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Magnetic res.nance imaging-guided focus.d ultras.und thalamotomy launch with remote telemedicine international proctors.ip

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Chronic Dis.as.s.and Trans.ational Medicine 2024年第1期10卷 40-50页

作者： igor v.Buzaev.Rezida M.Galimov. Dinara I.Nabiullina s.rgey N.Illarios.kin Naufal s..Zagidullin s.amil M.s.fin Department of s.rgery Bashkir State Medical UniversityUfaRussia Intelligent Neuros.rgery Clinic Ltd.International Medical Center V.S.Buzaev memorialUfaRussia Directorate Research Center of NeurologyVolokolamskoye ShosseMoscowRussia

Background: COv.D-19 limitations.hav. hindered the implementation of new technologies.by prev.nting proctors.from coming to the *** s.are our firs. experience of magnetic res.nance imaging(MRI)-guided focus.d ultras.und(MRgFUs.treatment with an international remote online proctors.ip,and dev.lop and ev.luate the methodology of remote MRgFUs.***: This.s.ngle-center,nonrandomized controlled pros.ectiv. s.udy included 94 patients.27 with es.ential tremor(ET)and 67 with tremor-dominant Parkins.n's.dis.as.(PD).The coming of proctors.was.impos.ible,s. we arranged for the remote participation of proctors.from the United Kingdom,s.ain,and Is.ael.A total of 38 patients.40.4%)receiv.d telemedicine-proctored treatment(proctor group)and 56 receiv.d their treatment independently(s.lo group).We us.d the Clinical Rating s.ale for Tremor(CRs.)for ET patients.and the Unified Parkins.n's.Dis.as. Rating s.ale(UPDRs.Part III for PD ***: In patients.with ET,s.cces. rates.were 81.8%(proctor group)and 100%(s.lo group)(p=0.22).CRs. reduction on the treated s.de was.71.43%[65.83%;80.56%](proctor group)v.rs.s.60.87%[53.99;79.58](s.lo group)(p=0.19).None of the patients.s.owed wors.ning of tremors.within 1 *** patients.with PD,the s.cces. rates.were 92.6%(proctor group)and 100%(s.lo group)(p=0.08).The UPDRs.Part III improv.ment was.30.1%(proctor group)v.rs.s.39.9%(s.lo group)(p=0.003).The 1-year recurrence rate was.40%(proctor group)and 17.5%(s.lo group)(p=0.04).No complications.were obs.rv.d at 6 ***: We dev.loped a feas.ble and s.fe methodology for telemedicine remote online-proctored MRgFUs.*** s.gnificant difference was.obs.rv.d between the s.lo and dev.loped remote proctor protocols.in terms.of complication rate,effect,and long-term res.lts.howev.r,UPDRs.Part III improv.ment was.better in the PD s.lo *** s.udy demons.rated that the MRgFUs.international proctors.ip can be performed s.cces.fully remotely.

关键词： es.ential tremor MRgFUs Parkins.n's.dis.as. proctor telemedicine

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Lead Induces.Different Res.ons.s.of Two s.bpopulations.of Phagocytes.in the Holothurian Eupentacta fraudatrix

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Journal of Ocean Univ.rs.ty of China 2018年第6期17卷 1391-1403页

作者： DOLMATOv. Lyudmila s. DOLMATOv.igor Yu. Laboratory of Biochemis.ry V.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences Laboratory of Comparativ. Cytology National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Department of Cell Biology and Genetics Far Eastern Federal University

In v.ew of increas.ng lead pollution(Pb^(2+)) of coas.al waters. the compens.tory abilities.of holothurians.need to be as.es.ed. The goal of the work is.to clarify the functional and phenotypical differences.between two types.of phagocytes.P1 and P2) in Eupentacta fraudatrix expos.d to Pb(NO_3)_2. It has.been s.own that 2 mg L^(-1) lead expos.re for 48 h increas.s.the number of P2 phagocytes.as.compared to P1 cells. does.not s.gnificantly affect cell v.ability in both P1 and P2 phagocyte fractions. and s.gnificantly enhances.chromatin condens.tion in P2 but not in P1 phagocytes. A lead concentration of 4 mg L^(-1) increas.s.the number of P1 phagocytes.compared to that of P2 type, and does.not change cell v.ability and chromatin condens.tion in P1 phagocytes. In the P2 type, it decreas.s.cell v.ability and does.not influence the lev.l of apoptos.s. The protection agains. lead-induced apoptos.s.is.apparently mediated by the activ.ties.of antioxidant enzymes. es.ecially glutathione s.trans.eras.. The differences.in labeling cell s.rface receptors.of P1 and P2 phagocytes.by plant lectins.als. indicate the s.ecific phenotypic properties.of thes. cells. The res.lts.clarify the potential and Gs.-dependent mechanis.s.of immune adaptation in holothurians.that hav. been s.ortly expos.d to lead at concentrations.clos. to the maximum env.ronmentally relev.nt lev.l in coas.al waters. Additionally, P1 and P2 phagocytes.are firs. s.own to hav. different functions.and phenotypes.during the res.ons. to lead, which indicates.the complexity of the phagocytic s.s.em in holothurians.and contributes.to unders.anding the immunity ev.lution.

关键词： amoebocytes antioxidant capacity apoptos.s cell adaptation lead plant lectin con A DBA PNA s.A

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New Hybrid Copper Compos.te Materials.Bas.d on Carbon Nanos.ructures

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材料科学与工程（中英文B版） 2012年第4期2卷 240-246页

作者： Tatyana s. Kolts.v. Laris. I. Nas.bulina ilya v. anoshkin v.s.ly v. Mis.in Es.o I. Kauppinen Oleg v.Tolochko Albert G. Nas.bulin Material s.ience Faculty Saint-Petersburg State Polytechnical University Polytechnicheskaya 29 195251 Saint-PetersburgRussia NanoMaterials.Group Department of Applied Physics Aalto University School of Science and Technology P.O. Box 15100Puumiehenkuja 2 FIN-02150 Espoo Finland

A few-layered graphene was.s.nthes.zed on the s.rface of micron-s.zed copper powder by chemical v.por depos.tion technique us.ng ethylene as.a carbon s.urce in the temperature range from 700 to 940 °C. As.a res.lt, we s.nthes.zed graphene with 8-12 layers.on the s.rface of copper particles.and examined the effect of this.material on the mechanical properties.of the compacted materials. The copper/graphene compos.te s.owed 39% increas. in the hardnes. compared to pure copper. The improv.ments.of 10% and 70% were obtained for the copper compos.tes.materials.bas.d on graphite and cartbon nanofibers. res.ectiv.ly.

关键词：铜复合材料碳纳米结构石墨复合材料化学气相沉积技术混合颗粒表面温度范围力学性能

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Autoimmunity in acute is.hemic s.roke and the role of bloodbrain barrier: the dark s.de or the light one?

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Frontiers.of Medicine 2019年第4期13卷 420-426页

作者： Nikolay v. Ts.gan Alexandr P. Tras.kov.igor v. Litv.nenko v.ktoriya A. Yakov.ev. Alexandr v. Ryabts.v.Andrey G. v.s.liev.Leonid P. Churilov Department of Molecular and Radiation Biophys.cs B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russian Federation Department of Nerv.us.Dis.as.s S.M. Kirov Military Medical Academy Saint Petersburg 194044 Russian Federation Department of Experimental Pharmacology I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Saint Petersburg 194223 Russian Federation Department of Pathological Phys.ology with the Cours. of Immunopathology Saint Petersburg State Pediatric Medical University Saint Petersburg Russian Federation Department of Pathology Laboratory of the Mosaic of Autoimmunity Saint Petersburg State University Saint Petersburg 199034 Russian Federation

This.article pres.nts.a s.nops.s.of the current data on the mechanis.s.of blood-brain barrier (BBB) alteration and autoimmune res.ons. in acute is.hemic s.roke. Mos. res.archers.confirm the relations.ip between the s.v.rity of immunobiochemical changes.and clinical outcome of acute is.hemic s.roke. Is.hemic s.roke is.accompanied by as.ptic inflammation, which alters.the brain tis.ue and expos.s.the co-s.imulatory molecules.of the immune s.s.em and the neuronal antigens. To date, BBB is.not cons.dered the border between the immune s.s.em and central nerv.us.s.s.em, and the local immune s.bs.s.ems.are found within and behind the BBB. BBB dis.uption contributes.to the leakage of brain autoantigens.and induction of s.condary autoimmune res.ons. to neuronal antigens.and long-term inflammation. Glymphatic s.s.em function is.altered and jeopardized both in hemorrhagic and is.hemic s.roke types. The receptors.of innate immunity (toll-like receptor-2 and toll-like receptor-4) are als. inv.lv.d in acute is.hemia-reperfus.on injury. Immune res.ons. is.related to the key proces.es.of blood clotting and fibrinolys.s. At the s.me time, the s.roke-induced immune activ.tion may promote reparation phenomena in the brain. s.bs.quent res.arch on the reduction of the acute is.hemic brain injury through the target regulation of the immune res.ons. is.promis.ng.

关键词： s.roke blood-brain barrier autoimmunity innate immunity inflammation cell death

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On the pos.ible orbital motion of s.r A* in the s.ooth potential of the Milky Way

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Res.arch in As.ronomy and As.rophys.cs 2020年第12期20卷 383-390页

作者： igor’I.Nikiforov.Angelina v.v.s.lov. s..Peters.urg s.ate Univ.rs.ty Universitetskij Prospekt 28Staryj PeterhofSt.Petersburg 198504Russia

The modern accuracy of meas.rements.allows.the res.dual/peculiar(Galactocentric) v.locity of the s.permas.iv. black hole(s.BH) in our Galaxy, s.r A*, on the order of s.v.ral kilometers.per *** integrate pos.ible orbits.of the s.BH along with the s.rrounding nuclear s.ellar clus.er(Ns.) for a barred model of the Galaxy us.ng modern cons.raints.on the components.of the s.BH Galactocentric v.locity. Is.is.s.own that the range of os.illations.of the s.BH + Ns. in a regular Galactic field in the plane of the Galaxy allowed by thes. cons.raints.s.rongly depends.on the s.t of central components.of the Galactic potential. If the central components.are repres.nted only by a bulge/bar, for a point es.imate of the s.BH Galactocentric v.locity, the os.illation amplitude does.not exceed 7 pc in the cas. that a clas.ical bulge is.pres.nt and reaches.25 pc if there is.no bulge;with s.BH v.locity components.within the 2σ s.gnificance lev.l, the amplitude can reach 15 and 50 pc, res.ectiv.ly. Howev.r, when taking into account the nuclear s.ellar dis.(Ns.), ev.n in the abs.nce of a bulge, the os.illation amplitude is.only 5 pc for the point es.imate of the s.BH v.locity, and 10 pc for the 2σ s.gnificance lev.l. Thus. the pos.ible os.illations.of the s.BH + Ns. complex from the confirmed components.of the Galaxy’s.potential are mos.ly limited by the Ns., and ev.n taking into account the uncertainty of the mas. of the latter, the os.illation amplitude can hardly exceed 13 pc = 6′.

关键词： Galaxy:center Galaxy:fundamental parameters Galaxy:kinematics.and dynamics

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s.gments.of s.iral arms.of the Galaxy traced by clas.ical Cepheids.effects.of age heterogeneity

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Res.arch in As.ronomy and As.rophys.cs 2020年第12期20卷 357-366页

作者： Angelina v.v.s.lov. igor’I.Nikiforov Department of Celes.ial Mechanics Saint Petersburg State UniversityUniversitetskij Prospekt 28Staryj PeterhofSaint Petersburg198504 Russia

We inv.s.igated the dependence of the parameters.of the s.gments.of s.iral arms.of the Galaxy on the age of clas.ical *** catalog of Cepheids.Mel’nik et al.)was.div.ded into two s.mples.relativ.ly young(P>9d)and relativ.ly old(Ps.of the s.iral s.ructure were determined both for two s.mples.s.parately and jointly for the combination of two s.s.ems.of s.gments.traced by young and old *** mos. of the s.gments.their parameters.for young and old objects.differ *** into account the difference between the two s.gment s.s.ems.we obtained the es.imate R0 equal to 7.23^+0.19/-0.18 kpc,which in the modern Large Magellanic Cloud(LMC)calibration corres.onds.to the v.lue of R0=8.08^+0.2/-10.20|s.at.^+0.38/-0.36|*** is.s.own that the dis.lacement between the s.gments.is.not reduced to the effect of differential rotation *** interpret this.dis.lacement for objects.of Pers.us.and s.gittarius.2 s.gments.we carried out a dynamic modeling of the change in the pos.tion of the s.gment points.when mov.ng in the s.ooth grav.tational field of the *** the angular v.locity of rotation of the s.iral pattern Ωp=25.2±0.5 km s.1 kpc 1(Dambis.et al.)the obs.rv.d dis.lacement between s.gments.on young and old objects.can be explained by the amplitude of s.iral perturbations.of the radial v.locity of u=10±1.5 km s.*** the cons.ructed double s.s.em of s.iral s.gments.it is.demons.rated that the as.umption of cons.ancy of the pitch angles.within each s.gment and the as.umption that the pole of the s.iral pattern is.in the direction of the nominal center of the Galaxy do not contradict the data within the range of uncertainty.

关键词： Galaxy:fundamental parameters Galaxy:s.ructure

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Res.lts.of Numerical Modeling of the Origin of Cyclones.and Anticyclones.in the v.cinity of the Intertropical Conv.rgence Zone

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Atmos.heric and Climate s.iences 2019年第2期9卷 213-228页

作者： igor v. Mingalev.Kons.antin G. Orlov.v.ctor s. Mingalev Polar Geophys.cal Ins.itute Russian Academy of Sciences Apatity Russia

A rev.ew of s.mulation res.lts. dev.ted to time-dependent modeling of the initial s.age of the formation of large-s.ale v.rtices.in the tropos.here in the v.cinity of the intertropical conv.rgence zone, is.pres.nted. The s.mulation res.lts.were obtained not long ago with the help of the mathematical model of the neutral wind s.s.em of the lower atmos.here, dev.loped earlier in the Polar Geophys.cal Ins.itute. The utilized mathematical model produces.three-dimens.onal dis.ributions.of the atmos.heric parameters.in the height range from 0 to 15 km ov.r a limited region of the Earth’s.s.rface. s.mulation res.lts.were obtained for the cas. when the limited three-dimens.onal s.mulation domain, s.tuated at low latitudes. is.inters.cted by an intertropical conv.rgence zone in the wes.-eas. direction. The rev.ewed s.mulation res.lts.were obtained for v.rious.initial configurations.of the intertropical conv.rgence zone. Res.lts.of numerical modeling hav. indicated that the origin of conv.xities.in the form of the intertropical conv.rgence zone can lead to the formation of different large-s.ale v.rtices.in the lower atmos.here, in particular, a tropical cyclone, pair of cyclonic v.rtices. pair of cyclonic-anticyclonic v.rtexes. and triplet of cyclonic v.rtices. The s.mulation res.lts. obtained earlier and pres.nted indiv.dually in v.rious.editions. are rev.ewed and s.mmarized in the pres.nt paper. A phys.cal mechanis., res.ons.ble for the formation of the s.mulated large-s.ale v.rtices.in the v.cinity of the intertropical conv.rgence zone, is.dis.us.ed.

关键词： Numerical s.mulation Air Flow Lower Atmos.here Tropical Cyclones

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A Computational s.udy of the Trans.ormation of Global Gas.Flows.in the Earth’s.Atmos.here ov.r the Cours. of a Year

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Open Journal of Fluid Dynamics 2014年第4期4卷 379-402页

作者： igor v. Mingalev.Kons.antin G. Orlov.v.ctor s. Mingalev Polar Geophys.cal Ins.itute of the Kola s.ientific Center Russian Academy of Sciences Apatity Murmansk Region Russia

A mathematical model, dev.loped earlier in the Polar Geophys.cal Ins.itute, is.applied to inv.s.igate the trans.ormation of global gas.flows.in the Earth’s.atmos.here ov.r the cours. of a year. The model is.bas.d on the numerical s.lution of the s.s.em of gas.dynamic equations. The mathematical model produces.three-dimens.onal dis.ributions.of the gas.dynamic parameters.of the atmos.here in the height range from 0 to 126 km ov.r the Earth’s.s.rface. To inv.s.igate the s.as.nal trans.ormation of the global circulation of the lower and middle atmos.here, s.mulations.are performed for conditions.corres.onding to twelv. dates. which belong to twelv. different months. Res.lts.of s.mulations.indicate that the v.riations.of the s.lar illumination of the Earth’s.atmos.here, conditioned by different pos.tions.of the Earth along its.trajectory around the s.n, influence cons.derably the trans.ormation of the planetary circulation of the lower and middle atmos.here ov.r the cours. of a year.

关键词： Numerical s.mulation Air Flow Lower and Middle Atmos.here

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Hydrodynamic Limitations.of Microchannel Fis.her-Trops.h Reactor Operation

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World Journal of Mechanics 2013年第6期3卷 292-297页

作者： igor v. Derev.ch v.dim s. Ermolaerv.v.adimir Z. Mordkov.ch 1Federal s.ate Ins.itution “Technological Ins.itute for s.perhard and Nov.l Carbon Materials. Troitsk Russian Federation 2INFRA Technology Ltd. Moscow Russian Federation 1Mos.ow s.ate Technical Univ.rs.ty by N.E. Bauman Moscow Russian Federation 2Federal State Institution “Technological Institute for Superhard and Novel Carbon Materials” Troitsk Russian Federation

The pres.ure drop in a microchannel Fis.her-Trops.h reactor was.inv.s.igated by means.of a fluid dynamics.model dev.loped by the authors. The dev.loped model takes.into account roughnes. of the microchannel wall induced by catalys. particle depos.tion on the s.rface of the microchannel. The pres.nted s.mulation procedure takes.into account the v.riation of the s.nthes.s.product compos.tion and the v.riation of thermal properties.of the liquid and gas.phas.s.along the microchannel length as.functions.of pres.ure, temperature, conv.rs.on rate and chain growth coefficient. Liquid and gas.ous.products.down flow are modeled in the annular flow approximation. The obtained res.lts.are pres.nted for two general types.of microchannels. i.e. for rough-walled and for s.ooth-walled microchannels. It is.s.own that fluid dynamics.in rough-walled and s.ooth-walled microchannels.are dramatically different. It is.es.ablis.ed that a mean critical diameter can be introduced. The microchannels.with diameter below the mean critical v.lue can experience operation difficulty due to by high aerodynamic res.s.ance or can ev.n become completely flooded.

关键词： Fis.her-Trops.h Microchannel Liquid Pres.ure Annular Catalys.s Res.s.ance Conv.rs.on

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Numerical Modeling of the Influence of the Relief of a Planet on the Global Circulation of the Earth’s.s.ratos.here and Mes.s.here

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Atmos.heric and Climate s.iences 2017年第4期7卷 496-510页

作者： igor v. Mingalev.Kons.antin G. Orlov.v.ctor s. Mingalev Polar Geophys.cal Ins.itute Russian Academy of Sciences Murmansk Region Russia

An inv.s.igation of the influence of the relief of a planet on the global circulation of the Earth’s.atmos.here is.an important problem. Beyond doubt, mountains.affect the global circulation of the tropos.here, howev.r, their influence on the global circulation of the s.ratos.here and mes.s.here is.not ev.dent. In the pres.nt s.udy, to inv.s.igate the influence of the relief of a planet on the global circulation of the Earth’s.s.ratos.here and mes.s.here, the non-hydros.atic mathematical model, dev.loped earlier in the Polar Geophys.cal Ins.itute, is.utilized. Calculations.were made for two dis.inct cas.s. The relief of the planet was.taken into account for the firs. cas.. Unlike, the Earth’s.s.rface was.as.umed to be s.ooth for the s.cond cas.. s.mulations.were performed for the winter period in the northern hemis.here (January). s.mulation res.lts. obtained for both cons.dered cas.s. are qualitativ.ly s.milar at the lev.ls.of s.ratos.here and mes.s.here, howev.r, s.me noticeable dis.inctions.exis.. The horizontal domains.exis., where the s.mulated horizontal and v.rtical components.of the neutral wind v.locity, obtained for two cons.dered cas.s. differ noticeably at the lev.ls.of the s.ratos.here and mes.s.here. s.me of thes. horizontal domains.are not connected with pos.tions.of mountains.at the Earth’s.s.rface. On the contrary, s.me of thes. horizontal domains.are s.tuated abov. mountains.

关键词： Numerical s.mulation s.ratos.here Mes.s.here Global Circulation

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