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Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer

World Journal of Gastroenterology 2008年第31期14卷 4880-4888页

作者： Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama Departments of Surgery Graduate School of Medicine Gunma University Gunma 371-8511 Japan Departments of Tumor Pathology Graduate School of Medicine Gunma University Gunma 371-8511 Japan Laboratory of Molecular and Genetic Information Institute for Molecular and Cellular Biosciences University of Tokyo Tokyo 113-0032 Japan

AIM： To investigate the clinical significance of BMP and activin membrane-bound inhibitor （BAMBI） which is a pseudoreceptor of transforming growth factorbeta （TGF-β） type 1 receptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers （CRCs）. We studied BAMBI expression in CRCs. METHODS： We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β- catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison ***： Immunohistochemical analysis revealed that BAMBI expression was observed in 148 （80.8%）, and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis （TNM） stage （P 〈 0.05）. Clear associations were found between BAMBI and β-catenin （P = 0.035） and p53 （P =0.049） expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% （P = 0.037） for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox＇s multivariate analysis, lymph node metastases （relative risk 6.685; P 〈 0.001） and depth of invasion （RR 14.0; P = 0.013） were significant indicators for recurrence, and strong BAMBI expression （RR 2.26; P = 0.057） tended to be significant. CONCLUSION： BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC.

关键词： BMP and activin membrane-bound inhibitor Colorectal cancer Transforming growth factor-beta signal Prognosis Wnt signal

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Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy

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World Journal of Gastroenterology 2017年第35期23卷 6437-6447页

作者： Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita Department of Radiology Center of Advanced MedicineNippon Medical School Department of Radiology Ebina-Sogo Hospital Department of Radiology Tamanagayama HospitalNippon Medical School Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical School Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School

AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B *** The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR *** Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients.

关键词： Hepatocellular carcinoma location Transarterial chemoembolization efficacy Child-Pugh Modified response evaluation criteria in solid tumors Central zone Peripheral zone

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Successful outcome of retrograde pancreatojejunostomy for chronic pancreatitis and infected pancreatic cysts:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7224-7230页

作者： Koichi Kimura Eisuke Adachi Ayako Toyohara Sachie Omori Kaoru Ezaki Ryo Ihara Takahiro Higashi Kippei Ohgaki Shuhei Ito Shin-ichiro Maehara Toshihiko Nakamura Yoshihiko Maehara Department of Surgery Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan Department of Internal Medicine Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan

BACKGROUND Chronic pancreatitis occasionally requires surgical treatment that can be performed with various ***,this type of surgery presents with postoperative *** report a case of a successful retrograde pancreatojejunostomy for chronic pancreatitis and infected pancreatic *** SUMMARY A 62-year-old male with a 10-year history of chronic pancreatitis presented with epigastric pain for one week and a 20 kg weight loss over one *** tomography showed stones in the pancreas(mainly the head),expansion of the main pancreatic duct,and thinning of the pancreatic *** resonance imaging showed infected pancreatic cysts connected to the stomach with a fistula from the splenic hilum to the caudal portion of the liver’s lateral *** endoscopic retrograde pancreatography was performed;the guide wires could not pass through the stones in the pancreas and therefore,drainage of the main pancreatic duct was not ***,a distal pancreatomy and splenectomy were performed;however,the pancreatic juice in the remaining parenchyma was blocked by the ***,we performed a retrograde pancreatojejunostomy and Roux-en-Y *** patient had no postoperative complications and was discharged from the hospital on postoperative day *** A distal pancreatomy,retrograde pancreatojejunostomy,and Roux-en-Y anastomosis could be an effective surgical procedure for intractable chronic pancreatitis.

关键词： Chronic pancreatitis Infected pancreatic cyst Distal pancreatomy Retrograde pancreatojejunostomy Pancreatic stones Case report

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活性炭纤维纸板作双层电容器的可极化电报

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新型炭材料 1992年第2期8卷 34-38页

作者： ichiro TANAHASHI 朱卉云

活性炭纤维纸作为双层电容器的可极化电极而得到了发展。ACF纸板由活性炭纤维(ACF)炭纤维(CF)和纸浆通过抄纸工艺而制作.ACF纸板的特殊表面积与ACF的含量成正比,ACF纸板的电阻随着沥青型CF的加入而显著降低。天然浆是粘结ACF纸板的合适... 详细信息

活性炭纤维纸作为双层电容器的可极化电极而得到了发展。ACF纸板由活性炭纤维(ACF)炭纤维(CF)和纸浆通过抄纸工艺而制作.ACF纸板的特殊表面积与ACF的含量成正比,ACF纸板的电阻随着沥青型CF的加入而显著降低。天然浆是粘结ACF纸板的合适材料。制作的双层电容器的电容量和ACF含量成正比,阻抗主要受CF的种类和含量的影响。电容器在-25-80℃范围内显示出较好的性能和较好的充放电特点(10000次循环)。

关键词：活性炭纤维电容器电极

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添加酚醛树脂调制煤焦油沥青

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新型炭材料 1991年第2期7卷 16-17,11页

作者： ichiro Veno 梁德儒

一、引言对于像C-C复合材料这样的高性能产品,基体粘合剂性质的控制是非常重要的,它直接影响成焦后的炭收率及光学组织结构。作者发展了一种沥青与酚醛树脂混合新技术,混合物成焦后能得到最大炭收率和细镶嵌结构。

关键词：酚醛树脂煤焦油沥青

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A Filtering Effect on Evolution of Magnetostatic Wave Envelope Solitons

A Filtering Effect on Evolution of Magnetostatic Wave Envelo...

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1996年中日联合微波技术会议

作者： Ken’ichiro Yashiro Sumio Ohkawa Graduate School of Science and Technology Chiba UniversityChiba 260Japan

＜正＞Taking account of the fact that iniignetostatic waves arc highly dispersive,a new equation governing magnetostatic wave envelope *** has been derived and it has been applied to study on a filtering effect on an ...

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Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

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World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

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Strain Induced Metastable Phase and Phase Revolution in PbTiO3-CoFe204 Nanocomposite Film

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Chinese Physics Letters 2014年第1期31卷 174-177页

作者：胡传圣罗震林孙霞潘国强何庆文闻周兴泰 ichiro Takeuchi 高琛 National Synchrotron Radiation Laboratory & School of Nuclear Science and Technology University of Science and Technology of China Hefei 230026 Department of Physics University of Science and Technology of China Hefei 230026 Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences P. O. Box 800-204 Shanghai 201800 Department of Materials Science and Engineering University of Maryland College Park Maryland 20742 USA Department of Materials Science and Engineering & CAS Key Laboratory of Materials for Energy Conversion University of Science and Technology of China Hefei 230026

An inter-component epitaxial strain-induced PbTiOa metastable phase is observed in a PbTiO3-GoFe2O4 epitaxial composite film, corresponding to the dielectric anomaly reported previously. High-resolution synchrotron radiation X-ray diffraction and first principles calculation demonstrate the coexistence of different PbTi03 phases, even a possible morphotropie phase boundary in the film, elucidating the underlying microscopic rneehanism of the formation of Pb TiO3 metastable phase. This sheds light on the design and manipulation of electromechanical properties of epitaxial films, through the strain engineering.

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Developments and Applications of Supported Liquid Phase Catalysts

Developments and Applications of Supported Liquid Phase Cata...

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中国化学会第九届全国络合催化学术讨论会

作者： Shin-ichiro Fujita Masahiko Arai Division of Chemical Process Engineering Graduate School of Engineering Hokkaido UniversitySapporo 060-8628Japan Division of Chemical Process Engineering Graduate School of Engineering Hokkaido UniversitySapporo 060-8628Japan

＜正＞It is of practical importance to use heterogeneous catalytic reactions in organic synthesis for easy catalyst - product separation and catalyst recovery and recycling and various techniques are applicable to heterogenize the catalytic reaction systems. When an organometallic catalyst is used, a liquid - liquid biphasic system is useful and easy to prepare and handle. In many cases, water and

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EXPERIMENTAL STUDY ON COOLABILITY CHARACTERISTICSOF PARTICULATE CORE-METAL DEBRIS BED WITHOXIDIZATION PART2:ZIRCALOY-2 DEBRIS BED

EXPERIMENTAL STUDY ON COOLABILITY CHARACTERISTICSOF PARTICUL...

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第十三届国际核工程大会

作者： Hiroomi Aoki Ken-ichiro Sugiyama Hokkaido University Hokkaido University

＜正＞ In order to understand the appearance and disappearance of hot spot in the TMI-2 accident, the coolability characteristics of Zircaloy-2 particulate debris bed into which vapor and water penetrate are studied in the present paper. In the vapor penetration experiment, it is found that Zircaloy-2 debris particles are effectively broken into small pieces by oxidization of vapor flow with 20cm/s in short time period on the condition of an

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