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Lead Induces Different Responses of Two Subpopulations of Phagocytes in the Holothurian Eupentacta fraudatrix

Journal of Ocean University of China 2018年第6期17卷 1391-1403页

作者： DOLMATOvA Lyudmila S. DOLMATOv igor Yu. Laboratory of Biochemistry V.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences Laboratory of Comparative Cytology National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Department of Cell Biology and Genetics Far Eastern Federal University

In view of increasing lead pollution(Pb^(2+)) of coastal waters, the compensatory abilities of holothurians need to be assessed. The goal of the work is to clarify the functional and phenotypical differences between two types of phagocytes(P1 and P2) in Eupentacta fraudatrix exposed to Pb(NO_3)_2. It has been shown that 2 mg L^(-1) lead exposure for 48 h increases the number of P2 phagocytes as compared to P1 cells, does not significantly affect cell viability in both P1 and P2 phagocyte fractions, and significantly enhances chromatin condensation in P2 but not in P1 phagocytes. A lead concentration of 4 mg L^(-1) increases the number of P1 phagocytes compared to that of P2 type, and does not change cell viability and chromatin condensation in P1 phagocytes. In the P2 type, it decreases cell viability and does not influence the level of apoptosis. The protection against lead-induced apoptosis is apparently mediated by the activities of antioxidant enzymes, especially glutathione S-transferase. The differences in labeling cell surface receptors of P1 and P2 phagocytes by plant lectins also indicate the specific phenotypic properties of these cells. The results clarify the potential and GSH-dependent mechanisms of immune adaptation in holothurians that have been shortly exposed to lead at concentrations close to the maximum environmentally relevant level in coastal waters. Additionally, P1 and P2 phagocytes are first shown to have different functions and phenotypes during the response to lead, which indicates the complexity of the phagocytic system in holothurians and contributes to understanding the immunity evolution.

关键词： amoebocytes antioxidant capacity apoptosis cell adaptation lead plant lectin con A DBA PNA SBA

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New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

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World Journal of Gastroenterology 2023年第37期29卷 5292-5304页

作者： vasiliy Ivanovich Reshetnyak igor veniaminovich Maev Department of Propaedeutics of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia

Primary biliary cholangitis(PBC)is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in *** to cholangiocytes triggers the development of intrahepatic cholestasis,which progresses to cirrhosis in the terminal stage of the *** data indicate that damage to biliary epithelial cells[(BECs),cholangiocytes]is most likely associated with the intracellular accumulation of bile acids,which have potent detergent properties and damaging effects on cell *** mechanisms underlying uncontrolled bile acid intake into BECs in PBC are associated with pH change in the bile duct lumen,which is controlled by the bicarbonate(HCO3-)buffer system“biliary HCO3-umbrella”.The impaired production and entry of HCO3-from BECs into the bile duct lumen is due to epigenetic changes in expression of the X-linked microRNA *** on the growing body of knowledge on the molecular mechanisms of cholangiocyte damage in patients with PBC,we propose a hypothesis explaining the pathogenesis of the first morphologic(ductulopenia),immunologic(antimitochondrial autoantibodies)and clinical(weakness,malaise,rapid fatigue)signs of the disease in the asymptomatic *** review focuses on the consideration of these mechanisms.

关键词： Primary biliary cholangitis Antimitochondrial autoantibodies MicroRNA 506 Inositol-1,4,5-trisphosphate receptor type 3 Chloride/bicarbonate anion exchanger 2 Biliary bicarbonate umbrella Dihydrolipoyl transacetylase(E2 subunit) Pyruvate dehydrogenase complex

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Current management of noninfectious hepatic cystic lesions:A review of the literature

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World Journal of Hepatology 2013年第9期5卷 462-469页

作者： Francisco igor Macedo Department of Surgery Providence Hospital and Medical CentersSouthfieldMI 48075United States

Nonparasitic hepatic cysts consist of a heterogeneous group of disorders, which differ in etiology, prevalence,and manifestations. With improving diagnostic techniques, hepatic cysts are becoming more *** advancements in minimally invasive technology created a new Era in the management of hepatic cystic disease. Herein, the most current recommendations for management of noninfectious hepatic cysts are described, thereby discussing differential diagnosis, new therapeutic modalities and outcomes.

关键词： simple hepatic cyst Noninfectious Polycystic liver disease Cystadenoma Cystadenocarcinoma Caroli’s disease sclerotherapy Fenestration

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Giga- and terahertz-range nanoemitter based on peapod structure

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Nano Research 2015年第8期8卷 2595-2602页

作者： Michail M. Slepchenkov Anna S. Kolesnikova George v. Savostyanov1 igor S. Nefedov Ilya v. Anoshkin Albert G. Nasibulin Olga E. Glukhova Department of Physics Saratov State University Saratov 410012 Russia Department of Radio Science and Engineering Aalto University Aalto P.O. Box 13000 Finland kolkovo Institute of Science and Technology Skolkovo 143025 Russia

We propose a theoretical model of a nanoemitter for giga- and terahertz-range waves. The model is based on a peapod structure comprising a carbon nanotube with chiral indices （10, 10）. Three encapsulated and partially polymerized fuUerene C60 molecules and a positively charged C60 fullerene are trapped inside the nanotube. The motion of the charged fullerene and the radiation frequency were controlled using an external electric field. Stable terahertz radiation at a frequency of 0.36 THz was produced at 300 K with an external electrical field of 10 v/μm. Stable radiation in the gigahertz range was observed at 50 K with an electric field below 10 v/m. A theoretical simulation was performed using the tight-binding molecular dynamics method with a description of the van der Waals interaction by the Morse potential. The system described by the theoretical model was experimentally observed.

关键词： fullerenes nanotubes electronics simulations molecular modeling

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IR-transparent MgO-Gd_(2)O_(3) composite ceramics produced by self-propagating high-temperature synthesis and spark plasma sintering

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Journal of Advanced Ceramics 2021年第2期10卷 237-246页

作者： Dmitry A.Permin Maksim S.Boldin Alexander v.Belyaev Stanislav S.Balabanov vitaly A.Koshkin Atrem A.Murashov igor v.Ladenkov Evgeny A.Lantsev Ksenia E.Smetanina Nadia M.Khamaletdinova G.G.Devyatykh institute of chemistry of high-purity substances of the ras nizhny novgorod603137russia Lobachevsky state university of nizhny novgorod nizhny novgorod603950russia “Joint-stock company”research and production enterprise“salut” nizhny novgorod603950russia G.A.Razuvaev institute of organometallic chemistry of the ras nizhny novgorod603137russia

A glycine–nitrate self-propagating high-temperature synthesis(SHS)was developed to produce composite MgO-Gd_(2)O_(3) *** X-ray powder diffraction(XRD)analysis confirmed the SHS-product consists of cubic MgO and Gd_(2)O_(3) phases with nanometer crystallite size and retains this structure after annealing at temperatures up to 1200℃.Near full dense high IR-transparent composite ceramics were fabricated by spark plasma sintering(SPS)at 1140℃and 60 *** in-line transmittance of 1 mm thick MgO-Gd_(2)O_(3) ceramics exceeded 70%in the range of 4–5 mm and reached a maximum of 77%at a wavelength of 5.3 *** measured microhardness Hv0.5 of the MgO-Gd2O3 ceramics is 9.5±0.4 GPa,while the fracture toughness(KIC)amounted to 2.0±0.5МPa·m1/*** characteristics demonstrate that obtained composite MgO-Gd_(2)O_(3) ceramic is a promising material for protective infra-red(IR)windows.

关键词： MgO-Gd_(2)O_(3) self-propagating high-temperature synthesis(SHS) spark plasma sintering(SPS) optical properties infra-red(IR)ceramics

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Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana v.Kharissova Lucy T.González Yolanda Peña Méndez igor E.Uflyand Idalia Gómez de la Fuente Universidad Autónoma de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Department of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its composites with inorganic additives,dopants,and polymers is a rapidly developing branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for medical *** a gap of insufficient generalization of recent achievements in the field of the HA/Carbon composites,in this review we present the state of the art of the field of HA composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a variety of classic and less-common methods,such as co-precipitation(with or without ultrasonic treatment),CvD,hot isostatic pressing,hydrothermal,spark plasma sintering,biomimetic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of various synthesis techniques can be also carried out for composite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitative amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with simultaneous enhancement of mechanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum dots Fullerenes Nanodiamonds

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The Modern Development of New Promising Fields in Forensic Examinations

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Journal of Forensic Science and Medicine 2021年第4期7卷 137-144页

作者： igor v.Borysenko Oleg Yu.Bululukov valeriy D.Pcholkin vasyl v.Baranchuk vladlena O.Prykhodko Department of Criminalistics Yaroslav Mudryi National Law UniversityKharkivUkraine Department of Criminal Procedure Criminalistics and ExpertologyKharkiv National University of Internal AffairsKharkivUkraine Organizational and Analytical Department of the Organizational and Analytical Support and Rapid Response Main Department of the National Police in KyivKyivUkraine

The relevance of the study is forensic expert activity in terms of forensic examinations have been so transformed that existing theoretical provisions do not already solve traditional problems in some fields;their solvation requires new approaches of both theoretical and practical *** this regard,the purpose of this study is to analyze the content of new innovative directions in forensic examinations,including criminalistic ones,and the possibility of their effective application in forensic expert *** methodological basis of the study is the dialectical method of scientific knowledge,which allowed the authors to consider the theoretical and scientific,and practical foundations of modem trends in forensic examinations,including criminalistic *** also helped to identify promising fields of examinations necessary for crime ***,authors singled out the following advanced fields:biometric and computer forensic analyses,polygraph,and odor and trace evidence *** materials of the article are of practical value for forensic experts and criminologists,law enforcement agencies.

关键词： Analysis of digital evidence odor evidence analysis polygraph psychophysiological examinations trace evidence analysis

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THE EXPERIMENTAL STUDY OF STRESS-RELATED PATHOLOGICAL CHANGES IN CEREBRAL vENOUS BLOOD FLOW IN NEWBORN RATS ASSESSED BY DOCT

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Journal of Innovative Optical Health Sciences 2013年第3期6卷 76-85页

作者： OXANA v.SEMYACHKINA-GLUSHKOvSKAYA vLADISLAv v.LYCHAGOv OLGA A.BIBIKOvA igor A.SEMYACHKIN-GLUSHKOvSKIY SERGEY S.SINDEEv EKATERINAM.ZINCHENKO MOHHANAD M.KASSIM AL-FATLE FATEMA ALI AL HASSANI LEITH MARIA v.ULANOvA vALERY v.TUCHIN Department of Biology Saratov State UniversityAstrachanskaya Str.83410012 SaratovRussian Federation Department of Biology Al-Mustansiriya UniversityBaghdadIraq Institute of Precise Mechanics and Control of Russia Academy of Science Rabochaya 28 410028 SaratovRussian Federation Optoelectronics and Measurement Techniques Laboratory University of Oulu P.O.BOX 450090014 University of OuluFinland

In experiments on newbom rats with stress related intracrani al hemorhage(ICH)using Doppler optical coberence tomognaphy(DOCT)we have shown that latent stage of ICH(4 h after stress)is characterized by decrease of venous blood outflow and the loss of sensitivity of sagittal vein to vasoconstrictor ffect of *** incidence of ICH(24 h after stress)was accompanied by progressi on of early pathological changes in cerebral venous blood flow(CvBF)and development of venous *** into consideration of this fact,we suggest that the suppression of CvBF related to the severity to the deleterious effect of stress on the brain hemodynamics in newborn *** facts allow us to conclude that the venous insufficiency with the loss of vasoconstrictor response to adrenaline is an informative and sensitive component of pattern of CvBF that can be important diagnostic criteria of risk of ICH development in newborns.

关键词： Doppler optical coherence tomography stress related intracnanial hemorthage cerebral venous blood flow adrenaline

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Investigation of coupled cobalt-silver nanoparticle system by plan view TEM

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Progress in Natural Science:Materials International 2012年第3期22卷 186-192页

作者： Daniel Fox Ruggero verre Brendan J. O'Dowd Sunil K. Arora Colm C. Faulkner igor v. Shvets School of Physics and CRANN Trinity College Dublin CRANN Advanced Microscopy Laboratory Trinity College Dublin

We present a transmission electron microscopy (TEM) investigation of a coupled cobalt and silver nanoparticle system. A plan view in situ lift-out method for preparing samples for TEM using the focused ion beam (FIB) microscope was used. This technique is used to prepare high quality TEM samples with site specificity in a short time and with a high success rate. We demonstrate the ability of the plan view sample preparation technique to provide information about an ordered system of nanoparticles which could not be observed using standard FIB cross sectioning of the sample. High resolution TEM and energy dispersive X-ray spectroscopy mapping of both cross sectional and plan view samples are presented, clearly showing the significant benefit of plan view TEM analysis for certain samples.

关键词： Focused ion beam Transmission electron microscopy Lift-out Co Ag Nanoparticle

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Wireless Infrared Pyrometer with Fiber Optic: Construction and Processing Algorithms

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Wireless Engineering and Technology 2014年第2期5卷 25-33页

作者： igor Ya. Orlov igor A. Nikiforov Alexander v. Afanasjev Lobachevsky State University of Nizhny Novgorod (National Research University) Nizhny Novgorod Russia

In this paper, developed wireless portable infrared pyrometer with dual channel fiber optic is described. The pyrometer measures surface temperature in wide infrared spectral range of 2 - 25 um. A data processing algo... 详细信息

关键词： Infrared Radiometer Infrared Pyrometer Infrared Fiber Optic Synchronous Detection Method Wireless Data Transmission Reference Oscillation Temperature Compensation Data Processing Algorithms

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