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Translational Neurodegeneration 2019年第1期8卷 304-316页

作者： Oliver Goldhardt Inanna Warnhoff igo. yakushev Ilijana Begcevic Hans Förstl Viktor Magdolen Antoninus Soosaipillai Eleftherios Diamandis Panagiotis Alexopoulos Timo Grimmer Department of Psychiatry and Psychotherapy Klinikum rechts der IsarTechnical University of MunichSchool of MedicineIsmaninger Str.2281675 MunichGermany Department of Nuclear Medicine TUM-NICKlinikum rechts der IsarTechnical University of MunichSchool of MedicineIsmaninger Str.2281675 MunichGermany Department of Obstetrics&Gynecology Klinikum rechts der IsarTechnical University of MunichSchool of MedicineIsmaninger Str.2281675 MunichGermany Department of Pathology and Laboratory Medicine Mount Sinai Hospital60 Murray St.TorontoOntario M5T 3L9Canada Department of Laboratory Medicine and Pathobiology Faculty of MedicineUniversity of TorontoMedical Science Building1 King’s College CircleTorontoOntario M5S 1A8Canada Department of Psychiatry University hospital of RionUniversity of Patras26500 Rion PatrasPatrasGreece

Background:Alterations in the expression of human kallikrein-related peptidases(KLKs)have been described in patients with Alzheimer’s disease(AD).We elucidated the suitability of KLK6,KLK8 and KLK10 to distinguish AD from NC and explored associations with established AD ***:KLK levels in cerebrospinal fluid(CSF),as determined by ELISA,were compared between 32 AD patients stratified to A/T/(N)system with evidence for amyloid pathology and of 23 normal controls with normal AD *** between KLK levels and clinical severity,CSF and positron emission tomography(PET)based AD biomarkers were tested ***:Levels of KLK6 and KLK10 were significantly increased in ***6 differed significantly between AD A+/T+/N+and AD A+/T−/N+or NC with an AUC of *** pTau and tTau levels were significantly associated with KLK6 in ***:KLK6 deserves further investigations as a potential biomarker of Tau pathology in AD.

关键词： Alzheimer’s disease(AD),Kallikrein-like peptidase(KLK),KLK6,KLK8,KLK10,Cerebral amyloid load,Cerebrospinal fluid(CSF),Amyloid 1-42 Aβ1-42 Aβ42,Tau protein,Total tau,tTau,Phospho tau,pTau,Positron emission tomography(PET)

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Dynamics of canopy-dwelling arthropods under different weed management options,including glyphosate,in conventional and genetically modified insect-resistant maize

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Insect Science 2021年第4期28卷 1121-1138页

作者： Esteban García-Ruiz Guillermo Cobos Ismael Sánchez-Ramos Susana Pascual María-Cristina Chueca María-Concepción Escorial Inés Santín-Montanyá Íñigo.Loureiro Manuel González-Núñez Plant Protection Department Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)MadridSpain

The use of genetically modified varieties tolerant to herbicides(HT varieties)and resistant to insects(Bt varieties)in combination with application of a broad-spectrum herbicide such as glyphosate could be an effective option for the simultaneous control of weeds and pests in ***,the possible impact of these tools on nontarget arthropods still needs to be *** a field study in central Spain,potential changes in populations of canopy-dwelling arthropods in Bt maize under different weed management options,including glyphosate application,were ***-dwelling arthropods were sampled by visual inspection and yellow sticky *** Bt variety had no effect on any group of studied arthropods,except for the expected case of corn borers—the target pests of Bt *** the effects of herbicide regimes,the only observed difference was a lower abundance of Cicadellidae and Mymaridae on yellow sticky traps in plots not treated with pre-emergence *** effect was especially pronounced in a treatment involving two glyphosate *** decrease in Cicadellidae and Mymaridae populations was associated with a higher density of weeds in plots,which may have hindered colonization of the crop by *** differences,however,were only significant in the last year of the *** low likelihood of the use of glyphosate-and herbicide-tolerant varieties for weed control triggering important effects on the nontarget arthropod fauna of the maize canopy is discussed.

关键词： Bt maize canopy-dwelling arthropods GMHT maize glyphosate herbicide management parasitoids

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Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo.Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

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西班牙低碳能源社区的可扩展性：一种源自共享更新模式的经验方法

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城市规划学刊 2022年第1期 123-124页

作者： EKHI A IMANOL Z I?igo.C 王天奇内蒙古大学城市规划系

借助低碳能源体系和参与式治理模式，大量集体实践开始朝着可持续和有弹性的能源模式发展。作者认为必须持续扩大这种实践规模才能应对全球挑战。从共享更新模式来看，文章介绍的实证研究展示出当前西班牙自主改革行动的精确蓝图。通过...

借助低碳能源体系和参与式治理模式，大量集体实践开始朝着可持续和有弹性的能源模式发展。作者认为必须持续扩大这种实践规模才能应对全球挑战。从共享更新模式来看，文章介绍的实证研究展示出当前西班牙自主改革行动的精确蓝图。通过半结构化的深度访谈对其中18项内容进行识别和定性分析，探讨了改革实践的权力范围、权力分配和公民参与的重要性、规模的度量、提升形式和公共机构的作用。根据访谈结果，最终提出了旨在加强这种能源共享可扩展性的建议。

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Modeling Submicron Particles Collection in Laminar Forced Convection Gas Flow by a Rectangular Venturi Scrubber

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Open Journal of Air Pollution 2016年第1期5卷 10-26页

作者： Serge Wendsida igo.Kokou N’wuitcha Belkacem Zeghmati Xavier Chesneau Département Energie Institut de Recherche en Sciences Appliquées et Technologies (IRSAT/CNRST) Ouagadougou Burkina Faso GPTE-LES Département de Physique Université de Lomé Lomé Togo Laboratoire de Mathématiques et Physique des Systèmes (LAMPS) Perpignan France

Venturi scrubbers are usually used for large particles cleaning in turbulent gaseous flow. In this work, submicron particles scrubbing in laminar forced convection dusty air flow in a rectangular venturi scrubber have been numerically simulated. Hydrodynamics effects and scrubbing process are investigated in detail. Results are presented as flow velocity, axial pressure, streamlines pattern, particles and droplets mass fraction profile, and collect efficiency. They show that venturi scrubbers can be efficient for submicron particles scrubbing. In fact, a better collect efficiency is obtained at high particles-droplets residence time, high ratio droplets concentration/particles concentration, low venturi diameter ratioand low Reynolds numbers. There is a critical Reynolds number value for which the collect efficiency becomes very low and tends to be constant.

关键词： Venturi Scrubber Submicron Particles Diffusion Laminar Flow Collect Efficiency

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Evaluation of remote radiologist-interpreted point-of-care ultrasound for suspected dengue patients in a primary health care facility in Colombia

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Infectious Diseases of Poverty 2023年第5期12卷 45-57页

作者： Lyda Osorio Iñigo.Prieto Daniela Zuluaga Deliana Ropero Neelesh Dewan Jonathan D.Kirsch Epidemiology and Population Health Research Group(GESP) School of Public HealthUniversidad del ValleCaliColombia Department of Radiology School of MedicineUniversidad del ValleCaliColombia Division of General Internal Medicine Department of Internal MedicineUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA Department of Internal Medicine University of Miami Miller School of MedicineMiamiFLUSA

Background Early identification of plasma leakage may guide treatment decisions in dengue *** study evaluated the value of point-of-care ultrasound(POCUS)to detect plasma leakage and predict hospitalization or referral to a higher level of care in suspected dengue patients under routine conditions at a primary care facility in *** We conducted a cohort study between April 2019 and March 2020 in a primary care hospital in Cali,*** prospectively included and followed 178 patients who were at least 2 years old with fever of less than 10 days and clinician-suspected dengue.A trained general practitioner performed a standardized POCUS *** were quality-rated and overread by an expert radiologist,and her results and those of the general practitioner were compared using the Kappa *** regression was used to identify factors associated with plasma leakage at enrollment and explore its prognostic value regarding hospital admission or referral to a higher level of *** Half(49.6%)POCUS images were of suitable quality to be *** proportion of plasma leakage reported by the radiologist was 85.1%(95%CI:78.6-90.2%)and 47.2%by the study physician(Kappa=0.25,95%CI:0.15-0.35).The most frequent ultrasound findings were ascites(hepatorenal 87.2%,splenorenal 64%,or pelvic 21.8%)and gallbladder wall thickening(10.5%).Plasma leakage was higher in subjects with thrombocytopenia(aOR=4,95%CI:1.3-12.1)and lower in patients 30-59 years old(aOR=0.1,95%CI:0.0-0.4)than in those 18 years old or *** evidence of plasma leakage(aOR=8.2,95%CI:2.2-29.9),thrombocytopenia(aOR=6.3,95%CI:2.4-16.0)and pulse pressure(aOR=1.1,95%CI:1.07-1.2)were associated with hospital admission or referral to a higher level of *** Ultrasound is useful to detect plasma leakage in primary care and,challenges remain to guarantee high-quality images and diagnostic accuracy,for which a standardized dengue POCUS protocol and training pr

关键词： Dengue Ultrasound Plasma leakage Primary care Colombia

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Momentum considerations inside near-zero index materials

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Light(Science & Applications) 2022年第8期11卷 1782-1789页

作者： Michaël Lobet Iñigo.Liberal Larissa Vertchenko Andrei VLavrinenko Nader Engheta Eric Mazur John A.Paulson School of Engineering and Applied Sciences Harvard University9 Oxford StreetCambridgeMA02138USA Department of Physics and Namur Institute of Structured Materials University of NamurRue de Bruxelles 515000NamurBelgium Electrical and Electronic Engineering Department Universidad Pública de NavarraCampus ArrosadíaPamplona31006Spain Department of Photonics Engineering Technical University of DenmarkØrsteds Plads 345ADK-2800 KgsLyngbyDenmark Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA

Near-zero index (NZI) materials, i.e., materials having a phase refractive index close to zero, are known to enhance or inhibit light-matter interactions. Most theoretical derivations of fundamental radiative processes rely on energetic considerations and detailed balance equations, but not on momentum considerations. Because momentum exchange should also be incorporated into theoretical models, we investigate momentum inside the three categories of NZI materials, i.e., inside epsilon-and-mu-near-zero (EMNZ), epsilon-near-zero (ENZ) and mu-near-zero (MNZ) materials. In the context of Abraham–Minkowski debate in dispersive materials, we show that Minkowski-canonical momentum of light is zero inside all categories of NZI materials while Abraham-kinetic momentum of light is zero in ENZ and MNZ materials but nonzero inside EMNZ materials. We theoretically demonstrate that momentum recoil, transfer momentum from the field to the atom and Doppler shift are inhibited in NZI materials. Fundamental radiative processes inhibition is also explained due to those momentum considerations inside three-dimensional NZI materials. Absence of diffraction pattern in slits experiments is seen as a consequence of zero Minkowski momentum. Lastly, consequence on Heisenberg inequality, microscopy applications and on the canonical momentum as generator of translations are discussed. Those findings are appealing for a better understanding of fundamental light-matter interactions at the nanoscale as well as for lasing applications.

关键词： materials. momentum Minkowski

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Dispersion coding of ENZ media via multiple photonic dopants

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Light(Science & Applications) 2022年第8期11卷 1865-1875页

作者： Ziheng Zhou Hao Li Wangyu Sun Yijing He Iñigo.Liberal Nader Engheta Zhenghe Feng Yue Li Department of Electronic Engineering Tsinghua University100084BeijingChina Department of Electrical and Electronic Engineering Public University of NavarrePamplona31006Spain Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA

Epsilon-near-zero (ENZ) media are opening up exciting opportunities to observe exotic wave phenomena. In this work, we demonstrate that the ENZ medium comprising multiple dielectric photonic dopants would yield a comb-like dispersion of the effective permeability, with each magnetic resonance dominated by one specific dopant. Furthermore, at multiple frequencies of interest, the resonant supercouplings appearing or not can be controlled discretely via whether corresponding dopants are assigned or not. Importantly, the multiple dopants in the ENZ host at their magnetic resonances are demonstrated to be independent. Based on this platform, the concept of dispersion coding is proposed, where photonic dopants serve as “bits” to program the spectral response of the whole composite medium. As a proof of concept, a compact multi-doped ENZ cavity is fabricated and experimentally characterized, whose transmission spectrum is manifested as a multi-bit reconfigurable frequency comb. The dispersion coding is demonstrated to fuel a batch of innovative applications including dynamically tunable comb-like dispersion profiled filters, radio-frequency identification tags, etc.

关键词： dopant dispersion media

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CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo.Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.Iribarren Carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

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X-Ray and VUV Spectra from the Laser Plasma Produced with “Kanal-2” Facility

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Journal of Modern Physics 2014年第2期5卷 92-97页

作者： Andrey Aleksandrovich Kologrivov Mikhail Vladimirovich Osipov Victor Nikolaevich Puzyrev Alexandr Nikolaevich Starodub Oleg Feliksovich yakushev P. N. Lebedev Physical Institute of RAS Moscow Russia

The paper presents experimental results obtained on “Kanal-2” facility. Laser radiation focusing on the surface of plane magnesium targets created the high temperature plasma, which emitted X-ray and vacuum ultraviolet (VUV) radiation. This radiation spectrum was investigated with two spectrographs: the mica crystal spectrograph (working range 8.2 ? - 9.6 ?) and the grazing incidence VUV spectrograph (working rage 30 ? - 130 ?). A set of beryllium stepwise attenuators appended the diagnostic complex and allowed us to get an approximated picture of a continuous spectrum within the range of 2.2 ? - 6.2 ?. The estimation of the plasma electron temperature Te from the ratio between the intensity of the dielectronic satellites and the resonance line gives Te ~ 180 eV. The ratio between the intensity of the resonance and intercombination lines gives the electron density of the emitting zone ne ~ 2 × 1019 cm-3. Some lines observed within the spectral range of 8.5 ? - 9.1 ? belong to none of the transitions of Mg ions. Perhaps the observed spectrum is determined by the transitions in so-called hollow ions of Mg, i.e. in the ions with unfilled inner shells. The spectra obtained with the grazing incidence spectrograph and with the minimum-directioned discrepancy iteration method of spectrum reconstruction from the attenuation curve in the beryllium stepwise attenuators are also presented.

关键词： Laser Plasma X-Ray Spectra VUV Spectra Plasma Diagnostics

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