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Protection-Free Site-Directed Peptide or Protein S-Glycosylation and Its Application in the Glycosylation of Glucagon-like Peptide 1

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CCS Chemistry 2022年第6期4卷 1930-1937页

作者： Gefei Li Yuankun Dao Juan Mo Suwei Dong Shin-ichiro Shoda Xin-Shan Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversityAoba-kuSendai 980-8579

The development of a facile cysteine-directed S-glycosylation strategy would facilitate the intensive investigation of the effect of glycosylation on protein translational ***,we introduce glycosyl Bunte salt as an efficient glycosyl donor for site-selective peptide/protein *** coupling reaction with cysteine thiols under alkaline buffer conditions proceeded chemoselectively,delivering homogeneous glycoconjugates and inorganic salt as the only byproduct.A series of sugar moieties,including monosaccharides and oligosaccharides,were successfully conjugated to the peptides and protein via the disulfide ***,this protocol was applied to the glycosylation of the glucagon-like peptide 1(GLP-1)variant,and its glycosylated effect on blood glucose control was also studied.

关键词： site-selective S-glycosylation peptide/protein-modification glycosyl Bunte salt disulfide bond GLP-1

Environmental pressure rather than ongoing hybridization is responsible for an altitudinal cline in the morphologies of two oaks

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Journal of Plant Ecology 2020年第4期13卷 413-422页

作者： ichiro Tamaki Yae Yamada Gifu Academy of Forest Science and Culture 88 SodaiMinoGifu 501-3714Japan

在相关类群之间的接触区,表型变异可能源于遗传和/或环境梯度。本研究旨在阐明两种栎属植物[Quercus crispula(QCC)和***(QCM)],在其接触区沿海拔梯度形成叶片形态表型变异的原因。对于源自接触区48个个体和QCC和QCM的每个参照种群24个... 详细信息

在相关类群之间的接触区,表型变异可能源于遗传和/或环境梯度。本研究旨在阐明两种栎属植物[Quercus crispula(QCC)和***(QCM)],在其接触区沿海拔梯度形成叶片形态表型变异的原因。对于源自接触区48个个体和QCC和QCM的每个参照种群24个个体样本,我们测定其6种叶片形态特征,同时记录13个核微卫星位点的基因型。我们通过构建模型解释表型变异(叶片形态)与环境(海拔)和遗传(参照种群世系)梯度的关系。研究结果表明,形态和遗传标记均能较好地区分参照种群中的两个品种。我们能够确认形态和遗传标记的作用。接触区种群内的个体具有略偏向QCM分支的中间世系,其形态分布与参照种群中两个变种的形态分布重叠。海拔会显著影响叶片形态性状,而遗传对叶片形态性状无显著影响。接触区种群的世系和种间杂合性分布与F2或后代杂交种中的分布相似。这些结果表明,在两种栎属植物QCC和QCM之间的接触区,并没有发生杂交,但环境压力通过表型可塑性和/或功能基因的变异,导致了其在形态性状上的海拔梯度效应。

关键词：栎属植物蒙古栎叶片形态微卫星杂交带

The cardiovascular action of hexarelin

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Journal of Geriatric Cardiology 2014年第3期11卷 253-258页

作者： Yuanjie MAO Takeshi Tokudome ichiro Kishimoto Department of Biochemistry National Cerebral and Cardiovascular Center Suita 0saka 565-8565 Japan Department of Medicine Prince George's Hospital Center Cheverly Maryland 20785 USA Department of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Sulfa Osaka 565-8565 Japan

Hexarelin，合成生长释放荷尔蒙的肽，能绑在并且在类似于它的自然模拟 ghrelin 的大脑激活生长荷尔蒙促泌素受体(GHSR ) 。然而，在心和血容器的 GHSR 的外部分发建议 hexarelin 可能在生长荷尔蒙版本和 neuroendocrine 效果以外有直... 详细信息

Hexarelin，合成生长释放荷尔蒙的肽，能绑在并且在类似于它的自然模拟 ghrelin 的大脑激活生长荷尔蒙促泌素受体(GHSR ) 。然而，在心和血容器的 GHSR 的外部分发建议 hexarelin 可能在生长荷尔蒙版本和 neuroendocrine 效果以外有直接心血管的行动。而且， non-GHSR CD36 被表明了是为 hexarelin 的特定的心脏的受体；并且调停它的 cardioprotective 效果。什么时候与 ghrelin 相比， hexarelin 是化学上更稳定并且机能上地更多的有势力。因此，它可以是为一些心血管的条件的一个有希望的治疗学的代理人。在这简明评论，我们为 hexarelin 的心血管的行动讨论当前的证据。

关键词：心血管作用生长激素释放肽生长素释放肽天然类似物内分泌效应保护作用分布表心脏

A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： Nobuo Sugimoto Atsushi Shimizu ichiro Matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio

CONVERGENCE ANALYSIS FOR A NONCONFORMING MEMBRANE ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2005年第4期23卷 373-382页

作者： Dong-yang Shi Shao-chun Chen ichiro Hagiwara Department of Mathematics Zhengzhou University Zhengzhou 450052 China Tokyo Institute of Technology 2-12-1 Ohokayama Megro Tokyo 152-8552 Japan

Regular assumption of finite element meshes is a basic condition of most analysis of finite element approximations both for conventional conforming elements and nonconforming elements. The aim of this paper is to present a novel approach of dealing with the approximation of a four-degree nonconforming finite element for the second order elliptic problems on the anisotropic meshes. The optimal error estimates of energy norm and L^2-norm without the regular assumption or quasi-uniform assumption are obtained based on some new special features of this element discovered herein. Numerical results are given to demonstrate validity of our theoretical analysis.

关键词： Anisotropic mesh Nonconforming finite element Optimal estimate

Impact of Jumihaidokuto(Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2019年第11期25卷 820-824页

作者： Hiroyuki Murota Hiroaki Azukizawa ichiro Katayama Department of Dermatology Course of Integrated Medicine Graduate School of Medicine Osaka University

Objective:To study the effect of Jumihaidokuto(Shi-Wei-Bai-Du-Tang,十味败毒汤)in the management of chronic spontaneous ***:A randomized two-arm,parallel group study was conducted to compare the effect of Jumihaidokuto(6 g daily)with a control for 8 *** therapy(e.g.,antihistamines)was ***?one subjects with severe chronic urticaria were enrolled in this *** primary treatment outcome was the severity score proposed by the Japanese Dermatological *** outcomes were quality of life(Skindex-16),itch intensity(Visual Analogue Scale),and patients'subjective disability due to wheal or *** the subjects were randomly assigned to groups by block randomization,10 received Jumihaidokuto,and 11 did *** subjects had already taken ***:Improvement was significant when comparing the severity score of the Jumihaidokuto group with that of the control group(P<0.01).Skindex-16 values for both groups gradually decreased in the same ***:Concomitant use of Jumihaidokuto with antihistamine was more effective than antihistamine alone in the management of chronic idiopathic urticaria.

关键词： Jumihaidokuto crude drug extract Shi-Wei-Bai-Du-Tang Chinese medicine antihistamine chronic spontaneous urticaria severity quality of life

Sepsis caused by endoscopic clipping for colonic diverticular bleeding: A rare complication

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World Journal of Gastroenterology 2009年第30期15卷 3817-3818页

作者： Keiichiro Kume Masahiro Yamasaki ichiro Yoshikawa Third Department of Internal Medicine University of Occupational and Environmental HealthJapanSchool of MedicineKitakyusyu 807-8555Japan

We herein report the rare complication of sepsis caused by endoscopic clipping for colonic diverticular bleeding. A 78-year-old man with a 12-h history of near syncope and painless hematochezia was admitted to our hospital. Following the transfusion of 4 U of blood and continued hematochezia, a colonoscopy was performed. Active bleeding was seen as continuous arterial spurting from a single diverticulum located in the middle ascending colon. This diverticulum was seamed by four endoclips. The next day, the patient became febrile with a temperature of 39.2℃. Laboratory data included a white blood cell count of 18 100/mm3 and a C-reactive protein level of 3.4 mg/dL. He was diagnosed with sepsis since Escherichia coli was detected in the blood culture. Antibiotics were started. Four days later his fever had improved and laboratory data improved 9 d later.

关键词：结肠镜败血症并发症出血内镜剪辑蛋白水平大肠杆菌

Tentative New Terminology: Initial Comedonal Phase Preceding Acute Inflammatory Phase of Acne Vulgaris—Importance of Early Treatment

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 179-181页

作者： ichiro Kurokawa Yuko Nomura Toshitatsu Nogita Department of Dermatology Meiwa Hospital Nishinomiya Japan Nomura Dermatology Clinic Yokohama Japan Shinjuku Minamiguchi Dermatology Clinic Tokyo Japan

We report a case of a 12-year-old female with closed and open comedo without inflammatory lesions at the first visit. She had been treated with topical adapalene once daily, and closed and open comedo subsided without inflammatory lesions one month after the treatment without any side effects induced by adapalen. The recurrence of comedo had not been observed afterwards. In the Japanese Dermatological Association (JDA) guidelines for the treatment of acne vulgaris, comedonal phase has not been stated. Then we propose the tentative new terminology of a comedonal phase and emphasize its importance in the early initial treatment for comedo to prevent the development of the acute inflammatory phase such as red papules and pustules and formation of acne scars.

关键词： Comedonal Phase New Terminology Early Initial Treatment

Camera array calibration for light field acquisition

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Frontiers of Computer Science 2015年第5期9卷 691-702页

作者： Yichao XU Kazuki MAENO Hajime NAGAHARA Rin-ichiro TANIGUCHI Graduate School of Information Science and Electrical Engineering Kyushu University Fukuoka 819-0395 Japan

Light field cameras are becoming popular in com- puter vision and graphics, with many research and commercial applications already having been proposed. Various types of cameras have been developed with the camera array being one of the ways of acquiring a 4D light field image using multiple cameras. Camera calibration is essential, since each application requires the correct projection and ray geometry of the fight field. The calibrated parameters are used in the fight field image rectified from the images captured by multiple cameras. Various camera calibration approaches have been proposed for a single camera, multiple cameras, and a moving camera. However, although these approaches can be applied to calibrating camera arrays, they are not effective in terms of accuracy and computational cost. Moreover, less attention has been paid to camera calibration of a light field camera. In this paper, we propose a calibration method for a camera array and a rectification method for generating a light field image from the captured images. We propose a two-step algorithm consisting of closed form initialization and nonlinear refinement, which extends Zhang＇s well-known method to the camera array. More importantly, we introduce a rigid camera constraint whereby the array of cameras is rigidly aligned in the camera array and utilize this constraint in our calibration. Using this constraint, we obtained much faster and more accurate calibration results in the experiments.

关键词： light field camera array calibration rectification digital refocusing