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Incidental focal colorectal ^(18)F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography

World Journal of Gastroenterology 2013年第22期19卷 3453-3458页

作者： Soung Hoon Cho Sang Woo Kim Won Chul Kim Jae Myung Park ie ryung yoo Sung Hoon Kim Seong Taek Oh Division of Gastroenterology Department of Internal Medicine Seoul St. Mary's Hospital The Catholic University of Korea Seoul 137-701 South Korea Department of Radiology Seoul St. Mary's Hospital The Catholic University of Korea Seoul 137-701 South Korea Department of Surgery Seoul St. Mary's Hospital The Catholic University of Korea Seoul 137-701 South Korea

AIM: To assess the clinical significance of incidental focal colorectal 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake on 18 F-FDG-positron emission tomography/computed tomography (PET/CT). METHODS: The records of all the cases which had undergone colonoscopy after PET/CT within a two weeks interval were reviewed. Adenomas were considered advanced when they were villous, ≥ 10 mm in size, or had high-grade dysplasia. Colorectal cancers and advanced adenomas are collectively referred to as advanced colorectal neoplasms. Receiver-operating characteristic curve analysis was used to determine thesignificant predictive maximum standardized uptake value (SUVmax) cutoff value for advanced colorectal neoplasms and cancer. RESULTS: Ninety-five colorectal lesions matched the site of incidental focal colorectal 18 F-FDG uptake on PET/CT and 146 did not. Colonoscopy showed advanced colorectal neoplasms corresponding to the site of 18 F-FDG uptake in 49 of the 95 (51.5%) lesions with incidental uptake. Of the lesions without incidental uptake, only 6 of 146 (4.1%) had advanced colorectal neoplasms on colonoscopy, indicating a statistically significant difference between the two groups (P < 0.001). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of incidental focal 18 F-FDG uptake in identifying advanced colorectal neoplasms were 89.1%, 75.3%, 51.6%, 95.9%, and 78.4%, respectively. In detecting only CRC, these values were 89.2%, 69.6%, 34.7%, 97.3%, and 72.6%, respectively. The significant SUVmax cutoff value for advanced colorectal neoplasms (area under the curve 0.755, P < 0.001) was 4.35, with a sensitivity, specificity, PPV, NPV, and accuracy of 75.5%, 65.2%, 69.8%, 71.4% and 70.5%, respectively. For CRC, 5.05 was the significant SUVmax cutoff value (area under the curve 0.817, P < 0.001), with a sensitivity, specificity, PPV, NPV, and accuracy of 84.8%, 71.0%, 80.9%, 89.8%, and 75.8%, respectively. CONCLUSION: The prese

关键词： Positron emission tomography Adenomas Computed tomography Colorectal cancer Colonoscopy

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Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

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World Journal of Gastroenterology 2012年第36期18卷 5072-5077页

作者： Jang Eun Lee Sang Woo Kim Jin Su Kim Kyu Yong Choi Won Kyung Kang Seong Taek Oh ie ryung yoo Sung Hoon Kim Department of Internal Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea Department of Surgery College of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea Department of Radiology Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of South KoreaSeoul 137-701South Korea

AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography(FDG-PET)/computed tomography(CT) in patients with resectable colorectal ***:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were *** data including pathologic stage at presentation,histology,treatment,disease-free survival and the maximum standardized uptake value(SUVmax) of the primary tumor on FDG-PET/CT were retrospectively *** follow up duration was 756(range,419-1355).The primary end point was disease-free ***:Twenty-five of 163 patients(15.3%) had *** median SUVmax values of the recurrence and no-recurrence groups were 8.9(range,5-24) and 8.2(range,0-23,P = 0.998).Receiver operating characteristic(ROC) curve analysis showed no significant association between SUVmax and recurrence(area under the curve = 0.5,P = 0.998,95% CI:0.389-0.611).Because a statistically significant value was not found,SUVmax was dichotomized at its median of *** disease-free survival curve was analyzed using the median SUVmax(8.6) as the cut *** and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different(P = 0.52,P = 0.25).CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival.

关键词： Positron-emission tomography Colorectalneoplasms Disease-free survival Recurrence Prognosis

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Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第25期18卷 3215-3222页

作者： Myeong Jun Song Si Hyun Bae ie ryung yoo Chung-Hwa Park Jeong Won Jang Ho Jong Chun Byung Gil Choi Hae Giu Lee Jong Young Choi Seung Kew yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Nuclear Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM： To investigate the correlation of 18F-fluorodeoxy- glucose （18F-FDG） positron emission tomography （PET） with clinical features and the prediction of treatment response. METHODS： A total of 83 hepatocellular carcinoma （HCC） patients undergoing 18F-FDG PET before transar- terial chemolipiodolization with systemic chemo-infusion between October, 2006 and May, 2009 were retrospec-tively enrolled. The patients included 68 men and 15 women （mean age, 60 ~ 10.7 years）. The effect of 18F- FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors. The PET parameters of maximal standardized uptake value of the tumor （Tsuvmax）, the ratio of the tumor maximal standardized uptake value （SUV） to the liver maximal SUV （Tsuvmax/Lsuwax） and the ratio of tumor maximal SUV to the liver mean SUV （msuvmax/LSUVrnean） were tested as predictive factors. RESULTS： Among the 3 SUV parameters, the TSUV- =maxdLsuvmean ratio （cutoff value of 1.90） was significantly associated with tumor burden including tumor size, tu- mor number, α-fetoprotein levels and tumor stage （P 〈 0.001, P = 0.008, P = 0.011, P 〈 0.001, respectively）. The objective response rates in patients with a high SUV ratio （≥ 1.90） were significantly better than those with a low SUV ratio （〈 1.90）（P = 0.020）. The overall survival rates of patients exhibiting a low Tsuvmax/Lsu- Vmean ratio （〈 1.90） and those with a high SUV ratio （≥1.90） was 38.2 and 10.3 mo, respectively （P 〈 0.01）. However, the time to progression showed no significant difference between the groups （P = 0.15）. CONCLUSION： 18F-FDG PET can be an important predictor of HCC treatment. In particular, the Tsuvmax/ Lsuwean ratio （cutoff value of 1.90） can provide useful information in treatment prognosis for HCC patients treated with Iocoregional therapy.

关键词： 18F-fluorodeoxyglucose positron emissiontomography Transarterial chemolipiodolization withsystemic chemo-infusion Treatment response Predic-tive factor, Overall survival

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卵巢恶性肿瘤患者治疗后FDGPET/CT显像的临床意义

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中华核医学与分子影像杂志 2017年第6期37卷 382-382页

作者：唐军 Eun Ji Han Hye Lim Park Yong Seok Lee Eun Kyung Park Min Jong Song ie ryung yoo Sung Hoon Kim Woo Hee Choi 苏州大学附属第二医院核医学科 Department of Radiology Daejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT... 详细信息

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT显像结果与患者总体生存率的关系。结果 268例卵巢恶性肿瘤患者[平均年龄（50±13）岁]共行416次PET/CT显像,其中87次（21%）结果阳性,329次结果阴性;灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为98.8%、98.2%、98.3%、93.1%和99.7%。362次随访显像中,38次（11%）的显像结果使患者治疗决策发生了改变;54次因临床有可疑征象而进行的PET/CT显像中,9次（17%）显像排除了肿瘤复发。PET/CT显像后进行了中位时间26.7个月的随访,24例（9%）患者在随访期内死亡。单因素分析结果发现,患者年龄、国际妇产科联盟（FIGO）分期、复发病史和PET/CT显像结果均与患者的总体生存率相关。多因素分析结果显示,PET/CT显像结果与患者的总体生存率相关（P<0.05）。结论卵巢恶性肿瘤治疗后FDG PET/CT是诊断复发和第二原发肿瘤的有效方法,其便于对患者采用更合适的治疗手段,并能帮助预测预后。

关键词： FDG PET/CT 复发性卵巢恶性肿瘤诊断准确性预后

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Virological response to adefovir monotherapy and the risk of adefovir resistance

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World Journal of Gastroenterology 2011年第30期17卷 3526-3530页

作者： Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul yoo Joon Hyeok Lee Hyang ie Lee Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine135-710 SeoulSouth Korea Department of Internal Medicine Eulji University Hospital302-799 DaejeonSouth Korea

AIM:To evaluate virological response to adefovir(ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine(LAM)-resistant chronic hepatitis B ***:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for>96 wk were analyzed for ADV ***:At week 48 and 96,eight(10%)and 14(18%)of 77 LAM-resistant patients developed the ADV-resistant strain(rtA181V/T and/or rtN236T mutations),*** B virus(HBV)DNA levels during therapy were significantly higher in patients who developed ADV resistance than in those who did *** of ADV resistance at week 96 was 11%,8%and 6%among patients with complete virological response(HBV DNA levelients with partial virological response(HBV DNA level≥60 to 2000 IU/mL);and 32%,34% and 33%among patients with inadequate virological response(HBV DNA levels>2000 IU/mL)at week 12,week 24 and week 48,*** DNA levels >2000 IU/mL at week 24 showed best performance characteristics in predicting ADV ***:Development of ADV resistance mutations was associated with HBV DNA levels,which could identify patients with LAM resistance who are likely to respond to ADV monotherapy.

关键词： Hepatitis B virus Viral DNA Adefovir Lamivudine Drug resistance

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韩国的汉字使用政策及小学汉字教育研究

韩国的汉字使用政策及小学汉字教育研究

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作者：刘美龄（yoo MI ryung）山东大学

学位级别：硕士

本文将重点探究汉字教育对提高韩国语水平的影响,通过把握当前韩国小学汉字教育的现状,从汉字教育的重要性和必要性出发,甄选出适用于全国的基础汉字并构建完备的汉字教育体制。笔者认为这是十分必要的,以此为基础,本文还将探讨适用于... 详细信息

本文将重点探究汉字教育对提高韩国语水平的影响,通过把握当前韩国小学汉字教育的现状,从汉字教育的重要性和必要性出发,甄选出适用于全国的基础汉字并构建完备的汉字教育体制。笔者认为这是十分必要的,以此为基础,本文还将探讨适用于小学阶段的汉字教育方案。在过去的几千年间,韩民族在语言上使用韩国语,同时也在文字上使用汉字。即使在世宗大王颁布了训民正音之后,汉字词都在韩民族的文字和语言生活中占据着核心地位。另外,韩国语中有百分之七十以上的词汇都是汉字词,这些汉字词既是韩国语的核心又是韩国语的重要组成部分。因此,现实生活中汉字教育的重要性也就不言而喻了。汉字是一种全球化文字,目前全世界一半以上人口都在使用。汉字还在韩国语的词汇体系中占据着重要部分,与韩国语有着不可分割的关系。利用汉字,韩国的先辈们不仅编纂了那些承载其思想和情感的史料和典籍,还为后人留下了不计其数的文献和名著。我们不仅可以通过文字教育继承前人的思想,还可以取其精华,去其糟粕,加以优化改善,使其成为韩国未来社会发展的智慧源泉。由此可见,汉字和汉文教育在韩国人的日常生活中极具实用价值,其必要性自然可见一斑。当今时代是一个高度产业化的时代,也是一个全球化和专业化的时代。中国、韩国和日本等国家在东亚政治经济文化领域发挥着核心作用。为了进一步推动各国间频繁的经济交流,汉字教育不仅极具必要性,而且也是社会发展的迫切需要。近几年来,中韩两国政治外交日渐紧密,两国贸易额也大幅增长。尤其是亚洲,不认识汉字就很难进行正常的文化交流。然而,汉字在韩国的使用范围却在不断萎缩。究其缘由,虽然一部分受到韩国语固有词的影响,但是其根源则是忽略汉字教育的重要性和必要性的语言文字政策。当前,社会和公共教育中对汉字和汉文的认识比以往任何时候都高。在这种社会氛围的感染下,小学汉字教育的必要性一直受到热议。因此,本文的主旨就在于通过分析当前韩国汉字教育的现状,探讨为什么在小学阶段一定要进行汉字教育以及汉字教育的重要性和必要性。汉字词占据了韩国语词汇总量的百分之七十之多,通过学习和熟识汉字可以更加明确地理解韩国语词汇的含义,所以在早期教育阶段,学习汉字将事倍功半。事实上,最适合学习语言的时期就是青春期之前接受小学教育的时期。因为,此时人体大脑的灵活性最强,学习外语的速度更快且效果更好。所以,汉字教育从小学阶段就开始实施是非常可取的。如果我们能从小就接受韩国语教育的同时,接受汉字教育,学习语言的难度将大幅减小,学生理解韩国语的能力也将大幅提高。小学时期是接触汉字的第一个阶段。目前,韩国语词汇中相当大的一部分都是汉字词,如果不能良好地掌握汉字词,学生就无法准确地理解韩国语的意义。尤其是在小学国语、数学、社会、科学等学习过程中,学生遇到的生活用语和专业性强的专业用语大部分都是汉字词。由此可见,只有展开与汉字词相关的教育,学生才能够更加准确地理解韩国语,并且丰富韩国人的语言生活。另外,在小学教授汉字词时,教师们应尽其所能地多教一些汉字。在过去很长一段时间里,相关学术领域和专家学者都大力推崇在小学阶段实施汉字教育。为了推进小学阶段的汉字教育,专家学者们坚持不懈地努力开展相关研究。由此可见,在小学实施汉字教育迫在眉睫。目前,有越来越多的学校开始利用自由课时间和早自习时间指导学生学习汉字。很多学校虽然已经意识到了汉字教育的必要性,也实施了汉字教育,但是因为既定正规课程已经确定,且汉字不是正规课程,所以效果并不理想。目前,很多因素阻碍着小学阶段汉字教育的开展,例如,专业教师不足、学校教材不统一、教育行政问题、教育质量和水平差异、学习激励机制不完善、基础教育阶段应学汉字不明确以及缺乏连贯性等等。与初高中教育课程不同,小学阶段对汉字教育的需求最为迫切。然而,实际情况却不容乐观,目前韩国小学不仅没有系统的汉字教育课程,甚至没有国家指定的应学基础汉字。学界和研究人员曾指出,目前的教育体系存在问题,并做出了大量先行研究。然而,国家层面付出的努力实在不尽如人意,令人倍感惋惜。施行汉字教育不仅能够提高学生的语言运用能力,而且可以帮助学生学习其他学科。因此,即将实施的小学教科书汉字表记,就是为了让学生通过理解教科书上表记的汉字并认知韩国语词汇,从而在学习课文的过程中提高语言表达能力,并在此过程中学会对多种类型的文章批判地理解和接受词汇。这与国语科教学课的目标相一致。在二十一世纪,汉字教育将会成为韩国小学的正规教育科目。我们必须要大胆改进语言文字政策,才能使汉字教育更具发展活力,才能使小学阶段的汉字教育早日成为现实。

关键词：提高国语能力小学汉字教育汉字词汉字表记汉字教育的必要性提高语言运用能力

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