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Bioengineering breakthroughs:The impact of stem cell models on advanced therapy medicinal product development

World Journal of Stem Cells 2024年第10期16卷 860-872页

作者： José Mauro Granjeiro Priscila Grion de Miranda Borchio icaro paschoal brito ribeiro Katiucia Batista Silva Paiva Division of Biological Metrology The National Institute of MetrologyQualityand TechnologyDuque de Caxias 25250020Rio de JaneiroBrazil Laboratory of Regenerative Medicine Arthur SáEarp Neto UniversityPetropolis 25680120Rio de JaneiroBrazil Laboratory of Extracellular Matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508000São PauloBrazil

The burgeoning field of bioengineering has witnessed significant strides due to the advent of stem cell models,particularly in their application in advanced therapy medicinal products(ATMPs).In this review,we examine the multifaceted impact of these developments,emphasizing the potential of stem cell models to enhance the sophistication of ATMPs and to offer alternatives to animal *** cell-derived tissues are particularly promising because they can reshape the preclinical landscape by providing more physiologically relevant and ethically sound platforms for drug screening and disease *** also discuss the critical challenges of reproducibility and accuracy in measurements to ensure the integrity and utility of stem cell models in research and ***,this review highlights the imperative of stem cell models to align with regulatory standards,ensuring using stem cells in ATMPs translates into safe and effective clinical *** regulatory approval serving as a gateway to clinical adoption,the collaborative efforts between scientists and regulators are vital for the progression of stem cell applications from bench to *** advocate for a balanced approach that nurtures innovation within the framework of rigorous validation and regulatory compliance,ensuring that stem cell-base solutions are maximized to promote public trust and patient health in ATMPs.

关键词： Stem cells Advanced therapy medicinal products Tissue-engineered products Health Three-dimensional cell culture

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Using hot-vapor bypass for pressure control in distillation columns

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Chinese Journal of Chemical Engineering 2018年第1期26卷 144-151页

作者： Stefano Ciannella Arthur Siqueira Damasceno icaro Caze Nunes Gilvan Wanderley de Farias Neto Wagner Brandao Ramos Romildo Pereira brito Department of Chemical Engineering Federal University of Campina GrandeCarnpina Grande 58109-970ParafbaBrazil

Distillation column control is widely explored in literature due to its complexity and importance in chemical and petrochemical industries. In this process, pressure represents one of the most important variables to be controlled. However, there are few studies about how pressure affects the dynamic behavior of distillation columns and most research on distillation column control involve direct manipulation of cooling fluid through the condenser. Nevertheless, such an approach demands constant changes in cooling fluid flowrates that are commonly by the order of tons per hour, which can be difficult to work or even unfeasible in a real plant. Furthermore, this strategy is usually avoided, as it can cause fouling and corrosion acceleration. The hot-vapor bypass strategy fits well as a solution for these issues, eliminating the need to dynamically manipulate cooling fluid flowrates in the condensation unit. This work presents the modeling and simulation of a conventional distillation column for the separation of water and ethanol, in which a comparative study between a conventional pressure control and a control using hot-vapor bypass was performed. The main results were obtained through dynamic simulations which considered various disturbances in the feed stream, and demonstrated superior performance by the hot-vapor bypass system over the usual scheme proposed in literature, while evaluating the lntegral Absolute Error （IAE） norm as the control performance index.

关键词： Distillation Pressure control Hot-vapor bypass

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