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Brain Science Advances 2024年第1期10卷 57-71页

作者： Gehan S.Georgy ibrahim M.ibrahim Laila Mohamed E.Amer Ebtehal Mohammad F. Pharmacology Department Egyptian Drug Authority(EDA)Giza P.O.29Egypt Molecular Drug Evaluation Department Egyptian Drug Authority(EDA)Giza P.O.29Egypt Histology Department Faculty of MedicineAl-Azhar UniversityDamietta P.O.11651Egypt

Dapoxetine is a newer anti-depressant that is used for severe forms of depression via selective serotonin reuptake inhibition *** aimed to evaluate the effect of different doses of dapoxetine lonely or with acetaminophen(AMP).Seven groups of albino rats were used where dapoxetine was administered orally at the doses of 3,5,and 8 mg/kg body weight for a period of 14 days in groups 2,4,and 6,***(67.5 mg/kg body weight)was co-administered with dapoxetine(3,5,and 8 mg/kg body weight)for 14 days in groups 3,5 and 7,*** in mid and high dose plus AMP increased body weight and hematological *** and rearing were declined with mid and high doses of dapoxetine+AMP,contrary to *** was decreased with high doses of dapoxetine+*** dose of dapoxetine+AMP induced lowering of serotonin and dopamine as well as increasing of *** derived neurotrophic factor was decreased in all *** stress biomarkers were augmented with high dose of dapoxetine+*** doses of dapoxetine and/or AMP induced loss of the Purkinje cell layer at *** high dose of dapoxetine+AMP denotes behavioral,histopathological and neurochemical alterations,even though no serotonin syndrome occurs.

关键词： acetaminophen dapoxetine neurotransmitters oxidative stress biomarkers

Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and Fisheries 2024年第1期9卷 57-65页

作者： Mohammed F.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-Hais Mohamed G.Elhanafy Emad H.El-Bilawy Amr I.Zaineldin Mohamed F.A.Abdel-Aziz ibrahim A.Abouelsaad ibrahim TEl-Ratel Kumbukani Mzengereza Ronick S.Shadrack Islam I.Teiba Faculty of Agriculture Tanta UniversityTanta31527Egypt King Salman International University South Sinai46618Egypt Faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt Fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and Fisheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi Faculty of Aquaculture and Marine Fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).Fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(SOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

Enhancing Canola Yield and Photosynthesis under Water Stress with Hydrogel Polymers

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1623-1645页

作者： Elham A.Badr Gehan Sh.Bakhoum Mervat Sh.Sadak ibrahim Al-Ashkar Mohammad Sohidul Islam Ayman El Sabagh Magdi T.Abdelhamid Field Crops Research Department National Research CentreCairo12622Egypt Botany Department National Research CentreCairo12622Egypt Plant Production Department College of Food and Agriculture SciencesKing Saud UniversityRiyadh12271Saudi Arabia Department of Agronomy Hajee Mohammad Danesh Science and Technology UniversityDinajpur5200Bangladesh Department of Field Crops Faculty of AgricultureSiirt UniversitySiirt56100Turkey Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Research Centers Montana State UniversityBozemanMT 59717USA

While Egypt’s canola production per unit area has recently grown,productivity remains low,necessitating increased *** are water-absorbent polymer compounds that can optimize irrigation schedules by increasing the soil’s ability to retain ***,twoﬁeld experiments were conducted to examine hydrogel application to sandy soil on canola growth,biochemical aspects,yield,yield traits,and nutritional quality of yielded seeds grown under water deﬁcit stress *** experiments were conducted by arranging a split-plot layout in a randomized complete block design(RCBD)with three times replications of each *** water stress at 75%or 50%of crop evapotranspiration(ETc)lowered chlorophyll a,chlorophyll b,caro-tenoids,and total pigments content,indole-3-acetic acid,plant development,seed yield,and oil and total carbo-hydrates of seed yield,hydrogel treatment enhanced all of the traits mentioned ***,hydrogel enhanced to gather compatible solutes(proline,amino acids,total soluble sugars),phenolics content in leaves,seed protein,and crop water productivity,which increased while the plants were under water *** results revealed that the full irrigation(100%ETc)along with hydrogel compared to water-stressed(50%ETc)led to enhanced seed yield(kg ha^(-1)),Oil(%),and Total carbohydrates(%)of rapeseed by 57.1%,11.1%and 15.7%,***,under water-stressed plots with hydrogel exhibited enhancement by 10.0%,3.2%and 5.1%in seed yield(kg ha^(-1)),oil(%),and total carbohydrates(%)of rapeseed by 57.1%,11.1%and 15.7%,respec-tively compared to *** a result,the use of hydrogel polymer will be a viable and practical solution for increasing agricultural output under water deﬁcit stress situations.

关键词： Hydrogel oil osmolytes rapeseed yield water stress

In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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Medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： Hayder M Abdulhamza Muthanna S.Farhan Sara.S Hassan Hany Aqeel Al-Hussainy Amjad ibrahim Oriabi Department of Pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-Manara College for Medical Sciences Department of PharmacyIraq Department of Pharmacy Hilla University CollegeBabylonIraq Dr Hany Akeel Institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of CHIKV with 745 antiviral compounds using an ML-based QSAR model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for MD simulation based on the control(Silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent RMSD and the least conformational variation,indicating high *** also showed the lowest binding free energy(ΔG¼31.31 kcal/mol),indicating energetically favourable *** and FEL also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating CHIKV.

关键词： Chikungunya virus Machine learning based QSAR Molecular dynamic solution Helicase

Enhancing Mild Cognitive Impairment Detection through Efficient Magnetic Resonance Image Analysis

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Computers, Materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif Mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah Shahid Shahid Iqbal Mutasem K.Alsmadi Yazeed Yasin Ghadi Syed Aziz Shah Mostafa M.ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of Management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).Mild cognitive impairment(MCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify MCI,AD,and normal control(NC)*** paper focuses on using gray matter(GM)scans obtained through magnetic resonance imaging(MRI)for the diagnosis of individuals with MCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and MCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose MCI,AD,and normal control individuals using GM *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

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半金属氢氧化物材料用于电化学水氧化

Science China Materials 2024年第5期67卷 1551-1558页

作者：王静 Mohammed-ibrahim Jamesh 高强韩波孙睿敏 Hsien-Yi Hsu 周成冈蔡钊 Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074China School of Energy and Environment Department of Materials Science and EngineeringCity University of Hong KongKowloon TongHong Kong999077China

寻找具有高本征活性的水氧化催化剂材料对许多清洁能源技术的发展至关重要.氢氧化物半导体对析氧反应具有一定的电催化活性.然而,该材料导电性较差,限制着其电催化本征活性的提升.本文提出一种兼具高导电性和高催化活性的半金属氢氧化... 详细信息

寻找具有高本征活性的水氧化催化剂材料对许多清洁能源技术的发展至关重要.氢氧化物半导体对析氧反应具有一定的电催化活性.然而,该材料导电性较差,限制着其电催化本征活性的提升.本文提出一种兼具高导电性和高催化活性的半金属氢氧化物析氧电催化材料.通过阳离子掺杂和阴离子空位协同作用,镍铁水滑石半导体可转化为半金属材料,其电阻率降低了两个数量级.相应半金属氢氧化物阵列电极的电催化活性显著提升,在10 mA cm^(-2)电流密度下其析氧过电势仅为195 mV,Tafel斜率仅为40.9 mV dec^(-1),显著优于商用RuO_(2)催化剂(316 mV,99.6 mV dec^(-1)).原位拉曼光谱和理论计算结果表明,半金属氢氧化物可在较低过电位下转化为羟基氧化物中间体,有助于高价态金属活性位点的形成与稳定,从而提升材料的析氧本征活性.本研究表明,兼具优异导电性和催化活性的半金属氢氧化物可作为先进的电极材料.

关键词： electrocatalyst hydroxide semi-metal electric conductivity intrinsic activity

Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation

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World Journal of Nephrology 2024年第3期13卷 34-40页

作者： Emad A Shdaifat Firas T Abu-Sneineh Abdallah M ibrahim Community Nursing Department Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia Department of Fundamental Nursing Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia

BACKGROUND Among diverse profound impacts on patients’quality of life(QoL),end-stage renal disease(ESRD)frequently results in increased levels of depression,anxiety,and *** replacement therapies such as hemodialysis(HD)and transplantation(TX)are intended to enhance QoL,although their ability to alleviate psychological distress remains *** research posits the existence of a significant correlation between negative emotional states and QoL among ESRD patients,with varying effects observed in HD and TX *** To examine the relationship between QoL and negative emotional states(depression,anxiety,and stress)and predicted QoL in various end-stage renal replacement therapy patients with *** This cross-sectional study included HD or TX patients in the Eastern Region of Saudi *** 36-item Short Form Survey and Depression Anxiety Stress Scale(DASS)was used for data collection,and correlation and regression analyses were *** The HD and TX transplantation groups showed statistically significant inverse relationships between QoL and DASS *** patients with high anxiety levels and less education scored low on the physical component summary(PCS).In addition,the results of the mental component summary(MCS)were associated with reduced *** with older transplant patients,TX patients’PCS scores were lower,and depression,stress,and negative working conditions were highly correlated with MCS *** The findings of this study revealed notable connections between well-being and mental turmoil experienced by individuals undergoing HD and *** PCS of HD patients is affected by heightened levels of anxiety and lower educational attainment,while the MCS of transplant patients is influenced by advancing age and elevated stress *** insights will contribute to a more comprehensive understanding of patient support.

关键词： Anxiety Depression End-stage renal disease Hemodialysis Patient Reported Outcome Measures Psychological distress Quality of life Renal replacement therapy outcomes Saudi Arabia Stress

Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad ibrahim Devinder Kaur Ajit Singh Arimi Fitri Mat Ludin Noor ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

Drug Use and Abuse among Orthopedic Ward Patients—A Revolving Cycle of Menace in Atbuth, Bauchi

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Journal of Biosciences and Medicines 2024年第9期12卷 13-20页

作者： Yusuf Stephen Shaphat Shuaibu ibrahim Timothy Emuan Buhari Abdullahi Zailani Bukar Shehu Aminu Umar Shirama Yakubu Bababa ibrahim Babangida Hussaini Blessing Eneh Vincent Department of Orthoepaedics and Trauma Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria Department of Radiology Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria Department of Nursing Abubakar Tafawa Balewa University Teaching Hospital Bauchi Nigeria

Background: The use of drugs for purposes other than those for which they are meant to be used or in excess amounts. Psychoactive drugs are some of the drugs more commonly abused, also, antibiotics and other medications too can be misused. Drug abuse and misuse can lead to serious social, medical and emotional harm to the patients, and antibiotic resistance that makes treatment harder are also likely complications. Method: Patients in both male and female wards of the Orthoepaedics Department of ATBUTH, Bauchi were interviewed using a structured questionnaire and their responses were recorded and data were analyzed using the SPSS version 29. Results: A total of 112 patients were interviewed, 76 males and 36 females. Thirty-two (28.6%) patients had taken various kinds of unprescribed medications while on admission: 9 patients had taken unprescribed tramadol, 4 patients had taken codeine, 6 Ampiclox, 5 flagyl and about 8 patients had taken different kinds of traditional medications while on admission. Among the 32 patients, 23 (72%) are aged less than 30 years, 5 (16%) are aged between 30 and 50 years and 4 (12%) are aged above 50 years. Sixteen (50%) had such medications brought to them by relatives or friends, 10 (30%) were given by other patients on admission, 5 (15%) brought or bought the drugs by themselves while 1 (5%) were given by a non-clinical staff of the hospital. Conclusion: Drug misuse and abuse is a very serious, deleterious practice with destructive consequences in its wake, such consequences as drug dependency with all its antecedent effects, antibiotic resistance and difficulties in controlling/managing infections are but a few. So, it’s very important to both educate patients about these terrible practices and cope with the spread of them in our wards and hospitals.

关键词： Drug Abuse Misuse Dependency Resistance

Frequency of Rotavirus among under 5 Children Admitted to Wad Madani Pediatric Teaching Hospital with Diarrhea, Gezira State, Sudan (2021-2022)

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Open Journal of Medical Microbiology 2024年第3期14卷 206-214页

作者： Rehab ibrahim Ali Babekir Adil Mergani Babiker Bakri Yosif Mohamed Nour Department of Microbiology Faculty of Medical Laboratory Science University of Gezira Wad Medani Sudan National Cancer Institute University of Gezira Wad Medani Sudan Department of Medical Parasitology Faculty of Medical Laboratory Science University of Gezira Wad Medani Sudan

Rotavirus is the leading cause of acute gastroenteritis and responsible for 20% of death in children under 5 years of age approximately 111 million episodes of gastroenteritis due to Rotavirus in under 5 children, which result in 25 million visits to clinic, 2 million hospitalization and 352,000 - 592,000 deaths. Children in the poorest countries account 82% of rotaviruses death. Diarrhea disease are major cause of death and disease among children under five years, a child on average suffers 2 to 3 attacks of diarrhea every year. Stools samples were collected from 196 children suffering from diarrhea and were tested for rotaviruses by immune chromatography test antigen (ICT-Ag), ELISA and RT PCR The data were analyzed using statistical package for the Social Sciences (SPSS). The results showed that prevalence of rotavirus was 26/196 (13.3%) by ICT Ag and ELISA and confirmed by RT-PC R. 87.8% of the children were vaccinated by Rota vaccine, 70% of their mothers not using soap for cleaning the children and thought diarrhea not infectious disease and believed it was caused by teething. In conclusion there was a decrease in prevalence of diarrhea by Rotavirus due to insertion of Rota vaccine in routine vaccination, rotavirus infection mostly occurs in poor family that not able to provide safe water and due to poor sanitation and low education of mother beside that some children suffered from malnutrition, so it recommended to incorporate ELISA as a diagnostic tool in routine diagnosis of rotavirus among children suffered from gastroenteritis.

关键词： Diarrhea Rotavirus Under 5 Laboratory Diagnosis Sudan