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Lead Induces Different Responses of Two Subpopulations of Phagocytes in the Holothurian Eupentacta fraudatrix

Journal of Ocean University of China 2018年第6期17卷 1391-1403页

作者： DOLMATOVA Lyudmila S. DOLMATOV igor Yu. Laboratory of Biochemistry V.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences Laboratory of Comparative Cytology National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Department of Cell Biology and Genetics Far Eastern Federal University

In view of increasing lead pollution(Pb^(2+)) of coastal waters, the compensatory abilities of holothurians need to be assessed. The goal of the work is to clarify the functional and phenotypical differences between two types of phagocytes(P1 and P2) in Eupentacta fraudatrix exposed to Pb(NO_3)_2. It has been shown that 2 mg L^(-1) lead exposure for 48 h increases the number of P2 phagocytes as compared to P1 cells, does not significantly affect cell viability in both P1 and P2 phagocyte fractions, and significantly enhances chromatin condensation in P2 but not in P1 phagocytes. A lead concentration of 4 mg L^(-1) increases the number of P1 phagocytes compared to that of P2 type, and does not change cell viability and chromatin condensation in P1 phagocytes. In the P2 type, it decreases cell viability and does not influence the level of apoptosis. The protection against lead-induced apoptosis is apparently mediated by the activities of antioxidant enzymes, especially glutathione S-transferase. The differences in labeling cell surface receptors of P1 and P2 phagocytes by plant lectins also indicate the specific phenotypic properties of these cells. The results clarify the potential and GSH-dependent mechanisms of immune adaptation in holothurians that have been shortly exposed to lead at concentrations close to the maximum environmentally relevant level in coastal waters. Additionally, P1 and P2 phagocytes are first shown to have different functions and phenotypes during the response to lead, which indicates the complexity of the phagocytic system in holothurians and contributes to understanding the immunity evolution.

关键词： amoebocytes antioxidant capacity apoptosis cell adaptation lead plant lectin con A DBA PNA SBA

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Uncertainty of Climate Response to Natural and Anthropogenic Forcings Due to Different Land Use Scenarios

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Advances in Atmospheric Sciences 2011年第5期28卷 1215-1232页

作者： Alexey V.ELISEEV igor I.MOKHOV A. M. Obukhov Institute of Atmospheric Physics Russian Academy of Sciences3 Pyzhevsky 119017 Moscow Russia

The *** Institute of Atmospheric Physics,Russian Academy of Sciences （IAP RAS） climate model （CM） of intermediate complexity is extended by a spatially explicit terrestrial carbon cycle *** experiments with the IAP RAS CM are performed forced by the reconstructions of anthropogenic and natural forcings for the 16th to the 20th centuries and by combined SRES （Special Report on Emission Scenarios） A2-LUH （Land Use Harmonization） anthropogenic scenarios for the 21st ***,the impact of uncertainty in land-use scenarios on results of simulations with a coupled climate-carbon cycle model is *** simulations of the model realistically reproduced historical changes in carbon cycle *** the IAP RAS CM,climate warming reproduced in the 20th and 21st centuries enhanced terrestrial net primary production but terrestrial carbon uptake was suppressed due to an overcompensating increase in soil *** year 2100,the simulations the model forced by different land use scenarios diverged markedly,by about 70 Pg （C） in terms of biomass and soil carbon stock but they differed only by about 10 ppmv in terms of atmospheric carbon dioxide content.

关键词： terrestrial carbon cycle climate model anthropogenic scenarios uncertainty in projections

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New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

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世界胃肠病学杂志:英文版 2023年第37期29卷 5292-5304页

作者： Vasiliy Ivanovich Reshetnyak igor Veniaminovich Maev Department of Propaedeutics of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia

Primary biliary cholangitis(PBC)is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in *** to cholangiocytes triggers the development of intrahepatic cholestasis,which progresses to cirrhosis in the terminal stage of the *** data indicate that damage to biliary epithelial cells[(BECs),cholangiocytes]is most likely associated with the intracellular accumulation of bile acids,which have potent detergent properties and damaging effects on cell *** mechanisms underlying uncontrolled bile acid intake into BECs in PBC are associated with pH change in the bile duct lumen,which is controlled by the bicarbonate(HCO3-)buffer system“biliary HCO3-umbrella”.The impaired production and entry of HCO3-from BECs into the bile duct lumen is due to epigenetic changes in expression of the X-linked microRNA *** on the growing body of knowledge on the molecular mechanisms of cholangiocyte damage in patients with PBC,we propose a hypothesis explaining the pathogenesis of the first morphologic(ductulopenia),immunologic(antimitochondrial autoantibodies)and clinical(weakness,malaise,rapid fatigue)signs of the disease in the asymptomatic *** review focuses on the consideration of these mechanisms.

关键词： Primary biliary cholangitis Antimitochondrial autoantibodies MicroRNA 506 Inositol-1,4,5-trisphosphate receptor type 3 Chloride/bicarbonate anion exchanger 2 Biliary bicarbonate umbrella Dihydrolipoyl transacetylase(E2 subunit) Pyruvate dehydrogenase complex

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The left-right side-specific endocrine signaling:implications for neurological deficits in stroke and neurodevelopmental disorders

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Neural Regeneration Research 2022年第11期17卷 2431-2433页

作者： Georgy Bakalkin Nikolay Lukoyanov igor Lavrov Mengliang Zhang Department of Pharmaceutical Biosciences Uppsala University Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto Instituto de Investiga??o e Inova??o em SaúdeInstituto de Biologia Molecular e Celular Department of Neurology Mayo Clinic Department of Molecular Medicine University of Southern Denmark

Brain injury-induced neurological deficits typically develop on the contralateral side of the body and include abnormal posture,motor weakness,and *** is believed that the interruption of descending neural pathways th... 详细信息

关键词： neurological typically deficit

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新形势下的俄中政治对话:成果和共同任务

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俄罗斯研究 2024年第1期 3-8页

作者：伊戈尔·莫尔古洛夫陈胜男(翻译) 不详郑州大学外国语与国际关系学院

2024年是中俄建交75周年,从相互视为友好国家到建立建设性伙伴关系,从建立战略协作伙伴关系到全面战略协作伙伴关系,中俄关系的定位经历数次提升,稳步迈上一个又一个台阶。中俄作为全面战略协作伙伴,发展关系已经远远超出双边范畴,双方... 详细信息

2024年是中俄建交75周年,从相互视为友好国家到建立建设性伙伴关系,从建立战略协作伙伴关系到全面战略协作伙伴关系,中俄关系的定位经历数次提升,稳步迈上一个又一个台阶。中俄作为全面战略协作伙伴,发展关系已经远远超出双边范畴,双方在涉及彼此核心利益的问题上始终坚定相互支持,坚定推动平等有序的世界多极化和普惠包容的经济全球化,团结进步力量,不断凝聚构建人类命运共同体的国际共识。中俄关系已成为当今国际舞台上具有强劲内生动力和高度成熟的一对大国关系,堪称当代国际关系的典范。

关键词：中俄关系新型大国关系全球转型世界秩序

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A model study of the effect of weather forcing on the ecology of a meromictic Siberian lake

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Journal of Oceanology and Limnology 2018年第6期36卷 2018-2032页

作者： igor G.PROKOPKIN Egor S.ZADEREEV Institute of Biophysics SB RAS Krasnoyarsk Scientific Center660036AkademgorodokKrasnoyarskRussia Siberian Federal University 660079Svobodniiav.79KrasnoyarskRussia

We used a Lake Shira numerical model to estimate the response of the ecosystem of a saline meromictic lake to variations in weather parameters during the growing season. The sensitivity analysis of the model suggests that compared to other external(nutrient inflows) and internal(spring biomasses of food-web components) factors, weather parameters are among the most influential for both mixolimnetic(phyto-and zooplankton) and monimolimnetic(purple sulfur bacteria, sulfur reducing bacteria and hydrogen sulfide) food-web components. Calculations with different weather scenarios shows how changes in the water temperature and mixing depth af fect mixolimnetic and monimolimnetic food-web components and the depth of the oxic-anoxic interface in a meromictic lake. When weather forcing stimulates an increase in the biomass of food-web components in the mixolimnion, it produces cascading effects that lead to three results: 1) a higher content of detritus in the water column; 2) a higher content of hydrogen sulfide in the monimolimnion; 3) raising of the oxic-anoxic interface closer to the water-air surface. This cascading effect is complicated by the negative correlation between two light dependent primary producers located at diff erent depths—phytoplankton in the mixolimnion and purple sulfur bacteria at the oxic-anoxic interface. Thus, weather conditions that stimulate higher phytoplankton biomass are associated with a higher detritus content and lower biomass of purple sulfur bacteria, a higher content of hydrogen sulfide and a shallower oxic-anoxic interface. The same weather conditions(higher wind, lower cloud cover, and lower air temperature) promote a scenario of less stable thermal stratification. Thus, our calculations suggest that weather parameters during the summer season strongly control the mixing depth, water temperature and the mixolimnetic food web. An effect of biogeochemical and physical interactions on the depth of the oxicanoxic interface is also detecta

关键词： meromictic lake numerical model weather forcing sensitivity analysis stratifi cation food web

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Provenance of Precambrian Fe- and Al-rich Metapelites in the Yenisey Ridge and Kuznetsk Alatau, Siberia: Geochemical Signatures

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Acta Geologica Sinica(English Edition) 2007年第3期81卷 409-423页

作者： igor I. LIKHANOV Vladimir V. REVERDATTO Institute of Geology and Mineralogy Siberian Branch Russian Academy of SciencesPr. Acad. Koptyuga3Novosibirsk630090Russian Federation

Major, trace and rare earth element contents of Fe- and Al-rich metapelites from the Korda （Yenisey Ridge） and Amar （Kuznetsk Alatau） formations were determined to examine the nature, origin and evolution of their protoliths. Results indicate that these rocks are the redeposited and metamorphosed products of Precambrian kaolinitic weathering crusts, while the geochemical distinctions between the studied metapelites are determined by different weathering conditions in the source area and tectonic settings. The protolith of the Korda Formation metapelites was produced by erosion products of the post-Archean granitoid rocks, which accumulated under humid climate conditions in shallow-water basins along the continental margin. The geochemical characteristics of the deeper primary deposits of the Amar Formation suggest that volcanogenic material of mafic composition derived from an island-arc environment had a major role in supplying the erosion zone. These results agree with lithofacies data and with the geodynamic reconstruction of the evolution of the Yenisey Ridge and Kuznetsk Alatau during the Mesoproterozoic and Neoproterozoic, respectively. It was shown that REEs had limited mobility during contact metamorphism. The coherent mobility of REEs during collisional metamorphism may be attributed both to mineral reactions responsible for modal changes and to local chemical heterogeneity inherited from the initial protolith.

关键词： geochemistry protolith pelitic schists Kuznetsk Alatau Yenisey Ridge Russia

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First principles calculation of spin-related quantities for point defect qubit research

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npj Computational Materials 2018年第1期4卷 32-44页

作者： Viktor Ivády igor A.Abrikosov Adam Gali Department of Physics Chemistry and BiologyLinköping UniversitySE-58183 LinköpingSweden Wigner Research Centre for Physics Hungarian Academy of SciencesPO Box 49Budapest H-1525Hungary Materials Modeling and Development Laboratory National University of Science and Technology‘MISIS’119049 MoscowRussia Department of Atomic Physics Budapest University of Technology and EconomicsBudafokiút 8Budapest H-1111Hungary

Point defect research in semiconductors has gained remarkable new momentum due to the identification of special point defects that can implement qubits and single photon emitters with unique ***,these implementations are among the few alternatives for quantum technologies that may operate even at room temperature,and therefore discoveries and characterization of novel point defects may highly facilitate future solid state quantum *** principles calculations play an important role in point defect research,since they provide a direct,extended insight into the formation of the defect *** the last decades,considerable efforts have been made to calculate spin-dependent properties of point defects from first *** developed methods have already demonstrated their essential role in quantitative understanding of the physics and application of point defect ***,we review and discuss accuracy aspects of these novel ab initio methods and report on their most relevant applications for existing point defect qubits in *** pay attention to the advantages and limitations of the methodological solutions and highlight additional developments that are expected in the near ***,we discuss the opportunity of a systematic search for potential point defect qubits,as well as the possible development of predictive spin dynamic simulations facilitated by ab initio calculations of spin-dependent quantities.

关键词： defect quantities principles

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Analysis of the Vibrissa Parametric Resonance Causing a Signal Amplification during Whisking Behaviour

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Journal of Bionic Engineering 2016年第2期13卷 312-323页

作者： Tatiana Volkova igor Zeidis Hartmut Witte Manuela Schmidt Klaus Zimmermann Technische Universiat Ilmenau Technical Mechanics Group 98693 Max-Planck-Ring 12 Ilmenau Germany Technische Universitat Ilmenau Biomechatronics Group 98693 Max-Planck-Ring 12 Ilmenau Germany Friedrich-Schiller-Universitat Jena Institute of Systematic Zoology and Evolutionary Biology with Phyletic Museum 07743 Erbertstrafle 1 Jena Germany

The paper deals with the mechanical vibrational motion ofvibrissae during natural exploratory behaviour of mammals. The theoretical analysis is based on a mechanical model of a cylindrical beam with circular natural configuration under an applied periodic force at the tip, which corresponds to the surface roughness of an investigated object. The equation of motion of the beam is studied using the Euler-Bemoulli beam theory and asymptotic methods of mechanics. It is shown that from the me- chanical point of view the phenomenon of parametric resonance of the vibrissa is possible. It means that the amplitude of forced vibrations of a vibrissa increases exponentially with time, if it is stimulated within a specific resonance frequency range, which depends on biomechanical parameters of the vibrissa. The most intense parametric resonance occurs, when the excitation frequency is close to the doubled natural frequency of free vibrations. Thus, it may be used to distinguish and amplify specific periodic components of a complex roughness profile during texture discrimination.

关键词： vibrissa whisking vibration tactile sensor beam theory parametric resonance

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Influence of Magnetic Field and Lighting during the Creation Process of Nanohybrid Semiconductor-Nematic Structures on Their Impedance and Photo Response

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Journal of Materials Science & Technology 2011年第11期27卷 973-978页

作者： Fedir Ivashchyshyn Ivan Grygorchak Olena Sudakova igor Bordun Miroslav Micov Lviv Polytechnic National University 12 Bandera Str. Lviv 79013 Ukraine

In this work, for the first time, photosensitive nanostructures with alternate semiconductor and magnetic oriented nematic molecular nanolayers were obtained. The established dependency on the ordering type of kinetic and optical properties is deserving attention. For the first time, the notion of ＇rotary＇ polaron in such structures is introduced and microscopic model is created, which explains band structure transformation. The model is well coordinated with experimental optical data, which, at the same time, indicate the prospects of application of materials obtained due to the intercalation engineering for photoenergetics.

关键词： Nanocomposites Heterostructures Intercalation Liquid crystals Impedancespectroscopy Photoelectromotive force

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