检索结果-南通市图书馆

Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins

引用

Journal of Pharmaceutical Analysis 2023年第3期13卷 305-314页

作者： Chi soo Park Minju Kang Ahyeon kim Chulmin Moon Mirae kim Jieun kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung kim Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974Republic of Korea

Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to ***-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-Ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been *** this study,N-glycans of CTLA4-Igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage *** linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion *** isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization *** sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated *** study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein.

关键词： Therapeutic glycoprotein Sialylation Linkage isomer LC-MS/MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis and characterization of red-emitting Yb/Ho-CaSiO3 upconversion phosphors

引用

Progress in Natural Science:Materials International 2022年第5期32卷 594-601页

作者： Bina Chaudhary Yuwaraj K.Kshetri Dhani Ram Dhakal soo Wohn Lee Tae-Ho kim Department of Fusion Science and Technology Sun Moon University Research Center for Green Advance Materials Sun Moon University Department of Environmental and Bio-Chemical Engineering Sun Moon University

Host material plays an important role in obtaining efficient photon upconversion and downshifting ***, fluoride and oxyfluoride glasses-based materials are used for high-efficiency photon ***, the poor thermal stability of fluoride glasses and the toxicity of fluorine ions limit their applications. In this report, Yb/Ho-doped CaSiO3wollastonite phosphors have been demonstrated as efficient red-emitting upconversion phosphors. The phosphors have been synthesized by microwave hydrothermal process followed by heat treatment at 1050°C in the air environment. 2M phase of the β-wollastonite has been confirmed by X-ray diffraction and Raman spectroscopy while the existence of the Yb and Ho dopants in the CaSiO3lattice has been confirmed by X-ray photoelectron spectroscopy. The synthesized samples showed strong red upconversion emission centered at 662 nm and near-infrared downshifting emissions at 2016 nm upon 980 nm excitation. The emissions were found to depend significantly on the Ho concentration. Temporal evolution of the main emission bands was investigated to show that the energy transfer upconversion from Yb to Ho ions was responsible for the efficient upconversion and downshifting phenomenon.

关键词： Wollastonites Upconversion Downshifting Red-emitting phosphors

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A Review on Interface Engineering of MXenes for Perovskite Solar Cells

引用

Nano-Micro Letters 2023年第8期15卷 270-308页

作者： Srikanta Palei G.Murali Choong‑Hee kim Insik In Seul‑Yi Lee soo‑Jin Park Department of Chemistry Inha University100 InharoIncheon 22212South Korea Department of Polymer Science and Engineering Department of IT‑Energy Convergence(BK21 Four)Chemical Industry InstituteKorea National University of TransportationChungju 27469South Korea

With an excellent power conversion efficiency of 25.7%,closer to the Shockley–Queisser limit,perovskite solar cells(PSCs)have become a strong candidate for a next-generation energy ***,the lack of stability and reliability in PSCs remained challenging for ***,such as interfacial and structural engineering,have a more critical influence on enhanced ***,two-dimensional materials,have emerged as promising materials in solar cell applications due to their metallic electrical conductivity,high carrier mobility,excellent optical transparency,wide tunable work function,and superior mechanical *** to different choices of transition elements and surface-terminating functional groups,MXenes possess the feature of tuning the work function,which is an essential metric for band energy alignment between the absorber layer and the charge transport layers for charge carrier extraction and collection in ***,adopting MXenes to their respective components helps reduce the interfacial recombination resistance and provides smooth charge transfer paths,leading to enhanced conductivity and operational stability of *** review paper aims to provide an overview of the applications of MXenes as components,classified according to their roles as additives(into the perovskite absorber layer,charge transport layers,and electrodes)and themselves alone or as interfacial layers,and their significant importance in PSCs in terms of device performance and ***,we discuss the present research status and future directions toward its use in PSCs.

关键词： MXenes Perovskite solar cells Additives Interfacial layer Electrodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new analytical approach for identifying market contagion

引用

Financial Innovation 2022年第1期8卷 1097-1131页

作者： Hee soo Lee Tae Yoon kim Department of Business Administration Sejong University209 Neungdong-ro Gwangjin-guSeoul 05006Korea Department of Statistics Keimyung University1095 Dalgubeol-daeroDaegu 704-701Korea.

This study proposed a new analytical approach to identify the excessive comovement of two markets as *** goal is achieved by linking latent-factor and single-equation error correction models and evaluating the breaks in the short-and long-term relationships and correlatedness in the linked *** results demonstrated that a short-term relationship representing the market speed ratio between two markets plays a key role in contagion *** a long-term relationship or correlatedness is broken(comovement change)due to a break in the short-term relationship(market speed ratio),contagion is highly likely and should be formally *** posterior probabilities were calculated to determine the ***,this study applied this analytical Bayesian approach to empirically test the contagion effects of the *** market during the global financial crisis between 2007 and 2009 using 22 developed equity markets.

关键词： Contagion test Market integration Bayesian approach Comovement Market speed ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

引用

Journal of Magnesium and Alloys 2022年第9期10卷 2516-2533页

作者： Man soo Joun Mohd Kaswandee Razali Jae Dong Yoo Min Cheol kim Jeong Muk Choi ReCAFT Gyeongsang National UniversityGraduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea Gyeongsang National University Graduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea MFRC Research CenterJinju 52818South Korea Jinhap Daejeon 34302South Korea

Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated *** traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain *** coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural ***,metallurgy-related values can be calculated directly from the flow stress *** the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range.

关键词： Flow stress Power law model Piecewise bilinear function Numerical analysis Microstructural prediction Peak strain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enabling Digital Earth simulation models using cloud computing or grid computing-two approaches supporting high-performance GIS simulation frameworks

引用

International Journal of Digital Earth 2013年第4期6卷 383-403页

作者： ick-Hoi kim Ming-Hsiang Tsou Department of Geography San Diego State UniversitySan DiegoCAUSA

Geospatial simulation models can help us understand the dynamic aspects of Digital *** implement high-performance simulation models for complex geospatial problems,grid computing and cloud computing are two promising computational *** research compares the benefits and drawbacks of both in Web-based frameworks by testing a parallel Geographic Information System(GIS)simulation model(Schelling’s residential segregation model).The parallel GIS simulation model was tested on XSEDE(a representative grid computing platform)and Amazon EC2(a representative cloud computing platform).The test results demonstrate that cloud computing platforms can provide almost the same parallel computing capability as high-end grid computing ***,cloud computing resources are more accessible to individual scientists,easier to request and set up,and have more scalable software architecture for on-demand and dedicated Web *** advantages may attract more geospatial scientists to utilize cloud computing for the development of Digital Earth simulation models in the future.

关键词： grid computing cloud computing parallel computing simulation model geospatial cyberinfrastructure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neotectonic transpressional intraplate deformation in eastern Eurasia: Insights from active fault systems in the southeastern Korean Peninsula

引用

Geoscience Frontiers 2023年第4期14卷 123-136页

作者： Namgwon kim Seung-Ik Park Chang soo Cho Youngbeom Cheon Alexander L.Peace Department of Geology Kyungpook National UniversityDaegu 41566Republic of Korea Earthquake Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea Active Tectonics Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea School of Earth Environment and SocietyMcMaster UniversityHamiltonON L8S 4K1Canada

Transpression occurs in response to oblique convergence across a deformation zone in intraplate regions and plate *** Korean Peninsula is located at an intraplate region of the eastern Eurasian Plate and has been deformed under the ENE–WSW maximum horizontal compression since the late *** this study,we analyzed short-term instrumental seismic(focal mechanism)and long-term paleoseis-mic(Quaternary fault outcrop)data to decipher the neotectonic crustal deformation pattern in the south-eastern Korean ***(paleo-)seismic data acquired from an NNE–SSW trending deformation zone between the Yangsan and Ulleung fault zones indicate spatial partitioning of crustal deformation by NNW–SSE to NNE–SSW striking reverse faults and NNE–SSW striking strike-slip faults,supporting a strike-slip partitioned transpression *** instantaneous and finite neotectonic strains,estimated from the focal mechanism and Quaternary outcrop data,respectively,show discrepan-cies in their axes,which can be attributed to the switching between extensional and intermediate axes of finite strain during the accumulation of wrench-dominated ***,some major faults,including the Yangsan and Ulsan fault zones,are relatively misoriented to slip under the current stress condition but,paradoxically,have more(paleo-)seismic records indicating their role in accommodating the neotectonic transpressional *** propose that fluids,heat flow,and lithospheric structure are potential factors affecting the reactivation of the relatively misoriented major *** findings provide insights into the accommodation pattern of strain associated with the neotectonic crustal extrusion in an intraplate region of the eastern Eurasian Plate in response to the collision of the Indian Plate and the sub-duction of the Pacific/Philippine Sea Plates.

关键词： Transpression Strike-slip partition Intraplate strain accommodation Fault-slip analysis Slip tendency analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reconstruction of the lower back wound with delayed infection after spinal surgery:A case report

引用

世界临床病例杂志 2023年第27期11卷 6646-6652页

作者： DoWon kim sooA Lim SuRak Eo Jung soo Yoon Department of Plastic and Reconstructive Surgery DongGuk University Ilsan HospitalGoyang 10326South Korea

BACKGROUND Orthopedic surgeries after device implantation are susceptible to infections and may require device removal in the worst *** this reason,many efforts are being made to control infections after spinal surgery;however,the number of infec-tion cases is increasing owing to the increasing number of elderly *** SUMMARY A 75-year-old male with a chronic spinal defect due to previous spine surgery underwent reconstruction using a perforator-based island *** bursectomy and confirmation that there was no connection with the deep tissue,reconstruction was ***,wound disruption occurred with abscess formation on postoperative day 29,which led to an imaging workup revealing delayed deep tissue *** Infection is one of the most common causes of surgical wound dehiscence and is associated with devastating results if not controlled promptly and *** should always suspect delayed infections when reconstructing chronic soft tissue defects.

关键词： Surgical wound dehiscence Surgical wound infection Lumbar spine Complications Abscess Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

引用

Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk kim Hyun-Ju Park Hyo Won Chang Ji Hyun Back Su Jin Lee Yae Eun Park Eun Hye kim Yeonsun Hong Gijung Kwak ick Chan Kwon Ji Eun Lee Yoon Se Lee Sang Yoon kim Yoosoo Yang Sun Hwa kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D Face Reconstruction from a Single Image Using a Combined PCA-LPP Method

引用

Computers, Materials & Continua 2023年第3期74卷 6213-6227页

作者： Jee-Sic Hur Hyeong-Geun Lee Shinjin Kang Yeo Chan Yoon soo Kyun kim Department of Computer Engineering Jeju National UniversityJeju63243Korea School of Games Hongik UniversitySejong30016Korea Department of Artificial Intelligence Jeju National UniversityJeju63243Korea

In this paper, we proposed a combined PCA-LPP algorithm toimprove 3D face reconstruction performance. Principal component analysis(PCA) is commonly used to compress images and extract features. Onedisadvantage of PCA is local feature loss. To address this, various studies haveproposed combining a PCA-LPP-based algorithm with a locality preservingprojection (LPP). However, the existing PCA-LPP method is unsuitable for3D face reconstruction because it focuses on data classification and *** the existing PCA-LPP, the adjacency graph, which primarily shows the connectionrelationships between data, is composed of the e-or k-nearest neighbortechniques. By contrast, in this study, complex and detailed parts, such aswrinkles around the eyes and mouth, can be reconstructed by composing thetopology of the 3D face model as an adjacency graph and extracting localfeatures from the connection relationship between the 3D model *** verified the effectiveness of the proposed method. When theproposed method was applied to the 3D face reconstruction evaluation set,a performance improvement of 10% to 20% was observed compared with theexisting PCA-based method.

关键词： Principal component analysis locality preserving project 3DMM face reconstruction face modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：