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Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa M. Hamed Khaled M. EL-Shahat Aliaa Mahmoud Mahmoud Abdallah ibraheem haggag Emad Moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of Medical Physics Al Azhar University Cairo Egypt Department of Medical Physics International Medical Center (IMC) Cairo Egypt Department of Medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain Metastases PTV

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Radiotherapy to the Left Breast with 3DCRT, IMRT or VMAT: International Medical Center Experience

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Journal of Cancer Therapy 2021年第3期12卷 107-115页

作者： Hany S. Attallah Radwa M. Hamed Haytham A. Abdelkader Mahmoud M. Abdallah Aliaa Mahmoud ibraheem haggag Bassam E. Makram Ahmed M. El-Saeed Department of Radiation Oncology Inattentional Medical Center Cairo Egypt Department of Radiation Oncology Helwan University Cairo Egypt

Radiation therapy after conservative breast surgery is an integral part of the treatment of early breast cancer. The aim of radiotherapy is to achieve the best coverage of the Planning Target Volume (PTV), while reducing the dose to the Organs at Risk (OAR). Such goals are not always achievable with the conformal three dimensions plans (3DCRT). Recently, radiation oncologist uses Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) for irradiating the breast. In this study, we compared 3DCRT, IMRT and VMAT for left breast cancer patients in terms of PTV coverage, OAR. We

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Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

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Journal of Cancer Therapy（癌症治疗） 2024年第7期 265页

作者： Hany S.Attallah Radwa M.Hamed Khaled M.EL-Shahat Aliaa Mahmoud Mahmoud Abdallah ibraheem haggag Emad Moustafa Adel Yassin

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