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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo ignacio gracia-fernandez Peter M.Elias Jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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Current Zoology 2020年第5期66卷 493-503页

作者： Francesc Rubio-gracia Emili Garcia-Berthou Helena Guasch Lluis Zamora Anna Vila-Gispert Institute of Aquatic Ecology University of Girona17003 GironaSpain Integrative Freshwater Ecology Group Centre d'Tstudis Avanqats de BlanesCSIC17300 BlanesSpain

Energy metabolism fuels swimming and other biological *** compared the swimming performance and energy metabolism within and across eight freshwater fish *** swim tunnel respirometers,we measured the standard metabolic rate(SMR)and maximum metabolic rate(MMR)and calculated the critical swimming speed(Ucrit).We accounted for body size,metabolic traits,and some morphometric ratios in an effort to understand the extent and underlying causes of *** mass was largely the best predictor of swimming capacity and metabolic traits within ***,we found that predictive models using total length or SMR,in addition to body mass,signicantly in creased the explained variation of Ucrit and MMR in certain fish *** predictive models also underlined that,once body mass has been accounted for,Ucrit can be independently affected by total length or *** study exemplifies the utility of multiple regression models to assess within-species *** interspecific level,our results showed that variation in UcriX can partly be explained by the variation in the interrelated traits of MMR,finen ess,and muscle *** the species studied,bleak Al burn us alburnus performed best in terms of swimming performance and *** contrast,pumpkinseed Lepomis gibbosus showed very poor swimming performance,but attained lower mass-specific cost of transport(MCOT)than some rheophilic species,possibly reflecting a cost reduction strategy to compensate for hydrod yn amic *** con elusion,this study provides insight into the key factors in fluenci ng the swimming performa nee of fish at both intra-and in terspecific levels.

关键词： body size maximal metabolic rate morphology swimming efficiency

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Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 711-717页

作者： María Teresa Pérez-gracia Antonio Tarín-Pelló Beatriz Suay-García Área de Microbiología.Departamento de Farmacia Universidad Cardenal Herrera-CEU.CEU UniversitiesAlfara del Patri-arca(Valencia)Spain ESI International Chair@CEU-UCH Departamento de MatemáticasFísica y Ciencias TecnológicasUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del Patriarca(Valencia)Spain

In May 2022, the UK International Health Regulations National Focal Point notified World Health Organization of 176 cases of severe acute hepatitis of unknown etiology in children under 10 years of age. From that moment on, cases of severe acute hepatitis of unknown origin in children began to be reported in several countries. As of June 17, 2022, a total of 991 cases had been reported in 35 countries worldwide, 50 children needed a liver transplant and 28 patients died. According to information published by ECDC, 449 cases have been detected in 21 EU countries. The children were between 1 month and 16 years of age. Adenovirus was detected in 62.2% of the analyzed samples. So far, the cause of these cases is unknown and many hypotheses remain open, but hepatitis A-E viruses and COVID-19 vaccines have been ruled out. A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2. No other clear epidemiological risk factors have been identified to date. Thus, at this time, the etiology of the current cases of hepatitis remains under active investigation.

关键词： Hepatitis Children Unknown origin SARS-CoV-2 Adenovirus

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The Consistency of the European Union Foreign Policy Towards One Belt One Road a Comparative Study on the Sino-Brussels and Sino-CEEC Relations

The Consistency of the European Union Foreign Policy Towards...

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作者： Miquel Salvad(?) gracia（明恪）山东大学

学位级别：硕士

In the context of China Going Global,this paper seeks to evaluate the degree of implication that the European Union（EU）has in the Chinese-led One Belt One Road（OBOR）.In order to assess the success or failure of the Beijing’s project,the role of the EU in-and towards-it is *** the OBOR unfolds its full potential,it would represent a change of paradigm in the global governance *** Sino-EU political relations are of three kinds:The "fragmented" one,where the member states,as individual agents,and China have their own bilateral agreements.A second kind of relations where Brussels（EU as a political unity）and Beijing interact as great powers in a bilateral or multilateral *** the third and most recent kind of relation,the "16+1" *** multilateral format,established in 2012,coordinates sixteen Central and Eastern European countries（CEEC）with the Middle Kingdom in a given cooperation *** of the three kinds of Sino-EU relations the "16+1" format stands up as a singular case and this is so because it is the only one that,although being within the legal umbrella of the EU,brings together European states,substantial number of which belong to the Union,without the supervision of Brussels,in relation with a third *** this situation,and leaving aside the "fragmented" kind of relations,the paper’s hypothesis states that the Sino-Brussels（R1）and the Sino-CEEC（R2）relations are not consistent with a unified EU foreign scope of *** order to carry on with the comparison,the paper proceeds by analyzing the scope of Brussels’ Foreign Policy towards China and contrasting it with the agreements that have been reached within the "16+1"*** a result of the research,the thesis validates the hypothesis by asserting that there is a qualitative difference in the nature of the Rl and R2 *** reason for the inconsistency has been identified in the CEEC lack of commitment with the notion of Normative Power *** inconsistency

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Crop phenotyping in a context of global change:What to measure and how to do it

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Journal of Integrative Plant Biology 2022年第2期64卷 592-618页

作者： Jose Luis Araus Shawn Carlisle Kefauver Omar Vergara-Díaz Adrian gracia-Romero Fatima Zahra Rezzouk Joel Segarra Maria Luisa Buchaillot Melissa Chang-Espino Thomas Vatter Rut Sanchez-Bragado JoséArmando fernandez-Gallego Maria Dolores Serret Jordi Bort Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelonaSpain AGROTECNIO Center LleidaSpain Plant Ecophysiology and Metabolism Lab ITQB NovaPlant Sciences DivisionOeirasPortugal Programa de Ingeniería Electrónica Facultad de IngenieríaUniversidad de IbaguéIbaguéColombia

High-throughput crop phenotyping,particularly under field conditions,is nowadays perceived as a key factor limiting crop genetic *** not only facilitates conventional breeding,but it is necessary to fully exploit the capabilities of molecular breeding,and it can be exploited to predict breeding targets for the years ahead at the regional level through more advanced simulation models and decision support *** terms of phenotyping,it is necessary to determined which selection traits are relevant in each situation,and which phenotyping tools/methods are available to assess such *** sensing methodologies are currently the most popular approaches,even when lab-based analyses are still relevant in many *** top of that,data processing and automation,together with machine learning/deep learning are contributing to the wide range of applications for *** review addresses spectral and red-green-blue sensing as the most popular remote sensing approaches,alongside stable isotope composition as an example of a lab-based tool,and root phenotyping,which represents one of the frontiers for field ***,we consider the two most promising forms of aerial platforms(unmanned aerial vehicle and satellites)and some of the emerging data-processing *** review includes three Boxes that examine specific case studies.

关键词： crop phenotyping deep learning models photosynthesis platforms remote sensing roots satellites sensors stable isotopes

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Corneal and intraocular pressure changes associated to the circadian rhythms:a narrative review

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1921-1928页

作者： Laura Barberán-Bernardos MiguelÁngel Ariza-gracia David P Piñero Department of Optics Pharmacology and AnatomyUniversity of AlicanteSan Vicente del Raspeig 03690AlicanteSpain ARTORG Center for Biomedical Engineering Research University of BernBern 3008Switzerland Department of Ophthalmology(IMQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

AIM:To synthesize the current body of research regarding the diurnal variations in intraocular pressure(IOP)and corneal biomechanical and morphological parameters,highlighting their significance in various eye ***:A comprehensive review of studies on the diurnal variations of IOP and corneal parameters was *** findings from various studies were assessed,including the Goldmann applanation tonometry(GAT)and non-contact *** on the variations in central corneal thickness(CCT),corneal curvature,and corneal biomechanics measured by the Ocular Response Analyzer system across different population groups was extracted and ***:In both healthy subjects and those with Fuchs dystrophy,IOP and CCT demonstrate marked diurnal *** remains the gold standard for tonometry,with the highest ***,its measurements are influenced by *** patients and those with pseudoexfoliation showed significant diurnal variations in *** biomechanical parameters,especially corneal hysteresis(CH)and the corneal resistance factor(CRF),largely remain stable throughout the day for most of eye conditions,with some ***,the corneal morphology diurnal variation,particularly curvature,yielded mixed conclusions across ***:Circadian rhythms significantly influence various corneal parameters,most notably IOP and *** studies should emphasize standardized approaches larger sample sizes,and delve deeper into less-explored areas,such as the effects of orthokeratology lenses on diurnal biomechanical shifts.

关键词： circadian rhythms intraocular pressure corneal thickness corneal biomechanics corneal curvature

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Carbon nanodots:A metal-free,easy-to-synthesize,and benign emitter for light-emitting electrochemical cells

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Nano Research 2022年第6期15卷 5610-5618页

作者： Yongfeng Liu Shi Tang Xiuyu Wu Nicolas Boulanger Eduardo gracia-Espino Thomas Wågberg Ludvig Edman Jia Wang Department of Physics UmeåUniversitySE-90187 UmeåSweden LunaLEC AB Linnaeus väg 24SE-90187 UmeåSweden College of Physical Science and Technology Yangzhou UniversityYangzhou 225009China

Light-emitting electrochemical cells(LECs)can be fabricated with cost-efficient printing and coating methods,but a current drawback is that the LEC emitter is commonly either a rare-metal complex or an expensive-to-synthesize conjugated ***,we address this issue through the pioneering employment of metal-free and facile-to-synthesize carbon nanodots(CNDs)as the emitter in functional LEC ***-shaped(average diameter=4.4 nm)and hydrophilic CNDs,which exhibit narrow cyan photoluminescence(peak=485 nm,full width at half maximum=30 nm)with a high quantum yield of 77%in dilute ethanol solution,were synthesized with a catalyst-free,one-step solvothermal process using low-cost and benign phloroglucinol as the sole starting *** propensity of the planar CNDs to form emission-quenching aggregates in the solid state was inhibited by the inclusion of a compatible 2,7-bis(diphenylphosphoryl)-9,9’-spirobifluorene host compound,and we demonstrate that such pristine host-guest CND-LECs turn on to a peak luminance of 118 cd·m^(−2)within 5 s during constant current-density driving at 77 mA·cm^(−2).

关键词： carbon nanodot light-emitting electrochemical cell phloroglucinol sustainable synthesis solution-based fabrication

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Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer

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World Journal of Gastroenterology 2009年第18期15卷 2290-2292页

作者： Jaime Ceballos-Viro José M López-Picazo José L Pérez-gracia Jesús J Sola Gregorio Aisa ignacio Gil-Bazo Department of Oncology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain Department of Pathology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain

Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic *** constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological ***,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced *** is the first reported case in the literature of FCH after conventional chemotherapy for a solid *** addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed.

关键词： Fibrosing cholestatic hepatitis Immunosuppression Chemotherapy Lung cancer Hepatitis Bvirus Lamivudine

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Liver dysfunction and SARS-CoV-2 infection

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World Journal of Gastroenterology 2021年第26期27卷 3951-3970页

作者： Abraham Edgar gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron Department of Internal Medicine General HospitalNational Medical Center"La Raza"Instituto Mexicano del Seguro SocialMexico City 02990Mexico Gastroenterology Service and Department of Internal Medicine Faculty of MedicineUniversity Hospital"Dr.JoséE.González"Universidad Autónoma de Nuevo LeónMonterrey 64460Mexico Centro de Estudio e Investigación en Enfermedades Hepáticas y Toxicológicas(CEIHET) Pachuca 42184Mexico Departments of Hospital Medicine and Pediatric Hospital Medicine Cleveland ClinicClevelandOH 44195United States

Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic *** damage is among the main extrapulmonary ***-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five *** liver test results have been associated with a more severe course of COVID-19 and other complications,including *** linking COVID-19 to liver injury are *** consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe *** manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient ***,we mention the ideas and recommendations to be considered for future research.

关键词： SARS-CoV-2 Coronavirus COVID-19 Liver Liver diseases Liver failure Liver injury Cirrhosis

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Thou shalt not get fat: Medical representations and self-images of obesity in a Mediterranean society

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Health 2013年第7期5卷 1180-1189页

作者： Mabel gracia-Arnaiz Department of Anthropology Philosophy and Social Work University Rovira i Virgili Tarragone Spain

This paper examines the link between lipophobia and representations and experiences of obesity in Catalonia (Spain) from two points of view: that of the physicians and other health professionals who diagnose and treat obesity as an illness, and that of their patients, especially those between adolescence and early adulthood. The qualitative data demonstrate that the increasing social rejection of fat people can be traced not only to moralizing discourses on “excessive” food consumption or the commodification of slenderness and health, but also to the recent definition of obesity as a disease. The medicalization of fatness, far from helping to destigmatize obesity, is becoming a way of resignifying it in moral terms. While doctors’ and patients’ perspectives diverge in some ways, they converge in others. In this text, I focus on the points of convergence arguing that biomedical understandings of obesity and overweight are characterized by a profound ambivalence. Young patients are regarded both as innocent victims of a permissive consumer society, and guilty of not following doctors’ orders. Although the family is held accountable for overweight or obesity in children, as young people become more independent, guilt is individualized and environmental causes are limited to inappropriate diet and insufficient exercise. Most narratives of young people with weight problems reflect similar ideas about the causes and the responsibility for obesity. Their acceptance of the basic premise that deviating from weight standards and rules for healthy eating are voluntary actions leads them to lose faith in themselves. The stigmatization of obesity thus becomes a vicious circle: the obese acceptance—even consider normal—the incriminations leveled at them, and blame themselves for their situation and their inability to prevent it.

关键词： Obesity Medicalization Lipophobia Stigmatization Young People

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