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Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein

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World Journal of Gastroenterology 2011年第2期17卷 151-163页

作者： Olav A Gressner ieva Peredniene Axel M Gressner Institute of Clinical Chemistry and Pathobiochemistry Central LaboratoryRWTH-University Hospital Wisplinghoff Medical Laboratories Classen-Kappelmann-Str.2450931 CologneGermany Synlab Lab Services Gubener Str.3986156 AugsburgGermany

AIM:To investigate the mechanisms involved in a possible modulator role of interleukin(IL) -6 signalling on CYR61-CTGF-NOV(CCN) 2/connective tissue growth factor(CTGF) expression in hepatocytes(PC) and to look for a relation between serum concentrations of these two parameters in patients with acute inflammation. METHODS:Expression of CCN2/CTGF,p-STAT3,p-Smad 3/1 and p-Smad2 was examined in primary freshly isolated rat or cryo-preserved human PC exposed to various stimuli by Western blotting,electrophoretic mobility shift assay(EMSA) ,reporter-gene-assays and reversetranscriptase polymerase chain reaction. RESULTS:IL-6 strongly down-regulated CCN2/CTGF protein and mRNA expression in PC,enhanceable by extracellular presence of the soluble IL-6 receptor gp80,and supported by an inverse relation between IL-6 and CCN2/CTGF concentrations in patients'*** inhi-bition of TGFβ1 driven CCN2/CTGF expression by IL-6 did not involve a modulation of Smad2(and Smad1/3) ***,the STAT3 SH2 domain binding peptide,a selective inhibitor of STAT3 DNA binding activity,counteracted the inhibitory effect of IL-6 on CCN2/CTGF expression much more pronounced than pyrrolidine-dithiocarbamate,an inhibitor primarily of STAT3 *** EMSA confirmed STAT3 binding to the proposed proximal STAT binding site in the CCN2/CTGF promoter. CONCLUSION:CCN2/CTGF is identified as a hepatocellular negative acute phase protein which is downregulated by IL-6 via the STAT3 pathway through interaction on the DNA binding level.

关键词： Hepatocytes Interleukin-6 Connective tissue growth factor STAT3 Liver fibrosis Acute phase reaction

Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1454-1462页

作者： ieva Stundiene Vaidota Maksimaityte Valentina Liakina Jonas Valantinas Centre of Hepatology Gastroenterology and DieteticsFaculty of MedicineVilnius UniversityVilnius 03101Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania Clinic of Gastroenterology Nephrourology and SurgeryFaculty of MedicineVilnius UniversityVilnius 03101Lithuania

BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular *** we present a rare,ulcerative form of marginal zone lymphoma which mimics the Crohn’s disease(CD)of upper digestive *** SUMMARY A 50-year-old man was presented with recurrent episodes of malaise and melena also weight *** of the small bowel demonstrated an ulcer in the ***,biopsies showed lymphoplasmacytic *** of CD was *** treatment consisted of prednisone and azathioprine and was followed by azathioprine 100 mg per day with good clinical response in the following 2 years until *** this time the results of endoscopic biopsies derived from proximal wall of stomach revealed Helicobacter pylori-negative marginal zone lymphoma of the gastric *** confirmed atypical CD20-positive cell *** on these biopsies,marginal zone lymphoma of mucosa-associated lymphoid tissue was ***,the contact with the patient was lost until one year later he was hospitalized with nausea,vomiting and severe pain because of gastrointestinal *** months later after laparotomy,the patient was treated with a course of *** remission was observed following 6 cycles of *** This case report highlights the clinical relevance of knowledge and awareness of marginal zone lymphoma simulating CD.

关键词： Crohn disease Mucosa-associated lymphoid tissue lymphoma Rare diagnosis Gastrointestinal diseases Thiopurines Case report

Natural antioxidants in the management of Parkinson's disease: Review of evidence from cell line and animal models

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Journal of Integrative Medicine 2021年第4期19卷 300-310页

作者： Reem Abdul-Latif ieva Stupans Ayman Allahham Benu Adhikari Thilini Thrimawithana Discipline of Pharmacy School of Health and Biomedical SciencesRoyal Melbourne Institute of Technology UniversityBundooraVIC 3084Australia Biosciences and Food Technology School of ScienceRoyal Melbourne Institute of Technology UniversityBundooraVIC 3084Australia

Parkinson’s disease(PD) is a chronic progressive neurodegenerative disease. It results from the death of dopaminergic neurons. The pathophysiological mechanisms in idiopathic PD include the production of α-synuclein and mitochondrial respiratory function-affecting complex I, caused by reactive oxygen ***, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba,Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from oxidative stress in animal and cell models of PD. However, the clinical efficacy of these phytochemicals needs to be optimised and further investigated.

关键词： Parkinson’s disease Neurodegeneration Antioxidants Plant Alternative and complementary medicine

Menstrual cycle abnormalities in women with inflammatory bowel disease and effects of biological therapy on gynecological pathology

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World Journal of Clinical Cases 2023年第21期11卷 4989-4995页

作者： Vaidota Malinauskiene Anastasija Zuzo Valentina Liakina Edita Kazenaite ieva Stundiene Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius TechVilnius 10223Lithuania

Inflammatory bowel disease(IBD)is a chronic condition that affects young individuals in their reproductive *** may have long-term implications on their reproductive,sexual,and mental *** has been related to menstrual ***,the administration of biological therapy can also result in gynecological issues in addition to the disease *** purpose of this review was to present potential menstrual cycle problems in patients with IBD,as well as the impact of adalimumab and other anti-tumor necrosis factor medications on gynecological pathology.

关键词： Menstrual disorders Inflammatory bowel disease Adalimumab Infliximab Anti-tumor necrosis factor-α

Multi-organ IgG4-related disease continues to mislead clinicians: A case report and literature review

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World Journal of Clinical Cases 2020年第15期8卷 3267-3279页

作者： Sandra Strainiene Lukas Sarlauskas Ilona Savlan Valentina Liakina ieva Stundiene Jonas Valantinas Clinic of Gastroenterology Nephrourology and SurgeryCentre of HepatologyGastroenterology and DieteticsInstitute of Clinical MedicineVilnius UniversityVilnius 01513Lithuania Clinic of Internal Diseases Family Medicine and OncologyCentre of Internal DiseasesInstitute of Clinical MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a multisystemic mass forming immune-mediated disease that affects almost every organ and is a diagnostic challenge for every *** is a lack of adequate epidemiological data worldwide,and evidence-based treatment recommendations are not yet *** report the first case of IgG4-RD from Lithuania and the Baltic Sea region presented with thyroiditis,orbital myositis,orbitopathy,uveitis,scleritis,sialadenitis,autoimmune pancreatitis and *** SUMMARY A 54-year-old Caucasian male was admitted to our tertiary Centre complaining of severe weight loss,diarrhoea,abdominal pain,salivary gland swelling,sicca symptoms and *** examination,bilateral palpable masses in the projection of major salivary glands,severe protrusion of the left eyeball and cachexia were *** patient was previously diagnosed with autoimmune thyroiditis and endocrine *** magnetic resonance imaging(MRI)of the head revealed enlarged extraocular muscles indicating orbital *** biopsy from the salivary gland mass indicated *** MRI showed signs of autoimmune pancreatitis,and a serological test revealed the elevated serum IgG4 *** patient was then diagnosed with IgG4-RD and successfully treated with *** was a significant clinical,serological and radiological improvement after one month of treatment and no signs of relapse within twenty ***,it took almost 18 years and the efforts of eight different medical specialists to establish the correct *** A comprehensive approach to the patient is essential to improving the recognition of rare immune system conditions,such as IgG4-RD.

关键词： IgG4-related disease Autoimmune pancreatitis Sialadenitis Orbitopathy Autoimmune thyroiditis Case report Literature review

Management of Flood syndrome:What can we do better?

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World Journal of Gastroenterology 2021年第32期27卷 5297-5305页

作者： Sandra Strainiene Milda Peciulyte Tomas Strainys ieva Stundiene Ilona Savlan Valentina Liakina Jonas Valantinas Clinic of Gastroenterology Nephrourology and SurgeryCentre of HepatologyGastroenterology and DieteticsInstitute of Clinical MedicineVilnius UniversityVilnius 03104Lithuania Clinic of Anesthesiology and Reanimatology Centre of AnesthesiologyIntensive Care and Pain ManagementInstitute of Clinical MedicineVilnius UniversityVilnius 03104Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania

Approximately 20%of cirrhotic patients with ascites develop umbilical *** patients usually suffer from multisystemic complications of cirrhosis,have a significantly higher risk of infection,and require accurate surveillance–especially in the context of the coronavirus disease 2019 *** rupture of an umbilical hernia,is an uncommon,life-threatening complication of largevolume ascites and end-stage liver disease resulting in spontaneous paracentesis,also known as Flood *** syndrome remains a challenging condition for clinicians,as recommendations for its management are lacking,and the available evidence for the best treatment approach remains *** this paper,four key questions are addressed regarding the management and prevention of Flood syndrome:(1)Which is the best treatment approach–conservative treatment or urgent surgery?(2)How can we establish the individual risk for herniation and possible hernia rupture in cirrhotic patients?(3)How can we prevent umbilical hernia ruptures?And(4)How can we manage these patients in the conditions created by the coronavirus disease 2019 pandemic?

关键词： Umbilical hernia rupture Ascites Cirrhosis Flood syndrome COVID-19 Literature review

Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review

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World Journal of Gastroenterology 2019年第32期25卷 4779-4795页

作者： ieva Stundiene Julija Sarnelyte Ausma Norkute Sigita Aidietiene Valentina Liakina Laura Masalaite Jonas Valantinas Vilnius University Institute of Clinical MedicineClinic of GastroenterologyNephrourology and SurgeryVilnius UniversityVilnius LT-03101Lithuania Vilnius University Institute of Clinical MedicineClinic of Internal diseasesFamily medicine and OncologyVilnius UniversityVilnius LT-03101Lithuania Vilnius University Institute of Clinical MedicineClinic of Cardiology and AngiologyVilnius UniversityVilnius LT-03101Lithuania Vilnius Gediminas Technical University Faculty of Fundamental SciencesDepartment of Chemistry and BioengineeringVilnius LT-10223Lithuania

BACKGROUND Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular *** circulation in liver cirrhosis causes functional and structural cardiac *** prevalence of left ventricle diastolic dysfunction(LVDD)in cirrhotic patients ranges from 25.7%to as high as 81.4%as reported in different *** several studies the severity of diastolic dysfunction(DD)correlated with a degree of liver failure and the rate of dysfunction was higher in patients with decompensated cirrhosis compared with *** directions of comprehensive assessment of cardiac function in cirrhotic patients might provide a better prognosis for these *** To clarify the correlation between the severity of liver cirrhosis and left ventricle diastolic dysfunction in the existing *** Through January and February of 2019 at Vilnius University we conducted a systematic review of the global existing literature on the prevalence of left ventricle diastolic dysfunction in patients with liver *** searched for articles in PubMed,Medline and Web of science *** were selected by using adequate inclusion and exclusion *** interest was the outcome of likely correlation between the severity of cirrhosis[evaluated by Child-Pugh classes,Model For End-Stage Liver Disease(MELD)scores]and left ventricle diastolic dysfunction[classified according to American Society of Echocardiography(ASE)guidelines(2009,2016)],as well as relative risk of dysfunction in cirrhotic *** analyses were performed to evaluate the ratio and grades of left ventricle diastolic dysfunction with respect to cirrhosis *** A total of 1149 articles and abstracts met the initial search *** articles which met the predefined eligibility criteria were included in the final ***,1067 patients(out of them 723 men)with liver cirrhosis were evaluated for left ventricle diastolic dysf

关键词： Liver cirrhosis Left ventricle Diastolic dysfunction Correlation Echocardiography Systematic review

Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis

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World Journal of Hepatology 2022年第7期14卷 1277-1290页

作者： Valentina Liakina Sandra Strainiene ieva Stundiene Vaidota Maksimaityte Edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius Gediminas Technical University(VILNIUS TECH)Vilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Therapeutic and Radiological Department Antakalnis PolyclinicVilnius 10207Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

Recently,the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma(HCC),even in the absence of *** from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced *** composition of the gut microbiota differs significantly in obese and lean individuals,especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla,and,after establishing steatohepatitis,it undergoes minor changes during the progression of the disease toward advanced *** studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed *** the contrary,the transplantation of healthy microbiota to obese mice relieves ***,further studies are needed to confirm these findings and the mechanisms *** this review,we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis(NASH).Furthermore,a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed,and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed.

关键词： Gut microbiota Hepatocellular carcinoma Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Microbiome

Synchronous endometrial and ovarian cancer: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4341-4349页

作者： DianaŽilovič RūtaČiurlienė EvelinaŠidlovska ieva Vaicekauskaitė Rasa Sabaliauskaitė Sonata Jarmalaitė Department of Oncogynecology National Cancer InstituteVilnius 08406Lithuania Institute of Biosciences Vilnius UniversityVilnius 10222Lithuania Laboratory of Clinical Oncology National Cancer InstituteVilnius 08406Lithuania National Center of Pathology Affiliate of Vilnius University Hospital Santaros KlinikosVilnius 08406Lithuania Laboratory of Genetic Diagnostic National Cancer InstituteVilnius 08406Lithuania

BACKGROUND Synchronous endometrial and ovarian cancer(SEOC)is a rare genital tract *** diagnosis is crucial for the disease management since prognosis and overall survival differ substantially between metastatic endometrial cancer(EC)or *** this review we present 2 cases of women who were diagnosed with SEOC,and discuss the clinical characteristic of SEOC,diagnostic and molecular profiling *** generation sequencing of 10 gene panel was performed on cancerous tissue and uterine lavage *** SUMMARY In our report patients with SEOC had endometroid type histology with early stage and low-grade histology for both EC and *** underwent surgical treatment and ***-generation sequencing of 10 gene-panel identified CTNNB1,PIK3CA,and PTEN gene mutations in ovarian tissue in one case,while none of these genes were mutated in other *** review in support to our data suggest a good prognosis for SEOC diagnosed at early *** Accurate diagnosis of SEOC is essential for disease management and gene mutation analysis can be helpful as a complementary diagnostic and prognostic tool.

关键词： Ovarian cancer Endometrial cancer Synchronous primary cancer Uterine lavage Case report