检索结果-南通市图书馆

Last line therapy with sorafenib in colorectal cancer: A retrospective analysis

World Journal of Gastroenterology 2016年第23期22卷 5400-5405页

作者： Ksenia Martchenko Irene Schmidtmann Thomas Thomaidis Verena Thole Peter R Galle Marc becker Markus Mohler Thomas C Wehler Carl C Schimanski Department of Internal Medicine Marienhospital 64285 Darmstadt Germany Institute of Medical Biostatistics Epidemiology and Informatics Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany First Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany Department of Internal Medicine Katholische Kliniken Mainz 55131 Mainz Germany Institute of Pathology Saarland University Medical Center 66421 Homburg Germany Third Department of Internal Medicine Johannes Gutenberg University Hospital of Mainz 55131 Mainz Germany

AIM: To analyze the efficacy of last line sorafenib treatment in colorectal cancer patients. METHODS: All patients receiving chemotherapy for colorectal cancer in the outpatient clinic of the University of Mainz since 2006 were retrospectively analyzed for last line sorafenib exposure. Charts of identified patients were analyzed for clinic-pathological parameters, like data on gender, age, date of initial diagnosis, UICC stage, number and kind of the pretherapies, therapy start and end of sorafenib, sorafenib mediated treatment cessation, side effects, response rates, time to progression and overall survival. RESULTS: Ten patients with a median of 3.0 prior chemotherapy lines had received a last line sorafenib therapy either alone(10%) or in combination with 5-fluorouracil derivates(90%). All patients suffered from colorectal cancer stage UICC 4 and were routinely seen in 2-wk intervals in the oncology outpatient clinic. Median duration of treatment was 142.0 d. At 8 wk 80% of patients showed stable disease but we did not observe any remissions. Median time to progression was 140.5 d(4.7 mo), while median overall survival reached 176.5 d. One patient ceased treatment due to side effects. Reason for treatment stop was bleeding complication in one case and non-specified sorafenib intolerance in another case. Due to the retrospective approach we did not further quantify side ***: This retrospective analysis encourages further investigation of sorafenib in colorectal cancer last line therapy.

关键词： Colorectal cancer Sorafenib Regorafenib Chemotherapy Last line

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

摩洛哥泥盆系调查与研究现状

引用

地球科学 2024年第10期49卷 3647-3673页

作者：王志宏曾雄伟危凯吴发富姚华舟 Ralph Thomas becker 古生物与地质环境演化湖北省重点实验室湖北武汉430205 中国地质调查局武汉地质调查中心(中南地质科技创新中心) 湖北武汉430205 地质古生物研究所德国明斯特大学北莱茵-威斯特法伦州明斯特48149 自然资源部地层与古生物重点实验室北京100037

摩洛哥泥盆系因其丰富的化石资源,在地质学尤其是古生物学领域享有盛誉,产出三叶虫、头足类、珊瑚、腕足类、牙形石、鱼类和植物等,化石的保存通常非常完好.这些化石为厘清地层序列,分析生物群落、古环境及关键地质事件等提供了重要的依... 详细信息

摩洛哥泥盆系因其丰富的化石资源,在地质学尤其是古生物学领域享有盛誉,产出三叶虫、头足类、珊瑚、腕足类、牙形石、鱼类和植物等,化石的保存通常非常完好.这些化石为厘清地层序列,分析生物群落、古环境及关键地质事件等提供了重要的依据.此外,摩洛哥具有独特的古地理位置,查明泥盆纪的岩石和生物类型及其时空分布,有助于更好地重建冈瓦纳古陆和劳俄古陆间海洋系统的演化过程.通过对已有文献资料的调研和系统梳理,回顾了摩洛哥地质调查的历史,分析了泥盆纪研究的3个主要阶段,近年来以多学科综合、跨地区合作为主要发展趋势,在古生物、古地理和古气候研究中取得了大量新发现新认识,充分利用好这座化石宝库,将有助于更好理解地球的演化历史和应对当今的生物多样性危机和环境问题.

关键词：摩洛哥泥盆纪地层对比古生物地质演化地层学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The current phosphate recycling situation in China and Germany:a comparative review

引用

Frontiers of Agricultural Science and Engineering 2019年第4期6卷 403-418页

作者： Qing XUE Xinyue HE Saskia D.SACHS Gero C.becker Tao ZHANG Andrea KRUSE Institute of Agricultural Engineering Conversion Technologies of Biobased ResourcesUniversity of Hohenheim70599 StuttgartGermany Biomass Engineering Center Beijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationKey Laboratory of Plant-Soil Interactions of Ministry of EducationCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China

Phosphorus(P)is an indispensable element for organisms but the primary source of P-mineral phosphate resources-are *** production has a high demand for fossil phosphate resources,but the resulting phosphate-rich residues are lack of *** leads to rapid reserves depletion and severe phosphate pollution *** sustainable way is to reuse the phosphate dispersed in various residues such as sewage sludge and livestock *** techniques have emerged to recover phosphate from wastes to close the phosphate *** it is a global issue,the regional situations regarding potential phosphate scarcity and its management differ *** is rich in phosphate resources,but over-exploitation has greatly increased the risk of phosphate rocks depletion,while in Germany the P resources depend on imports,but there is commitment to keep a balance between import and *** had led to great differences in the way the two countries deal with the"re-use"of phosphate in *** is now in a transition phase from the simple terminal pollution control to"waste"reuse and nutrient resources *** sign of this tendency is the mandatory garbage classification and preparation for further processing and *** was first implemented in Shanghai in 2019,whereas Germany has been following the legal framework for waste management since the 19 th *** are a series of laws to control the nutrient loss from municipal and agricultural activities,as for instance with sewage sludge ordinance and fertilizer *** of these laws have been newly revised *** sludge cannot be directly utilized on farmland as organic fertilizer any ***,phosphate and other nutrients should be recovered from sewage *** phosphate recovery technologies and related nutrient recycling schemes are *** review summarizes the current situation of phosphate-containing residues management and

关键词： phosphate recovery manure sewage sludge ordinances technologies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中德传统节日文化对比

中德传统节日文化对比

引用

作者： Alexander becker（贝克）厦门大学

学位级别：硕士

学习一门语言不仅指学习新的词语和语法。为了提高用目的语进行交际的能力,学习者还需要学习目的文化。为此,优秀方式之一是学习这个文化所庆祝的节日。由于传统节日悠久的历史与其周期性,传统节日不仅创造而且加强社会共同拥护的信仰... 详细信息

学习一门语言不仅指学习新的词语和语法。为了提高用目的语进行交际的能力,学习者还需要学习目的文化。为此,优秀方式之一是学习这个文化所庆祝的节日。由于传统节日悠久的历史与其周期性,传统节日不仅创造而且加强社会共同拥护的信仰、道德观念与价值观。在对外语言教学中运用节日,节日的娱乐活动提高文化教学趣味,同时节日让学习者在娱乐气氛下接触到母语者的文化。本文进行仔细的节日对比,指出中国与德国传统节日的文化异同,主要集中于两对传统节日:第一,春节与圣诞节;第二,端午节与复活节。这个对比特别关注这些节日的文化内涵,帮助教师懂得两国的节日文化差异。有效的对比教学法要求教师完全理解学生与目的语的文化,不过很多文献一般化“西方”文化,而不去具体追求每个节日所含的特殊性。本文的节日文化对比期于帮助汉语教师向德国学生进行更有效的文化教学。节日对比以后,笔者采用对比的结果设计在德国教春节的教案事例。中国的传统节日非常有利于进行文化教学,主要是因为如下三种原因:第一,节日的活动众多。这不仅使学生感兴趣,但是也是他们在课堂教学中能自身体验的文化方面。第二,中国节日的主题种类很多,强调中国人的各种观念与思想,如家庭主义、孝悌、爱国主义等等,适合进行多方面的文化教学。第三,节日的活动与传说展示中国人的日常生活习惯,比如春节的传说多次采用在中国很受欢迎的红色,除夕的祭祖表示老人在中国社会的高地位等等。

关键词：传统节日中德文化对比中华文化教学

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

钉螺肝脏线粒体的氧化磷酸化作用

引用

中国寄生虫学与寄生虫病杂志 1992年第2期10卷 113-116页

作者：宋庚明王根法 W.becker 中国预防医学科学院寄生虫病研究所(世界卫生组织血吸虫病疟疾和丝虫病合作中心)上海200025 汉堡大学动物学研究所

应用氧电极技术及比色法测得钉螺肝脏线粒体具有氧化磷酸化作用;二磷酸腺苷(ADP)可使线粒体氧化反应从0.187增至0.318μmol O_2/mg蛋白·20min。有氧代谢三核酸循环的中间物可增加钉螺肝脏线粒体氧化反应0.353—0.444μmol O_2/mg蛋白·... 详细信息

应用氧电极技术及比色法测得钉螺肝脏线粒体具有氧化磷酸化作用;二磷酸腺苷(ADP)可使线粒体氧化反应从0.187增至0.318μmol O_2/mg蛋白·20min。有氧代谢三核酸循环的中间物可增加钉螺肝脏线粒体氧化反应0.353—0.444μmol O_2/mg蛋白·20min。线粒体氧化反应同时偶联磷酸化反应。钉螺肝脏具有三磷酸腺苷酶(ATPase)活力。二硝基苯酚及溴乙酰胺可明显抑制钉螺线粒体氧化磷酸化作用,氧化反应分别从0.431降至0.245及0.282μmol O_2/mg蛋白·20min。溴乙酰胺并不抑制ATPase活力。

关键词：钉螺线粒体氧化磷酸化血吸虫

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Presence of Staphylococcus aureus in the Nasal Cavity of Children Attending a Public Daycare Center in Francisco Beltrao—Parana—Brazil

引用

Advances in Infectious Diseases 2013年第2期3卷 89-94页

作者： Sideney becker Onofre Géssica Araceli Costa Department of Biological Sciences and Pharmacy Faculty of Educational of Dois VizinhosUniao de Ensino do Sudoeste do ParanáDois VizinhosBrazil.

The objective of this study was to evaluate the presence of Staphylococcus aureus in the nasal cavity of children attending a daycare center in the town of Francisco Beltrao—PR, by comparing the frequency between age groups and genders. Antimicrobial susceptibility testing with different drugs was also carried out in the bacterial isolates. A prospective study involving 200 children aged 2 and 4 years, grouped by gender, was carried out. Samples were collected from the nasal vestibules of children, incubated and identified. Antimicrobial susceptibility testing was carried out in 30% of the S. aureus colonies. The results showed that 35% of children (10% female and 25% male) were colonized by S. aureus. The frequency of colonization in both male age groups was similar, with 201.93 ± 13.10 CFU/plate for 2-year-old and 266 ± 12.60 CFU/plate for 4-year-old. However, colonization averages for females were different, with 30.43 ± 1.17 CFU/plate for 2-year-old and 394.38 ± 10.70 CFU/plate for 4-year-old. In the antimicrobial susceptibility testing, some strains were resistant to oxacillin, erythromycin and tetracycline, in addition to showing intermediate susceptibility to cephalothin.

关键词： Nasal Cavity Frequency Susceptibility Antimicrobials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无菌培养条件下不同碳素和NH_4^+水平对刺线虫生活史的影响

引用

华南农业大学学报 2004年第3期25卷 48-50页

作者：罗大民王博方文珍 S.J.becker J.O.becker 厦门大学生命科学学院福建厦门361005 厦门市环保局福建厦门361006 Department of Nematology University of CaliforniaRiverside

在24℃无菌、无光照、不同碳素和氮素水平培养条件下,观察了以玉米切根根尖为食的长尾刺线虫 Belono-laimus longicaudatus的发育.结果表明,刺线虫完成生活史所需的最短时间没有明显受到不同碳素水平的影响.碳素缺乏时,刺线虫的存活率... 详细信息

在24℃无菌、无光照、不同碳素和氮素水平培养条件下,观察了以玉米切根根尖为食的长尾刺线虫 Belono-laimus longicaudatus的发育.结果表明,刺线虫完成生活史所需的最短时间没有明显受到不同碳素水平的影响.碳素缺乏时,刺线虫的存活率和成虫的比率明显下降.在5-10倍于标准B5培养基中NH4+水平的环境下,没有观察到NH4+对刺线虫的发育有不良影响.

关键词：无菌培养碳素氨根离子刺线虫生活史发育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer

引用

Cancer Communications 2024年第1期44卷 101-126页

作者： Monika Raab Izabela Kostova Samuel Peña-Llopis Daniela Fietz Monika Kressin Seyed Mohsen Aberoumandi Evelyn Ullrich Sven becker Mourad Sanhaji Klaus Strebhardt Department of Gynecology Medical SchoolGoethe-UniversityFrankfurt am MainGermany Translational Genomics in Solid Tumors West German Cancer CenterUniversity HospitalEssenGermany German Cancer Consortium(DKTK) EssenGermany German Cancer Research Center(DKFZ) HeidelbergGermany Histology and Embryology Institute for Veterinary AnatomyGiessenGermany Franfurt Cancer Institute(FCI) Goethe UniversityFrankfurt am MainGermany German Cancer Consortium(DKTK) Partner site Frankfurt/Mainza partnership between DKFZ and University Hospital FrankfurtFrankfurt am MainGermany Experimental Immunology Department for Children and Adolescents MedicineUniversity Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany

Background:The cellular tumor protein p53(TP53)is a tumor suppressor gene that is frequently mutated in human *** various cancer types,the very aggressive high-grade serous ovarian carcinoma(HGSOC)exhibits the high-est prevalence of TP53 mutations,present in>96%of *** intensive efforts to reactivate p53,no clinical drug has been approved to rescue p53 *** this study,our primary objective was to administer in vitro-transcribed(IVT)wild-type(WT)p53-mRNA to HGSOC cell lines,primary cells,and ortho-topic mouse models,with the aim of exploring its impact on inhibiting tumor growth and dissemination,both in vitro and in ***:To restore the activity of p53,WT p53 was exogenously expressed in HGSOC cell lines using a mammalian vector ***,IVT WT p53 mRNA was delivered into different HGSOC model systems(primary cells and patient-derived organoids)using liposomes and studied for proliferation,cell cycle progression,apoptosis,colony formation,and chromosomal *** alterations induced by p53 mRNA were analyzed using RNA sequencing in OVCAR-8 and primary HGSOC cells,followed by ingenuity path-way *** vivo effects on tumor growth and metastasis were studied using orthotopic xenografts and metastatic intraperitoneal mouse ***:Reactivation of the TP53 tumor suppressor gene was explored in differ-ent HGSOC model systems using newly designed IVT mRNA-based *** introduction of WT p53 mRNA triggered dose-dependent apoptosis,cell cycle arrest,and potent long-lasting inhibition of HGSOC cell *** analysis of OVCAR-8 cells upon mRNA-based p53 reactivation revealed significant alterations in gene expression related to p53 signaling,such as apoptosis,cell cycle regulation,and DNA *** p53 function concurrently reduces chromosomal instability within the HGSOC cells,under-scoring its crucial contribution in safeguarding genomic integrity by moderating the baselin

关键词： apoptosis cell cycle chromosomal instability HGSOC metastatic intraperitoneal mouse model HGSOC orthotopic Xenograft model high-grade serous ovarian cancer in vitro-transcribed p53-mRNA liposomal IVT mRNA delivery system patient-derived organoid patient-derived primary cancer cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CT as a first-line modality in elderly patients with stable blunt chest trauma

引用

Chinese Journal of Traumatology 2021年第5期24卷 255-260页

作者： Alexander becker Tamar Dola Yuri Berlin Dan Hershko Department of Surgery A Emek Medical CenterAfula18101Israel Faculty of Medicine.Technion-lsrael Institute of Technology Haifa31096Israel

Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma *** aimed to examine the impact of chest CT on the diagnosis and change of management plan in elderly patients with stable blunt chest *** hypothesized that chest CT may play an important role in providing optimal management to this subgroup of trauma patients.;A retrospective analysis was performed on all the admitted adult blunt trauma patients between January 2014 and December *** blunt chest trauma patients with abbreviated injury severity(AIS)ion or during hospitalization were included in the *** AIS is an international scale for grading the severity of anatomic injury following blunt *** outcome variables were occult injuries,change in management,need for surgical procedures,missed injuries,readmission rate,intensive care unit(ICU)and length of hospital stay.;There are 473 patients with blunt chest trauma included in the *** study patients were divided into two groups according to the age range:group 1:289 patients were included and aged 18-64 years;group 2:184 patients were included and aged 65-99 *** patients in group 2 more often required ICU admission(11.4%vs.5.2%),had a longer length of ICU stay(days)(median 11 vs.6,p=0.01),and the length of hospital stay(days)(median 14 vs.6,p=0.04).Injuries identified on chest CT has led to a change of management in 4.4%of young patients in group 1 and in 10.9%of elderly patients in group 2 with initially normal *** CT resulted in a change of management in 12.8%of young patients in group 1 and in 25.7%of elderly patients in group 2 with initially abnormal CXR.;Chest CT led to a change of management in a substantial proportion of elderly ***,we recommend chest CT as a first-line imaging modality in patients aged over 65 years with isolated b

关键词： Blunt chest trauma Elderly Chest computed tomography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

引用

Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg Alexander becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing Alexander Kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensitiesion measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：