检索结果-南通市图书馆

Variations in Toxic Metal Levels of Two Fish Species, Pomatomus saltatrix and Dicentrarchus labrax, and Risk Estimation for Children

引用

光谱学与光谱分析 2014年第2期34卷 300-307页

作者： Mehmet yaman ibrahim h yaman Firat University Sciences FacultyDepartment of ChemistryElazig-Turkey Carsamba State hospital Part of Children&#39 s Diseases CarsambaSamsun-Turkey

The concentrations of five toxic metals were monthly determined in two fish species,obtained from fish markets in Turkey during 2010—*** the determinations,AAS and ICP-AES were *** obtained lead concentrations for all studied Pomatomus saltatrix(mean 635μg·kg-1)and Dicentrarchus labrax(mean 463μg·kg-1)samples were found to be significantly higher than the maximum allowances concentration(MAC)of 300μg·*** chromium(324μg·kg-1)and Cu(940μg·kg-1)concentrations in Pomatomus saltatrix were higher than in Dicentrarchus labrax(268μg Cr·kg-1 and 600μg Cu·kg-1)while Ni in Pomatomus saltatrix(216μg·kg-1)was lower in Dicentrarchus labrax(291μg·kg-1).The estimated non-carcinogenic and carcinogenic health risks by the Target hazard Quotient and target carcinogenic risk indicate that there are no sytemic effects,and the risk of developing cancer over a human lifetime is between 2~9in 1 000 000.

关键词： Toxic metals Fish Atomic absorption ICP-AES Risk assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells

引用

Journal of Pharmaceutical Analysis 2018年第5期8卷 307-311页

作者： Selim Demir ibrahim Turan Rezzan Aliyazicioglu Serap Ozer yaman Yuksel Aliyazicioglu Department of Nutrition and Dietetics Faculty of Health SciencesKaradeniz Technical University61080 TrabzonTurkiye Department of Genetic and Bioengineering Faculty of Engineering and Natural SciencesGumushane University29100 GumushaneTurkiye Department of Biochemistry Faculty of PharmacyKaradeniz Technical University61080 TrabzonTurkiye Department of Medical Biochemistry Faculty of MedidneKaradeniz Technical University61080 TrabzonTurkiye

Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P vulgaris flower extract on human cervical cancer （heLa） cells. The cytotoxic effect of the extract on heLa cells was revealed using the MTT assay. Mechanisms involved in the extract＇s cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P vulgaris flower extract exhibited selective cytotoxic effects against heLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect ofP. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms.

关键词： Apoptosis Cell cycle Cervical cancer Cytotoxicity Primula vulgaris

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

引用

Journal of Pharmaceutical Analysis 2018年第6期8卷 394-399页

作者： ibrahim Turan Selim Demir Kagan Kilinc Serap Ozer yaman Sema Misir hanife Kara Berna Genc Ahmet Mentese Yuksel Aliyazicioglu Orhan Deger Department of Genetic and Bioengineering Faculty of Engineering and Natural Sciences Gumushane University Medicinal Plants Traditional Medicine Practice and Research Center Gumushane University Department of Nutrition and Dietetics Faculty of Health Sciences Karadeniz Technical University Department of Medical Biochemistry Faculty of Medicine Karadeniz Technical University Department of Biochemistry Faculty of Pharmacy Cumhuriyet University Program of Medical Laboratory Techniques Vocational School of Health Sciences Karadeniz Technical University

Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of *** extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer(WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential(MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.

关键词： Apoptosis Colon cancer Cytotoxicity Rosa canina Telomerase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biliary fistula and late recurrence of liver hydatid cyst:Role of cystobiliary communication:A prospective multicenter study

引用

World Journal of Methodology 2023年第4期13卷 272-286页

作者： Tamer A A M habeeb Mauro Podda Boris Tadic Vishal G Shelat yaman Tokat Mohamed ibrahim Abo Alsaad Abd-Elfattah Kalmoush Mohammed Shaaban Nassar Fawzy Metwally Mustafa Mahmoud hassib Morsi Badawy Mohamed Sobhy Shaaban Tarek Zaghloul Mohamed Mohammed ibrahim El Sayed henish hamdi Elbelkasi Mahmoud Abdou Yassin Abdelshafy Mostafa Amr ibrahim Waleed A-Abdelhady TamerMohamed Elshahidy Mohamed ibrahim Mansour Adel Mahmoud Moursi Mohamed Abdallah Zaitoun EhabShehata Abd-Allah Ashraf Abdelmonem Elsayed Rasha S Elsayed Ahmed M Yehia Amr Abdelghani Mohamed Negm heba Alhussein Abo-Alella Mostafa M Elaidy Department of General Surgery Faculty of Medicine Zagazig UniversitySharkia 44511Egypt Department of Surgical Science University of CagliariCagliari 09126Italy Clinic for Digestive Surgery–First Surgical Clinic University Clinical Centre of SerbiaBelgrade 11000Serbia Department of General Surgery Tan Tock Seng HospitalSingapore 018971Singapore Department of Liver Transplantation and hepatobiliary Surgery IstanbulTurkeyInternational Liver Centerand Acibadem Hospital GroupIstanbul 34000Turkey Department of General Surgery Faculty of Medicine-Merit UniversitySohag 82511Egypt Department of General Surgery Faculty of MedicineAl-Azher UniversityCairo 11765Egypt Department of General Surgery Mataryia Teaching HospitalCairo 11765Egypt

BACKGROUND hydatid cyst disease(hCD)is common in certain *** is associated with postoperative biliary fistula(POBF)and *** primary aim of this study was to identify whether occult cysto-biliary communication(CBC)can predict recurrent *** secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase(ALP)levels in predicting POBF and recurrent *** To identify whether occult CBC can predict recurrent *** secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent *** From September 2010 to September 2016,a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b hCD who underwent laparoscopic partial cystectomy with *** logistic regression analysis assessed independent factors determining biliary complications and *** There was a highly statistically significant association(P≤0.001)between cystic fluid biochemical indices and the development of biliary complications(of 16 patients with POBF,15 patients had high cyst fluid bilirubin and ALP levels),where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary *** was a highly statistically significant association(P≤0.001)between biliary complications,biochemical indices,and the occurrence of recurrent hCD(of 30 patients with recurrent hCD,15 patients had high cyst fluid bilirubin and ALP;all 16 patients who had POBF later developed recurrent hCD),where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts,*** Occult CBC can predict recurrent *** cyst fluid bilirubin and ALP levels predicted POBF and recurrent hCD.

关键词： Cysto-biliary communication Echinococcus granulosus hydatid disease recurrence hydatid fluid analysis Laparoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：