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temporal changes in physiological and performance responses across game-specific simulated basketball activity

Journal of Sport and Health Science 2018年第2期7卷 176-182页

作者： Aaron t.Scanlan Jordan L.Fox Nattai R.Borges Patrick S.tucker Vincent J.Dalbo Human Exercise and training Laboratory Central Queensland University Clinical Biochemistry Laboratory Central Queensland University School of Medical and Applied Sciences Central Queensland University

Purpose: the aims of this study were to:(1) provide a comprehensive physiological profile of simulated basketball activity and(2) identify temporal changes in player responses in controlled ***: State-level male basketball players(n = 10) completed 4 × 10 min simulated quarters of basketball activity using a reliable and valid courtbased test. A range of physiological(ratings of perceived exertion, blood lactate concentration([BLa~—]), blood glucose concentration([BGlu]), heart rate(HR), and hydration) and physical(performance and fatigue indicators for sprint, circuit, and jump activity) measures were collected across ***: Significantly reduced [BLa~—](6.19 ± 2.30 vs. 4.57 ± 2.33 mmol/L; p = 0.016) and [BGlu](6.91 ± 1.57 vs. 5.25 ± 0.81 mmol/L;p = 0.009) were evident in the second half. A mean HR of 180.1 ± 5.7 beats/min(90.8% ± 4.0% HR max) was observed, with a significant increase in vigorous activity(77%—95% HR max)(11.31 ± 6.91 vs. 13.50 ± 6.75 min; p = 0.024) and moderate decrease in near-maximal activity(>95% HR_(max))(7.24 ± 7.45 vs. 5.01 ± 7.20 min) in the second half. Small increases in performance times accompanied by a significantly lower circuit decrement(11.67% ± 5.55% vs. 7.30% ± 2.16%; p = 0.032) were apparent in the second ***: these data indicate basketball activity imposes higher physiological demands than previously thought and temporal changes in responses might be due to adapted pacing strategies as well as fatigue-mediated mechanisms.

关键词： Cardiovascular Game-play Hydration Rating of perceived exertion Simulation team sports

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Moving beyond hydroxychloroquine:the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies

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Cancer Communications 2019年第1期39卷 620-622页

作者： trace M.Jones Claudia Espitia Wei Wang Steffan t.Nawrocki Jennifer S.Carew University of Arizona Cancer Center TucsonAZ 85724USA Division of translational and Regenerative Medicine Department of MedicineUniversity of ArizonaTucsonAZ 85721USA Department of Pharmacology and toxicology University of ArizonaTucsonAZ 85721USA Arizona Center for Drug Discovery TucsonAZ 85721USA

Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived *** of its role in maintaining cellu-lar homeostasis,autophagy is frequently stimulated in response to stress conditions such as those imposed by chemotherapy,nutrient deprivation,and microenviron-mental *** this capacity,autophagy serves as a mechanism to generate alternative sources of metabolic fuel that promote survival when preferred energy gener-ating pathways are impaired[1].Over the past decade,stress-induced autophagy has emerged as an important driver of malignant progression and anticancer drug *** all classes of clinically relevant anti-cancer agents,as well as radiotherapy,have been dem-onstrated to stimulate autophagy in preclinical studies[2].In the overwhelming majority of cases,genetically or pharmacologically impairing autophagy has been shown to yield therapeutic benefit in a manner that significantly improves the efficacy of the relevant agents or modalities[3].

关键词： impaired autophagy beyond

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Intermediary RRt*-PSO:A Multi-Directional Hybrid Fast Convergence Sampling-Based Path Planning Algorithm

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Computers, Materials & Continua 2023年第8期76卷 2281-2300页

作者： Loc Q.Huynh Ly V.tran Phuc N.K.Phan Zhiqiu Yu Son V.t.Dao School of Industrial Engineering and Management International UniversityVietnam National University HCMCHo Chi Minh City700000Vietnam Department of Industrial Management National Taiwan University of Science and TechnologyTaipei City106335Taiwan

Path planning is a prevalent process that helps mobile robots find the most efficient pathway from the starting position to the goal position to avoid collisions with *** this paper,we propose a novel path planning algorithm-Intermediary RRt*-PSO-by utilizing the exploring speed advantages of Rapidly exploring Random trees and using its solution to feed to a metaheuristic-based optimizer,Particle swarm optimization(PSO),for fine-tuning and *** Phase 1,the start and goal trees are initialized at the starting and goal positions,respectively,and the intermediary tree is initialized at a random unexplored region of the search *** trees were grown until one met the other and then merged and re-initialized in other unexplored *** the start and goal trees merge,the first solution is found and passed through a minimization process to reduce unnecessary *** 2 begins by feeding the minimized solution from Phase 1 as the global best particle of PSO to optimize the *** simulating two special benchmark configurations and six practice configurations with special cases,the results of the study concluded that the proposed method is capable of handling small to large,simple to complex continuous environments,whereas it was very tedious for the previous method to achieve.

关键词： Motion planning global path planning rapidly exploring random trees particle swarm optimization

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Psychological and Social Factors that Influence Quality of Life： Gender, Age and Professional Status Differences

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Psychology Research 2017年第9期7卷 489-498页

作者： Gaspar, t. Cabrita, t., Rebelo, A. Gaspar de Matos, M. Lusiada University CLISSIS Lisbon Portugal ISAMB/University of Lisbon Lisbon Portugal University of Lisbon WJRC Lisbon Portugal

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Extrapancreatic necrosis volume:A new tool in acute pancreatitis severity assessment?

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World Journal of Clinical Cases 2021年第31期9卷 9395-9405页

作者： Bogdan Cucuteanu DragoşNegru Otilia Gavrilescu Iolanda Valentina Popa Mariana Floria Cătălina Mihai Cristina Cijevschi Prelipcean Mihaela Dranga Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania

BACKGROUND Many scores have been suggested to assess the severity of acute pancreatitis upon *** extrapancreatic necrosis volume is a novel,promising score that appears to be superior to other scores investigated so *** to evaluate the discriminatory power of extrapancreatic necrosis volume to identify severe cases of acute *** A total of 123 patients diagnosed with acute pancreatitis at Institute of Gastroenterology and Hepatology,St Spiridon Hospital between January 1,2017 and December 31,2019 were analyzed *** was classified according to the revised Atlanta classification(rAC)as mild,moderate,or *** was also evaluated by computed tomography and classified according to the computed tomography severity index(CtSI)and the modified CtSI(mCtSI).the results were compared with the extrapancreatic volume necrosis to establish the sensitivity and specificity of each *** the CtSI and mCtSI imaging scores and the extrapancreatic necrosis volume were highly correlated with the severity of pancreatitis estimated by the rAC(r=0.926,Ptively).the correlation of C-reactive protein with severity was positive but not as strong,and was not significant(r=0.133,P=0.154).the best predictor for the assessment of severe pancreatitis was the extrapancreatic necrosis volume[area under the curve(AUC)=0.993;95%confidence interval(CI):0.981-1.005],with a 99.5%sensitivity and 99.0%specificity at a cutoff value of 167 mL,followed by the mCtSI 2007 score(AUC=0.972;95%CI:0.946-0.999),with a 98.0%sensitivity and 96.5%specificity,and the CtSI 1990 score(AUC=0.969;95%CI:0.941-0.998),with a 97.0%sensitivity and 95.0%*** Radiological severity scores correlate strongly and positively with disease *** necrosis volume shows the best diagnostic accuracy for severe cases.

关键词： Acute pancreatitis Extrapancreatic necrosis volume Computed tomography index Modified computed tomography index C-reactive protein Severity score

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thermal Ablation in the Management of Adrenal Metastasis Originating from Non-small Cell Lung Cancer： A 5-year Single-center Experience

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Chinese Medical Journal 2017年第17期130卷 2027-2032页

作者： Evanthia I Botsa Ioanna L thanou Aspasia t Papatheodoropoulou Loukas I thanos First Pediatric Clinic National and Kapodistrian University of Athens Agia Sofia Children&#39 s Hospital Athens 11527 Greece Department of Medical Imaging and Interventional Radiology Sotiria General Hospital for Chest Diseases Athens 11527 Greece

Background：treatment of adrenal metastasis from lung carcinoma may prolong survival in the selected ***,not all patients can undergo surgery;thus,minimally invasive ablation procedures such as radiofrequency ablation （RFA） and microwave ablation （MWA） have gained acceptance as alternative treatment *** study summarized a 5-year single-center experience regarding the evaluation of safety and efficacy of computed tomography （Ct）-guided thermal ablation in the management of adrenal metastasis originating from non-small cell lung cancer （NSCLC）.Methods：the data of NSCLC patients ablated for adrenal metastasis at the Department of Diagnostic Imaging and Interventional Radiology,General Hospital Sotiria,were retrospectively *** were divided into two groups：RFA group and MWA group according to the therapeutic *** blood tests included measurement of international normalized ratio,partial thromboplastin time,and platelet enumeration.A dual-phase contrast-enhanced spiral Ct was performed immediately after the procedure to assess the immediate response after ablation and to screen for related ***-up was performed with Ct or magnetic resonance imaging at 1,3,6 months and 1 year after ablation and every 6 months ***：A total of 99 ablation sessions in 71 patients with adrenal metastasis originating from NSCLC were included in the final ***-limited,postablation syndrome occurred in 16/99 （16.1%） of ablation *** procedures were technically *** postablation imaging showed no contrast enhancement of the ablated tumor in all ***-up imaging at 3 months revealed local tumor progression in 8 （22.8%） patients of the RFA group and 7 （19.4%） patients of MWA group,all of them underwent a second session *** 1-year assessment revealed local recurrence of the ablated tumor in six patients （17.1%） of RFA group and seven patients （19.4%） of MWA grou

关键词： Adrenal Metastasis Microwave Nonsmall Cell Lung Cancer Radiofrequency Ablation

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基于势流理论和OpenFOAM的耦合模型对多向不规则波浪的模拟

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水科学进展 2016年第1期27卷 88-99页

作者：季新然柳淑学 Bo t.PAULSEN Harry B.BINGHAM 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024 丹麦技术大学机械学院代尔夫特三角洲研究中心

基于势流理论的数值水池可以快速计算波浪的传播及其对建筑物的作用,但是势流理论是基于波浪的无黏性假设的,而在工程中,通常需要在固体边界及波浪破碎的区域考虑黏性效应。针对基于求解Navier-Stokes方程的黏性水池计算量较大、速度较... 详细信息

基于势流理论的数值水池可以快速计算波浪的传播及其对建筑物的作用,但是势流理论是基于波浪的无黏性假设的,而在工程中,通常需要在固体边界及波浪破碎的区域考虑黏性效应。针对基于求解Navier-Stokes方程的黏性水池计算量较大、速度较慢的缺点,采用耦合的方法模拟多向不规则波浪的传播,即在外域通过基于势流理论的数值水池产生多向不规则波浪,内域采用求解Navier-Stokes方程和流体体积法(VOF方法)对自由表面进行追踪,通过外域所提供的边界波浪,内域计算可以在较小区域进行计算,从而达到减少计算量、提高计算效率的目的。

关键词：势流理论 OpenFOAM 耦合多向不规则波浪

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Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis

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World Journal of Gastroenterology 2015年第1期21卷 246-253页

作者： Yusuke Yamamoto Hisashi Ikoma Ryo Morimura Katsutoshi Shoda Hirotaka Konishi Yasutoshi Murayama Shuhei Komatsu Atsushi Shiozaki Yoshiaki Kuriu takeshi Kubota Masayoshi Nakanishi Daisuke ichikawa Hitoshi Fujiwara Kazuma Okamoto Chouhei Sakakura toshiya Ochiai Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Surgery North Medical Center Kyoto Prefectural University of MedicineKyoto 6028566Japan

AIM: to analyze hepatocellular carcinoma(HCC) patients with portal vein tumor thrombosis(PVtt) using the tumor-node-metastasis(tNM) staging ***: We retrospectively analyzed 372 patients with HCC who underwent hepatectomy between 1980 and *** studied the outcomes of HCC patients with PVtt to evaluate the American Joint Committee on Cancer tNM staging system(7th edition) for stratifying and predicting the prognosis of a large cohort of HCC patients after hepatectomy in a *** vein invasion(vp) 1 was defined as an invasion or tumor thrombus distal to the second branch of the portal vein,vp2 as an invasion or tumor thrombus in the second branch of the portal vein,vp3 as an invasion or tumor thrombus in the first branch of the portal vein,and vp4 as an invasion or tumor thrombus in the portal trunk or extending to a branch on the contralateral ***: the cumulative 5-year overall survival(5yr OS) and 5-year disease-free survival(5yr DFS) rates of the 372 patients were 58.3% and 31.3%,*** 5yr DFS and 5yr OS of vp3-4 patients(n = 10) were 20.0%,and 30.0%,respectively,which was comparable with the corresponding survival rates of vp1-2 patients(P = 0.466 and 0.586,respectively).In the subgroup analysis of patients with macroscopic PVtt(vp2-4),the OS of the patients who underwent preoperative transarterial chemoembolization was comparable to that of patients who did not(P = 0.747).there was a significant difference in the DFS between patients with stage Ⅰ HCC and those with stage Ⅱ HCC(5yr DFS 39.2% vs 23.1%,P theDFS for stage Ⅱ was similar to that for stage Ⅲ(5yrD FS 23.1% vs 13.8%,P = 0.330).In the subgroup analysis of stage Ⅱ-Ⅲ HCC(n = 148),only alpha-fetoprotein(AFP) > 100 mg/dL was independently associated with ***: Hepatectomy for vp3-4 HCC results in a survival rate similar to hepatectomy for *** stratified the stage Ⅱ-Ⅲ HCC patients according to prognosis.

关键词： Hepatocellular carcinoma Hepatectomy Portal vein t

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Hepatitis C virus treatment with glecaprevir and pibrentasvir in patients co-prescribed carbamazepine:three case reports

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World Journal of Gastrointestinal Pharmacology and therapeutics 2023年第4期14卷 33-38页

作者： Michael Braude Dilip t Ratnam Louise Marsh Joshua H Abasszade Anouk t Dev Department of Gastroenterology and Hepatology Monash HealthClayton 3168VICAustralia General Practice Margaret River Medical CentreMargaret River 6285Australia

BACKGROUND Highly effective and well-tolerated direct-acting antiviral(DAA)therapies have revolutionised the management of hepatitis C virus(HCV);however,niche populations face treatment *** co-prescribed with several firstgeneration anti-epileptic drugs(AEDs)are contraindicated due to drug-drug interactions.A common example is carbamazepine whereby steady-state carbamazepine reduces the maximum concentration and area under the curve of velpatasvir,glecaprevir and pibrentasvir due to potent cytochrome P450(CYP)3A4 *** also induces P-glycoprotein which reduces glecaprevir and pibrentasvir’s area under curve to infinite *** and glecaprevir-pibrentasvir are contraindicated in patients who are co-prescribed carbamazepine due to the risk of reduced DAA therapeutic effect and consequently,virological treatment *** presents a challenge for patients in whom carbamazepine substitution is medically unfeasible,impractical or ***,the properties of current generation DAA therapies,including high-potency non-structural protein 5A inhibitory effect,may be sufficient to overcome reduced bioavailability arising from carbamazepine related CYP 3A4 and P-glycoprotein *** SUMMARY We present a case series of three patients with non-cirrhotic,treatment-naïve,genotype 1a,1b,and 3a HCV who were treated with a 12 wk course of glecaprevir-pibrentasvir,while co-prescribed carbamazepine for seizure ***-pibrentasvir combination therapy was chosen due to its potent in vitro activity and low barrier to pan-genotypic resistance associated *** therapy was dose-separated from carbamazepine to maximise time to peak concentration,and taken with meals to improve *** virological response at 12 wk was achieved in each patient with no adverse *** DAA therapies,including glecaprevir-pibrentasvir,warrant consideration as a therapeutic agent in people with HCV w

关键词： Antiepileptic drugs Drug interactions Hepatitis C virus Sustained virological response Health care access Case repor

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MORPHOtROPIC PHASE BOUNDARY AND DIELECtRIC RELAXAtION StUDY OF(Bi_(0.5)Na_(0.5))tiO_(3)-BatiO_(3)LEAD-FREE CERAMIC

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Journal of Advanced Dielectrics 2012年第3期2卷 34-46页

作者： B.PARIJA S.PANIGRAHI t.BADAPANDA t.P.SINHA Department of Physics National Institute of Technology Rourkela-769008India C.V.Raman College of Engineering Bhubaneswar Department of Physics Bose Institute 93/1 A.P.C.RoadKolkata-700009India

We report the temperature and frequency dependence impedance spectroscopy of(1-x)(Bi_(0.5)Na_(0.5))tiO_(3-x)BatiO_(3)(abbreviated as BNt-Bt)ceramics with 0≤x≤0.07 prepared by conventional solid-state route.X-ray diffraction analysis indicated that a solid solution is formed when BatiO_(3)diffuses into the(Bi_(0.5)Na_(0.5))tiO_(3)lattice and a morphotropic phase boundary between rhombohedral and tetragonal locates at x=*** microstructure indicated that the grain size reduces and the shape changes from rectangular to quasi-spherical with increase in BatiO_(3)*** Impedance Spectroscopy analysis suggested the presence of temperature-dependent relaxation process in the *** modulus mechanism indicated the nonDebye type of conductivity relaxation in the materials,which is supported by impedance *** activation energies have been calculated from impedance,electric modulus studies and dc conductivity which suggests that the conductions are ionic in *** activation energy increases with increase of Bt content up to x=0.05 and decreases at x=0.07 which also indicates the presence of morphotropic phase boundary at x=0.07.

关键词： Morphtropic phase boundary(MPB) impedance spectroscopy electrical modulus relaxations conductivity

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