检索结果-南通市图书馆

Action of the Disintegrin Contortrostatin on Breast Cancer Cell Primary Cultures

Advances in Breast Cancer Research 2013年第4期2卷 161-169页

作者： ifigeneia marinou Sophia Havaki Nikos Goutas Dimitrios Vlachodimitropoulos Georgios Baltatzis Eumorphia G. Konstantakou Dimitrios J. Stravopodis Dimitrios G. Koudoumas Evangelos Marinos Mirsini Kouloukoussa 1st Department of Pathology Medical School University of Athens Athens Greece Department of Cell Biology and Biophysics Faculty of Biology University of Athens Athens Greece Laboratory of Experimental Surgery and Surgical Research University of Athens Athens Greece Laboratory of Forensic Medicine and Toxicology Medical School University of Athens Athens Greece Laboratory of Histology and Embryology Medical School University of Athens Athens Greece

Integrins mediate cell adhesion to the extracellular matrix (ECM). In particular, integrin alphavbeta3 recognizes the RGD motif as a ligand-binding site on various extracellular molecules of the extracellular matrix. Integrin aphavbeta3 has been associated with high malignant potential in breast cancer cells, and has signalized the onset of widespread metastasis. In recent years, several antagonists of integrin alphavbeta3, including snake venom disintegrins, have been used as potential anti-cancer agents. In the present work, the effect of contortrostatin, a disintegrin isolated from the venom of the snake Agkistrodon contortrix, was studied on primary cultures of human breast cancer cell. Scanning and transmission electron microscopy were employed in order to examine alterations in cell morphology and fluorescent microscopy and visualize changes in distribution of integrin alphavbeta3 and talin. Fluorescent localization of caspase 8 was made in order to visualize any sign of proapoptotosis and western immunoblotting of integrin, talin and annexin was undertaken in order to identify changes. The results suggest that the snake venom contortrostatin seriously affects cell morphology, adhesion and mobility and induces breast cancer cells to apoptosis.

关键词： Breast Cancer Disintegrins Contortrostatin Integrin Alphavbeta3 Apoptosis Primary Cultures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Use of Agent Based Modelling for Addressing the Social Component of Urban Water Management in Europe

引用

Computational Water, Energy, and Environmental Engineering 2021年第4期10卷 140-154页

作者： ifigeneia Koutiva Christos Makropoulos Department of Water Resources and Environmental Engineering School of Civil Engineering National Technical University of Athens Athens Greece

The paper aimed to provide a review of different tools that estimate how human behavior changes by water management strategies and quantify this change to support the decisions of urban water managers. To support decision makers, it is essential to be able to model the urban water system’s human part explicitly and link it to the hydro system’s response, rather than only explore the reaction of the system based on scenarios. To do so, tools are needed that can model the human part of the system, explore its reaction to potential changes and dynamically link back this to the techno-environmental model of the water system. This work reviews state-of-the-art ABMs that are publicly available focusing on the human part of the urban water system in Europe. The review leads to the proposals of three pillars for future development of ABMs for urban water management in Europe: end-user enablement;Machine Learning and Artificial Intelligence integration and adversaries modelling.

关键词： Agent-Based Modeling Urban Water Management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

成人抑郁症的管理:新版NICE指南更新总结

引用

英国医学杂志中文版 2022年第11期25卷 664-669页

作者： Tony Kendrick Steve Piling ifigeneia Mavranezouli Odette Megnin-Viggars Catherine Ruane Hilary Eadon Navneet Kapur on behalfof the Guideline Committee 岳玲(译) 何燕玲(校) University of Southampton SouthamptonUK University College London LondonUK National Guideline Alliance Royal Collegeof Obstetricians and GynaecologistsLondonUK National Institutefor Healthand Care Excellence LondonUK University of Manchester ManchesterUK Greater Manchester Mental Healthand Social Care Trust ManchesterUK 不详上海市精神卫生中心

自英国国家健康与临床优选研究所(NICE)2009年发布抑郁症指南版本^(1)以来,抑郁症的患病率有所上升^(2),特别是在COVID-19大流行期间的易感人群中^(3)。尽管增加了心理治疗^(4)和抗抑郁药^(5)的供应,但只有不到一半的抑郁症患者接受了治... 详细信息

自英国国家健康与临床优选研究所(NICE)2009年发布抑郁症指南版本^(1)以来,抑郁症的患病率有所上升^(2),特别是在COVID-19大流行期间的易感人群中^(3)。尽管增加了心理治疗^(4)和抗抑郁药^(5)的供应,但只有不到一半的抑郁症患者接受了治疗^(2)。

关键词：抑郁症抗抑郁药易感人群心理治疗患病率 NICE 流行期间

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Whole-genome resequencing of Cucurbita pepo morphotypes to discover genomic variants associated with morphology and horticulturally valuable traits

引用

Horticulture Research 2019年第1期6卷 568-584页

作者： Aliki Xanthopoulou Javier Montero-Pau ifigeneia Mellidou Christos Kissoudis JoséBlanca Belén Picó Aphrodite Tsaballa Eleni Tsaliki Athanasios Dalakouras Harry S.Paris Maria Ganopoulou Theodoros Moysiadis Maslin Osathanunkul Athanasios Tsaftaris Panagiotis Madesis Apostolos Kalivas Ioannis Ganopoulos Department of Genetics and Plant Breeding Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biochemistry and Molecular Biology Universitat de València46022 ValenciaSpain Institute of Plant Breeding and Genetic Resources Hellenic Agricultural Organization DEMETER(ex NAGREF)ThermiMacedonia 57001Greece Perrotis College American Farm SchoolThessaloniki 57001Greece Institute for the Conservation and Breeding of Agricultural Biodiversity(COMAV-UPV) Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain Department of Vegetable Crops and Plant Genetics Agricultural Research OrganizationNewe Ya’ar Research CenterRamat YishayIsrael Institute of Applied Biosciences(INAB) CERTHThermi-Thessaloniki 57001Greece Department of Biology Faculty of Science Chiang Mai UniversityChiang MaiThailand Center of Excellence in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang MaiThailand

Cucurbita pepo contains two cultivated subspecies,each of which encompasses four fruit-shape morphotypes(cultivar groups).The Pumpkin,Vegetable Marrow,Cocozelle,and Zucchini Groups are of *** and the Acorn,Crookneck,Scallop,and Straightneck Groups are of ***,a de novo assembly of the *** *** Zucchini genome was published,providing insights into its *** expand our knowledge of evolutionary processes within *** and to identify variants associated with particular morphotypes,we performed wholegenome resequencing of seven of these eight *** *** report for the first time whole-genome resequencing of the four ***(Pumpkin,Vegetable Marrow,Cocozelle,green Zucchini,and yellow Zucchini)morphotypes and three of the ***(Acorn,Crookneck,and Scallop)morphotypes.A high-depth resequencing approach was followed,using the BGISEQ-500 platform that enables the identification of rare variants,with an average of *** 94.5%of the clean reads were mapped against the reference Zucchini *** total,3,823,977 high confidence single-nucleotide polymorphisms(SNPs)were *** each accession,SNPs varied from 636,918 in green Zucchini to 2,656,513 in Crookneck,and were distributed homogeneously along the *** differences between subspecies pepo and ovifera in genetic variation and linkage disequilibrium are *** fact,comparison between subspecies pepo and ovifera indicated 5710 genes(22.5%)with Fst>0.80 and 1059 genes(4.1%)with Fst=1.00 as potential candidate genes that were fixed during the independent evolution and domestication of the two *** disequilibrium was greater in *** than in ***,perhaps reflective of the earlier differentiation of morphotypes within *** morphotype-specific genes have been *** results offer new clues that may provide an improved understanding of the underlying genomic regions involved

关键词： cultivar traits Whole

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：