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Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism

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Food Science and Human Wellness 2023年第6期12卷 2087-2094页

作者： William t.moore Jing Luo Dongmin Liu Department of Human Nutrition Foods and ExerciseCollege of Agricultural and Life SciencesVirginia TechBlacksburg 24060USA Department of Biology and Chemistry Liberty UniversityLynchburg 24515USA Department of Human Nutrition Foods and ExerciseVirginia Tech1981 Kraft DriveCorporate Research CenterBlacksburg 24061USA

Insulin resistance is a hallmark of type-2 diabetes(t2D)*** skeletal muscle(SkM)is the major tissue for insulin-mediated glucose disposal,insulin resistance in SkM is considered a major risk factor for developing ***,the identifi cation of compounds that enhance the ability of SkM to take up glucose is a promising strategy for preventing *** previous work showed that kaempferol,a fl avonol present in many foods,improves insulin sensitivity in obese mice,however,the mechanism underlying this beneficial action remains ***,we show that kaempferol directly stimulates glucose uptake and prevents lipotoxicity-impaired glucose uptake in primary human *** stimulates Akt phosphorylation in a time-dependent manner in human SkM *** effect of kaempferol on glucose uptake was blunted by inhibition of glucose transporter 4,phosphoinositide 3-kinase(PI3K),or *** addition,kaempferol induced AMPK phosphorylation,and inhibition of AMPK prevented kaempferol-stimulated Akt *** vivo,kaempferol administration induced rapid glucose disposal accompanied with increased Akt and AMPK phosphorylation in SkM tissue of the *** together,these fi ndings suggest that kaempferol stimulates glucose uptake in SkM via an AMPK/Akt dependent mechanism,and it may be a viable therapeutic agent for insulin resistance.

关键词： Kaempferol Skeletal muscle AMPK Akt Insulin resistance

Mitigation of atrazine,S-metolachlor,and diazinon using common emergent aquatic vegetation

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Journal of Environmental Sciences 2017年第6期29卷 114-121页

作者： Matthew t.moore Martin A.Locke Robert Krǒger Water Quality and Ecology Research Unit USDA Agricultural Research ServiceNational Sedimentation LaboratoryOxfordMS 38655USA

By the year 2050, the population of the United States is expected to reach over 418 million, while the global population will reach 9.6 billion. to provide safe food and fiber, agriculture must balance pesticide usage against impacts on natural resources. Challenges arise when storms cause runoff to be transported to aquatic receiving systems. Vegetated systems such as drainage ditches and constructed wetlands have been proposed as management practices to alleviate pesticide runoff. twelve experimental mesocosms （1.3 ±0.71 ± 0.61 m） were filled with sediment and planted with a monoculture of one of three wetland plant species （typha latifolia, Leersia oryzoides, and Sparganium arnericanurn）. three mesocosms remained unvegetated to serve as controls. All mesocosms were amended with 9.2 ± 0.8 μg/L, 12 ± 0.4 μg/L, and 3.1 ± 0.2 μg/L of atrazine, metolachlor, and diazinon, respectively, over a 4 hr hydraulic retention time to simulate storm runoff. Following the 4 hr amendment, non-amended water was flushed through mesocosms for an additional 4 hr. Outflow water samples were taken hourly from pre-amendment through 8 hr, and again at 12, 24, 48, 72, and 168 hr post-amendment. L. oryzoides and t. latifolia had mean atrazine, metolachlor, and diazinon retentions from B1%-55% for the first 4 hr of the experiment. Aside from S. arnericanum and atrazine （25% retention）, unvegetated controls had the lowest pesticide retention （17%-28%） of all compared mesocosms. While native aquatic vegetation shows promise for mitigation of pesticide runoff, further studies increasing the hydraulic retention time for improved efficiency should be examined.

关键词： Phytoremediation Pesticide Mesocosm Wetland

环境-行为与社会研究领域内正在出现的新方法

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建筑学报 2007年第2期 14-16页

作者： Gary t.moore 闵书徐雷蕾悉尼大学

简要地归纳了建筑与城市规划领域内的研究的性质与步骤,尤其着重阐述了与社会、与文化相关的研究。对一些基本的概念进行了定义区分和描述,其中包括方法论与具体的研究方法:基本研究与实用性的研究;以及科学研究与描述性的(和其它形式的... 详细信息

简要地归纳了建筑与城市规划领域内的研究的性质与步骤,尤其着重阐述了与社会、与文化相关的研究。对一些基本的概念进行了定义区分和描述,其中包括方法论与具体的研究方法:基本研究与实用性的研究;以及科学研究与描述性的(和其它形式的)研究。文中还阐述了一些其它的概念,包括怎样定义研究课题,怎样制定研究计划,怎样理解研究的反复性,怎样进行数据分析,怎样确保研究的可信性,以及怎样确保研究的道德性。

关键词：环境行为学实验性的半实验性的调研性的人种学基于文字的研究解释性的研究

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采用可编程串行接口设计背板

电子产品世界 2001年第9期8卷 61-63页

作者： Michael t.moore Cypress半导体公司

在网络路由器或交换机以及企业存储设备等系统中的高速背板中,通信系统正在使速度限制超越传统的1Gbps大关.PCI或VME之类的共享总线拓朴结构曾用于背板应用,然而,它们在可伸缩性、带宽和距离方面受到限制,即使最新的PCI-X也只能在刚过1G... 详细信息

在网络路由器或交换机以及企业存储设备等系统中的高速背板中,通信系统正在使速度限制超越传统的1Gbps大关.PCI或VME之类的共享总线拓朴结构曾用于背板应用,然而,它们在可伸缩性、带宽和距离方面受到限制,即使最新的PCI-X也只能在刚过1Gbyte/s的速率下使用.共享总线拓朴主要的限制因素在于高的I/O和有限的距离.由于任何一条引线或连线的损坏都将造成整个接口故障,所以可靠性也是共享总线的一个问题.共享总线的最大有效距离是18英寸.

关键词：串行接口背板通信网网络设备

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应用于存储及网络中的新一代存储器方案

电子测试（新电子） 2004年第5期 67-69页

作者： Michael t.moore Manoj Roge Cypress公司

近年来,由于因特网业务的平均带宽每6个月到9个月就增加一倍,因此对用于业务传输的网络容量(带宽)以及由该业务所生成的数据存储容量的要求也不断提高。诸如电子商务、数据挖掘、数据库、客户关系管理等应用产生了数量可观的数据进行处... 详细信息

近年来,由于因特网业务的平均带宽每6个月到9个月就增加一倍,因此对用于业务传输的网络容量(带宽)以及由该业务所生成的数据存储容量的要求也不断提高。诸如电子商务、数据挖掘、数据库、客户关系管理等应用产生了数量可观的数据进行处理,并且要求具有容错性能以及每周7天、每天24小时的全球范围内的快速数据存取。这就引发了对高容量、快速且可随时进行存取的存储器的需求。

关键词：存储器 SAN 存储区域网络 NAS 网络附属存储

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

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Microsystems & Nanoengineering 2023年第6期9卷 77-106页

作者： Sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe ignacio Ochoa Sara Oliván Jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA tissue Microenvironment Lab(tME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&Laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic t and natural killer cells).this microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and t regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

Nanoindentation in elastoplastic materials:insights from numerical simulations

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International Journal of Smart and Nano Materials 2010年第2期1卷 95-114页

作者： Steven W.moore Majid t.Manzari Yin-Lin Shen Department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDC 20052USA Department of Civil and Environmental Engineering The George Washington UniversityWashingtonDC 20052USA

Finite element simulations of nanoindentation were performed on an elastoplastic material using Berkovich and conical indenters to investigate the effects of geometry on the load-displacement response of the *** Berkovich indenter,widely used in nanoindentation experiments,is typically simplified to a theoretically equivalent 70.3°conical indenter for numerical simulations,which allows for a less computationally intensive two-dimensional(2D)axisymmetric *** studies into the validity of this equivalence assumption for indentations in elastoplastic materials have varying *** 2D and 3D finite element simulations,the present study investigates the response of elastoplastic materials,obeying a combined isotropic and kinematic hardening,to indentation with conical and Berkovich *** show that there is a clear difference in the load-displacement response of the selected material to the two *** Berkovich geometry is found to produce a more localized pattern of contact stresses and plastic strains,leading to a smaller mobilized force for the same magnitude of *** further validate the numerical simulations,experimental results of nanoindentation into an aluminium specimen were compared to elastoplastic finite element simulation *** suggest that machining-induced residual stresses have likely affected the experimental results.

关键词： nanoindentation finite element analysis elastoplasticity tip geometry

Correlates of subjectively and objectively measured physical activity in young adolescents

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Journal of Sport and Health Science 2015年第3期4卷 222-227页

作者： Kelly Kavanaugh Justin B. moore Leisha Johnson Hibbett Andrew t. Kaczynski Office of Practice and Community Engagement University of South Carolina Columbia SC 29208 USA Department of Health Promotion Education and Behavior University of South Carolina Columbia SC 29208 USA Coastal Community Action Newport NC 28570 USA

背景:很多研究利用自我报告评价青少年个体活动水平,而不是通过客观测量。利用自我报告方式得到的结果与客观测量体力活动相比,可能产生并不存在的关联。本研究旨在探讨与体力活动相关的假设在主客观测量体力活动间的联系。方法:通过加... 详细信息

背景:很多研究利用自我报告评价青少年个体活动水平,而不是通过客观测量。利用自我报告方式得到的结果与客观测量体力活动相比,可能产生并不存在的关联。本研究旨在探讨与体力活动相关的假设在主客观测量体力活动间的联系。方法:通过加速度计测量对被试青少年(共232人,其中男性101名,平均年龄12.3岁)进行至少4天体力活动检测,同时完成调查评估,包括中高强度体力活动(MVPA)、运动能力、参与度、享受度和自我效能感,并测量身高、体重和BMI。结果:用分层回归模型通过控制性别、种族和BMI的Z值,发现性别、BMI的Z值与客观测量得到的MVPA明显相关:同时,仅性别与客观测量的体力活动总量明显相关。相反,用单一模型衡量主观MVPA关系时发现,仅体力活动的享受度、自我效能感与自我报告的体力活动明显相关。结论:通过自我报告和使用加速度计的客观监测方法测量青少年MVPA,两者所得结果存在较大差异。今后研究若要确定与青少年MVPA相关的因素,应谨慎选择测量方式。

关键词：客观测量青少年体力体重指数加速度计模型控制测量参数平均年龄

Comparison of phase unwrapping algorithms for living cell's interference pattern

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Journal of Beijing Institute of technology 2013年第4期22卷 530-535页

作者：王霞佟洁王萌 SCHMIDt Greg moore Duncan t. MCGRAtH James L. School of Optoelectronics Beijing Institute of Technology Institute of Optics University of Rochester Biomedical Engineering University of Rochester

A multiphase microscopic interference system is designed to measure the height of cell which is important to the research of collective cell migration in physiology and medicine. this sys- tem can quantitatively measure cell height across a living monolayer without knowing the refractive index of cells. For the interference pattern, because the phases are all wrapped between - π to π, it is necessary to get the real phase through phase unwrapping,a method to restore the wrapped phase data of the object by using numerical calculations. three representative algorithms are selected to unwrap the interference pattern of ceils： branch-cut method, quality-guided method and network method. Although each of them can restore the phase, their performances are obviously different. We compare these methods and find that branch-cut method needs the smallest execution time and can obtain good unwrapped patterns when noises are not serious.

关键词： unwrapping algorithms interference pattern cell height branch-cut quality-guided