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Correlation of prefrontal activity measured by near-infrared spectroscopy (NIRS) with mood, BDNF genotype and serum BDNF level in healthy individuals

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Open Journal of Psychiatry 2012年第3期2卷 194-203页

作者： Daisuke Matsuzawa Kotaro Takeda Hiroyuki Ohtsuka Jun Takasugi Takashi Watanabe Junko Maeda Saeka Nagakubo Chihiro Sutoh ichiro shimoyama Ken Nakazawa Eiji Shimizu Clinical Research Center National Hospital Organization Murayama Medical Center Tokyo Japan Department of Cognitive Behavior Physiology Graduate School of Medicine Chiba University Chiba Japan Section for Human Neurophysiology Frontier Medical Engineering Chiba University Chiba Japan

Depression has been known to reduce the prefrontal activity associated with the execution of certain cognitive tasks, although whether a temporarily depressed or anxious mood in healthy individuals affects the prefrontal blood oxygen level during cognitive tasks is unknown. Combining the measurement of prefrontal activity with near-infrared spectroscopy (NIRS) and the two cognitive tasks, namely the letter version of the verbal fluency test (VFT-l) and the Stroop test, we measured the effect of a depressed or anxious mood and gender on the changes in the prefrontal oxygenated hemoglobin (Oxy-Hb) levels during those cognitive tests in healthy individuals. Depressed mood or anxious mood was assessed by the Hospital Anxiety and Depression Scale (HADS). Thereby we aimed to explore the possibility of NIRS measurement for detecting the early subclinical manifestation of major depression. Moreover, we examined the possible relationships between prefrontal activation and the functional Val66Met polymorphisms of the brain derived neurotropic factor (BDNF) gene and serum BDNF level. As a result, the increased prefrontal Oxy-Hb levels during cognitive tasks were significantly correlated with the severity of depressed mood in males. The course of the prefrontal Oxy-Hb increase was different depending on the cognitive tasks, i.e., the VFT-l or the Stroop test, in both genders. Correlations of BDNF genotype and serum BDNF level with the prefrontal Oxy-Hb levels during those cognitive tasks were negative. Our results suggest that the early subclinical manifestation of depressed mood in males might be detected by the NIRS measurement, which is not correlated with the individual properties of BDNF.

关键词： Near-Infrared Spectroscopy (NIRS) Depression Anxiety Brain Derived Neurotropic Factor (BDNF)

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Rational double points on Enriques surfaces

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Science China Mathematics 2021年第4期64卷 665-690页

作者： ichiro Shimada Department of Mathematics Graduate School of ScienceHiroshima UniversityHigashi-Hiroshima 739-8526Japan

We classify,up to some lattice-theoretic equivalence,all possible configurations of rational double points that can appear on a surface whose minimal resolution is a complex Enriques surface.

关键词： Enriques surface rational double points hyperbolic lattice

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Dual ultracontractivity and its applications

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Frontiers of Mathematics in China 2014年第4期9卷 899-928页

作者： ichiro SHIGEKAWA Department of Mathematics Kyoto University Kyoto 606-8502 Japan

The ultracontractivity is well studied and several equivalent conditions are known. In this paper, we introduce the dual notion of the ultracontractivity, which we call the dual ultracontractivity. We give necessary and sufficient conditions for the dual ultracontractivity. As an application, we discuss one-dimensional diffusion processes. We can write the conditions for the dual ultracontractivity in terms of speed measures.

关键词： Dual ultracontractivity one-dimensional diffusion processes Nashinequality interpolation

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Using sorbents to control heavy metals and particulate matter emission during solid fuel combustion

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Particuology 2009年第6期7卷 477-482页

作者： Hong Yao ichiro Naruse State Key Laboratory of Coal Combustion Huazhong University of Science and Technology Wuhan 430074 China Department of Mechanical Science & Engineering Nagoya University Nagoya 464-8603Japan

Some of the heavy metals in coal and wastes vaporize during combustion, concentrate in fine particulates, and emit with the flue gas into the atmosphere, to produce adverse effect on environment and health. This study first investigates the fate of the heavy metal species, especially Pb, Cd and Cr, known as semi-volatile, in various flue gases, especially in the presence of HCI and SO2, by chemical equilibrium calculation, in which, Si and Ca were proposed as base sorbent materials to capture Pb, Cd and Cr. Then Si- and Ca-based compounds as well as waste materials used as sorbents were optimized to capture the heavy metals. Finally, the optimal sorbent was tested in actual burning of dried sewage sludge as solid fuel, to evaluate the effectiveness of the sorbent. Calculated results show that Cl increases the volatility of most heavy metals, while SO2 enhances formation of condensed phases. Among the sorbents tested, kaolin appears most efficient to capture Pb and Cd. For sludge combustion with kaolin addition, both Pb and Cd were shifted from sub-micron to macro-sized particles, and accompanied by considerable decrease of 0.1 μm particles.

关键词： Combustion Heavy metal Paniculate matter Sorbent

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Some Issues on the Strength of the Lithosphere

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Journal of Earth Science 2011年第2期22卷 131-136页

作者： Shun-ichiro Karato Department of Geology and Geophysics Yale University

The strength of the oceanic and continental lithosphere has important controls on some of the major geological processes on earth including the operation of plate tectonics and the long-term stability of the continental roots. However, explaining these major geological features from the experi- mental and theoretical studies on the strength of rocks is challenging and some of the existing models for the strength of the lithosphere do not explain these main geological observations. A brief review is provided to summarize recent progress in these areas with the emphasis on experimental studies.

关键词： lithosphere plate tectonics continent.

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Silent microscopy to explore a brain that hears butterflies'wings

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Light(Science & Applications) 2022年第6期11卷 1026-1028页

作者： Shin-ichiro Terada Masanori Matsuzaki Department of Physiology Graduate School of MedicineThe University of TokyoTokyoJapan Brain Functional Dynamics Collaboration Laboratory RIKEN Center for Brain ScienceSaitamaJapan International Research Center for Neurointelligence(WPI-IRCN) The University of Tokyo Institutes for Advanced StudyTokyoJapan

A silent two-photon laser-scanning microscopy system,which eliminates mechanical vibrations in the audible range,has enabled the detection of auditory cortical neurons with responses at sound pressure levels as low as... 详细信息

关键词： eliminate system sound

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Statistical evaluation of cluster formation of relapse in neuromyelitis optica spectrum disorder

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Neural Regeneration Research 2024年第9期19卷 1888-1889页

作者： Tetsuya Akaishi ichiro Nakashima Department of Neurology Tohoku UniversitySendaiJapan Department of Neurology Tohoku Medical and Pharmaceutical UniversitySendaiJapan

Evaluating the cluster formation of clinical attacks in chronic relapsing diseases is an important statistical issue because the presence of attack clusters may influence therapeutic strategies for relapse *** recently reported the occurrence of unevenly clustered attacks in patients with anti-aquaporin-4(AQP4)antibody-positive neuromyelitis optica spectrum disorder(NMOSD)(Akaishi et al.,2020a).

关键词： AQP4 relapse

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Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators

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Asian Journal of Andrology 2023年第2期25卷 158-165页

作者： Sayuri Takahashi ichiro Takada Department of Urology The Institute of Medical ScienceThe University of TokyoShirokanedaiMinato-kuTokyo 108-8639Japan Department of Urology The Faculty of MedicineThe University of TokyoHongoBunkyo-kuTokyo 113-8655Japan

Prostate cancer is one of the most common diseases in men ***,radiation therapy,and hormonal therapy are effective treatments for early-stage prostate ***,the development of castration-resistant prostate cancer has increased the mortality rate of prostate *** develop novel drugs for castration-resistant prostate cancer,the molecular mechanisms of prostate cancer progression must be *** the signaling pathways regulating prostate cancer development,recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family(WNT)signaling pathways,mainly that involving WNT5A,in prostate cancer progression and metastasis;however,its role remains ***,chromatin remodelers such as the switch/sucrose nonfermentable(SWI/SNF)complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression ***,we review the roles of noncanonical WNT signaling pathways,chromatin remodelers,and epigenetic enzymes in the development and progression of prostate cancer.

关键词： chromatin remodeling histone-modifying enzymes prostate cancer WNT5A

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Siltation and radiocesium pollution of small lakes in different catchment types far from the Fukushima Daiichi nuclear power plant accident site

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International Soil and Water Conservation Research 2020年第1期8卷 56-65页

作者： Mikhail Komissarov Shin-ichiro Ogura Ufa Institute of Biology Russian Academy of SciencesPr.Oktyabrya 69Ufa450054Russia Graduate School of Agricultural Science Tohoku University232-3 YomogitaNaruko-onsenOsaki989-6711Japan

The Fukushima Daiichi nuclear power plant accident caused radioactive pollution in northeastern Honshu Island,*** study examined the influence of snowmelt and rainfall on soil erosion pro-cesses and siltation of small lakes in Miyagi Prefecture(150 km northwest of the power plant).Two sets of slopes and lakes,respectively in pasture and forest catchments,were *** thickness,soil infiltration,surface runoff volume,soil and sediment physicochemical properties,Cs concentration of precipitation,meltwater,and rainwater,and lake siltation rates were *** total radioactive Cs content in precipitation was 0.7-7.4 Bq·L^-1 and was below the Japanese standard(10 Bq·L^-1).Total radioactive Cs was at the allowable level in water flowing down the pasture catchment slope(0.1-9.2 Bq·L^-1)during snowmelt and rainfall,as well as in pasture(0.9-8.8 Bq·L^-1)and forest(0.7-5.2 Bq·L^-1)catchment lake *** was no soil erosion(surface runoff)in the forest *** losses in the pasture catchment were 23 due to rainfall and 9 kg ha^-1 yr^-1 following spring *** snow-melt,a 0.5 and 0.2 mm thick layer of silt was deposited in pasture and forest catchment lakes,respec-tively,and 1.4 and 0.6 mm were deposited during the rainfall *** siltation rates were 1.9 and 0.8 mm·yr^-1 for pasture and forest catchment lakes,*** upper layer of lake bottom sedi-ments is represented mainly by silt fractions(2-50μm),with high organic matter(4.0-5.7%)and radiocesium(1100-1600 kg·ha^-1)contents.

关键词： Fukushima Daiichi Radiocesium Siltation Suspended sediment Waterbodies Water turbidity

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Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia

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Neural Regeneration Research 2021年第10期16卷 1928-1934页

作者： Haruka Mizobuchi Gen-ichiro Soma Control of Innate Immunity Technology Research AssociationKagawaJapan Macrophi Inc. KagawaJapan Research Institute for Healthy Living Niigata University of Pharmacy and Applied Life SciencesNiigataJapan

Microglia,which are tissue-resident macrophages in the brain,play a central role in the brain innate immunity and contribute to the maintenance of brain *** is a component of the outer membrane of gram-negative bacteria,and activates immune cells including microglia via Toll-like receptor 4 *** is generally known as an endotoxin,as administration of highdose lipopolysaccharide induces potent systemic ***,it has long been recognized that lipopolysaccharide exacerbates *** contrast,our study revealed that oral administration of lipopolysaccharide ameliorates Alzheimer’s disease pathology and suggested that neuroprotective microglia are involved in this ***,other recent studies have accumulated evidence demonstrating that controlled immune training with low-dose lipopolysaccharide prevents neuronal damage by transforming the microglia into a neuroprotective ***,lipopolysaccharide may not a mere inflammatory inducer,but an immunomodulator that can lead to neuroprotective effects in the *** this review,we summarized current studies regarding neuroprotective microglia transformed by immune training with *** state that microglia transformed by lipopolysaccharide preconditioning cannot simply be characterized by their general suppression of proinflammatory mediators and general promotion of anti-inflammatory mediators,but instead must be described by their complex profile comprising various molecules related to inflammatory regulation,phagocytosis,neuroprotection,anti-apoptosis,and *** addition,microglial transformation seems to depend on the dose of lipopolysaccharide used during immune *** training of neuroprotective microglia using lowdose lipopolysaccharide,especially through oral lipopolysaccharide administration,may represent an innovative prevention or treatment for neurological diseases;however more vi

关键词： cognitive impairment endotoxin lipopolysaccharide low-dose microglia neuroprotection oral administration preconditioning tolerance trained innate immunity

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