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Cyberknife treatment for advanced or terminal stage hepatocellular carcinoma

World Journal of Gastroenterology 2015年第46期21卷 13101-13112页

作者： Hiroyuki Kato Hideo Yoshida Hiroyoshi Taniguch Ryutaro nomura Kengo Sato ichiro Suzuki Ryo Nakata Department of Gastroenterology Japanese Red Cross Medical Center Cyberknife Center Japanese Red Cross Medical Center

AIM: To investigate the safety and efficacy of the Cyberknife treatment for patients with advanced or terminal stage hepatocellular carcinoma(HCC).METHODS: Patients with HCC with extrahepatic metastasis or vascular or bile duct invasion were enrolled between May 2011 and June 2015. The Cyberknife was used to treat each lesion. Treatment response scores were based on Response Evaluation Criteria in Solid Tumors v1.1. The trends of tumor markers,including alpha fetoprotein(AFP) and proteins induced by vitamin K absence Ⅱ(PIVKA Ⅱ) were assessed. Prognostic factors for tumor response and tumor markers were evaluated with Fisher's exact test and a logistic regression model. Survival was evaluated with the Kaplan-Meier method and multivariate analysis was performed using the Cox proportional hazards ***: Sixty-five patients with 95 lesions were enrolled. Based on the Barcelona Clinic Liver Cancer classification,all patients were either in the advanced or terminal stage of the disease. The target lesions were as follows: 52 were bone metastasis; 9,lung metastasis; 7,brain metastasis; 9,portal vein invasion;4,hepatic vein invasion; 4,bile duct invasion; and 10 other lesion types. The response rate and disease control rate were 34% and 53%,respectively. None of the clinical factors correlated significantly with tumor response. Fiducial marker implantation was associated with better control of both AFP(HR = 0.152; 95%CI: 0.026-0.887; P = 0.036) and PIVKA Ⅱ(HR = 0.035; 95%CI: 0.003-0.342; P = 0.004). The median survival time was 9 mo(95%CI: 5-15 mo). Terminal stage disease(HR = 9.809; 95%CI: 2.589-37.17,P < 0.001) and an AFP of more than 400 ng/m L(HR = 2.548; 95%CI: 1.070-6.068,P = 0.035) were associated with worse survival. A radiation dose higher than 30 Gy(HR = 0.274; 95%CI: 0.093-0.7541,P = 0.012) was associated with better survival. In the 52 cases of bone metastasis,36 patients(69%) achieved pain relief. One patient had cerebral bleeding and another patient ha

关键词： Hepatocellular carcinoma Stereotactic body radioth

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Postoperative functional evaluation of gastrectomy for gastric cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 567-574页

作者： Eiji nomura Department of Gastroenterological and General Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

To improve the quality of surgical procedures for gastric cancer,it is essential to consider many components comprehensively,including gastric motility,small intestinal absorption,hormones that affect gastric motility and appetite,presence or absence of vagus nerve preservation,esophageal regurgitation on endoscopic findings,in addition to whether or not there is a physiological route for food passage through the ***,proper functional evaluation cannot be performed without considering the form and amount of energy in the nutritional supplement to be loaded,and the posture at the time of *** results of functional evaluation vary according to the method selected from many available options,but we believe that use of the most physiologically accurate,appropriate and selectable option will enable us to arrive at the best resection/reconstruction *** have reported that it is important to consider the preservation of three elements when performing gastrectomy:1)reduction of the extent of gastrectomy,2)preservation of the pylorus,and 3)preservation of the vagus nerve;among which preservation of the remnant stomach is the most ***,the selection of a reconstruction method that maintains secretion of hormones beneficial to gastric motility preserves the energy balance inherent in the human body,and also provides better quality of life.

关键词： Gastric cancer gastrectomy functional evaluation

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(Arylimido)vanadium(V)-Alkylidene Complexes as Catalysts for Ring-opening Metathesis Polymerization(ROMP) of Cyclic Olefins: Ligand Design for Exhibiting the High Activity

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Chinese Journal of Polymer Science 2019年第10期37卷 943-950,I0002页

作者： Kotohiro nomura Sapanna Chaimongkolkunasin Department of Chemistry Graduate School of Science Tokyo Metropolitan University

(Imido)vanadium(V)-alkylidene complexes of type V(CHSiMe3)(NR)(OR?)(PMe3)2 [R = Ad, C6H5, 2,6-Me2C6H3, 2,6-Cl2C6H3;R?= 2,6-Me2C6H3, 2,6-i Pr2C6H3, 2,6-F2C6H3, C6F5, C6Cl5] exhibited from moderate to remarkable catalytic activities for ringopening metathesis polymerization(ROMP) of norbornene(NBE). The catalytic activities were affected by the ligand substituents, and V(CHSiMe3)(N-2,6-Cl2C6H3)(OC6X5)(PMe3)2(X = F, Cl) demonstrated the exceptionally high catalytic activities for ROMP of *** complexes polymerized cycloheptene(CHPE) and cis-cyclooctene(COE), and ROMP of COE by the OC6 Cl5 analogue proceeded in a living manner even at 80℃, and the activity increased with increasing the temperature up to 120 ℃. Highly active catalysts for ROMP of cyclic olefins(NBE, cyclopentene, and CHPE) can be generated in situ by premixing isolated V(CHSiMe3)(NC6F5)(O-2,6-iPr2C6H3)(PMe3)2 with 1.0 equiv. of C6F5OH or C6Cl5OH via immediate phenoxy exchange;the activity was affected by the kind of phenol added [TOF in the ROMPs of NBE: 4.62 × 10^4 min^–1(upon addition of C6F5OH) versus 37.3 min^–1(none)].

关键词： Olefin metathesis Molecular catalyst Ring-opening metathesis polymerization Cyclic olefin Vanadium catalyst

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NONBRIDGED HALF-TITANOCENES CONTAINING ANIONIC ANCILLARY DONOR LIGANDS:PROMISING NEW CATALYSTS FOR PRECISE SYNTHESIS OF CYCLIC OLEFIN COPOLYMERS(COCs)

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Chinese Journal of Polymer Science 2008年第5期26卷 513-523页

作者： Kotohiro nomura Graduate School of Materials Science Nara Institute of Science and Technology(NAIST)Japan

Precise,efficient copolymerizations of ethylene with cyclic olefins[norbornene(NBE),cyclopentene(CPE)]using nonbridged half-titanocenes of type,Cp TiCl_2(L)(Cp =cyclopentadienyl group,L=aryloxo,ketimide)-MAO catalyst systems have been ***_2(N=C Bu_2)exhibited both remarkable catalytic activity and efficient NBE incorporation for ethylene/NBE copolymerization:the NBE incorporation by Cp TiCl_2(X)(X=N=C Bu_2,O-2,6- Pr_2C_6H_3; Cp =Cp,C_5Me_5,indenyl)was related to the calculated coordination ene...

关键词： Titanium Cyclic olefin copolymers Copolymerization Ethylene Homogeneous catalysts

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Tentative New Terminology: Initial Comedonal Phase Preceding Acute Inflammatory Phase of Acne Vulgaris—Importance of Early Treatment

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 179-181页

作者： ichiro Kurokawa Yuko nomura Toshitatsu Nogita Department of Dermatology Meiwa Hospital Nishinomiya Japan nomura Dermatology Clinic Yokohama Japan Shinjuku Minamiguchi Dermatology Clinic Tokyo Japan

We report a case of a 12-year-old female with closed and open comedo without inflammatory lesions at the first visit. She had been treated with topical adapalene once daily, and closed and open comedo subsided without inflammatory lesions one month after the treatment without any side effects induced by adapalen. The recurrence of comedo had not been observed afterwards. In the Japanese Dermatological Association (JDA) guidelines for the treatment of acne vulgaris, comedonal phase has not been stated. Then we propose the tentative new terminology of a comedonal phase and emphasize its importance in the early initial treatment for comedo to prevent the development of the acute inflammatory phase such as red papules and pustules and formation of acne scars.

关键词： Comedonal Phase New Terminology Early Initial Treatment

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Linear seesaw model with a modular S_(4)flavor symmetry

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Chinese Physics C 2022年第5期46卷 11-19页

作者： Takaaki nomura Hiroshi Okada College of Physics Sichuan UniversityChengdu 610065China Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We discuss a linear seesaw model with a field content as minimum as possible,introducing a modular S_(4)using gauged U(1)_(B−L) *** to the rank two neutrino mass matrix,we obtain a vanishing neutrino mass eigenvalue,and only the normal mass hierarchy of neutrinos is favored via the modular S_(4)*** our numericalΔχ^(2)analysis,we especially determine a relatively sharp prediction on the sum of neutrino masses to be approximately 60 meV,in addition to other predictions.

关键词： neutrino mass linear seesaw mechanism modular S_(4)flavor symmetry

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Calcium Signaling in Plant Endosymbiotic Organelles： Mechanism and Role in Physiology

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Molecular Plant 2014年第7期7卷 1094-1104页

作者： Hironari nomura Takashi Shiinab Department of Health and Nutrition Gifu Women's University 80 Taromaru Gifu 501-2592 Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural University Sakyo-ku Kyoto 606-8522 Japan

Recent studies have demonstrated that chloroplasts and mitochondria evoke specific Ca2＋ signals in response to biotic and abiotic stresses in a stress-dependent manner. The identification of Ca2＋ transporters and Ca2＋signaling mol- ecules in chloroplasts and mitochondria implies that they play roles in controlling not only intra-organellar functions, but also extra-organellar processes such as plant immunity and stress responses. It appears that organellar Ca2＋ signaling might be more important to plant cell functions than previously thought. This review briefly summarizes what is known about the molecular basis of Ca2＋ signaling in plant mitochondria and chloroplasts.

关键词： biotic stress abiotic stress calcium signaling calcium transport CAS chloroplast mitochondria.

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A multi-charged particle model with local U(1)_(μ-τ) to explain muon g-2,flavor physics,and possible collider signature

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Chinese Physics C 2022年第4期46卷 57-69页

作者： Nilanjana Kumar Takaaki nomura Hiroshi Okada Department of Physics and Astrophysics University of DelhiDelhi 110007India School of Physics KIASSeoul 02455Korea Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We consider a model with multi-charged particles,including vector-like fermions,and a charged scalar under a local U(1)_(μ−τ) *** search for an allowed parameter region explaining muon anomalous magnetic moment(muon g−2)and b→sℓ^(+)ℓ^(−) anomalies,satisfying constraints from the lepton flavor violations,Z boson decays,meson anti-meson mixing,and collider *** numerical analysis,we explore the typical size of the muon g−2 and Wilson coefficients to explain the b→sℓ^(+)ℓ^(−) anomalies in our model when all other experimental constraints are ***,we discuss the collider physics of the multicharged vectorlike fermions,considering a number of benchmark points in the allowed parameter space.

关键词： new gauge boson new gauge symmetry muon anomalous magnetic moment B meson decay anomalies collider physics

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Gene expression during genital morphogenesis in the ground beetle Carabus maiyasanus

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Insect Science 2020年第5期27卷 975-986页

作者： Shota nomura Tomochika Fujisawa Teiji Sota Department of Zoology Graduate School of ScienceKyoto UniversitySakyoKyotoJapan

To investigate the developmental genetics of genital formation in the carabid beetle Carabus maiyasanus,we compared gene expression patterns among five stages using transcriptomic RNA sequencing data from abdominal segments and genitalia in the third(last)larval instar(including prepupa)and pupal *** identified 18839 genes,of which 10796 were differentially expressed among stages or between *** were relatively few differentially expressed genes(DEGs)between the sexes(3%).The DEGs were clustered into six groups,mainly according to stage-specific expression *** in clusters 1-3 showed high expression levels before pupation and low expression levels during the pupal period,whereas genes in clusters 46 showed high expression levels from the prepupal to the pupal *** related to the initial pupation process and differentiation of genital discs in Drosophila were involved in clusters 4 and 6 and showed low expression levels at early third instar and elevated expression levels from the early prepupal stage,suggesting that the pupation process and genital differentiation started in the prepupal *** 4 and 5 included developmental genes related to organ size control,which may be important in the formation of internal genital structures during the pupal stage.

关键词： Carabus genitalia Ohomopterus pupation RNA-seq transcriptome

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Function-preserving gastrectomy for gastric cancer in Japan

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World Journal of Gastroenterology 2016年第26期22卷 5888-5895页

作者： Eiji nomura Kunio Okajima Department of Gastroenterology and General Surgery Tokai University Hachioji Hospital Hachioji Tokyo 192-0032 Japan Emeritus professor of Osaka Medical College Takatsuki Osaka 569-8686 Japan

Surgery used to be the only therapy for gastric cancer, and since its ability to cure gastric cancer was the focus of attention, less attention was paid to functionpreserving surgery in gastric cancer, though it was studied for gastroduodenal ulcer. Maki et al developed pylorus-preserving gastrectomy for gastric ulcer in 1967. At the same time, the definition of early gastric cancer(EGC) was being considered, histopathological investigations of EGC were carried out, and the validity of modified surgery was sustained. After the development of H2-blockers, the number of operations for gastroduodenal ulcers decreased, and the number of EGC patients increased simultaneously. As a result, the indications for pylorus-preserving gastrectomy for EGC in the middle third of the stomach extended, and various alterations were added. Since then, many kinds of function-preserving gastrectomies have been performed and studied in other fields of gastric cancer, and proximal gastrectomy, jejunal pouch interposition, segmental gastrectomy, and local resection have been performed. On the other hand, from the overall perspective, it can be said that endoscopic resection, which was launched at almost the same time, is the ultimate function-preserving surgery under the current circumstances. The current function-preserving gastrectomies that are often performed and studied are pylorus-preserving gastrectomy and proximal gastrectomy. The reasons for this are that these procedures that can be performed with systemic lymph node dissection, and they include three important elements:(1) reduction of the extent of gastrectomy;(2) preservation of the pylorus; and(3) preservation of the vagal nerve. In addition, these operations are more likely to be performed with a laparoscopic approach as minimally invasive surgery. Of the above-mentioned three elements, reduction of the extent of gastrectomy is the most important in our view. Therefore, we should try to reduce the extent of gastrectomy if cu

关键词： Early gastric cancer Function-preserving gastrectomy Quality of life Laparoscopic surgery

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