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Titanium-coated polypropylene mesh as innovative bioactive material in conservatives mastectomies and pre-pectoral breast reconstruction

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Bioactive Materials 2021年第12期6卷 4640-4653页

作者： Pietro Gentile Marco Bernini Lorenzo Orzalesi Silvia Sordi icro meattini Francesca Lessi Ashutosh Kothari Claudio Calabrese Department of Surgical Science University of Rome“Tor Vergata”Rome00133Italy Breast Surgery Breast UnitOncology DepartmentCareggi University Hospital50134FlorenceItaly Department of Experimental and Clinical Biomedical Sciences“M.Serio” University of Florence Radiation Oncology Unit-OncologyCareggi University HospitalFlorenceItaly Fondazione Pisana per la Scienza onlus Pisa 56122Italy Breast Surgery Unit Guy’s HospitalGuy’s and St.Thomas’NHS Foundation TrustLondonUnited Kingdom San Rossore Breast Unit Pisa 56122Italy

Breast reconstruction is rapidly evolving,thanks to the growing acceptance of synthetic meshes as innovative biomaterials.276 patients undergoing mastectomy(total of 328 mastectomies)were analyzed in a retrospective observational study to evaluate the pre-pectoral immediate breast reconstruction(IBR)using an implant wrapped with Titanium-Coated Polypropylene Mesh(TCPM)*** treated with tissue expander(TE),equally placed pre-pectorally(and wrapped with the same TCPM in 74.3%of the control group’breasts).163 patients,of the study group(SG),underwent mastectomy and pre-pectoral IBR with implant wrapped with TCPM,in a one-step surgery,called direct-to-implant technique(DTI),while 113 patients control group(CG)underwent mastectomy and *** technique has been performed in 192 breasts of the SG while TE procedure in 136 breasts of the *** BREAST-Q questionnaire has been provided before the treatment and 2 years *** scale has been used to evaluate capsular ***,surgical,and aesthetic outcomes along with BREAST-Q scores were ***,a histologic evaluation was conducted in 11 capsules’samples randomly chosen(6 derived from SG patients and 5 derived from CG).Complications were recorded in 43 cases(29SG-14CG):8 skin-nipple necrosis(5SG-3CG),8 wound dehiscence(6SG-2CG),3 hematomas(1SG-2CG),and 24 infections(8SG-16CG).Grade IV capsular contracture was detected in 9 breasts(1SG-8CG),whereas 254 breasts were grade I(110SG-144CG),33(10SG-23CG)grade II,and 32(4SG-28CG)grade *** wrinkling was detected in 18 cases(10SG-8CG)after 30 *** local tumor recurrence rate was 5.8%.Three recurrences were on the nipple-areola complex(1.9%).SG patients showed significantly higher rates in the BREAST-Q overall Satisfaction with Outcome(74.1),overall Satisfaction with Breasts(69.1),Psychosocial Well-being(81.9),and Sexual Well-being(63.1),versus CG’s patients(p<0.05).Histological analysis showed a process of normal tissue repair with

关键词： Mastectomy Pre-pectoral breast reconstruction Titanium-coated polypropylene mesh Immediate breast reconstruction

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Accuracy of Ultrasound Examination of Loco-Regional Lymph Nodes in Breast Cancer Follow-Up and Its Role in the Axillary Surgical Management

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Advances in Breast Cancer Research 2014年第1期3卷 5-11页

作者： Jacopo Nori icro meattini Dalmar Abdulcadir Elisabetta Giannotti Diego De Benedetto Luis Sanchez Lorenzo Orzalesi Simonetta Bianchi Leonardo Capaccioli Lorenzo Livi Breast Unit Department of Surgery and Translational Medicine AOU Careggi Florence Italy Department of Radiology AOU Careggi Florence Italy Diagnostic Senology Unit AOU Careggi Florence Italy Pathological Anatomy Unit Department of Surgery and Translational Medicine AOU Careggi Florence Italy Radiotherapy Unit Clinical Physiopathology Department AOU Careggi Florence Italy

Objective: Major international guidelines have not standardized the sequence of diagnostic examinations during the follow-up of a patient with a diagnosed breast cancer. The aim of this study is to investigate the accuracy of sonography in the diagnosis of loco-regional lymphatic recurrences in comparison to the core needle biopsy results. Materials and Methods: Among 6455 patients who were followed up with clinical examination, mammography and ultrasound between January 2004 and November 2011, 125 (1.93%) patients had to be investigated with a core needle biopsy of a sonographically suspicious loco-regional lymph node. Results: Among the whole series, a total of 142 ultrasound-guided core needle biopsies were performed. Follow-up for the primary tumor lasted for a median time of 6.1 years (range 1 - 27 years). Ultrasound of suspicious loco-regional lymph nodes showed a sensitivity of 89.5%, a specificity of 87.1% and a positive predictive value of 89.5%. Conclusions: In our experience, ultrasound of suspicious loco-regional lymph nodes showed good accuracy and it should be a part of the standard examinations performed during follow-up for breast cancer.

关键词： Ultrasound Loco-Regional Lymph Nodes Breast Cancer Follow-Up Sentinel Node Dissection Axillary Surgery

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Medical Students’Views on Psychiatry in Germany and Italy:Survey

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International Journal of Mental Health Promotion 2023年第9期25卷 985-993页

作者： Andy Man Yeung Tai Janet Suen Mostafa Mamdouh Kamel Georg Schomerus Angelo Giovanni icro Maremmaniz Reinhard Michael Krausz Department of Psychiatry Faculty of MedicineUniversity of British ColumbiaVancouverCanada Department of Neuropsychiatry Tanta UniversityTanta31511Egypt Department of Psychiatry University of LeipzigLeipzig04109Germany Azienda Ospedaliera Universitaria Pisana Health Universitaria PisanaPisa56126Italy

Objectives:In 2019,the Insititue for Health Metrics and Evaluation reported that 16%of life lost were attributed to mental *** a result,global shortage of psychiatrists is a pressing issue due to the increasing burden of mental *** 2016,a mere 5%of US medical students chose psychiatry as a career,a trend mirrored in Germany and *** the medical students of 2016 have graduated or transitioned into residency in 2023,their attitudes towards psychiatry could have contributed to today’s shortage of *** global mental health burden has only been exacerbated by the COVID-19 *** study explores the attitudes of German and Italian medical students towards psychiatry,their career aspirations,and the influence of factors such as personal experience and education on their interest in the ***:A cross-sectional survey was conducted among 799 medical students in two European countries in *** answered questions about their attitudes towards psychiatry,their psychiatric education,and personal *** analyses were performed using chi-square tests and a significance level of ***:The number of years in medical school,personal experiences,and perceived quality of education significantly affected specialty choice and ranking of psychiatry compared to other ***,psychiatric placements,and views on psychiatric instructors also played a significant role in choosing psychiatry as a ***:Assessing medical students’attitudes towards psychiatry and the factors that influence their career choices,such as psychiatric education and personal experiences,can inform changes to attract students to the *** the worldwide shortage of psychiatrists is crucial to reduce the burden of mental health and substance use disorders.

关键词： Medical students psychiatry lived experiences stigma education

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