检索结果-南通市图书馆

Direct muscle neurotization after end-to-end and end-to-side neurorrhaphy An experimental study in the rat forelimb model

引用

Neural Regeneration Research 2012年第29期7卷 2273-2278页

作者： igor papalia Giulia Ronchi Luisa Muratori Alessandra Mazzucco Ludovico Magaudda Stefano Geuna Department of Biomorphology and Biotechnologies University of MessinaMessina 98100Italy Neuroscience Institute of the Cavalieri Ottolenghi Foundation (NICO)&Department of Clinical and Biological Sciences University of TurinTorino 10043Italy

The need for the continuous research of new tools for improving motor function recovery after nerve injury is justified by the still often unsatisfactory clinical outcome in these patients. It has been previously shown that the combined use of two reconstructive techniques, namely end-to-side neurorrhaphy and direct muscle neurotization in the rat hindlimb model, can lead to good results in terms of skeletal muscle reinnervation. Here we show that, in the rat forelimb model, the combined use of direct muscle neurotization with either end-to-end or end-to-side neurorrhaphy to reinnervate the denervated flexor digitorum muscles, leads to muscle atrophy prevention over a long postoperative time lapse （10 months）. By contrast, very little motor recovery （in case of end-to-end neurorrhaphy） and almost no motor recovery （in case of end-to-side neurorrhaphy） were observed in the grasping activity controlled by flexor digitorum muscles. It can thus be concluded that, at least in the rat, direct muscle neurotization after both end-to-end and end-to-side neurorrhaphy represents a good strategy for preventing denervation-related muscle atrophy but not for regaining the lost motor function.

关键词： nerve injury nerve reconstruction microsurgery axonal regeneration denervation muscle atrophy Schwann cells stereology grasping test rats

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The reasons for end-to-side coaptation:how does lateral axon sprouting work?

引用

Neural Regeneration Research 2017年第4期12卷 529-533页

作者： Stefano Geuna igor papalia Giulia Ronchi Francesco Stagno d'Alcontres Konstantinos Natsis Nikolaos A. Papadopulos Michele R. Colonna Department of Clinical and Biological Sciences University of Turin Turin Italy Department of Biomedical and Dental Sciences and Morphological and Functional Sciences University of Messina Messina Italy Department of Human Pathology of the Adults the Children and the Adolescents University of Messina Messina Italy Department of Anatomy Faculty of Health Sciences School of Medicine Aristoteles University Thessaloniki Greece Department of Plastic Surgery and Burns Alexandroupoli University General Hospital Democritus University of Thrace Alexandroupoli Greece

Nerve fibers are attracted by sutureless end-to-side nerve coaptation into the recipient nerve. Opening a window in the epineurium enhances axon attraction and myeliuation. The authors analyze the features of nerve repair by end-to-side coaptation. They highlight the known mechanisms of axon sprouting and different hypotheses of start up signals （presence or absence of an epineurial window, role of Schwann cells, signaling from the distal trunk）. The clinical literature is also presented and differences between experimental and clinical applications are pointed out. The authors propose their point of view and perspectives deriving from recent experimental and clinical experiences.

关键词： peripheral nerve repair nerve coaptation end-to-side nerve repair side-to-side nerve repair epineurial window Schwann cells nerve regeneration nerve babysitter procedures nerve transfer nerve graft glues in nerve repair

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：