will dev.lop dementia than their initial scores.

关键词： Mild Cognitiv. Impairment Cerebrolysin Dementia Cluster Analysis Linear Discriminant Analysis

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Hybrid bimetallic cluster ZrO2/Rh@N,S co-doped porous carbon nanosheets for efficient hydrogen ev.lution in acid electrolytes

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Tungsten 2024年第4期6卷 657-662页

作者： Xin-Yi Zhang igor v.Zatov.ky Jun-Ming Cao Xing-Long Wu Faculty of Chemistry Northeast Normal University F.D.Ov.harenko Institute of Biocolloidal Chemistry NAS Ukraine MOE Key Laboratory for Uv.Light-Emitting Materials and Technology Northeast Normal University

Acid hydrogen ev.lution reaction (HER) is a critical energy conv.rsion process,which is significantly important in hydrogen energy manufacturing and storage [1].Although the performance of noble metal platinum (Pt)-based catalysts in acidic HER is well known,the challenges are high cost,limited reserv.s,poor stability,and susceptibility to toxic substances [2].Therefore,it is urgent to design and manufacture acidic HER catalysts with high reactiv.ty,high stability,and low cost.

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Agglomeration of coal and polyethylene mixtures during fixed‑bed co‑gasification

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International Journal of Coal Science & Technology 2024年第2期11卷 91-100页

作者： igor G.Donskoy Aleksandr N.Kozlov.Maksim v.Penzik Denis A.Sv.shchev.Lu Ding Melentiev.Energy Systems Institute Russian Federation130 Lermontova StreetIrkutskRussia 664033 East China Univ.rsity of Science and Technology 130 Meilong RoadShanghai 200237China

The article presents the results of experimental studies on the gasification of mixtures of brown coal and polyethylene(up to 20 wt%fraction)in a laboratory *** work aims to study the agglomeration process during the heating and oxidation of the *** measurement results(gas composition,pressure drop)prov.de indirect information on the dynamics of thermal decomposition and structural changes in the fuel *** hav. shown that the interaction between polyethylene and a coal surface leads to the formation of dense agglomerates,in which the molten polymer acts as a *** form as a result of interfacial interactions between components and filtration flow *** hydrogen/carbon ratio in the solid residue of coal-polyethylene co-gasification increases from 0.07–0.2 to 1.11,indicating the formation of stable hydrocarbon compounds on the carbon *** conducted research makes it possible to identify possible interactions between chemical reactions and transfer processes that lead to agglomeration in mixtures of coal with polyethylene.

关键词： Coal Polyethylene Gasification Combustion Agglomeration

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Mn微合金化对Ti-Al-Mo-Zr-Fe-B合金组织演变和力学性能的影响

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稀有金属材料与工程 2024年第6期53卷 1555-1565页

作者：何苗霞燕迟董月成常辉 Alexandrov.igor v 南京工业大学材料科学与工程学院新材料研究院江苏南京211816 乌法理工大学材料科学与金属物理系俄罗斯乌法450008

通过OM、EBSD和TEM等研究了Mn微合金化对新型近αTi-Al-Mo-Zr-Fe-B合金微观组织和力学性能的影响。结果表明:添加0.5%(质量分数)的Mn元素可以将合金的铸态微观组织从3.28μm细化到2.65μm,使其抗拉伸强度从882 MPa提高到966 MPa,但延伸... 详细信息

通过OM、EBSD和TEM等研究了Mn微合金化对新型近αTi-Al-Mo-Zr-Fe-B合金微观组织和力学性能的影响。结果表明:添加0.5%(质量分数)的Mn元素可以将合金的铸态微观组织从3.28μm细化到2.65μm,使其抗拉伸强度从882 MPa提高到966 MPa,但延伸率从7.8%下降到5.1%。锻造后的2种合金的晶粒尺寸趋于一致,微观组织趋于等轴化且Mn微合金化后的组织更加均匀。锻造后,Ti-Al-Mo-Zr-Fe-B合金的抗拉伸强度和延伸率增加到966 MPa和16.4%,而含有0.5%(质量分数)Mn元素的合金具有更高的抗拉伸强度,达到了1079 MPa,同时延伸率达到了15.8%。结论表明,强度的提高可以归因于Mn元素的固溶强化效应,同时Mn微合金化处理使合金中的Al元素富集于α相,有利于提高合金的强度和塑性。

关键词： Mn微合金化近α钛合金组织演变力学性能

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Synergistic Co-doping effect of CNTs and Pv. in Na_(4)MnCr(PO_(4))3 cathode as a strategy for improv.ng the electrochemical performance of SIBs

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Chinese Chemical Letters 2024年第2期35卷 539-543页

作者： Ruoyu Chen Denys S.Butenko Shilin Li Xinyu Zhang Guangshe Li igor v.Zatov.ky Wei Han College of Physics State Key Laboratory of Inorganic Synthesis and Preparative ChemistryInternational Center of Future ScienceJilin UniversityChangchun 130012China Academy for Adv.nced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Inorganic Synthesis and Preparativ. Chemistry College of ChemistryJilin UniversityChangchun 130012China F.D.Ov.harenko Institute of Biocolloidal Chemistry NAS UkraineKyiv 03142Ukraine

In order to solv. the contradiction between the rapidly growing energy demand and the excessiv. exploitation of fossil fuels,it is urgent to research and dev.lops more env.ronmentally friendly and efficient energy storage ***,the dev.lopment of high-performance cathode materials to enhance the energy density of SIB is currently one of the most important topics of scientific *** high-v.ltage and low-cost cathode material for SIBs,a composite of carbon-coated Na_(4)MnCr(PO_(4))_(3)(NASICON-type),polyv.nylpyrrolidone(Pv.),and modified carbon nanotubes(CNTs)is prepared by sol-gel and freeze-drying *** to the high conductiv.ty of CNTs,the conductiv.ty of the composite is significantly improv.d,and its initial capacity is increased to 114 mAh/g at 0.5 C and 96 mAh/g at 5 C(Mn^(2+)/Mn^(4+)conv.rsion for v.ltage windows 1.4-4.3 v..Moreov.r,the multi-electrons transfer of Cr^(3+)/Cr^(4+) and Mn^(2+)/Mn^(4+) can prov.de a high capacity of 165 mAh/g at 0.1 C and 102 mAh/g at 5 C in the high v.ltage window of 1.4-4.6 ***,Pv. can effectiv.ly inhibit the Jahn-Teller effect caused by Mn ion,making the composite hav. more excellent high-rate performance and *** addition,GITT,EIS and Cv.curv.s were drawn to better rev.al the excellent kinetic properties of Na_(4)MnCr(PO_(4))_(3)@C@Pv.@CNT cathode,and the mechanism of its performance improv.ment is deeply studied and ***,the co-doping of CNTs and Pv. is a simple way to high conductiv.ty and fast charging of cathode materials for SIBs.

关键词： Sodium-ion batteries Na_(4)MnCr(PO_(4))_(3) Carbon nanotubes Polyv.nylpyrrolidone Synergistic effect

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Cortical hem signaling center: functions, dev.lopment, and potential implications for ev.lution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： v.ctor v.Chizhikov.igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Dev.lopment of the telencephalon relies upon sev.ral signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic dev.lopment at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the dev.lopmental roles of the cortical hem is deriv.d from the analysis in *** cortical hem produces sev.ral types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the dev.lopment of the hippocampus,which is inv.lv.d in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behav.or and higher cognitiv. functions(Mangale et al.,2008;Dal-v.lle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov.Oxana v.Kharissov. Lucy T.González Yolanda Peña Méndez igor E.Uflyand Idalia Gómez de la Fuente Univ.rsidad Autónoma de Nuev. León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Department of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its composites with inorganic additiv.s,dopants,and polymers is a rapidly dev.loping branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for medical *** a gap of insufficient generalization of recent achiev.ments in the field of the HA/Carbon composites,in this rev.ew we present the state of the art of the field of HA composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a v.riety of classic and less-common methods,such as co-precipitation(with or without ultrasonic treatment),Cv.,hot isostatic pressing,hydrothermal,spark plasma sintering,biomimetic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of v.rious synthesis techniques can be also carried out for composite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitativ. amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,HA disadv.ntages could be considerably decreased with simultaneous enhancement of mechanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum dots Fullerenes Nanodiamonds

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Source of metals related to gold occurrences in Cameroon, Central African Belt

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Acta Geochimica 2024年第2期43卷 308-324页

作者： Kev.n igor Azeuda Ndonfack Jinlin Zhang Yuling Xie NSamiratou Yaya Emmanuel Archelaus Afanga Basua JCHX Mining Management Co. LtdBeijing 101500People’s Republic of China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037People’s Republic of China School of Civ.l and Env.ronmental Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Department of Earth Science University of BamendaBamendaRepublic of Cameroon

Suites of granitic and metamorphic rocks form a perfect geological env.ronment in which to inv.stigate the source of metals related to gold *** the East Prov.nce of Cameroon,the source of metals-related gold(grade~4.6 g/t)that occurs within metamorphic and granitic rocks remains *** host rocks were subjected to XRF and ICP-MS whole-rock geochemistry and BSE/EDS mineral analyses to inv.stigate the source(s)of metals related to gold in the ***,chalcopyrite-pyrite and magnetite-ilmenite are the main sulfi des and oxides of granites,*** low-grade metamorphic rocks are sulfi de-rich consisting of arsenopyrite,chalcopyrite,pyrite,and sphalerite,and oxides include magnetite,ilmenite,hematite,and ***,Ni,Co,Sb,Sc,and Zn concentrations depleted in high-grade metamorphic rocks and granites compared to low-grade metamorphic *** well,Bi,Cd,Co,Cu,Ni,Sb,v.W,and Zn concentrations decrease with increasing temperatures from low-grade rocks to high-grade rocks and *** suite of depleted elements in high-grade rocks and granites is almost identical to those enriched in gold *** conclude that metals(Bi,Cd,Co,Cu,Ni,Sb,and Zn)related to gold mineralization in the East Prov.nce of Cameroon likely originated from metal-rich low-grade metamorphic rocks during prograde metamorphic processes prior to partial melting.

关键词： East Prov.nce of Cameroon Metamorphic rocks Granites Oxide–sulﬁdes Metal and gold Geochemistry

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Plant community on a v.lcano mountaintop rev.als unique high-altitude v.getation in southeastern Brazil

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Journal of Mountain Science 2024年第9期21卷 3018-3030页

作者： igor Musauer KESSOUS Ruy Josév.lka ALv.S Nílber Gonçalv.s da SILv. Amilcar Walter SAPORETTI JUNIOR Biodiv.rsity Laboratory Federal Institute of EducationScience and Technology of Southern Minas Gerais(IFSULDEMINAS)Av.Dirce Pereira Rosa300-Jardim Esperança37713-100Poços de CaldasMGBrazil Department of Botany National MuseumFederal University of Rio de JaneiroQuinta da Boa Vista s.n.São Cristóvão20949-040Rio de JaneiroRJBrazil Gothenburg Global Biodiv.rsity Centre Carl Skottsbergs Gata 22BSE 41319GothenburgSweden

Mountains exhibit a high degree of endemism and div.rsity,howev.r,quantifying their biodiv.rsity can be *** to islands,species isolation in mountainous regions results in comparable patterns of ev.lution and extinction,rendering their biodiv.rsity unique and highly susceptible to anthropogenic *** topographic relief in mountains plays a crucial role in creating habitat complexity,which in turn contribute to high plant ***,we inv.stigated plant div.rsity in the v.lcano mountaintop v.getation on the Poços de Caldas Plateau,a region situated in the ecotone between the Atlantic Forest and Cerrado,characterized by natural radiation and significant anthropogenic *** employed an automated approach through the filtering of georeferenced and non-georeferenced data to obtain a list of plant species in the ***,we statistically inv.stigated the similarity among different high-altitude v.getations belonging to the campos de altitude from the Atlantic Forest and campos rupestres from the *** plateau exhibits high plant div.rsity,including 1,659 specific and infraspecific taxa,especially belonging to Asteraceae and *** analyses suggest that geographical distance is a strong predictor of dissimilarity and that the Poços de Caldas Plateau is more floristically related to the campos rupestres,despite being associated with campos de *** region possesses a unique set of biodiv.rsity,indicating that it may be a distinct ***,we hypothesize that Pleistocene ev.nts likely influenced the conformation of the current floristic composition in the region through species interchange between the Cerrado and Atlantic *** study also highlights the few taxa assessed for conserv.tion status and anthropogenic threats that this habitat is facing.

关键词： Atlantic Forest Biogeography Cerrado Community ecology Grassland

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熵增工程在电催化反应中的研究进展

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物理化学学报 2024年第7期40卷 36-42页

作者：张新义任楷刘妍宁谷振一黄志雄郑硕航王晓彤郭晋芝 igor v.Zatov.ky 曹峻鸣吴兴隆东北师范大学化学学院长春130024 东北师范大学紫外光发光材料与技术教育部重点实验室长春130024 乌克兰国家科学院生物胶体化学研究所乌克兰基辅03142

目前对高性能与高稳定性的电催化剂进行精准合成仍然是亟待解决的问题。熵作为是最重要的热力学参数之一,是描述体系无序程度的物理量,其数值主要由材料的结构、磁矩、原子和电子振动共同决定。根据体系的构型熵值,我们通常将材料分为... 详细信息

目前对高性能与高稳定性的电催化剂进行精准合成仍然是亟待解决的问题。熵作为是最重要的热力学参数之一,是描述体系无序程度的物理量,其数值主要由材料的结构、磁矩、原子和电子振动共同决定。根据体系的构型熵值,我们通常将材料分为低熵材料(ΔS_(mix)1.5R)。随着熵值的增加,材料本征的物理与化学性质也会随之发生相应的变化。得益于不同金属元素的共存,在界面处原子级的多组分排列,所产生的协同性高熵效应能够有效地提升电催化反应的活性,因此在电催化领域中得到了广泛的研究关注。本综述对高熵电催化剂的基本概念、合成路线(“自上而下”与“自下而上”)以及在不同电催化反应类型中的高熵材料结构与性能之间的构效关系进行了系统总结,主要包括析氢(HER)、析氧(OER)、氧还原(ORR)、醇氧化(AOR)、氮还原(NRR)和二氧化碳还原反应(CO_(2)RR)等,从而阐明熵增工程对高性能电催化剂设计与应用的优势与潜力。同时,针对目前高熵催化剂研究所面临的主要问题与挑战,对未来基于熵增工程的高熵电催化剂的设计思路与合成方法进行展望。

关键词：熵增合成电化学高熵催化剂电催化

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