检索结果-南通市图书馆

Virologica Sinica 2014年第6期29卷 343-352页

作者： Lilith torres Qiyi Tang Department of Microbiology Ponce Health Sciences UniversityPonce Research InstitutePoncePR 00716USA

Three crucial hurdles hinder studies on human cytomegalovirus(HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was first accomplished, functional studies on individual genes have been the mainstream in the CMV field. Gene regulation has therefore been elucidated in a more detailed fashion. However, viral gene regulation is largely controlled by both cellular and viral components. In other words, viral gene expression is determined by the virus–host interaction. Generally, cells respond to viral infection in a defensive pattern; at the same time, viruses try to counteract the cellular defense or else hide in the host(latency). Viruses evolve effective strategies against cellular defense in order to achieve replicative success. Whether or not they are successful, cellular defenses remain in the whole viral replication cycle: entry, immediate–early(IE) gene expression, early gene expression, DNA replication, late gene expression, and viral egress. Many viral strategies against cellular defense, and which occur in the immediate–early time of viral infection, have been documented. In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.

关键词： cytomegalovirus(CMV) major immediate early promoter(MIEP) IE1 pp71 nuclear domain 10(ND10) intrinsic cellular defense enhancer virus-host interaction

Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 493-495页

作者： Osonuga io Osonuga OA Osonuga A Onadeko AA Osonuga AA Department of Physiology Olabisi Onabanjo University Department of Pharmacology Olabisi Onabanjo University School of Medical Sciences University of Cape Coast Department of Nursing University of Cape Coast

Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar ***:Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw,respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control,and they were given waterad ***:Artemether caused significant reduction(Pion of the drug use however showed gradual recovery of the depressed indices of the blood ***:The results suggest that artemether can induce reversible changes in hematological profiles of rats by extension man. This can probably aggravate anemia when artemether is administered to malaria patients. Hence, the study supports the use of the drug with cautione specially in patients prone to anemic tendencies.

关键词： Artemether Anemia Antimalaria Hematology Hematological profile Malaria Anemic tendency

Fabrication of 3D air-core MEMS inductors for very-highfrequency power conversions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2018年第1期4卷 509-517页

作者： Hoa Thanh Le io Mizushima Yasser Nour Peter Torben Tang Arnold Knott Ziwei Ouyang Flemming Jensen Anpan Han National Center for Micro-and Nanofabrication DanchipTechnical University of Denmark2800 Kongens LyngbyDenmark Department of Electrical Engineering Technical University of Denmark2800 Kongens LyngbyDenmark IPU Nils Koppels Allé2800 Kongens LyngbyDenmark

We report a fabrication technology for 3D air-core inductors for small footprint and very-high-frequency power *** process is scalable and highly generic for fabricating inductors with a wide range of geometries and core *** demonstrate spiral,solenoid,and toroidal inductors,a toroidal transformer and inductor with advanced geometries that cannot be produced by wire winding *** inductors are embedded in a silicon substrate and consist of through-silicon vias and suspended *** inductors fabricated with 20 and 25 turns and 280-350μm heights on 4-16 mm2 footprints have an inductance from 34.2 to 44.6 nH and a quality factor from 10 to 13 at frequencies ranging from 30 to 72 *** air-core inductors show threefold lower parasitic capacitance and up to a 140% higher-quality factor and a 230% higher-operation frequency than silicon-core inductors.A 33 MHz boost converter mounted with an air-core toroidal inductor achieves an efficiency of 68.2%,which is better than converters mounted with a Si-core inductor(64.1%).Our inductors show good thermal cycling stability,and they are mechanically stable after vibration and 2-m-drop tests.

关键词： MEMS inductor PwrSoC TSVs very high frequency 3D

Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White JoséAntonio González Moreno Daniel Angel torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez Luis Jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor Jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

OsDMI3,a Ca^(2+)/calmodulin kinase,integrates and amplifies H_(2)O_(2) and Ca^(2+) signaling in ABA-mediated responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第6期16卷 968-970页

作者： Miguel-Angel torres Diego Jose Berlanga Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPM28223 Pozuelo de AlarconMadridSpain Departamento de Biotecnologia-Biologia Vegetal Escuela Técnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUPM28040 MadridSpain

Abscisic acid(ABA)is an important hormone that regulates both plant development and stress responses(Chen et al.,2020).In the absence of ABA,group A PROTEIN PHOSPHATASE 2Cs(PP2Cs)interact with and inhibit SUCROSE-NON-FERMENTING 1-RELATED KINASES 2(SnRK2s).When ABA is present,ABA receptor PYRABACTIN RESISTANCE 1 and PYRABACTIN RESISTANCE 1-LIKE PROTEINS bind to and inhibit PP2Cs,allowing phosphorylation and activation of SnRK2s that,in turn,phosphorylate downstream targets,such as transcription factors,ion channels,and transporters(Figure 1).

关键词： SnRK2 Figure

FAST SPECTRAL GALERKIN METHOD FOR LOGARITHMIC SINGULAR EQUATioNS ON A SEGMENT＊

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2018年第1期36卷 128-158页

作者： Carlos Jerez-Hanckes Serge Nicaise Carolina Urzua-torres School of Engineering Pontificia Universidad Catolica de Chile 782-0436 Santiago Chile. LAMAV Universite de Valenciennes and CNRS 59313 Valenciennes France. Seminar for Applied Mathematics ETH Zurich Raemistrasse 101 8092 Zurich Switzerland.

We present a fast Galerkin spectral method to solve logarithmic singular equations on segments. The proposed method uses weighted first-kind Chebyshev polynomials. Conver- gence rates of several orders are obtained for fractional Sobolev spaces H^-1/2 （or H00^-l/2）. Main tools are the approximation properties of the discretization basis, the construction of a suitable Hilbert scale for weighted L2-spaces and local regularity estimates. Numerical experiments are provided to validate our claims,

关键词： Screen problems Boundary integral operators Spectral methods.

Interpreting Morphologically Homogeneous(Paleo-)Populations as Ecological Species Enables Comparison of Living and Fossil Organism Groups,Exemplified by Nummulitid Foraminifera

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2022年第6期33卷 1362-1377页

作者： Johann Hohenegger Ana Ivis torres-Silva Wolfgang Eder Institute for Paleontology University of Vienna1090ViennaAustria

Morphologically homogeneous groups,either living populations or fossil paleo-populations,must be regarded as ecological species,independent of their molecular genetic resemblance in living *** is always expressed during development by structure genes initiated from a network of regulator genes acting at different times and intensities,additionally being subjected to epigenetic ***,homogeneous populations influenced by the environment represent species better than the reproduction(biological species)or molecular-genetic approach using ancestral sequences like *** and fossil representatives of nummulitid foraminifera were chosen to demonstrate complete reconstruction of morphology using metrical growth-invariant and growth-independent *** these characters,6 models were established to define ecological species in living and fossil ***,a distinction between evolutionary and environmental effects in fossil forms was possible using discriminant analysis showing characters that are responsible for differentiating between evolutionary and environmental trends.

关键词： ecological species growth-invariant metrical characters morphology homogeneity nummulitids

Hierarchical dispatch of multiple microgrids using nodal price:an approach from consensus and replicator dynamics

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1573-1584页

作者： Miguel A.VELASQUEZ Oscar torres-PEREZ Nicanor QUIJANO Angela CADENA Department of Electrical and Electronics Engineering Universidad de los AndesBogotaColombia

A hierarchical approach for the energy management of geographically close microgrids connected through a dedicated AC power network is proposed in this *** proposed approach consists of a two-layer energy management system(EMS)for networked *** the lower layer,each micro grid solves its own economic dispatch problem through a distributed model predictive control approach that respects capacity limits and ramp-rate constraints of distributed *** the upper layer,the energy trading in the network of microgrids decides how to optimally trade the energy based on the marginal cost information from the lower layer in order to improve global optimization objectives,e.g.,social *** order to solve the trading problem,a consensusbased algorithm and a replicator dynamics algorithm are proposed assuming that the marginal cost function of the microgrid is known and *** is shown that both algorithms converge to the same solution,which is equivalent to the minimization of operation *** consensus-based algorithm is extended in order to tackle more general marginal cost functions and trading network ***,the effect of ramp constraints and network limits is *** show the effectiveness of the proposed algorithms for three interconnected microgrids with different characteristics.

关键词： Consensus Economic dispatch Hierarchical control Networked microgrids Ramp limits Replicator dynamics

A Novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar Ramos-Martínez Iván Ramos-Martínez Quiroz-Mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México Departamento de Investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de Investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico Departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico Departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de Investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio Nacional de ptica de la Visin-Centro de Investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular Degeneration

The Use of Triancinolone for the Treatment of Keloid Scars

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio torres Anderson Alves Brandão Delma dos Santos Assis Mercadante Jessyka Oliveira Barbosa Batista William Felix de Oliveira Pacheco Elisangelo Aparecido Costa Da Silva Douglas Henrique Farias de Oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRio Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection