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多发性硬化症患者生活质量问卷的跨文化适应性和有效性:一项在土耳其多发性硬化症样本中进行的研究

世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 56-56页

作者： idiman e Uzunel F Ozakbas S. 蔡同建 Dokuz eylü l University Faculty of Medicine Department of Neurology Balcova 35340 Inciralti Izmir Turkey

Objective: Multiple sclerosis (MS) is a chronic progressive disease with multiple neurological impairments. The disease can also dramatically affect the health-related quality of life of patients. The objective of this study was to investigate the validation of the translated and cross-culturally adapted MSQOL- 54 in 183 Turkish MS patients. Methods: 183 adults classified as having definite MS patients were enrolled into the study. Patients were classified into four severity groups according to the expanded disability status scale (eDSS); group I(eDSS 0- 4), group II (eDSS 4.5- 5.5), group III (eDSS 6- 6.5) and group IV (eDSS 7- 8). MSQOL- 54 questionnaire were translated and culturally adapted into Turkish. Associations between age, gender, disease duration,eDSS score, marital status, education and health insurance and the MSQOL- 54 physical and mental health composite scores were determined. Results: The mean age of the 183 patients (138 female and 45 male) was 39 ± 10 years. The questionnaire was well accepted but small cultural adaptations were required. eDSS scores showed significant associations with the MSQOL- 54 physical and mental health composite scores. From the different eDSS groups only, the group I (eDSS 0- 4) score was significantly associated with the physical health composite as well as the disease duration showed significant correlation with the physical and mental composite scores. None of the other eDSS groups and the other parameters showed correlation with physical health composite or mental health composite. Conclusion: Assessment of quality of life of MS patients in addition to disease severity and disability level is important, because it provides unique information that is important to patients and to clinicians. A translation of an existing MS-targeted HRQOL measure from US english into Turkish was easily administered and well accepted in a Turkish MS sample.

关键词：生活质量问卷多发性硬化症成年患者土耳其适应性跨文化健康相关生活质量身体健康状况精神健康状况慢性进行性疾病

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