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Green and Sustainable Chemistry 2017年第2期7卷 172-184页

作者： Marcelo R. R. Tappin Felipe M. Knopp igor C. Cardoso Roberta T. Santos Bruna S. Drummond Antonio C. Siani Elba P. S. Bon Maria Antonieta Ferrara Institute of Drug Technology Oswaldo Cruz Foundation Rio de Janeiro Brazil Chemistry Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil

The bioconversion of the hydrophobic and volatile limonene to perillic acid, a potential anticancer agent, by the yeast Yarrowia lipolytica was studied in two steps. Firstly, experimental design was used for process optimization using high-purity limonene as substrate and secondly orange essential oil containing 89.1% limonene was used as substrate under the previously optimized conditions. Limonene concentration and pH were identified by fractional factorial design as significant factors and were optimized by central composite design. Under optimized process conditions (0.16% (v/v) limonene;pH 6.9), the 24 h biotransformation process resulted in the accumulation of 0.368 g·L-1 of perillic acid corresponding to a molar yield of 23.1%. A subsequent substrate addition under the same reaction conditions doubled perillic acid concentration to 0.793 g·L-1 and a molar yield of 24.2%. The use of orange essential oil under the optimized reaction conditions increased both perillic acid accumulation and yield to 0.872 g·L-1 and 29.7%, respectively. The robustness of Y. lipolytica allowed the efficient biotransformation of a crude by-product of the citrus industry into a valuable fine chemical.

关键词： Yarrowia lipolytica Bioconversion Perillic Acid Limonene Orange Essential Oil

Effects of intragastric balloon placement in metabolic dysfunctionassociated fatty liver disease: A systematic review and metaanalysis

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World Journal of Hepatology 2021年第7期13卷 815-829页

作者： João Remíde Freitas Júnior igor Braga Ribeiro Diogo Turiani Hourneaux de Moura vitor Massaro Takamatsu Sagae Gabriel Mayo vieira de Souza Guilherme Henrique Peixoto de Oliveira Sergio A Sánchez-Luna Thiago Ferreira de Souza Eduardo Turiani Hourneaux de Moura Cláudia Pinto Marques Souza de Oliveira Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Serviço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUSP Departamento de GastroenterologiaFaculdade de MedicinaUniversidade de Sao PauloSao PauloSPBR Division of Gastroenterology and Hepatology Department of Internal MedicineBasil I.Hirschowitz Endoscopic Center of ExcellenceThe University of Alabama at BirminghamBirminghamAL 35294United States Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil

BACKGROUND Metabolic dysfunction-associated fatty liver disease corresponds to a clinical entity that affects liver function triggered by the accumulation of fat in the liver and is linked with metabolic *** To evaluate the effects of the intragastric balloon(IGB)in patients with metabolic dysfunction-associated fatty liver disease through the assessment of liver enzymes,imaging and several metabolic *** A comprehensive search was done of multiple electronic databases(MEDLINE,EMBASE,LILACS,Cochrane and Google Scholar)and grey literature from their inception until February *** criteria involved patients with a body mass index>25 kg/m2 with evidence or previous diagnosis of hepatic *** analyzed before and after 6 mo of IGB removal were alanine aminotransferase(IU/L),gamma-glutamyltransferase(IU/L),glycated hemoglobin(%),triglycerides(mg/dL),systolic blood pressure(mmHg),homeostatic model assessment,abdominal circumference(cm),body mass index(kg/m2)and liver volume(cm3).RESULTS Ten retrospective cohort studies evaluating a total of 508 patients were *** 6 mo of IGB placement,this significantly reduced alanine aminotransferase[mean difference(MD):10.2,95%confidence interval(CI):8.12-12.3],gammaglutamyltransferase(MD:9.41,95%CI:6.94-11.88),glycated hemoglobin(MD:0.17%,95%CI:0.03-0.31),triglycerides(MD:38.58,95%CI:26.65-50.51),systolic pressure(MD:7.27,95%CI:4.79-9.76),homeostatic model assessment(MD:2.23%,95%CI:1.41-3.04),abdominal circumference(MD:12.12,95%CI:9.82-14.41)and body mass index(MD:5.07,95%CI:4.21-5.94).CONCLUSION IGB placement showed significant efficacy in improving alanine aminotransferase and gamma-glutamyltransferase levels in patients with metabolic dysfunctionassociated fatty liver disease as well as improving metabolic markers related to disease progression.

关键词： Intragastric balloon Metabolic dysfunction-associated fatty liver disease Homeostatic model assessment Abdominal circumference Body mass index

video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis

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World Journal of Gastrointestinal Endoscopy 2018年第12期10卷 400-421页

作者： Hélcio Pedrosa Brito igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura Department of Endoscopy of Clinics Hospital of Sao Paulo University Sao Paulo 05403-00Brazil Molecular and Cell Biology University of CaliforniaCaliforniaBerkeleyCA 94720United States

AIM To compare the diagnostic accuracy of video capsule endoscopy(vCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular *** MEDLINE(via PubMed), LILACS(via BvS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing vCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc *** In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 vCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by vCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source.

关键词： Small bowel bleeding Hemorrhage Upper gastrointestinal bleeding Obscure hemorrhage Enteroscopy

Antibiotic prophylaxis to prevent complications in endoscopic retrograde cholangiopancreatography:A systematic review and meta-analysis of randomized controlled trials

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 718-730页

作者： Maria Fernanda Shinin Merchan Diogo Turiani Hourneaux de Moura Guilherme Henrique Peixoto de Oliveira igor Mendonça Proença Epifanio Silvino do Monte Junior Edson Ide Caroline Moll Sergio A Sánchez-Luna Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of Internal Medicine University of Alabama at Birmingham Heersink School of MedicineBirminghamAL 35233United States

BACKGROUND The prophylactic use of antibiotics in endoscopic retrograde cholangiopancreatography(ERCP)is still *** To assess whether antibiotic prophylaxis reduces the rates of complications in patients undergoing elective *** This systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines.A comprehensive search of multiple electronic databases was *** randomized controlled trials were *** outcomes analyzed included bacteremia,cholangitis,sepsis,pancreatitis,and *** risk of bias was assessed by the Cochrane revised Risk-of-Bias tool for randomized controlled *** quality of evidence was assessed by the Grading of Recommendation Assessment,Development,and ***-analysis was performed using the Review Manager 5.4 *** Ten randomized controlled trials with a total of 1757 patients that compared the use of antibiotic and non-antibiotic prophylaxis in patients undergoing elective ERCP were *** was no significant difference between groups regarding incidence of cholangitis after ERCP[risk difference(RD)=-0.02,95%confidence interval(CI):-0.05,0.02,P=0.32,cholangitis in patients with suspected biliary obstruction(RD=0.02,95%CI:-0.08 to 0.13,P=0.66),cholangitis on intravenous antibiotic prophylaxis(RD=-0.02,95%CI:-0.05 to 0.01,P=0.25),septicemia(RD=-0.02,95%CI:-0.06 to 0.01,P=0.25),pancreatitis(RD=-0.02,95%CI:-0.06 to 0.01,P=0.19),and allcause mortality(RD=0.00,95%CI:-0.01 to 0.01,P=0.71).However,the antibiotic prophylaxis group presented a 7%risk reduction in the incidence of bacteremia(RD=-0.07,95%CI:-0.14 to-0.01,P=0.03).CONCLUSION The prophylactic use of antibiotics in patients undergoing elective ERCP reduces the risk of bacteremia but does not appear to have an impact on the rates of cholangitis,septicemia,pancreatitis,and mortality.

关键词： Endoscopy Antibiotics Endoscopic retrograde cholangiopancreatography Cholangitis Infection

Sodium picosulphate or polyethylene glycol before elective colonoscopy in outpatients?A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2018年第12期10卷 422-441页

作者： Rodrigo Silva de Paula Rocha igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Maurício Kazuyoshi Minata Flávio Hiroshi Ananias Morita Júlio Cesar Martins Aquino Elisa Ryoka Baba Nelson Tomio Miyajima Eduardo Guimaraes Hourneaux de Moura Gastrointestinal Endoscopy Unit Hospital das Cliicas da Faculdade de Medicina da Universidade de Sao PauloSao Paulo 05403-010Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States

AIM To determine the best option for bowel preparation [sodium picosulphate or polyethylene glycol(PEG)] for elective colonoscopy in adult *** A systematic review of the literature following the PRISMA guidelines was performed using Medline, Scopus, EMBASE, Central, Cinahl and Lilacs. No restrictions were placed for country, year of publication or language. The last search in the literature was performed on November 20th, 2017. Only randomized clinical trials with full texts published were included. The subjects included were adult outpatients who underwent bowel cleansing for elective colonoscopy. The included studies compared sodium picosulphate with magnesium citrate(SPMC)and PEG for bowel preparation. Exclusion criteria were the inclusion of inpatients or groups with specific conditions, failure to mention patient status(outpatient or inpatient) or dietary restrictions, and permission to have unrestricted diet on the day prior to the exam. Primary outcomes were bowel cleaning success and/or tolerability of colon preparation. Secondary outcomes were adverse events, polyp and adenoma detection rates. Data on intention-totreat were extracted by two independent authors and risk of bias assessed through the Jadad scale. Funnel plots, Egger's test, Higgins' test(I2) and sensitivity analyses were used to assess reporting bias and heterogeneity. The meta-analysis was performed by computing risk difference(RD) using MantelHaenszel(MH) method with fixed-effects(FE) and random-effects(RE) *** Manager 5(RevMan 5) version 6.1(The Cochrane Collaboration) was the software chosen to perform the ***662 records were identified but only 16 trials with 6200 subjects were included for the meta-analysis. High heterogeneity among studies was found and sensitivity analysis was needed and performed to interpret data. In the pooled analysis,SPMC was better for bowel cleaning [MH FE, RD 0.03, IC(0.01, 0.05), P = 0.003, I2= 33%, NNT 34], for tole

关键词： Sodium picosulphate Polyethylene glycol Bowel cleaning success Tolerability Colonoscopy Randomized clinical trials Meta-analysis

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一种原子气室制备碱金属充制工艺设备的研制

真空科学与技术学报 2020年第11期40卷 1050-1053页

作者：王华栋高炳天刘立美冯浩 Gao Xingmin Shevchenko.O.v. 兰州工业学院兰州730050 兰州空间技术物理研究所兰州730000 兰州工业学院航空航天配套装备应用技术研究所兰州730050 乌克兰国立技术大学基辅03056

原子气室是新型量子仪表如量子频标和量子传感器等的核心部件,在其制备过程中,碱金属真空充制设备和充制质量控制是工艺和技术难点之一。运用麦克斯韦速率分布规律和Langmuir物质蒸发与凝结理论,研制了一种原子气室制备过程中碱金属充... 详细信息

原子气室是新型量子仪表如量子频标和量子传感器等的核心部件,在其制备过程中,碱金属真空充制设备和充制质量控制是工艺和技术难点之一。运用麦克斯韦速率分布规律和Langmuir物质蒸发与凝结理论,研制了一种原子气室制备过程中碱金属充制的自动化控制工艺设备。实现了碱金属充制过程量化控制。经铷泡充制实验验证,充铷量在500±100μg以内的铷泡占已所充铷泡的比率由35%提高至73%;离散度由±550减小至±250μg。该技术和设备可用于原子气室批量制备,具有广泛的应用推广价值。

关键词：原子气室碱金属真空充制工艺设备

2022年欧洲血管外科学会(ESvS)下肢慢性静脉疾病管理临床实践指南(全译)

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中华血管外科杂志 2023年第1期8卷 76-158页

作者： Marianne G.De Maeseneer Stavros K.Kakkos Thomas Aherne Niels Baekgaard Stephen Black Lena Blomgren Athanasios Giannoukas Manjit Gohel Rick de Graaf Claudine Hamel-Desnos Arkadiusz Jawien Aleksandra Jaworucka-Kaczorowska Christopher R.Lattimer Giovanni Mosti Thomas Noppeney Marie JoseevanRijn Gerard Stansby 无 Philippe Kolh Frederico Bastos Gongalves Nabil Chakfé Raphael Coscas Gert J.deBorst Nuno v.Dias Robert J.Hinchliffe igor B.Koncar Jes S.Lindholt Santi Trimarchi Rikka Tulamo Christopher P.Twine Frank vermassen Anders Wanhainen Martin Bjorck Nicos Labropoulos Fedor Lurie Armando Mansilha Isaac K.Nyamekye Marta Ramirez Ortega Jorge H.Ulloa Tomasz Urbanek Andre M.van Rij Marc E.vuylsteke 荷兰鹿特丹伊拉斯谟医疗中心皮肤科希腊帕特雷帕特雷大学血管外科爱尔兰科尔克大学医院和爱尔兰国立大学戈尔韦分校血管外科丹麦哥本哈根大学根措夫特医院和国家教学研究医院血管外科英国伦敦盖伊和圣托马斯医院及国王学院瑞典厄勒布罗大学医学院心血管和胸外科希腊塞萨利大学健康科学学院医学院拉里萨大学医院血管外科英国伦敦剑桥大学医院和帝国理工学院德国弗里德里希沙芬诊所诊断和介入放射科法国巴黎圣约瑟夫医院集团法国卡昂圣马丁私立医院血管内科波兰托伦市路德维克·赖德吉耶医学院尼古拉·哥白尼大学血管外科和血管学系波兰戈佐市静脉和美容医学中心、外科和妇科中心伦敦西北大学医疗保健NHS信托基金会英国伦敦帝国学院意大利卢卡Maria Domenica Barbantini诊所血管科纽伦堡MarthaMaria医院血管和血管内外科德国雷根斯堡大学医院血管和内皮外科荷兰鹿特丹伊拉斯谟医疗中心血管外科英国泰恩河畔纽卡斯尔弗里曼医院纽卡斯尔大学 ESvS Guidelines Committee 比利时利日利日大学生物医学和临床前科学系葡萄牙里斯本诺瓦德里斯本大学圣玛尔塔医院里斯本中心医院和诺瓦医学院法国斯特拉斯堡大学血管外科和肾移植系巴黎援助公社(AP-HP)CHU AmbroiseParé 法国布洛涅比兰科特巴黎萨克莱大学凡尔赛大学圣昆廷分校血管外科荷兰乌得勒支大学医学中心血管外科瑞典马尔默隆德大学斯科纳大学医院血管中心和马尔默临床科学英国布里斯托尔布里斯托尔大学塞尔维亚贝尔格莱德大学医学院塞尔维亚临床中心血管和血管内外科诊所丹麦欧登塞大学医院心胸血管外科意大利米兰大学临床与社区科学系米兰IRCCS CaGranda Ospedae Maggiore Policlinico基金会芬兰赫尔辛基赫尔辛基大学医院和赫尔辛基大学英国布里斯托尔北布里斯托尔NHS信托基金会布里斯托尔大学比利特根特大学医院瑞典乌普萨拉大学外科学系瑞典乌梅奥大学外科和围手术期科学系爱沙尼亚塔尔图塔尔图大学临床医学研究所外科学系美国纽约州石溪市石溪大学医学中心美国俄亥俄州托莱多普惠约布斯特血管研究所密歇根大学葡萄牙波尔图大学医学院英国伍斯特伍斯特郡皇家医院伍斯特郡急症医院NHS信托西班牙马德里La Luz Quiron Salud医院哥伦比亚波哥大安第斯大学圣菲基金会波兰卡托维兹西里西亚医科大学普通外科、血管外科、血管和静脉科新西兰达尼丁奥塔哥大学外科学系比利时Tielt圣安德列齐肯胡斯血管外科

2022年指南与2015年指南相比的新内容是什么?与2015年版《慢性静脉疾病(chronic venous disease,CvD)管理指南》1相比,该指南的总体结构做了很大修改,使其更加实用和方便。在不同章节中增加了关于管理策略的相关内容,并附有流程图。

关键词：临床实践指南血管外科学慢性静脉疾病管理指南流程图总体结构管理策略

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti vincent Boudry Mohammed Boukidi igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&Tv Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 Gev Linac,a 1.1 Gev Damping Ring,a Booster capable of achieving energies up to 180 Gev,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise