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High Voltage 2020年第5期5卷 556-568页

作者： Johnatan M.Rodríguez-serna Ricardo Albarracín-Sánchez Abdullahi A.Mas'ud Department of Electrical and Electronic Engineering Automatic Controland Applied PhysicsSchool of Industrial Design and Engineering(ETSIDI)Universidad Politécnica de Madrid(UPM)Ronda de Valencia 328012MadridSpain 2Department of Electrical EngineeringUniversidad de AntioquiaCalle 67 No.53-108MedellínColombia 3Department of Electrical and Electronic Engineering TechnologyJubail Industrial College31961JubailSaudi Arabia

During the last two decades,partial discharges(PDs)modelling methods have been used as a complement of insulation diagnosis systems of electrical ***-element-analysis models for simulating PDs in cavities within solid dielectric materials are reviewed and a novel model is presented,which combines the main advantages of electrostatic and electric current *** theoretical background is presented and some limitations and restrictions are discussed.A case of study was implemented for three different ageing conditions and simulation results exhibit good agreement with reported values by other authors in the *** analysis of variations of PD behaviour with ageing as a function of temperature and pressure is briefly *** is concluded that more research is needed to include physical and chemical interactions on the void surface and that the cavity surface conductivity plays a fundamental role in the PD simulations at advanced ageing conditions.

关键词： element analysis solid

Use of pCONUS HPC for the treatment of unruptured wide- necked bifurcation aneurysms: early clinical experience using single antiplatelet therapy

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Stroke & Vascular Neurology 2021年第1期6卷 57-64页

作者： Marta Aguilar Perez Victoria Hellstern Carmen serna Candel Christina Wendl Hansjorg Bazner Oliver Gansladt Hans Henkes Neuroradiologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Institut fur Rontgendiagnostik Zentrum fur NeuroradiologieFakultat für Medizin der Universitat RegensburgRegensburgGermany Neurologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Neurochirurgische NeurozentrumKlinikum StuttgartStuttgartGermany Medizinische Fakultat Universitat Duisburg-EssenEssenGermany

Background In recent years,a growing number of stents and stent-like devices have become available to facilitate the treatment of challenging ***,the need for dual antiplatelet therapy can limit their use,especially in ruptured *** hydrophilic polymer coating(pHPC,phenox)is a novel glycan-based multilayer polymer that reduces platelet *** study aims to report our initial experience using the pCONUS HPC device for the treatment of unruptured wide-necked bifurcation aneurysms(WNBA)using acetylsalicylic acid(ASA)as single antiplatelet therapy(SAPT).Methods We retrospectively identified all patients who were treated with the pCONUS HPC for unruptured WNBA in a multi-staged procedure using ASA as *** were made of periprocedural complications,clinical outcome and angiographic and clinical *** We identified 15 patients with 15 *** average age was 69 years old(range,41-76).Seven aneurysms were located in the middle cerebral artery,five in the anterior communicating artery,two at the basilar tip and one in the posterior communicating *** post-treatment angiography showed five aneurysms with modified Raymond-Roy classification(mRRC)grade Ⅰ and four aneurysms with mRRC grade Ⅱ.There were no haemorrhagic *** patients developed thrombus formation during the second treatment session,all of them completely resolving after administration of glycoprotein Ⅱb/Ⅲa *** follow-up data were available for 10 patients and showed adequate occlusion(mRRC Ⅰ or Ⅱ)in eight aneurysms(80%).In-stent stenosis was observed in one patient whereas two patients showed de novo stenosis in one of the efferent *** This early experience on the use of the pCONUS HPC device suggests that it can be useful for treating unruptured WNBA under ASA as *** investigation with a randomised treatment registry and larger cohort is needed.

关键词： treatment bifurcation HPC

Understanding bottom-up continuous hydrothermal synthesis of nanoparticles using empirical measurement and computational simulation

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Nano Research 2016年第11期9卷 3377-3387页

作者： Jose Sierra-Pallarest Thomas Huddle Juan Garcia-serna Esther Alonso Fidel Mato Igor Shvets Olaf Luebben Maria Jose Cocero Edward Lester Fluids Engineering Group Energy and Fluid Mechanics Engineering Department University of Valladolid Paseo del Cauce 59 47010 Valladolid Spain Advanced Materials Research Group the University of Nottingham University Park Nottingham NG7 2RD UK High Pressure Processes Group Department of Chemical Engineering and Environmental Technology University of Valladolid C/Prado de la Magdalena s/n 47011 Valladolid Spain School of Physics Trinity College Dublin College green Dublin 2 Ireland

Continuous hydrothermal synthesis was highlighted in a recent review as an enabling technology for the production of nanoparticles. In recent years, it has been shown to be a suitable reaction medium for the synthesis of a wide range of nanomaterials. Many single and complex nanomaterials such as metals, metal oxides, doped oxides, carbonates, sulfides, hydroxides, phosphates, and metal organic frameworks can be formed using continuous hydrothermal synthesis techniques. This work presents a methodology to characterize continuous hydrothermal flow systems both experimentally and numerically, and to determine the scalability of a counter current supercritical water reactor for the large scale production （〉1,000 T-year-1） of nanomaterials. Experiments were performed using a purpose-built continuous flow rig, featuring an injection loop on a metal salt feed line, which allowed the injection of a chromophoric tracer. At the system outlet, the tracer was detected using UV/Vis absorption, which could be used to measure the residence time distribution within the reactor volume. Computational fluid dynamics （CFD） calculations were also conducted using a modeled geometry to represent the experimental apparatus. The performance of the CFD model was tested against experimental data, verifying that the CFD model accurately predicted the nucleation and growth of the nanomaterials inside the reactor.

关键词： nanoparticle computational fluid dynamics synthesis supercritical inorganics

A new series of environment-friendly reddish inorganic pigments based on AFeO_(3)(A=Ln,Y) with high NIR solar reflectance

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Journal of Materiomics 2021年第5期7卷 1061-1073页

作者： Maria Fortuño-Morte Pablo serna-Gallén Héctor Beltrán-Mir Eloísa Cordoncillo Departamento de Química Inorgánica y Orgánica Universitat Jaume IAv.Sos Baynat s/n12071Castellóde la PlanaSpain

Environment-friendly pigments based on AFeO_(3)(A=La,Pr,Nd,Sm,Gd,Tb,Y or Yb)with high nearinfrared(NIR)reflectance were synthesised by a coprecipitation method at 1200℃.The Rietveld refinement analysis showed single-phase orthorhombic perovskite for all *** pigments,which showed reddish hues,offered good colour stability after mixing these pigments in powder form with siloxane transparent paint and two different *** powderepaint mixtures produced with GdFeO_(3),TbFeO_(3) and YFeO_(3) pigments have the highest NIR solar reflectance,reaching values of R=50%.The temperature shielding studies conducted using TbFeO_(3) pigmentepaint mixture for a roof coating yielded a reduction of 3.2℃ in comparison to a commercial ***,the glazes that were pigmented using GdFeO_(3),TbFeO_(3) and YFeO_(3) compositions also presented the most intense reddish colours.A study of the thermal and chemical stability of the pigment with the highest NIR solar reflectance showed good stability in both *** reddish pigments that were prepared can therefore be good candidates for use in different applications such as cool pigments or pigments for ceramic glazes at high temperatures.

关键词： High NIR reflectance Cool pigment Reddish pigment Environment-friendly Coprecipitation

Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： Javier Martfn-Sanchez Antonio Mariscal Marta De Luca Aitana Tarazaga Martin-Luengo Georg Gramse Alma Halilovic Rosalia serna Alberta Bonanni Ilaria Zardo Rinaldo Trotta Armando Rastelli Institute of Semiconductor and Solid State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain Department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. Remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. Power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional (2D)materials dielectric encapsulation transition metaldichalcogenides semiconductors photoluminescence WSe2

Hybrid silicon slotted photonic crystal waveguides:how does third order nonlinear performance scale with slow light?

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Photonics Research 2016年第6期4卷 257-261页

作者： Junfei Xia Samuel serna Weiwei Zhang Laurent Vivien éric Cassan Centre de Nanosciences et de Nanotechnologies UMR 9001 (CNRS/Université Paris-Sud)Université Paris-Saclay Laboratoire Charles Fabry Institut d’Optique CNRS Université Paris-Sud

We investigate in this paper the influence of slow light on the balance between the Kerr and two-photon absorption(TPA) processes in silicon slotted hybrid nonlinear waveguides. Three typical silicon photonic waveguide geometries are studied to estimate the influence of the light slow-down factor on the mode field overlap with the silicon region, as well as on the complex effective nonlinear susceptibility. It is found that slotted photonic crystal modes tend to focalize in their hollow core with increasing group index(n_G) values. Considering a hybrid integration of nonlinear polymers in such slotted waveguides, a relative decrease of the TPA process by more factor of 2 is predicted from n_G=10 to n_G=50. As a whole, this work shows that the relative influence of TPA decreases for slotted waveguides operating in the slow light regime, making them a suitable platform for third-order nonlinear optics.

关键词： mode Hybrid silicon slotted photonic crystal waveguides:how does third order nonlinear performance scale with slow light

Controlling self-assembling and tumor cell-targeting of protein-only nanoparticles through modular protein engineering

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Science China Materials 2020年第1期63卷 147-156页

作者： Eric Volta-Duran Olivia Cano-Garrido Naroa serna Hector Lopez-Laguna Laura Sanchez-Garcia Mireia Pesarrodona Alejandro Sanchez-Chardi Ramon Mangues Antonio Villaverde Esther Vazquez Ugutz Unzueta Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra08193 BarcelonaSpain Departament de Genetica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra08193 BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)C/Monforte de Lemos 3-528029 MadridSpain Nanoligent SL Edifici EUREKAUniversitat Autonoma de BarcelonaBellaterra08193 BarcelonaSpain Institut dInvestigacions Biomèdiques Sant Pau and Josep Carreras Research Institute Hospital de la Santa Creu i Sant Pau08041 BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciencies AmbientalsFacultat de BiologiaUniversitat de BarcelonaAv.Diagonal 64308028 BarcelonaSpain Institute for Research in Biomedicine(IRB Barcelona) The Barcelona Institute of Science and Technology08028 BarcelonaSpain

Modular protein engineering is suited to recruit complex and multiple functionalities in single-chain polypeptides. Although still unexplored in a systematic way, it is anticipated that the positioning of functional domains would impact and refine these activities, including the ability to organize as supramolecular entities and to generate multifunctional protein materials. To explore this concept, we have repositioned functional segments in the modular protein T22-GFP-H6 and characterized the resulting alternative fusions. In T22-GFP-H6, the combination of T22 and H6 promotes selfassembling as regular nanoparticles and selective binding and internalization of this material in CXCR4-overexpressing tumor cells, making them appealing as vehicles for selective drug delivery. The results show that the pleiotropic activities are dramatically affected in module-swapped constructs, proving the need of a carboxy terminal positioning of H6 for protein self-assembling, and the accommodation of T22 at the amino terminus as a requisite for CXCR4^+ cell binding and internalization. Furthermore, the failure of self-assembling as regular oligomers reduces cellular penetrability of the fusions while keeping the specificity of the T22-CXCR4 *** these data instruct how multifunctional nanoscale protein carriers can be designed for smart, protein-driven drug delivery, not only for the treatment of CXCR4^+ human neoplasias, but also for the development of anti-HIV drugs and other pathologies in which CXCR4 is a relevant homing marker.

关键词： nanoparticles protein materials recombinant proteins drug delivery self-assembling cancer cell targeting

Evaluation of Mean Crystallite Size on Magnetic Powder by Scanning Electron Microscopy and Synchrotron Diffractometry

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Materials Sciences and Applications 2014年第8期5卷 504-511页

作者： Eguiberto Galego Marilene Morelli serna Rubens Nunes de Faria Junior Instituto de Pesquisas Energéticas e Nucleares IPEN-CNENSao PauloBrazil

This paper presents the results of investigations carried out with Pr-based magnetic powders. The magnetically hard powders were produced from homogenised alloys using a high temperature hydrogen pulverization process. Alloys and powders were investigated by scanning electron microscopy and by energy dispersive X-ray analysis. Mean crystallite size of the pulverized material was estimated using synchrotron powder diffractometry and the Scherrer method. A comparison between these two investigation techniques has been carried out. The effects of copper on the properties of the magnetic powders have been studied. It has been shown that the addition of this alloying element had a marked effect on the microstructure of the powders.

关键词： Rare Earth Alloys Magnetic Powders Hydrides Synchrotron Radiation

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4^(+) head and neck squamous cell carcinoma tumors

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2578-2591页

作者： Elisa Rioja-Blanco Irene Arroyo-Solera Patriciaálamo Isolda Casanova Alberto Gallardo Ugutz Unzueta Naroa serna Laura Sánchez-García Miquel Quer Antonio Villaverde Esther Vázquez Ramon Mangues Lorena Alba-Castellón Xavier León Institut d'InvestigacióBiomèdica Sant Pau(IIB-Sant Pau) Barcelona 08041Spain Institut de Recerca contra la Leucèmia Josep Carreras Barcelona 08025Spain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)Madrid 28029Spain Department of Pathology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193Spain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193Spain Department of Otorhinolaryngology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma(HNSCC) mortality. The overexpression of chemokine receptor 4(CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4^(+)tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4^(+)HNSCC cells, achieving a high accumulation in CXCR4^(+)tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4^(+)cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted proteinonly nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients.

关键词： Targeted drug delivery Protein nanoparticles CXCR4 receptor HNSCC Cell targeting Recombinant proteins Nanotoxins Cancer therapy

Mode selection and dispersion engineering in Bragg-like slot photonic crystal waveguides for hybrid light-matter interactions

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Photonics Research 2018年第1期9卷 54-60页

作者： samuel serna weiwei zhang thi hong cam hoang carlos alonso-ramos delphine marris-morini laurent vivien eric cassan Centre de Nanosciences et de Nanotechnologies UMR 9001 (CNRS/Universite Paris-Sud) Universite Paris-Saclay 91405 Orsay France

We introduce a family of slot photonic crystal waveguides(SPh CWs) for the hybrid integration of low-index active materials in silicon photonics with energy-confinement factors of ~30% in low-index regions. The proposed approach, which is based on a periodic indentation of the etched slot in the middle of the SPh CW, makes it possible to reconcile a simultaneously narrow and wide slot for exploiting the two modes of even symmetry of a SPh CW. The resulting mode-selection mechanism allows a flexible choice of the modes to be used. Furthermore,the proposed structure offers tremendous flexibility for adjusting the dispersive properties of the slot-confined modes, in particular of their slow-light effects. Flat band slow light in a bandwidth of about 60 nm with a group velocity dispersion factor jβ_2 j below 1 ps^2∕mm is numerically demonstrated by this approach, corresponding to a normalized delay bandwidth product of around 0.4. These results, obtained from hollow-core periodic waveguides that are directly designed in view of hybrid integration of active materials in mechanically robust structures(not based on free-standing membranes) could pave the way for the realization of on-chip slow-light bio-sensing,active hybrid-silicon optoelectronic devices, or all-optical hybrid-silicon nonlinear functionalities.

关键词：光子晶体波导通讯技术发展现状