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Open Journal of Psychiatry 2017年第2期7卷 103-114页

作者： Suriya Nisar Abu Talib iftikhar haider naqvi Jawahar Lal Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan Dow University of Health Sciences Karachi Pakistan Medical Unit-III Civil Hospital Karachi Pakistan

Background: Post myocardial infarction depression is common and puts a negative effect on recovery. Modified Nursing interventions effectively reduce the frequency and severity of depression in such patients. Objective: The study aimed to determine the effectiveness of Modified Nursing Interventions Classification (NIC) in reducing the severity of depression among patients with Myocardial Infarction. Methods: Sixty-eight stable patients with myocardial infarction (>1 month history) having mild to moderate depression in accordance to Patient Health Questionnaire-9 (PHQ-9) [with a score of 5 to 14] were enrolled. Patients were assorted into interventional and control group. Modified Nursing Intervention was offered in Interventional Group. The frequency and effectiveness of Modified Nursing Intervention among the groups were determined and compared. Results: Both moderate and mild level depression was decreased in Intervention Group as compare to Control Group. Baseline mean depression PHQ-9 score was 2.35 point statistically significantly higher in the Control Group than Interventional Group (Conclusion: Modified Nursing intervention is effective in reducing the frequency and severity of depression compared to routine care in patients with Myocardial infarction.

关键词： Modified Nursing Intervention Classification Depression Myocardial Infarction

Antituberculosis Drug-Induced Liver Injury: An Ignored Fact, Assessment of Frequency, Patterns, Severity and Risk Factors

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Open Journal of Gastroenterology 2015年第12期5卷 173-184页

作者： iftikhar haider naqvi Khalid Mahmood Abu Talib Aamer Mahmood Department of Medicine Dow University of Health Sciences Karachi Pakistan Agha Khan University Hospital Karachi Pakistan

Background/Aims: Antituberculosis drug-induced liver injury (TB DILI) is a frequent medical problem in Pakistan. Critical understanding of various aspects of TB DILI is not only important to manage liver injury but may also prevent unnecessary discontinuation of antituberculosis treatment. The study is aimed to determine the frequency, types, severity and patterns of TB DILI. Study further evaluates various risk factors of TB DILI. Materials and Methods: This is a prospective cohort study of two seventy-eight patients with the diagnosis of tuberculosis, where patients were followed during tuberculosis treatment. TB DILI was defined in accordance to international DILI expert working group. Results: Out of two seventy eight-patients, ninety-five (34.14%) had TB DILI. The most common pattern of TB DILI was hepatocellular (63.15%) followed by mixed (23.15%) and Cholestatic (13.68%). Most of the patients had mild DILI (43.15%) followed by moderate (30.52%), severe (20.01%) and very severe (5.26%). Age > 35 years, concomitant hepatotoxic drugs, extrapulmonary TB and malnutrition are important risk factors for TB DILI. Conclusion: All patterns of TB DILI with varying severity were present. Age > 35 years, malnutrition, extrapulmonary TB and concomitant use of hepatotoxic drugs were risk factors for TB DILI.

关键词： Antituberculosis Drug-Induced Liver Injury Antituberculosis Treatment Subjective Global Assessment Liver Function Test

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

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Open Journal of Gastroenterology 2014年第3期4卷 105-117页

作者： iftikhar haider naqvi Khalid Mahmood Abu Talib Mohammad Ubaid Aamer Mahmood Agha Khan University Karachi Pakistan Department of Medicine Civil Hospital Karachi Dow University of Health Sciences Karachi Pakistan

Cirrhosis is an immunocompromised state that leads to various infections, with an estimated 30% mortality. Pakistan already has a high morbidity and mortality related to complications of cirrhosis. Where the data on infection among cirrhotics is scanty, this study aimed to determine the frequency, microbiological spectrum and various risk factors of infections in cirrhosis of liver. This is a prospective cohort study conducted at a tertiary care hospital. The microbiological spectrum and frequency of infections was determined in cirrhotics. Various risk factors for infection among cirrhotics were evaluated like upper gastrointestinal bleed, use of proton pump inhibitors, malnutrition and severity of cirrhosis. Out of eleven hundred and forty-one patients with cirrhosis of liver, four hundred and ninety (42.94%) patients had infections. All kinds of infections like peritoneal, respiratory, urinary tract and skin were present in cirrhosis of liver where ascitic fluid infections (AFI) were the commonest i.e. 44.89%. The risk factors for bacterial infections among patients with cirrhosis of liver were upper gastrointestinal bleeding (odd ratio = 4.57, p = 0.0001), use of proton pump inhibitors (odd ratio = 2.57, p = 0.0001), degree of malnutrition (odd ratio = 10.34, p = 0.0001) and severity of cirrhosis (odd ratio = 12.99, p = 0.000). All types of infections occurred with varying frequency in cirrhosis of liver. Upper gastrointestinal bleeding, severity of cirrhosis, use of high dose proton pump inhibitors and severe malnutrition are important risk factors for infections among cirrhotics.

关键词： Liver Cirrhosis Proton Pump Inhibitors Ascites Bacterial Infections

Spectrum of Diseases, Disease Related Mortality and Overall Financial Burden of Hospitalized Patients in Medical Wards of Tertiary Care Public Hospital

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Open Journal of Epidemiology 2017年第4期7卷 337-348页

作者： iftikhar haider naqvi Khalid Mahmood Abu Talib Syed Muhammad Kashif Ali Sajjad Department of Medicine Dow University of Health Sciences Karachi Pakistan

Background: Detailed assessment of pattern of diseases and trend of mortalities tends to aid in formulating pivotal aspects of in-hospital policies, standards of care and so consequently promoting efficient work system. This also reserves limited resources keeping within the limit of financial grasp. The study aims to reimburse the colossal paucity of data covering epidemiological burden of diseases, impact on mortality as well as financial burden in socioeconomically challenged public health system. Methods: This was a retrospective cross-sectional hospital based study conducted in department of Medicine, Civil Hospital Karachi, from February 2016 to July 2016 using questionnaire based data collection system. Results: Eight thousand and fifty three (8053) cases with almost equal gender proportion were analyzed. Chronic liver disease (CLD) was the most rampant disease, followed by cerebrovascular accident (CVA), tuberculosis and diabetes. Overall 51% cases were attributed to infectious diseases. Overall the average percentage mortality was found to be 20% of all cases. Mean duration of stay was 7.56 ± 7 days. Estimated average total in-hospital expenditure per patient on each visit or stay was 159.15 ± 41.2 $USD (16670.96 ± 4315.7 PKR). Average total diagnostic and medications costs per visit or stay were 89.74 ± 31.2 $USD (9400.26 ± 3268.2 PKR) and 48.68 ± 18.0 $USD (5099.23 ± 1885.5 PKR) respectively. Conclusion: Chronic liver disease, cerebrovascular accident and diabetes were most frequent reasons of hospital admission and mortality. Recognition of most common and fatal diseases with their expenditure is going to lead to formulation of targeted policies both of which would be effective and efficient.

关键词： Communicable Diseases Mortality Health Economics Epidemiology Infectious Diseases

Peripheral Neuropathy and Vasculopathy;Frequency and Associated Risk Factors in Newly Diagnosed Treatment Naive Type 2 Diabetes

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Open Journal of Endocrine and Metabolic Diseases 2018年第5期8卷 125-136页

作者： iftikhar haider naqvi Abu Talib Syed Tahseen Akhter Syeda Rida Abdi Saiyeda Nayema Zehra Rizvi Muhammad Ubaid Department of Medicine Dow University of Health Sciences Karachi Sindh Pakistan Florence Medical Centre Karachi Pakistan Civil Hospital Karachi Karachi Pakistan

Background: The prevalence of diabetes in Pakistan is 11.45%. The reported prevalence of diabetic foot ulceration in Pakistan is between 4% and 10%, with the amputation rate of 8% - 21%. Peripheral neuropathy and vasculopathy are main underlying cause of diabetic foot ulcers. Methodology: It was a cross-sectional non-interventional cohort study where all newly diagnosed treatment naïve type 2 diabetic patients were enrolled. Peripheral neuropathy and vasculopathy were detected by Michigan neuropathy screening instrument (MNSI) and ankle brachial index (ABI) respectively. Risk factors for peripheral neuropathy and vasculopathy were determined by univariate and multivariate logistic regression analysis. Statistical significance was considered with P value of Result: Fifty seven patients (37.7%) had early neuropathy with MNSI score of 3.3 ± 0.4. Thirty seven patients (20.6%) had vasculopathy with ABI score of 0.76 ± 0.11. Age (Odd ratio 1.07 (1.02 - 1.11), p 0.003), duration of symptoms (Odd ratio 1.11 95% CI: 1.05 - 1.17, p ≤ 0.001), high HbA1C % (Odd ratio 1.94 95% CI: 1.54 - 2.45, P ≤ 0.001), albumin creatinine ratio (Odd ratio 1.01, 95% CI: 1.00 - 1.01, P ≤ 0.001 ) and cholesterol level (Odd ratio 1.01 95% CI: 1.01 - 1.02, p = 0.001) were found as risk factors for early neuropathy and vasculopathy. Conclusion: Peripheral neuropathy and vasculopathy are frequently reported complications among newly diagnosed treatment naïve patients of type 2 DM. Age, duration of symptoms prior to diagnosis, metabolic parameters like raised HbA1C, hyperlipidemia and spot random albumin creatinine ratio are found to be risk factors for both peripheral neuropathy and vasculopathy.

关键词： Peripheral Neuropathy Peripheral Vasculopathy Type 2 Diabetes Mellitus

Upper Gastrointestinal Endoscopic Outcomes in Patients with Gastrointestinal Symptoms: Retrospective Analysis at a Tertiary Care Hospital

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Open Journal of Gastroenterology 2019年第8期9卷 141-157页

作者： iftikhar haider naqvi Abu Talib Muqadus Tabraze Omer Mustafa Siddiqui Maheen Fatima Hussaini Neha Saleem Paryani Rida Effendi Samrah lnam Siddiqui Syeda Zuhaa Hassan Maham Munawar Zaiya Waseem Ameer Ahmed Khan Zafir Zohab Hussain Khan S. Zain Naeem Rizvi Sofia Fatima Farooqui Misbah Munaf Hasan Obaid Faryal Khan Dow University of Health Sciences Department of Medicine Karachi Pakistan

Background: Endoscopic procedures are frequently performed to rule out any disease process which eventuates with either a positive or negative outcome. Association of patient demographics, clinical features with endoscopic outcomes are of paramount importance for better understanding and practice of endoscopy. Objectives: This study aimed to determine the frequency of positive endoscopic findings in patients with gastrointestinal symptoms compared to those with negative findings. As a secondary objective, the association between relevant demographics, symptoms, laboratory investigations and procedural outcomes of the participants and positive endoscopic findings were also assessed. Methods: A retrospective analysis of all the patients who underwent esophagogastroduodenoscopy from January 2017 to December 2017 was conducted. A total of 1066 endoscopy records were retrieved and using a convenience sampling technique, relevant data were manually entered to the questionnaires. Records with incomplete or inconsistent data were disregarded as per the exclusion criteria, resulting in 1011 patient records ultimately utilized for the study. All data were entered and analyzed using IBM SPSS 23.0. Results: The study comprised a total of 1011 patients where 52.2% were females and 47.8% males while the mean age of patients was 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding was gastritis (49.1%). Approximately 14.5% had positive investigation findings for HBsAg and 23.1% were seropositive for anti-HCV antibody. P-values statistically significant were for age (p = 0.044), hematemesis (p = 0.002), betel quid addiction (p = 0.044), anti-HCV antibody (p = 0.043), HCV-RNA (p = 0.041) and “H. pylori” antigen (p = 0.032). Conclusion: Both genders were almost equally included where most patients presented between the 3rd and 5th decades of life. A high incidence of gastritis was noted. Positive endoscopic findings were associated with be

关键词： Esophagogastroduodenoscopy Endoscopy Gastritis Esophageal Varices

Intelligent Breast Cancer Prediction Empowered with Fusion and Deep Learning

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Computers, Materials & Continua 2021年第4期67卷 1033-1049页

作者： Shahan Yamin Siddiqui iftikhar Naseer Muhammad Adnan Khan Muhammad Faheem Mushtaq Rizwan Ali naqvi Dildar Hussain Amir haider School of Computer Science National College of Business Administration and EconomicsLahore54000Pakistan School of Computer Science Minhaj University LahoreLahore54000Pakistan Department of Computer Science&Information Technology Superior UniversityLahore54000Pakistan Department of Computer Science Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Information Technology Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea School of Computational Sciences Korea Institute for Advanced Study(KIAS)85 HoegiroDongdaemunguSeoul02455Korea Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea

Breast cancer is the most frequently detected tumor that eventually could result in a significant increase in female mortality *** to clinical statistics,one woman out of eight is under the threat of breast *** and inheritance patterns may be a reason behind its spread among ***,some preventive measures,such as tests and periodic clinical checks can mitigate its risk thereby,improving its survival chances *** diagnosis and initial stage treatment can help increase the survival *** that purpose,pathologists can gather support from nondestructive and efficient computer-aided diagnosis(CAD)*** study explores the breast cancer CAD method relying on multimodal medical imaging and decision-based *** multimodal medical imaging fusion,a deep learning approach is applied,obtaining 97.5%accuracy with a 2.5%miss rate for breast cancer prediction.A deep extreme learning machine technique applied on feature-based data provided a 97.41%***,decisionbased fusion applied to both breast cancer prediction models to diagnose its stages,resulted in an overall accuracy of 97.97%.The proposed system model provides more accurate results compared with other state-of-the-art approaches,rapidly diagnosing breast cancer to decrease its mortality rate.

关键词： Fusion feature breast cancer prediction deep learning convolutional neural network multi-modal medical image fusion decision-based fusion

Papaya Ring Spot Virus:An Understanding of a Severe Positive-Sense Single Stranded RNA Viral Disease and Its Management

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Phyton-International Journal of Experimental Botany 2022年第10期91卷 2099-2110页

作者： Muhammad Umer Mustansar Mubeen Yasir iftikhar haider Ali Muhammad Zafar-ul-Hye Rafia Asghar Mazhar Abbas Malik Abdul Rehman Ernesto A.Moya-Elizondo Yuejun He Institute for Forest Resources and Environment of Guizhou and Forestry College Research Centre of Forest EcologyGuizhou UniversityGuiyang550025China Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan College of Bioscience University of BirminghamBirminghamB152TTUK Department of Soil Science Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Department of Plant Pathology PMAS University of Arid AgricultureRawalpindi43490Pakistan Department of Agriculture and Agribusiness Management University of Karachi Karachi75270Pakistan Citrus Research Institute Sargodha40100Pakistan Department of Plant Production Faculty of AgronomyUniversidad de ConcepciónChillán3780000Chile

Viral diseases have been studied in-depth for reducing quality,yield,health and longevity of the fruit,to highlight the economic ***-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit *** of the best examples is papaya ringspot virus(PRSV).It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae,Cucurbitaceae and *** virus has a serious threat to the production of papaya,which is famous for its high nutritional and pharmaceutical *** plant parts such as leaves,latex,seeds,fruits,bark,peel and roots may contain the biological compound that can be isolated and used in pharmaceutical industries as a disease *** disease symptoms consist of vein clearing and yellowing of young *** ring spot patterns with concentric rings and spots on fruit reduce its quality and *** virus has two major strains P and *** former cause disease in papaya and cucurbits while the later one in *** comprises 94.4%protein,including a 36 kDa coat protein which is a component responsible for a non-persistent transmission through aphids,and 5.5%nucleic *** protection,development of transgenic crops,exploring the resistant sources and induction of pathogen derived resistance have been recorded as effective management of *** with these practices reduced aphid population through insecticides and plant extracts have been found ecofriendly approaches to minimize the disease *** of transgenic crops is a big challenge for the success of disease resistant papaya *** aim of this review is to understand the genomic nature of PRSV,detection methods and the different advanced control meth*** review article will be helpful in developing the best management strategies for controlling PRSV.

关键词： Papaya obligate parasite +ssRNA PRSV aphid genomic characterization and functions

Antagonistic Potential of Bacterial Species against Fungal Plant Pathogens(FPP)and Their Role in Plant Growth Promotion(PGP):A Review

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Phyton-International Journal of Experimental Botany 2022年第9期91卷 1859-1877页

作者： Amjad Ali Yasir iftikhar Mustansar Mubeen haider Ali Muhammad Ahmad Zeshan Zohaib Asad Muhammad Zafar-ul-Hye Malik Abdul Rehman Mazhar Abbas Muhammad Rafique Muhammad Usman Ghani Department of Plant Protection Sivas University of Science and TechnologySivas58140Turkey Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan College of Bioscience University of BirminghamBirminghamB152TTUK Department of Plant Pathology PMAS University of Arid AgricultureRawalpindi43490Pakistan Department of Soil Science Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Citrus Research Institute Sargodha40100Pakistan Department of Agriculture and Agribusiness Management University of Karachi75270KarachiPakistan Pest warning&Quality Control of Pesticides SahiwalPunjab40210Pakistan Institute of Soil and Environmental Sciences University of AgricultureFaisalabad38000Pakistan

Since the 19th century to date,the fungal pathogens have been involved in causing devastating diseases in *** types of fungal pathogens have been observed in important agricultural crops that lead to significant pre and postharvest *** application of synthetic fungicide against the fungal plant pathogens(FPP)is a traditional management practice but at the same time these fungicides kill other beneficial microbes,insects,animal,and humans and are harmful to *** antagonistic microorganism such as bacteria are being used as an alternate strategy to control the *** antagonistic species are cost-effective and eco-friendly in *** biocontrol bacteria have a broad mechanism against fungal pathogens present in the phyllosphere and rhizosphere of the *** antagonistic bacteria have different strategies against the FPP,by producing siderophore,biofilm,volatile organic compounds(VOCs),through parasitism,antibiosis,competition for limited resources and induce systemic resistance(ISR)in the host plant by activating the immune *** commercial bio-products synthesized by the major bacterial species Pseudomonas syringae,Burkholderia cepacia,Streptomyces griseoviridis,Pseudomonas fluorescens and Bacillus subtilis are used to control Fusarium,Pythium,Rhizoctonia,Penicillium,Alternaria,and *** commercial bio-formulations of bacteria act as both antifungal and plant growth *** Plant growth-promoting rhizobacteria(PGPR)played a significant role in improving plant health by nitrogen-fixing,phosphorus solubilization,phytohormones production,minimizing soil metal contamination,and by ACC deaminase antifungal *** articles are available on the specific antifungal activity of bacteria in plant ***,this review article has summarized the information on biocontrol activity of bacteria against the FPP and the role of PGPR in plant growth *** review also provided a complete picture

关键词： Fungi plant pathogens synthetic fungicide antagonism bio-products PGPR

Biotechnological leap in biopharmaceuticals:Current status and challenges ahead

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Journal of Coastal Life Medicine 2017年第1期5卷 36-46页

作者： Tazeen iftikhar Butt Muhammad Shoaib Amjad Tatheer Fatima Butt Wasi haider Butt Kainat Fatima Malik Sidra Sabir Department of Biotechnology Women University of Azad Jammu&KashmirBaghPakistan Department of Botany Women University of Azad Jammu&KashmirBaghPakistan Department of Botany Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan Department of Medicine Fatima Jinnah Medical UniversityLahorePakistan Department of Computer Engineering National University of Sciences and TechnologyIslamabadPakistan Department of Plant Science Quaid-i-Azam UniversityIslamabadPakistan

Fermentation based vaccine production system is replaced by edible vaccine technology. Plant derived vaccines are produced by using transgenic plants which have immunogenic properties. For combating infectious diseases especially in developing countries there is a practical need of new technology to produce and deliver inexpensive vaccines. We have best option of plant derived edible vaccines. There are many benefits of plant derived vaccinesi.e. they are cheaper, simple and easy to administer, more stable, extra versatile, with more acceptance power and highly efficient. Some plant derived vaccines are under clinical trials to use commercially and many are under research. This paper reviews the current status and future of this technology.

关键词： Plant-based vaccine Recombinant protein Transgenic plant Broad immune protection