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Could JC virus provoke metastasis in colon cancer?

World Journal of Gastroenterology 2014年第42期20卷 15745-15749页

作者： Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto course in Surgical Biotechnology and Regenerative Medicine University of Palermo Euro-Mediterranean Institute of Science and Technology (IEMEST) Unit of Pathology Ospedali Riuniti Villa Sofia - Cervello University of Palermo DIBIMIS Unit of Internal Medicine Ospedali Riuniti Villa Sofia - Cervello University of Palermo Oncology Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto Department of Surgical and Oncological Disciplines School of Medicine University of Palermo Unità Operativa di Medicina interna e trapiantologia Ospedale San Raffaele

AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors.

关键词： John Cunningham virus Colon cancer Me-tastasis

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Prunus genetics and applications after de novo genome sequencing:achievements and prospects

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Horticulture Research 2019年第1期6卷 1222-1246页

作者： Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao ignazio Verde Albert G.Abbott Pere Arús IRTA Centre de Recerca en Agrigenòmica CSIC-IRTA-UAB-UBCampus UABEdifici CRAGCerdanyola del Vallès(Bellaterra)08193 BarcelonaSpain UMR 1332 BFP INRAUniversity of BordeauxA3C and Virology Teams33882 Villenave-d’Ornon CedexFrance Allergy Research Center Zhejiang University310058 HangzhouChina Clemson University ClemsonSC 29634USA Department of Horticulture Michigan State University1066 Bogue StreetEast LansingMI 48824-1325USA Department of Horticulture Washington State UniversityPullmanWA 99164-6414USA Biotechnology Laboratory La Platina Research StationInstituto de Investigaciones AgropecuariasSanta Rosa11610 La PintanaSantiagoChile Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria(CREA)-Centro di ricerca Olivicoltura Frutticoltura e Agrumicoltura(CREA-OFA)RomeItaly University of Kentucky 106 T.P.Cooper HallLexingtonKY 40546-0073USA

Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry.

关键词： Prunus breeding achievements

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Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

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World Journal of Hepatology 2011年第11期3卷 278-284页

作者： Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini Liver Unit Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense 8700149 Rome Italy Department of Digestive and Liver Disease Azienda Ospedaliera Sant’AndreaVia Grottarossa 1035/1039000189 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Liver Unit Ospedale Sandro PertiniVia dei Monti Tiburtini 38500157 Rome Italy Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense87 00149 Rome Italy Medicine of Migration National Institute for Migrant Health and Poverty Via di S. Gallicano 25/a 00153Rome Italy Department of Medical Pathophysiology University of Rome "La Sapienza" Viale del Policlinico 15500161 Rome Italy Liver Unit Campus Biomedico UniversityVia álvaro del Portillo 21 00128Rome Italy Histopathology Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149Rome Italy Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Department of Infectious and Tropical Disease University of Rome"La Sapienza"Viale del Policlinico155 00161 Rome Italy Liver Unit Ospedale Villa BetaniaVia Niccolò Piccolomini 2700165 RomeItaly Liver Unit Policlinico CasilinoVia Casilina104900169 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Infectious and Parasitic Diseases Policlinico San Matteo P.zzale Golgi 2 2710 PaviaItaly

AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection.

关键词： Hepatitis C virus infection Diffuse large B cell lymphoma Indolent lymphoma Pegylated interferon Lymphomagenesis

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The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts

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Science China(Technological Sciences) 2018年第5期61卷 643-652页

作者： AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Perugia Perugia 06123 Italy Uninettuno University Rome 00186 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma Tor Vergata Rome 00133 Italy Istituto Nazionale di Fisica Nucleare (INFN) TIFPA Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Trento Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Roma Tor Vergata Rome 00133 Italy IFAC-CNR Sesto Fiorentino (FI) 50019 Italy Dipartimento di Fisica e Astronomia Universita di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Napoli Naples 80126 Italy Istituto Nazionale di Fisica Nucleare (INFN) LNE Frascati (RM) 00044 Italy Agenzia Spaziale Italiana (ASI) SSDC Rome 00133 Italy

CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).

关键词：卫星发射中心粒子带子空间管理合作开发空间机构轻原子核意大利

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The Neurologist in the Emergency Room: Prospective Study of the Neurological Emergency Group in Lombardia

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Journal of Health Science 2019年第4期7卷 254-261页

作者： MariaLuisa Delodovici Marco Mauri Megi Meneri Marco Gallazzi Elena Ballabio Giuseppina Borutti Maria Vittoria Calloni Elisa Candeloro Bruno Censori Claudio De Piazza Laura Fusi Franca Mazzucchelli ignazio Santilli Elisabetta Forapani Chiara Scaccabarozzi Maria Sessa Lucia Tancredi Massimiliano Braga Dept. of Neurology and Stroke Unit Ospedale di Circolo e Fondazione MacchiUniversità dell’InsubriaASST-Settelaghile Luigi Borri 57 21100 VareseItaly Dept. of Neurology Ospedale di Desio (MB) Director G. Mazzini 1 20832 Desio (MB)Italy Dept. of Neurology ASST Lecco-Ospedale A. Manzonidell’Eremo 9/11 23900 LeccoItaly Dept. of Neurology Ospedale di Cremona ASST Cremona Directorle Concordia 1 26100 CremonaItaly Dept. of Neurology Ospedale Sant’Anna ComoRavona 20 22042 SFermo della BattagliaComoItaly Dept. of Neurology Ospedale di Vimercate (MB) Santi Cosma e Damiano 10 20871 Vimercate (MB)Italy Dept. of Neurology Ospedale S. Carlo BorromeoA. Mosca 12 20152 MilanoItaly Dept. of Neurology Director Ospedale Civile di VogheraVolturno 14 Voghera 27058 (PV)Italy Dept. of Neurology Ospedale di Legnano ASST Ovest MilanesePapa Giovanni Paolo II20025 Legnano (MI)Italy Dept. of Neurology Fondazione IRCCS C. Mondino Mondino 2Pavia 27100Italy Dept. of Neurology ASST Papa Giovanni XXIII Piazza OMS 1 24127 BergamoItaly Dept. of Neurology Ospedale Valduce ComoDante Alighieri 11 22100 ComoItaly Dept. of Neurology Ospedale di Saronno ASST Valle olonaPiazzale Borella 1 Saronno 21047 (VA)Italy Dept. of Neurology Ospedale S. Antonio Abate Gallarate. Pastori 4 21013 Gallarate VareseItaly

Purpose of the work was to quantify the workloads and the neurologist’s commitment in ER, to verify the management of urgencies and appropriateness of neurological counseling requests. Neurologic emergencies are frequent in elderly patients and are associated with high morbidity and mortality. Due to the aging population, neurologic pathologies in emergency room (ER) are widely expected to increase. The role of the neurologist in this context is controversial. Methods: in 14 operative units of neurology a prospective collection of neurological evaluations in ER was carried out using boards of detection of the most frequent neurological clinical pictures seen in the course of a week. Data were collected from 738 cases. Attention was focused on cerebrovascular diseases (CVD), impairment of consciousness, epilepsy, headache, dizziness, head trauma and disorders of the peripheral nervous system (PNS). Achievements: neurological consultations were on average 5% of total accesses to ER. The most common pathology seen was ischemic stroke. After counseling most patients were discharged home. The CVD required the greatest commitment to the specialist. The usefulness of the specialized neurological “filter” has been confirmed in a non-simple operative context, aimed at optimizing the appropriateness of the hospitalization and the economy of the diagnostic path.

关键词： Emergency room neurological diseases neurology workload

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为银行业联盟画上句号新欧盟银行业监管与问题解决机制

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博鳌观察 2014年第3期 58-60页

作者：伊格纳奇·奥安格洛尼(ignazio Angeloni) 德莫斯德尼斯·伊奥恩诺(Demosthenes Ioannou) 竹西欧洲央行监事会欧洲央行不详

欧盟法律框架中银行业联盟的两大支柱过去两年来,欧洲银行业监管和问题解决的制度框架发生了根本性变化。欧盟的金融危机清晰凸显了单一金融市场、金融稳定与国家级银行监管和解决制度碎片化间的矛盾。因此,2012年,欧洲的国家元首、政... 详细信息

欧盟法律框架中银行业联盟的两大支柱过去两年来,欧洲银行业监管和问题解决的制度框架发生了根本性变化。欧盟的金融危机清晰凸显了单一金融市场、金融稳定与国家级银行监管和解决制度碎片化间的矛盾。因此,2012年,欧洲的国家元首、政府首脑呼吁成立欧洲银行业联盟,以补充欧洲经济与货币联盟（EMU）的不足。银行业联盟有两大支柱：其一是单一监管机制（SSM）,负责欧元区银行业的有效监管（以及可能加入SSM的欧盟成员国的银行业）;其二是单一解决机制（SRM）,负责快速有效解决濒临破产银行带来的问题。

关键词：问题解决银行监管欧盟法律欧元区政府首脑资本要求金融危机新巴塞尔协议银行运营压力测试

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Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

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Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

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