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Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics Letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar Sánchez-López ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

Navigating the controversy regarding antibiotic prophylaxis in acute variceal bleeding

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World Journal of Gastroenterology 2024年第18期30卷 2485-2487页

作者： David Aguirre-Villarreal ignacio García-Juárez Department of Gastroenterology and Liver Transplant Unit Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

Antibiotic prophylaxis in patients with cirrhosis and acute variceal bleeding is part of the standard of care according to most clinical ***,with recent evidence arguing against antibiotic prophylaxis,the role of this... 详细信息

关键词： Cirrhosis Acute variceal bleeding Antibiotic prophylaxis Endoscopic band ligation Spontaneous bacterial peritonitis

Advancing understanding and management of invasive fungal diseases in the intensive care unit:Insights from FUNDICU consensus definitions

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Journal of Intensive Medicine 2024年第4期4卷 482-483页

作者： ignacio Martin-Loeches Department of Intensive Care Medicine Multidisciplinary Intensive Care Research Organization(MICRO)St James’HospitalDublinIreland Hospital Clinic Universitat de BarcelonaIDIBAPSCIBERESBarcelonaSpain

Invasive fungal diseases(IFDs)are increasingly relevant in critical care medicine.[1]Due to the population being admitted to an intensive care unit(ICU),the type of patient has significantly changed over the last two decades.[2]More often,patients affected by comorbid conditions are candidates for being admitted to an *** are mainly two sources of patients.

关键词： admitted unit diseases

Insights into complications after unicompartmental knee arthroplasty

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World Journal of Clinical Cases 2024年第25期12卷 5662-5664页

作者： Tomas Nicolino ignacio Garcia-Mansilla Knee Division Hospital Italiano de Buenos AiresCapital Federal 1109Argentina

Zhao's study,offers a comprehensive analysis of unicompartmental knee arthroplasty(UKA)revision *** study provides a detailed,case-by-case analysis of the factors leading to knee revision surgery in 13 *** only elucidates the complexities of UKA revisions but also underscores the importance of continuous improvement in surgical techniques and the adoption of innovative technologies.

关键词： Unicompartmental knee arthroplasty UKA Complications Revision Total knee arthroplasty

Optimizing artificial intelligence in sepsis management: Opportunities in the present and looking closely to the future

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Journal of Intensive Medicine 2024年第1期4卷 34-45页

作者： Darragh O’Reilly Jennifer McGrath ignacio Martin-Loeches Department of Intensive Care Medicine Multidisciplinary Intensive Care Research Organization(MICRO)St James’HospitalDublinIreland Department of Respiratory Intensive care Hospital ClinicUniversitat de BarcelonaIDIBAPSCIBERESBarcelonaSpain

Sepsis remains a major challenge internationally for healthcare *** incidence is rising due to poor public awareness and delays in its recognition and subsequent *** sepsis,mortality increases with every hour left *** intelligence(AI)is transforming worldwide healthcare delivery at *** review has outlined how AI can augment strategies to address this global disease *** and machine learning(ML)algorithms can analyze vast quantities of increasingly complex clinical datasets from electronic medical records to assist clinicians in diagnosing and treating sepsis earlier than traditional *** review highlights how these models can predict the risk of sepsis and organ failure even before it *** gives providers additional time to plan and execute treatment plans,thereby avoiding increasing complications associated with delayed diagnosis of *** potential for cost savings with AI implementation is also discussed,including improving workflow efficiencies,reducing administrative costs,and improving healthcare *** these advantages,clinicians have been slow to adopt AI into clinical *** of the limitations posed by AI solutions include the lack of diverse data sets for model building so that they are widely applicable for routine clinical ***,the subsequent algorithms are often based on complex mathematics leading to clinician hesitancy to embrace such ***,we highlight the need for robust political and regulatory frameworks in this area to achieve the trust and approval of clinicians and patients to implement this transformational technology。

关键词： Artificial intelligence Data science Machine learning Intensive care unit(ICU) Critical care Sepsis

Damage Mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia

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Journal of Biosciences and Medicines 2024年第4期12卷 49-59页

作者： ignacio Vélez-Rodríguez Victoria Carranza-Aranda Facultad Mexicana de Medicina Universidad La Salle Tlalpan M&#233xico Hospital General de Mé xico Cuauht&#233moc M&#233xico

Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lymphoid progenitor cells, pro-B cells, pre-B cells, and mature cells). The process of B cell maturation depends on precise communication within the cell: signals activate specific genes that are essential for proper development. Errors in this intricate signaling network can lead to issues with B cell function and contribute to disease. B-lineage acute lymphoid leukemias, malignancies of precursor-stage B lymphoid cells inhibit lymphoid differentiation, leading to abnormal cell proliferation and survival. The process of developing leukemia (leukemogenesis) can be triggered by an overproduction of both hematopoietic stem cells (the cells that form all blood cells) and the immature versions of white blood cells called lymphoblasts. Acute lymphoblastic leukemia (ALL) with the presence of the Philadelphia chromosome (ALL Ph) is classified as a high-risk manifestation of the disease, this chromosome is the product of the reciprocal translocation, whose product is a BCR-ABL fusion protein. It is a highly active tyrosine kinase that can transform hematopoietic cells into cytokine-independent. Hyperphosphorylation cascades inhibit the differentiating function of IKZF1 as a tumor suppressor gene which leads to an abnormal proliferation of B cells due to the presence of the Philadelphia chromosome;it inhibits the differentiating process, leukemogenesis involving immature B cells in the bloodstream can result from the uncontrolled growth and division of hematopoietic stem cells and immature lymphoblasts (the precursors to B cells).

关键词： Acute Lymphoblastic Leukemia IKAROS Dephosphorylation Philadelphia Chromosome CK2

Solar-assisted photocatalytic water splitting using defective uiO-66 solids from modulated synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia M.Rueda-Navarro María Cabrero-Antonino Paula Escamilla Valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer ignacio Vayá Guillaume Maurin Herme G.Baldoví Sergio Navalón Departamento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia Molecular(ICMOL) Universitat de ValènciaPaterna 46980Spain ICGM Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

Metal-organic frameworks(MOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from *** paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative uiO-66 organic modulators for synthesizing visible light responsive uiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different uiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) was the most active photocatalyst,followed by uiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic *** uiO-66(Zr)-NH_(2) solid was more active than the parent MOF in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous *** on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photoluminescence and photoelectrochemical measurements together with density functional theory(DFT)*** results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker uiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(MOFs) uiO-66 materials carboxylic acid modulators water splitting solar light

Patellar reconstruction in primary total knee arthroplasty using bone chips from routine cuts:A case report and review of literature

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World Journal of Methodology 2024年第2期14卷 158-166页

作者： Juan ignacio Perez-Abdala Franco L De Cicco Tomas Nicolino Juan Astoul Institute of Orthopaedics“Carlos E.Ottolenghi” Italian Hospital of Buenos AiresCapital Federal 1198Argentina

BACKGROUND Total patellectomy is currently reserved for exceptional cases,such as recalcitrant patellofemoral instability and comminuted fractures,due to its demonstrated negative impact on knee ***,managing patellectomy is crucial to mitigate its inherent deleterious *** techniques have been described,including autologous or allogeneic bone grafts for reconstruction and soft tissue realignment to enhance the extensor *** SUMMARY A 73-year-old male underwent a patellectomy due to a comminuted fracture,subsequently developing osteoarthritis and experiencing a decline in functional *** with total knee replacement,we conducted a patellar reconstruction,incorporating routine bone cuts and utilizing bone chips to fashion a new *** intervention resulted in the restoration of full extension and improvement of knee *** Patellar reconstruction demonstrates benefits on knee mechanics and stabilization,contributing to enhanced outcomes and satisfaction following knee *** present an affordable technique for managing patellectomized patients undergoing total knee replacement.

关键词： Patellectomy Patella Reconstruction Knee arthroplasty Autologous bone Knee osteoarthritis Case report

左炔诺孕酮宫内节育系统与醋酸甲羟孕酮分别联合经宫颈子宫内膜电切术治疗围绝经期异常子宫出血的临床效果比较

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中国性科学 2024年第7期33卷 70-74页

作者：兰星李媛李莎浙江省绍兴市中心医院医共体总院产科浙江绍兴312030 浙江省绍兴市中心医院医共体总院妇产科浙江绍兴312030

目的比较左炔诺孕酮宫内节育系统与醋酸甲羟孕酮分别联合经宫颈子宫内膜电切术(TCRE)治疗围绝经期异常子宫出血患者的临床效果。方法选取2019年4月至2023年4月浙江省绍兴市中心医院医共体总院收治的86例围绝经期异常子宫出血患者作为研... 详细信息

目的比较左炔诺孕酮宫内节育系统与醋酸甲羟孕酮分别联合经宫颈子宫内膜电切术(TCRE)治疗围绝经期异常子宫出血患者的临床效果。方法选取2019年4月至2023年4月浙江省绍兴市中心医院医共体总院收治的86例围绝经期异常子宫出血患者作为研究对象。根据随机数字表法将其分为联合组(左炔诺孕酮宫内节育系统联合TCRE)与孕酮组(醋酸甲羟孕酮联合TCRE),各43例。比较两组治疗第3个月的疗效,术前及术后第3个月的月经情况(月经周期、月经时间)、血液指标、性激素指标,统计术后3个月内再出血率及药物不良反应发生情况。结果治疗第3个月,联合组疗效显著优于孕酮组,差异具有统计学意义(P0.05)。结论与醋酸甲羟孕酮联合TCRE比较,左炔诺孕酮宫内节育系统联合TCRE可显著提升围绝经期异常子宫出血患者的临床疗效,更利于月经、性激素及血液指标恢复,术后再出血风险低,安全性好。

关键词：左炔诺孕酮宫内节育系统醋酸甲羟孕酮异常子宫出血经宫颈子宫内膜电切术