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First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus

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World Journal of Gastroenterology 2020年第43期26卷 6710-6769页

作者： maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed m Khassouan Zaher Koutoubi Rahul Nathwani mazen S Taha Jimmy K Limdi Gastroenterology and Endoscopy Department Ibrahim Bin Hamad Obaid Allah HospitalMinistry of Health and PreventionRas Al KhaimanUnited Arab Emirates Department of Gastroenterology Sheikh Shakbout Medical CityAbu DhabiUnited Arab Emirates Department of Gastroenterology Valiant ClinicDubaiUnited Arab Emirates Department of Gastroenterology and Endoscopy American HospitalDubaiUnited Arab Emirates Gastroenterology and Endoscopy Unit Al Zahra HospitalDubaiUnited Arab Emirates Gastroenterology Division Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Digestive Disease Unit Rashid HospitalDubaiUnited Arab Emirates Digestive Disease Institute Cleveland ClinicAbu DhabiUnited Arab Emirates Department of Gastroenterology Mediclinic City HospitalDubaiUnited Arab Emirates Gastroenterology and Hepatology Tawam HospitalAl AinUnited Arab Emirates Department of Gastroenterology The Pennine Acute Hospitals NHS TrustManchester Academic Health SciencesUniversity of ManchesterManchester M85RBUnited Kingdom

Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal *** incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is *** progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with *** guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based *** up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications.

关键词： Ulcerative colitis Crohn’s disease Infliximab Adalimumab Vedolizumab Ustekinumab Tofacitinib

阿那其根醇提取物对金黄色葡萄球菌防突变时间窗的影响

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新疆医学 2021年第1期51卷 118-121页

作者：陈瑶杨浩娜迪热·伊卜拉伊木金小越新疆医科大学第六附属医院乌鲁木齐830002 新疆霍城县市场监督管理局伊犁市霍城县835200

目的观察阿那其根醇提取物对金黄色葡萄球菌的抑菌作用及防突变时间窗的影响。方法通过牛津杯法测定阿那其根醇提取物对金黄色葡萄球菌的抑菌圈和最小抑菌浓度(mIC),采用标准琼脂平板稀释法测定最小防耐药浓度(mPC),通过考察阿那其根醇... 详细信息

目的观察阿那其根醇提取物对金黄色葡萄球菌的抑菌作用及防突变时间窗的影响。方法通过牛津杯法测定阿那其根醇提取物对金黄色葡萄球菌的抑菌圈和最小抑菌浓度(mIC),采用标准琼脂平板稀释法测定最小防耐药浓度(mPC),通过考察阿那其根醇提取物最小抑菌浓度、最小防耐药浓度对培养不同时间的金黄色葡萄球菌的影响,明确阿那其根醇提取物对金黄色葡萄球菌的耐药时间点及防突变时间窗。结果阿那其根醇提取物对金黄色葡萄球菌的mIC为0.3 g/m L、mPC为0.6 g/mL,阿那其根醇提取物对金黄色葡萄球菌防突变时间窗为19-22 h。结论阿那其根醇提取物对金黄色葡萄球菌具有抑菌作用,且对金黄色葡萄球菌有明确的防突变时间窗,为临床应用提供指导。

关键词：阿那其根醇提取物金黄色葡萄球菌防突变时间窗

阿那其根醇提取物对咳嗽变异性哮喘豚鼠脑组织TNF-α和IL-6水平的影响

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新疆医学 2020年第4期50卷 334-338页

作者：杨浩陈瑶娜迪热·伊卜拉伊木金小越新疆医科大学第六附属医院药学部乌鲁木齐830002 新疆霍城县市场监督管理局新疆伊犁市霍城县835200

目的观察阿那其根醇提取物(EEAP)对咳嗽变异性哮喘(CVA)豚鼠脑组织炎症因子和氧化指标的影响。方法将48只雄性豚鼠随机分为6组,分别为空白对照组、CVA模型组、EEAP低剂量组(160 mg/kg)、EEAP中剂量组(320 mg/kg)、EEAP高剂量组(640mg/kg... 详细信息

目的观察阿那其根醇提取物(EEAP)对咳嗽变异性哮喘(CVA)豚鼠脑组织炎症因子和氧化指标的影响。方法将48只雄性豚鼠随机分为6组,分别为空白对照组、CVA模型组、EEAP低剂量组(160 mg/kg)、EEAP中剂量组(320 mg/kg)、EEAP高剂量组(640mg/kg)和阳性对照组(醋酸泼尼松,250mg/kg),每组8只。除空白对照组外,其余各组豚鼠均皮下注射1 mg/mL卵清蛋白(OVA)-费氏完全佐剂溶液致敏,并雾化吸入1%OVA-生理盐水溶液以激发哮喘。末次雾化后,各给药组大鼠均灌胃相应药物,对照组和模型组大鼠均灌胃等体积水。雾化吸入10-4mol/L的辣椒素溶液诱导各组豚鼠咳嗽,记录咳嗽次数。elISA法检测各组豚鼠脑组织肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、超氧化物歧化酶(SOD)和丙二醛(mDA)水平。结果1.与空白组相比,CVA模型组豚鼠咳嗽次数显著升高,差异具有统计学意义(PmDA水平无差异,无统计学意义(P>0.05,P>0.05)。4.空白对照组与CVA模型组豚鼠咳嗽次数与脑组织TNF-α和IL-6水平呈正相关(R=0.658,P=0.006;R=0.623,P=0.01)。结论EEAP具有降低咳嗽变异性哮喘豚鼠脑组织TNF-α和IL-6水平,改善大脑炎性,但其作用机制仍需进一步研究。

关键词：阿那其根醇提取物咳嗽变异性哮喘脑组织抗炎

Healthcare workers' knowledge towards Zika virus infection in Indonesia:A survey in Aceh

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Asian Pacific Journal of Tropical medicine 2017年第2期10卷 182-186页

作者： Harapan Harapan Alma Aletta Samsul Anwar Abdul m.Setiawan Reza maulana Nur Wahyuniati muhammad R.Ramadana Sotianingsih Haryanto Alfonso J.Rodriguez-morales Kurnia F.Jamil medical Research Unit School of MedicineSyiah Kuala University Tropical Disease Centre School of MedicineSyiah Kuala University Department of microbiology School of MedicineSyiah Kuala University Department of Family medicine School of MedicineSyiah Kuala University Department of Statistics Faculty of Mathematics and Natural SciencesSyiah Kuala University Department of microbiology Faculty of Medicine and Health SciencesState Islamic University of Maulana Malik Ibrahim Department of Clinical Pathology Faculty of Medicine and Health SciencesJambi University Public Health and Infection Research Incubator and Group Faculty of Health SciencesUniversidad Tecnologica de Pereira Department of Internal medicine School of MedicineSyiah Kuala University

Objective:To assess the knowledge on Zika virus(ZIKV) infection among healthcare providers(doctors) in Aceh province,***:A self-administered internet based survey was conducted from 3 may to 3 June 2016 among the members of doctor organizations in Aceh province.A set of validated,pre-tested questionnaire was used to measure knowledge regarding ZIKV infection and to collect a range of explanatory variables.A two-steps logistic regression analysis was employed to assess the association of participants' demographic,workplace characteristics and other explanatory variables with the ***:A total of 442 participants included in the final analysis and 35.9% of them(159) had a good knowledge on ZIKV *** model revealed that type of occupation,type of workplace,availability of access to medical journals and experience made Zika disease as differential diagnose were associated with knowledge on ZIKV *** addition,three significant source of information regarding ZIKV were online media(60%),medical article or medical news(16.2%) and television(13.2%).Conclusion:The knowledge of the doctors in Aceh regarding ZIKV infection is relatively *** who have a good knowledge on ZIKV infection are more confident to established ZIKV disease as differential diagnosis in their clinical ***,such program to increase healthcare providers' knowledge regarding ZIKV infection is needed to screen potential carriers of ZIKV infection.

关键词： Zika virus Zika fever Knowledge Attitude Health care worker Indonesia

ABI-007,一种不用聚氧乙基代蓖麻油,蛋白质稳定的紫杉醇纳米制剂Ⅰ期临床和药物动力学的研究

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ABI-007,一种不用聚氧乙基代蓖麻油,蛋白质稳定的紫杉醇纳米制剂...

作者： Nuhad K.ibrahim Neil Desai Sewa Legha Patrick Soon-Shiong Richard L.Theriault Edgardo Rivera Bita Esmaeil Sigrid E.Ring Agop Bedikian Gabriel N.Hortobagyi Julie A ellerhorst 乳腺肿瘤医学系

目的:ABI-007是一种不用聚氧乙基代蓖麻油(Cremophor E1),且蛋白质稳定的紫杉醇纳米制剂。不使用聚氧乙基代蓖麻油Cremophor EI可使ABI-007给药前不用进行常规预防超敏反应的预处理。此外,这种新制剂可使得紫杉醇在溶液中以更高的浓度存...

目的:ABI-007是一种不用聚氧乙基代蓖麻油(Cremophor E1),且蛋白质稳定的紫杉醇纳米制剂。不使用聚氧乙基代蓖麻油Cremophor EI可使ABI-007给药前不用进行常规预防超敏反应的预处理。此外,这种新制剂可使得紫杉醇在溶液中以更高的浓度存在,这样就可以减少输液的体积和时间,I期临床试验是要研究ABI-007的毒性,最大耐药剂量(mTD)和药物动力学。实验设计:ABI-007在门诊病人中使用,病人不用预先用药,30分钟滴注。ABI-007的剂量范围是从135(0级)到375mg/m2(3级)。16个病人参加了药物动力学的研究。结果:十九个病人在进行输液治疗期间没有观察到急性超敏反应。血药毒性是缓和的且无而非蓄积性。以3级(375mg/m2)治疗的6个病人中的3人发生剂量限制性毒性,口腔粘膜炎有2个病人,2个病人出现轻微的角膜炎。因此最大耐受剂量定为300 mg/m2(2级)。药物动力学分析显示当ABI-007的剂量在135-300mg/m2范围内时紫杉醇的Cmax和曲线下面积线形增加,Cmax和曲线下面积与病人个体毒性呈现出很好的相关性。结论:ABI-007提供了几个临床研究感兴趣的方面,包括快速输液率,不用预先用药处理和较高的紫杉醇最大耐药剂量,我们的研究结果为II期临床试验提供了该药抗肿瘤活性的依据。

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软件工程教育中的团队合作技能

南京工程学院学报:社会科学版 2023年第2期23卷 34-40页

作者：萨吉德·易卜拉欣·哈什米尤尼·马克库拉奥卢大学m3S研究小组芬兰奥卢90014

在专业的软件工程中,工作总是采取团队合作的方式完成。除了专业知识和技能外,软件工程教育还应为应届毕业生提供足够的专业团队合作相关技能,这是成功的专业软件工程职业生涯所需的技能。作为社会活动,团队合作实践在不同的文化中是不... 详细信息

在专业的软件工程中,工作总是采取团队合作的方式完成。除了专业知识和技能外,软件工程教育还应为应届毕业生提供足够的专业团队合作相关技能,这是成功的专业软件工程职业生涯所需的技能。作为社会活动,团队合作实践在不同的文化中是不同的。相关技能可能取决于学生的教育背景,课程和学术文化在他们的教育方式中起着至关重要的作用。因此,有必要让学生练习与团队合作相关的技能,以更好地为软件行业的未来团队合作做好准备。本研究的目的是调查团队合作相关技能在国际软件工程教育中的作用以及在设计教育时为何要考虑学生的文化背景。研究采取了焦点小组的研究方法,召开了一次由经验丰富的软件工程教师参加的焦点小组会议,并对数据进行了专题分析。研究结果表明,与团队合作相关的技能教育内嵌在软件工程课程的团队合作任务中。虽然这些团队合作学习活动旨在支持课程学习,学生们也应该学习并获得团队合作的经验,以实现他们的职业生涯。课程中的团队学习设计还应了解教学语境和学生的文化背景。在国际教育中,教学应适应文化语境,以取得良好的学习效果。

关键词：团队合作软件工程软件工程教育团队合作相关技能

Diabetes and Hypertension in a Santhal Tribe in Bangladesh: A Population Based Study

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Journal of Diabetes mellitus 2014年第2期4卷 133-140页

作者： m. Abu Sayeed Parvin Akter Khanam muhammad Tofazzal Hussain mir masudur Rhaman Shurovi Sayeed Tanjima Begum m. Abu Hana Golam morshed Akhter Banu Department of Community medicine Ibrahim Medical College Dhaka Bangladesh Department of Epidemiology BIRDEM Dhaka Bangladesh Institute of Nutrition and Food Science University of Dhaka Dhaka Bangladesh

BACKGROUND: Santhal (Santals) tribe is one of the oldest and largest aboriginal pre Aryan populations in India and Bangladesh. There was no published report on the prevalence of diabetes and hypertension. OBJECTIVE: To determine the prevalence of type 2 diabetes mellitus (T2Dm) and hypertension in a Santhal tribe of Bangladesh. RESEARCH DESIGN AND mETHODS: Eight villages inhabited largely by Santhal tribe were purposively selected. All Santhals aged 20 years or more were considered eligible and enlisted for the study. Investigations included socio-demographic information (age, sex, education, income), clinical history (general illness), anthropometry (height, weight, waist-girth, hip-girth) and blood pressure. Body mass index (BmI) and waist-to-hip ration (WHR) were calculated. Blood samples were collected for fasting plasma glucose (FPG), total cholesterol (Chol), triglycerides (TG), urea and creatinine. RESULTS: Thirteen hundred eligible Santhals were enlisted. Of them, 1049 (80.7%) participated in the study. The male and female participants were 40% and 60%, respectively. The prevalence of T2Dm was 0.6% and hyperglycemia (FPG > 5.5 mmol/l) was 10.0%. The prevalence of systolic hypertension (sHTN) was 24.4% and diastolic hypertension (dHTN) was 24.6%. Compared with the males the females had significantly higher prevalence of sHTN (OR, 2.20 with 95% CI, 1.62 - 3.02) and dHTN (OR, 1.81 with CI, 1.34 - 2.0);whereas, the prevalence of T2Dm and IFG did not differ. Regarding obesity 45% of the participants had BmI 23.1. Logistic regression estimated that the increasing age, female sex, higher FPG (>5.5 mmol/l) and higher Chol (>160 mg/dl) had independent risk for sHTN and dHTN. CONCLUSIONS: The Santhals had less risk for diabetes but increased risk for hypertension. The Santhal females had excess risk of hypertension. Advancing age, female sex, hyperglycemia and hypercholesterolemia were found to have significant risk for hypertension. Obesity had no effect on diabetes

关键词： Santhal Obesity Diabetes Hypertension Lipids

A Comparative Study of Fabrication of Long Wavelength Diode Lasers Using CCl2F2/O2 and H2/CH4

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Optics and Photonics Journal 2013年第2期3卷 21-24页

作者： B.Cakmak m.Biber T.Karacali C.Duman Erzurum Technical University Vice-PresidentErzurumTurkey Department of electrical and electronics Engineering Atatürk UniversityErzurumTurkey Agri ibrahim Cecen University Dean of the Faculty of Art and ScienceAgriTurkey Erzurum Vocational School Atatürk UniversityErzurumTurkey

We report comparatively on fabrication of two-section ridge-waveguide tapered 3 quantum well (QW) InGaAsP/InP (1300 nm) and 5 QW AlGaInAs/InP (1550 nm) diode lasers. Gas mixtures of CCl2F2/O2 and H2/CH4 were used to form ridge-waveguide on the lasers with InP-based material structures. As known, chlorine- and hydro-carbon based gases are used to fabricate ridge-waveguide structures. Here, we show the difference between the structures obtained by using the both gas mixtures in which surface and sidewall structures as well as performance of the lasers were analysed using scanning electron microscopy. It is demonstrated that gas mixtures of CCl2F2/O2 highly deteriorated the etched structures although different flow rates, rf powers and base pressures were tried. We also show that the structures etched with H2/CH4 gas mixtures produced much better results that led to the successful fabrication of two-section devices with ridge-waveguide. The lasers fabricated using H2/CH4 were characterized using output power-current (P-I) and spectral results.

关键词： Diode Lasers Fabrication Two-Section Ridge-Waveguide CCl2F2/O2 and H2/CH4

充填体荷载作用下金属矿山采空区顶板稳定性分析

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能源与环保 2023年第1期45卷 309-313,318页

作者：张东飞亚呼甫·依布拉英王斐孙文敬李再易康泰福西部矿业股份有限公司青海西宁810000

针对如何提高研究区深部矿体采矿活动安全性的问题,通过理论计算方法和数值模拟计算法对采空区顶板的稳定性进行了分析。结果表明,厚跨比理论、载荷传递交汇线理论和结构力学梁理论求得的采空区顶板安全厚度基本一致,具有较好的线性变... 详细信息

针对如何提高研究区深部矿体采矿活动安全性的问题,通过理论计算方法和数值模拟计算法对采空区顶板的稳定性进行了分析。结果表明,厚跨比理论、载荷传递交汇线理论和结构力学梁理论求得的采空区顶板安全厚度基本一致,具有较好的线性变化关系,获得采空区顶板安全距离为10.0~18.0 m(采空区跨度为20 m);通过数值模拟极端后,确定了研究区顶板的临界破坏厚度为12.5 m,最终确定了采空区顶板的安全厚度为15 m。此时,采空区的水平方向最大的位移量可达28.2 mm,垂直方向上最大下沉量可达368 mm;采空区开挖后的最小主应力为-1.42 mPa,最大主应力为-6.7 mPa。

关键词：采空区稳定性顶板厚度数值模拟安全距离