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2015年辽宁省阜新蒙古族自治县塔尺营子遗址试掘报告

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边疆考古研究 2019年第1期 1-52页

作者：滕铭予吉迪苏军强 ido wachtel Ahiad OVADIA Ofer MARDER 涂栋栋 Roi SHAVIT 马志坤陈秋荷杨晓燕 Chris J.Stevens Dorian Q.Fuller 王震王争王欢向明文崔嵩姚崇 Hagit PRIGOJIN Tiki STEINER Keren NEBENHAUS 刘西平吉林大学长春130012 耶路撒冷希伯来大学耶路撒冷91000 辽宁省文物考古研究所沈阳110003 本·古里安大学贝尔谢巴84001 西北大学文化遗产学院文化遗产研究与保护技术教育部重点实验室西安710069 中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟院重点实验室北京100101 中国科学院大学北京100049 中国科学院青藏高原研究所中国科学院高寒生态重点实验室北京100101 中国科学院青藏高原地球科学卓越创新中心北京100101 英国伦敦大学院大学考古研究所伦敦WC1H0AL 阜新市文物管理办公室阜蒙县博物馆美国匹兹堡大学

自2012年起,吉林大学和辽宁省文物考古研究所合作开展了"中国东北地区农业与定居的起源"项目,在阜新查海遗址的东部地区进行了区域性田野考古调查[1]。2015年,为了进一步了解阜新地区新石器时代不同阶段古代居民的经济生活,在前期进行... 详细信息

自2012年起,吉林大学和辽宁省文物考古研究所合作开展了"中国东北地区农业与定居的起源"项目,在阜新查海遗址的东部地区进行了区域性田野考古调查[1]。2015年,为了进一步了解阜新地区新石器时代不同阶段古代居民的经济生活,在前期进行的区域性田野考古调查工作的基础上,选择了贾家沟西遗址(田野调查时遗址编号为12D56)和塔尺营子遗址(田野调查时遗址编号为12D16)进行了试掘。本文是塔尺营子遗址的试掘报告。

关键词：兴隆洼文化植硅体分析附加堆纹阜新蒙古族自治县

Reply to Letter by Dr. Christoph Kupferschmid： Commentary on ＂Countries with high circumcision prevalence have lower prostate cancer mortality＂

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Asian Journal of Andrology 2016年第6期18卷 950-951页

作者： Mitchell S wachtel Shengping Yang Brian J Morris Texas Tech University Health Sciences Center Lubbock Texas USA School of Medical Sciences University of Sydney Sydney New South Wales Australia

Dear Editor, We thank Dr. Kupferschmid for his interest in our study, which examined male circumcision （MC） and prostate cancer mortality〉2 Considerable strong evidence has been accumulated since 1951.3 Most of his references4-10 do not address MC and the risk of death from prostate cancer. That is a different question than MC and the risk of developing prostate cancer, which none of his references validly assess. One reference addressed bacterial colonization,6 not prostate cancer. Another7 concerned sexually transmitted infections and prostate cancer.

关键词： EPIDEMIOLOGY RISK

Hepatoid carcinoma of the pancreas:a case report

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Chinese Medical Journal 2007年第20期120卷 1850-1852页

作者： LIU Chong-zhong HU San-yuan WANG Lei ZHI Xu-ting JIN Bin ZHU Min Mitchell S. wachtel Eldo E. Frezza Department of General Surgery Qilu Hospital Shan Dong University Jinan 250012 China Texas Tech University Health Sciences Center Texas 79415 USA

In 1970, a gastric adenocarcinoma patient with increased alpha fetoprotein （AFP） in his serum and liver metastatic tumor was reported by Bourreilile et al. At that time, it was realized that a gastric adenocarcinoma could produce AFP. In 1985, Ishikura et al reported a hepatocellular carcinoma （HCC）-like differentiation in a primary gastric tumor and first proposed the conception of a ＂hepatoid carcinoma＂. Subsequent documentation of this unique histopathologic feature has been made in other extrahepatic sites including the esophagus, papilla of Vater, colon, lung, gallbladder, adrenal gland, kidney, urinary bladder, ovary, uterus, vagina, testicle, and small intestine. However, the number of cases is very small. Hepatoid carcinoma is a primary extrahepatic neoplasm exhibiting features of hepatocellular carcinoma in terms of morphology, immunohistochemistry and biological behavior. But histopathologically it is very rare. Many but not all cases, present with an elevated serum AFP. Taking a wide view of various literatures it is evident that hepatoid carcinoma has mostly been found in the stomach and very rarely in the pancreas. To date, only eight cases of hepatoid carcinoma of the pancreas have been reported in the literature. We present a case of hepatoid carcinoma of the pancreas arising in an elderly man without evidence of residual disease eight months after local resection of the tumor.

关键词： hepatoid carcinoma pancreas alpha fetoprotein

Laparoscopic splenectomy： a 12-year single-center experience

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Chinese Medical Journal 2008年第8期121卷 766-768页

作者： CHEN Bo HU San-yuan WANG Lei WANG Ke-xin ZHANG Guang-yong ZHANG Hai-feng XUAN Shi-jin Mitchell S. wachtel Eldo E. Frezza Department of General Surgery Qilu Hospital of Shangong University Jinan Shandong 250012 China Department of General Surgery Linyi People's Hospital Linyi Shandong 276000 China Department of Pediatric Surgery Jinan Central Hospital affiliated to Shandong University Jinan Shandong 250013 China Department of Pathology Texas Tech University Health Sciences Center Lubbock Texas 79415 USA Department of General Surgery Texas Tech University Health Sciences Center Lubbock Texas 79415 USA

In 1991, Delaitre and Maignien performed the first splenectomy with a laparoscope. Laparoscopic splenectomy （LS） is now an accepted alternative to open splenectomy, but questions still remain, such as the appropriate manner in which to position the patient, the best means of assuring hemostasis, and whether LS can be performed in cases of splenomegaly.

关键词： splenectomy laparoscopy operative procedures

Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities

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Chinese Medical Journal 2008年第20期121卷 1969-1974页

作者： WANG Tian-tian Eldo E Frezza MA Rong HU San-yuan LIU Chong-zhong ZHANG Guang-yong Mitchell S. wachtel LU Xiao-mei FENG Jin-bo LU Cui-xia Department of General Surgery Qilu Hospital Shandong University Jinan Shandong 250012 China Texas Tech University Health Sciences Center Lubbock TX 79430 USA Department of Gynecology Jinan Central Hospital Jinan Shandong 250013 China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Jinan Shandong 250012 China Division of Statistics Shandong Center for Disease Control and Prevention Jinan Shandong 250012 China

Background WWOX and FHIT are two candidate tumor suppressor genes located in active fragile sites, the damage of which has been associated with the development of breast cancer. The association of the expression of these genes and the development of breast cancer has not been fully explored. We evaluated mRNA and protein expression of WWOX and FHIT in breast tissue with normal histological appearances, atypical ductal hyperplasia, ductal carcinoma in situ, and invasive cancer to see if a progressive decline in expression was present. Methods Reverse transcription-polymerase chain reaction and Western blotting were used to evaluate the specimens for mRNA and protein expression, including 28 specimens with normal tissue, 28 specimens with atypical ductal hyperplasia, 33 specimens with ductal carcinoma in situ, and 51 specimens with invasive ductal carcinoma. Results Compared with in situ and invasive cancer specimens, both normal and atypical hyperplasia specimens had greater rates of detectable mRNA （WWOX rate ratio=2.95, 95% CI 1.24-7.08; FHIT rate ratio=4.58, 95% CI 1.82-11.81） and Western blotting detectable protein （WWOX rate ratio=4.12, 95% CI 1.63-10.73; FHIT rate ratio=3.76, 95% CI 1.44-10.06）. For both proteins, differences between normal and atypical hyperplasia specimens and between in situ and invasive carcinoma specimens were explainable by chance （P 〉0.05 for each analysis）. Within each histological category, differences among fractions of specimens showed that FHIT and WWOX mRNA and protein expression were explainable by chance （P 〉0.05 for each analysis）. Conclusion Expression of FHIT and WWOX decreases along with breast tissue progress from a normal histological appearance to atypical ductal hyperplasia, in situ cancer, and the final invasive cancer.

关键词： breast neoplasms chromosome fragile sites tumor suppressor genes carcinogens

易用性与联通性——无线系统是今天对明天的回答

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A&S（安全&自动化） 2005年第9期 136-138页

作者： Alan wachtel

用户们对于产品的了解以及需求总是随着科技的飞速发展而改变。在美国家居网络市场（包括家用及办公用），无线网络系统的使用率已经达到52%。虽然其他国家在这方面比美国要落后，但是这种差距正在快速缩小。

关键词：无线系统易用性通性无线网络系统网络市场办公用使用率美国

Y（V1-xPx）O4:Eu3++SiO2磷光体

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发光学报 1976年第1期 4-5页

作者： A.wachtel 美国西屋研究实验室

根据过去Corth等人对YVO4:Eu—SiO2系统的研究,以过量很多SiO2的稀释这种磷光体会使荧光减少,但如按单位面积磷光体的减少量来计算,荧光减少的量还应比这大得多。本文作者的工作肯定了上述结果,

关键词：磷光体 SiO2 荧光弱光 V1-xPx)O4 媒熔剂助熔剂

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 237-251页

作者： Yangzom D.Bhutia Jiro Ogura Paul J.Grippo Carolina Torres Toshihiro Sato Mitchell wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam Devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju Jaya P.Gnana-Prakasam Vadivel Ganapathy Department of Cell Biology and Biochemistry Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Pharmaceutical Sciences Tohoku University Hospital1-1 Seiryo-machiAoba-kuSendaiMiyagi 980-8574Japan Department of Medicine University of Illinois at ChicagoChicagoIL 60607USA Department of Surgical Pathology Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Biological Sciences Texas Tech UniversityLubbockTX 79410USA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79410USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA Department of Ophthalmology St.Louis UniversitySt.LouisMO 63104USA

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.

关键词： SLC7A11 p53 Iron Heme Epithelial-mesenchymal transition

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国际学生在美国校园面临的挑战

湖南城市学院学报 2013年第6期34卷 84-89页

作者： David wachtel 陈学谦美国肯塔基州莱克星顿蓝草社区与技术学院湖南师范大学外国语学院长沙410081

进入美国高校学习的国际学生人数在逐年增加。他们在身份和文化背景方面存在着很大差异。在美学习期间,他们可能会遭遇到许多因为文化差异所带来的许多问题。同时,在生活和学习中也会遇到各种各样的挑战。

关键词：国际学生文化问题个人问题学习问题挑战