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Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms

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Journal of Molecular Cell Biology 2024年第1期16卷 15-28页

作者： Te Li Min Liu Fan Yu Song Yang Weiwen Bu Kai Liu Jia Yang Hua Ni Mulin Yang Hanxiao Yin Renjie Hong Dengwen Li Huĳie Zhao Jun Zhou Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Protein ScienceCollege of Life SciencesNankai UniversityTianjin 300071China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongShandong Provincial Key Laboratory of Animal Resistance BiologyCollege of Life SciencesShandong Normal UniversityJinan 250014China

Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan ***,the mechanistic link of cilia to CMD complications is still poorly ***,we describe significant cilium disassembly upon treatment of cells with pathologically relevant aldoses rather than the corresponding sugar ***,environmental aldehydes are able to trigger cilium disassembly by the steric hindrance effect of their formyl *** studies reveal that aldehydes stimulate extracellular calcium influx across the plasma membrane,which subsequently activates the calmodulin-Aurora A-histone deacetylase 6 pathway to deacetylate axonemal microtubules and triggers cilium *** vivo experiments further show that Hdac6 knockout mice are resistant to aldehyde-induced disassembly of tracheal cilia and sperm *** findings reveal a previously unrecognized role for formyl group-mediated cilium disassembly in the complications of CMDs.

关键词： carbohydrate metabolism disorder aldose aldehyde cilium disassembly formyl group calcium influx HDAC6

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上海程十发美术馆建筑隔震设计策略详析

建筑技术开发 2024年第4期51卷 19-21页

作者：吴靖杰同济大学建筑设计研究院(集团)有限公司上海200092

上海程十发美术馆通过采用隔震技术,提升了空间效果及建筑品质。美术馆为实现隔震建筑设计的水平位移要求,针对隔震缝位置选择,整体隔震防水,墙体楼梯隔震处理,电梯设备隔震设计,隔震沟构造等内容,形成了完整的建筑隔震设计体系与策略,... 详细信息

上海程十发美术馆通过采用隔震技术,提升了空间效果及建筑品质。美术馆为实现隔震建筑设计的水平位移要求,针对隔震缝位置选择,整体隔震防水,墙体楼梯隔震处理,电梯设备隔震设计,隔震沟构造等内容,形成了完整的建筑隔震设计体系与策略,实现了高品质的功能及建筑空间与效果。

关键词：程十发美术馆水平位移隔震构造

基于分层调制的物理层网络编码系统概率成形设计

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移动通信 2024年第5期48卷 21-26,36页

作者：林宇晨谢肇鹏陈平平福州大学物理与信息工程学院福建福州350116 福州大学先进制造学院福建泉州362251 数字智能化技术国家地方工程研究中心福建福州350116

分层调制是一种根据发送信号的相对重要性对数据流进行不等保护的关键技术。针对双向中继信道下基于分层调制技术的PNC系统进行研究。当系统采用均匀的输入分布时会产生成形损耗,由于传统的分布匹配器的非线性成形编译码过程不适用于PN... 详细信息

分层调制是一种根据发送信号的相对重要性对数据流进行不等保护的关键技术。针对双向中继信道下基于分层调制技术的PNC系统进行研究。当系统采用均匀的输入分布时会产生成形损耗,由于传统的分布匹配器的非线性成形编译码过程不适用于PNC系统,因此提出一种线性概率成形码本方案,以确保其成形编译码过程是线性的,进一步推导了成形系统可达速率表达式。仿真结果表明,所提出的线性成形方案在中低SNR具有0.3 dB的成形增益。

关键词：分层调制概率成形物理层网络编码

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全身麻醉下胸横肌平面-胸神经阻滞在乳腺癌手术患者中的价值

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南京医科大学学报（自然科学版） 2024年第5期44卷 666-671页

作者：吴春培孙正霞刘辉马丽丽谢辉兰卞清明江苏省肿瘤医院(南京医科大学附属肿瘤医院)麻醉科江苏省肿瘤防治研究所江苏南京210009 徐州医科大学麻醉学院江苏徐州221004

目的:评价胸横肌平面-胸神经(transversus thoracic muscle plane-pectoral nerves,TTP-PECS)阻滞用于减阿片类药物全麻下乳腺癌改良根治术中的安全性与可行性。方法:选择择期行乳腺癌改良根治术的患者60例,随机分为TTP-PECS阻滞联合减... 详细信息

目的:评价胸横肌平面-胸神经(transversus thoracic muscle plane-pectoral nerves,TTP-PECS)阻滞用于减阿片类药物全麻下乳腺癌改良根治术中的安全性与可行性。方法:选择择期行乳腺癌改良根治术的患者60例,随机分为TTP-PECS阻滞联合减阿片药物全麻组(TO组)和常规全身麻醉组(GA组),每组30例。观察并记录两组患者各时点收缩压、舒张压、心率;麻醉诱导前(T0)、插管前即刻(T1)、切皮时(T2)、切除乳腺标本时(T3)、手术结束时(T4)各时点安静及运动状态下的疼痛视觉模拟评分量表(visual analogue scale,VAS);术后24 h 40项恢复质量评分量表(quality of recovery-40,QoR-40)评分;围术期不良反应的发生率。结果:与T0比较,两组患者T1~T4时点收缩压、舒张压、心率均显著降低(P 0.05);TO组术后2 h、6 h、12 h安静及运动状态下VAS评分均显著低于GA组(P <0.05);TO组术后24 h QoR-40量表总评分及情绪状态、身体舒适度、心理支持、疼痛各项评分均显著高于GA组(P <0.05);TO组患者诱导期咳嗽反射及术后恶心呕吐的发生率显著低于GA组(P <0.05)。结论:TTP-PECS阻滞联合羟考酮-丙泊酚减阿片药物全身麻醉可安全用于乳腺癌改良根治术中,术后镇痛效果确切,降低术后恶心呕吐发生率,并能提高患者早期恢复质量。

关键词：胸横肌平面胸神经阻滞羟考酮丙泊酚全身麻醉乳腺癌

经阴道超声联合经腹部超声对凶险性前置胎盘的诊断价值分析

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四川生理科学杂志 2024年第5期46卷 1086-1088页

作者：张慧珍刘风杰贾欣欣郑州大桥医院超声科河南郑州450000

目的:探讨经阴道超声联合经腹部超声对凶险性前置胎盘(Permicious Placenta Previa,PPP)的诊断价值。方法:选取2021年1月至2023年1月期间本院产科收治的疑似PPP患者98例作为研究对象,均行经腹部超声、经阴道超声检查,分娩后均进行病理... 详细信息

目的:探讨经阴道超声联合经腹部超声对凶险性前置胎盘(Permicious Placenta Previa,PPP)的诊断价值。方法:选取2021年1月至2023年1月期间本院产科收治的疑似PPP患者98例作为研究对象,均行经腹部超声、经阴道超声检查,分娩后均进行病理检查。以病理结果为“金标准”,对比经腹部、经阴道超声检查结果与病理结果,对比联合检查结果与病理结果,对比经腹部、经阴道及联合检查诊断效能。结果:98例PPP疑似患者分娩后,经病理诊断PPP71例,非PPP27例,经阴道超声诊断真阳性55例,假阳性10例,假阴性16例,真阴性17例,诊断灵敏度为77.46%、特异度为62.96%、准确率为73.47%;经腹部超声诊断真阳性54例,假阳性9例,假阴性17例,真阴性18例,诊断灵敏度为76.06%、特异度为66.67%、准确率为73.47%;经腹部、经阴道超声联合诊断真阳性66例,假阳性4例,假阴性5例,真阴性23例,诊断灵敏度为92.96%、特异度为85.19%、准确率为90.82%,且联合诊断准确度、灵敏度、阴性预测值高于两项检查单独诊断,漏诊率低于单独诊断(P<0.05)。结论:经腹部、经阴道超声联合检查对PPP具有较高诊断价值,优于两项检查单独诊断,可作为临床诊断PPP的有效检查方式。

关键词：经阴道超声经腹部超声凶险性前置胎盘诊断价值

Utilizing 3,4-ethylenedioxythiophene(EDOT)-bridged non-fullerene acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2022年第2期31卷 194-204页

作者： Sung Jae Jeon Young Hoon Kim ie Na Kim Nam Gyu Yang Ji Hee Yun Doo Kyung Moon Nano and Information Materials(NIMs)Laboratory Department of Chemical EngineeringKonkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea Department of Academy of Applied Science and Technology Konkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea

A rational design of efficient low-band-gap non-fullerene acceptors(NFAs)for high-performance organic solar cells(OSCs)remains challenging;the main constraint being the decrease in the energy level of the lowest unoccupied molecular orbitals(LUMOs)as the bandgap of A-D-A-type NFAs ***,the short current density(J_(sc))and open-circuit voltage(V_(oc))result in a trade-off relationship,making it difficult to obtain efficient ***,three NFAs(IFL-ED-4 F,IDT-ED-4 F,and IDTT-ED-2 F)were synthesized to address the above-mentioned issue by introducing 3,4-ethylenedioxythiophene(EDOT)as aπ-*** NFAs exhibit relatively low bandgaps(1.67,1.42,and 1.49 eV,respectively)and upshifted LUMO levels(-3.88,-3.84,and-3.81 eV,respectively)compared with most reported low-band-gap ***,the photovoltaic devices based on IDT-ED-4 F blended with a PBDB-T donor polymer showed the best power conversion efficiency(PCE)of 10.4%with a high J_(sc) of 22.1 mA cm^(-2) and Voc of 0.884 V among the examined *** contrast,IDTT-ED-4 F,which was designed with an asymmetric structure of the D-p-A type,showed the lowest efficiency of 1.5%owing to the poor morphology and charge transport properties of the binary ***,when this was introduced as the third component of the PM6:BTP-BO-4 Cl,complementary absorption and cascade energy-level alignment between the two substances could be ***,the IDTT-ED-4 F-based ternary blend device not only improved the Jscand Voc,but also achieved a PCE of 15.2%,which is approximately 5.3%higher than that of the reference device with a minimized energy loss of 0.488 *** addition,the universality of IDTT-ED-2 F as a third component was effectively demonstrated in other photoactive systems,specifically,PM6:BTPe C9 and PTB7-Th:ieICO-4 *** work facilitates a better understanding of the structure–property relationship for utilizing efficient EDOT-bridged NFAs in high-performance OSC applications.

关键词： Non-fullerene acceptor 3,4-ethylenedioxythiophene Organic solar cell π-bridge π-spacer

IL-22 and its interaction with amino acid and glycolipid metabolite in polycystic ovary syndrome (PCOS) patients

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Chinese Medical Journal 2022年第10期135卷 1258-1260页

作者： Xinyu Qi Qixing ie Yanli Pang Jie Qiao Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing100191 China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing100191 China Key Laboratory of Assisted Reproduction Peking UniversityMinistry of EducationBeijing100191 China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing100191 China Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking UniversityBeijing100191 China Key Laboratory of Molecular Cardiovascular Science Peking UniversityMinistry of EducationBeijing100191 China

To the Editor:Polycystic ovary syndrome(PCOS)is a complex endocrine and metabolic disorder affecting women in the reproductive age,with a prevalence of 5.61%.However,the pathogenesis of this complex and heterogeneous endocrinopathy remains ***-ple studies have found that the amino acid metabolism of PCOS patients has significant differences from normal controls,and the abnormal amino acid metabolism may be related to insulin resistance,oxidative stress,and even ovulatory dysfunction in PCOS patients.

关键词： metabolism patients pathogenesis

‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel

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Journal of Molecular Cell Biology 2022年第1期14卷 47-55页

作者： Qiansen Zhang Jie Fu Shaoying Zhang Peipei Guo Shĳie Liu Juwen Shen Jiangtao Guo Huaiyu Yang Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China

Two-pore domain potassium (K2P) channels gate primarily within the selectivity filter, termed ‘C-type’ gating. Due to the lack of structural insights into the nonconductive (closed) state, ‘C-type’ gating mechanisms remain elusive. Here, molecular dynamics (MD) simulations on TREK-1, a K2P channel, revealed that M4 helix movements induce filter closing in a novel ‘deeper-down’ structure that represents a ‘C-type’ closed state. The ‘down’ structure does not represent the closed state as previously proposed and instead acts as an intermediate state in gating. The study identified the allosteric ‘seesaw’ mechanism of M4 helix movements in modulating filter closing. Finally, guided by this recognition of K2P gating mechanisms, MD simulations revealed that gain-of-function mutations and small-molecule activators activate TREK-1 by perturbing state transitions from open to closed states. Together, we reveal a ‘C-type’ closed state and provide mechanical insights into gating procedures and allosteric regulations for K2P channels.

关键词： K2P state selectivity filter C-type gating

Studies on the anti-aging properties of bovine whey supplementation on reproductive hormonal profiles and sperm structure and function of adult and senile rats

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Food Bioscience 2022年第1期45卷 301-312页

作者： Norhan TAH.Kandil Dalia AA.Sabry Nermeen ie.Ashry Hassan IH.El-Sayyad Zoology Department Faculty of ScienceMansoura UniversityEgypt

The purpose of this study was to investigate how well whey might protect against aging related alterations in sperm structure,seminal and antioxidant enzymes and serum hormonal *** Wistar albino rats aged 8 and 30-months were divided into two primary groups with or without whey supplementation(n=8).After the experiments of whey supplementation,the rats were euthanized,blood was collected,and serum was *** ultrastructure and flow cytometry of annexin-V and mitochondrial membrane potential were carried *** antioxidant and malondialdehyde concentrations were *** hormonal profiles of testosterone,growth(GH),follicle stimulating hormone(FSH),luteinizing hormone(LH)and thyroid stimulating hormone(TSH)as well as pituitary gland ultrastructure were *** showed that whey supplementation improved the structure and function of sperm and seminal fluid as well as the serum hormonal levels of *** aged rats,whey supplementation increased the serum levels of GH,FSH,LH and TSH as well as seminal superoxide *** supplementation also caused reduction of seminal alkaline and acid phosphatases and lipid peroxidation in aged rat compared to that in adult *** also improved sperm motility and viability but reduced sperm abnormalities by increasing sperm mitochondrial membrane potential and lowering annexin v *** conclusion,whey contains antioxidant components that alleviated oxidative stress involved in damaging sperm macromolecules during aging process.

关键词： Aging Sperm Seminal fluid Pituitary Hormones